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Original Article

Investigation of coated whey protein/alginate beads as sustained release dosage form in simulated gastrointestinal environment

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Pages 1103-1112 | Received 18 Aug 2008, Accepted 26 Jan 2009, Published online: 19 May 2009

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Read on this site (5)

Gislaine Ferreira Nogueira, Ana Silvia Prata & Carlos Raimundo Ferreira Grosso. (2017) Alginate and whey protein based-multilayered particles: production, characterisation and resistance to pH, ionic strength and artificial gastric/intestinal fluid. Journal of Microencapsulation 34:2, pages 151-161.
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Catarina Pinto Reis, Luís Vasques Roque, Marina Baptista & Patrícia Rijo. (2016) Innovative formulation of nystatin particulate systems in toothpaste for candidiasis treatment. Pharmaceutical Development and Technology 21:3, pages 282-287.
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Géraldine Hébrard, Valérie Hoffart, Jean-Michel Cardot, Muriel Subirade & Eric Beyssac. (2013) Development and characterization of coated-microparticles based on whey protein/alginate using the Encapsulator device. Drug Development and Industrial Pharmacy 39:1, pages 128-137.
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Tin Wui Wong & Harjoh Nurulaini. (2012) Sustained-release alginate-chitosan pellets prepared by melt pelletization technique. Drug Development and Industrial Pharmacy 38:12, pages 1417-1427.
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Antonio Moroni, William Drefko & Gerard Thone. (2011) Formulations of zero-order, pH-dependent, sustained release matrix systems by ionotropic gelation of alginate-containing mixtures. Drug Development and Industrial Pharmacy 37:2, pages 216-224.
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Articles from other publishers (18)

Davide Pedrali, Alessio Scarafoni, Anna Giorgi & Vera Lavelli. (2023) Binary Alginate-Whey Protein Hydrogels for Antioxidant Encapsulation. Antioxidants 12:6, pages 1192.
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Cuina Wang, Ru Zhao, Keyi He, Siyu Zhang, Alyssa H. Kemp & Mingruo Guo. (2023) Pharmacokinetic profile and sub-chronic toxicity of coenzyme Q10 loaded whey protein nanoparticles. Food Bioscience 52, pages 102347.
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Amos Nussinovitch & Madoka Hirashima. 2023. Use of Hydrocolloids to Control Food Appearance, Flavor, Texture, and Nutrition. Use of Hydrocolloids to Control Food Appearance, Flavor, Texture, and Nutrition 192 229 .
Ce Wang, Jia Wang, Yonghai Sun, Kalev Freeman, Monique Alyssa Mchenry, Cuina Wang & Mingruo Guo. (2022) Enhanced Stability and Oral Bioavailability of Cannabidiol in Zein and Whey Protein Composite Nanoparticles by a Modified Anti-Solvent Approach. Foods 11:3, pages 376.
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Md Saiful Islam, Joshua Reineke, Radhey Kaushik, Tofuko Woyengo, Aravind Baride, Mohammed S. Alqahtani & Omathanu Perumal. (2019) Bioadhesive Food Protein Nanoparticles as Pediatric Oral Drug Delivery System. ACS Applied Materials & Interfaces 11:20, pages 18062-18073.
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Hassana Hsein, Ghislain Garrait, Muhammad Ashraful Mumin, Eric Beyssac & Valérie Hoffart. (2017) Atomization of denatured whey proteins as a novel and simple way to improve oral drug delivery system properties. International Journal of Biological Macromolecules 105, pages 801-809.
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M. Zandi. (2017) Evaluation of the Kinetics of Ascorbic Acid (AA) Release from Alginate-Whey Protein Concentrates (AL-WPC) Microspheres at the Simulated Gastro-Intestinal Condition. Journal of Food Process Engineering 40:1, pages e12334.
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Hassana Hsein, Ghislain Garrait, Fahima Tamani, Eric Beyssac & Valérie Hoffart. (2016) Denatured Whey Protein Powder as a New Matrix Excipient: Design and Evaluation of Mucoadhesive Tablets for Sustained Drug Release Applications. Pharmaceutical Research 34:2, pages 365-377.
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Fatoumata Diarrassouba, Ghislain Garrait, Gabriel Remondetto & Muriel Subirade. 2017. Engineering Foods for Bioactives Stability and Delivery. Engineering Foods for Bioactives Stability and Delivery 199 224 .
Hassana Hsein, Ghislain Garrait, Eric Beyssac & Valérie Hoffart. (2015) Whey protein mucoadhesive properties for oral drug delivery: Mucin–whey protein interaction and mucoadhesive bond strength. Colloids and Surfaces B: Biointerfaces 136, pages 799-808.
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Y. Zhang, J. Gong, H. Yu, Q. Guo, C. Defelice, M. Hernandez, Y. Yin & Q. Wang. (2014) Alginate-whey protein dry powder optimized for target delivery of essential oils to the intestine of chickens. Poultry Science 93:10, pages 2514-2525.
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Marta Tomczyńska-Mleko & Stanisław Mleko. (2014) Whey protein aerated gels as matrices for controlled mineral release in simulated gastric conditions. Food Research International 62, pages 91-97.
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S. Wichchukit, M.H. Oztop, M.J. McCarthy & K.L. McCarthy. (2013) Whey protein/alginate beads as carriers of a bioactive component. Food Hydrocolloids 33:1, pages 66-73.
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Emmanuelle Déat-Lainé, Valérie Hoffart, Ghislain Garrait, Jean-François Jarrige, Jean-Michel Cardot, Muriel Subirade & Eric Beyssac. (2012) Efficacy of Mucoadhesive Hydrogel Microparticles of Whey Protein and Alginate for Oral Insulin Delivery. Pharmaceutical Research 30:3, pages 721-734.
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Emmanuelle Déat-Lainé, Valérie Hoffart, Jean-Michel Cardot, Muriel Subirade & Eric Beyssac. (2012) Development and in vitro characterization of insulin loaded whey protein and alginate microparticles. International Journal of Pharmaceutics 439:1-2, pages 136-144.
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S.B. Doherty, V.L. Gee, R.P. Ross, C. Stanton, G.F. Fitzgerald & A. Brodkorb. (2011) Development and characterisation of whey protein micro-beads as potential matrices for probiotic protection. Food Hydrocolloids 25:6, pages 1604-1617.
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Priya Bawa, Viness Pillay, Yahya Essop Choonara, Lisa Claire du Toit, Valence Methaius Kessy Ndesendo & Pradeep Kumar. (2011) A Composite Polyelectrolytic Matrix for Controlled Oral Drug Delivery. AAPS PharmSciTech 12:1, pages 227-238.
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Mecit H. Oztop, Moshe Rosenberg, Yael Rosenberg, Kathryn L. McCarthy & Michael J. McCarthy. (2010) Magnetic Resonance Imaging (MRI) and Relaxation Spectrum Analysis as Methods to Investigate Swelling in Whey Protein Gels. Journal of Food Science 75:8, pages E508-E515.
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