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Research Article

Application of cyclodextrins in antibody microparticles: potentials for antibody protection in spray drying

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Pages 1103-1111 | Received 05 May 2016, Accepted 06 Feb 2017, Published online: 01 Mar 2017

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Joana T. Pinto, Eva Faulhammer, Johanna Dieplinger, Michael Dekner, Christian Makert, Marco Nieder & Amrit Paudel. (2021) Progress in spray-drying of protein pharmaceuticals: Literature analysis of trends in formulation and process attributes. Drying Technology 39:11, pages 1415-1446.
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Shahriar Milani, Homa Faghihi, Abdolhosein Roulholamini Najafabadi, Mohsen Amini, Hamed Montazeri & Alireza Vatanara. (2020) Hydroxypropyl beta cyclodextrin: a water-replacement agent or a surfactant upon spray freeze-drying of IgG with enhanced stability and aerosolization. Drug Development and Industrial Pharmacy 46:3, pages 403-411.
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Articles from other publishers (22)

Dlivan Fattah Aziz, Mostafa Rostamnezhad, Kimia Azad, Yehia Ismail Khalil & Alireza Vatanara. (2023) Screening of sugars and cyclodextrins as carriers in montelukast dry powder inhalers processed by spray freeze drying. Advanced Powder Technology 34:10, pages 104152.
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Harry W. Pan, Jinlin Guo, Lingqiao Zhu, Susan W.S. Leung, Chenghai Zhang & Jenny K.W. Lam. (2023) Enhanced powder dispersion of dual-excipient spray-dried powder formulations of a monoclonal antibody and its fragment for local treatment of severe asthma. International Journal of Pharmaceutics 644, pages 123272.
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Amal Ali Elkordy, Amerah Parveen & Rita Haj-Ahmad. 2023. Formulation of Monoclonal Antibody Therapies. Formulation of Monoclonal Antibody Therapies 209 258 .
Harry W. Pan, Han Cong Seow, Jason C. K. Lo, Jinlin Guo, Lingqiao Zhu, Susan W. S. Leung, Chenghai Zhang & Jenny K. W. Lam. (2022) Spray-Dried and Spray-Freeze-Dried Powder Formulations of an Anti-Interleukin-4Rα Antibody for Pulmonary Delivery. Pharmaceutical Research 39:9, pages 2291-2304.
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Anna Lechanteur, Erwan Plougonven, Luisa Orozco, Geoffroy Lumay, Nicolas Vandewalle, Angélique Léonard & Brigitte Evrard. (2022) Engineered-inhaled particles: Influence of carbohydrates excipients nature on powder properties and behavior. International Journal of Pharmaceutics 613, pages 121319.
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Stephanie Hufnagel, Sawittree Sahakijpijarn, Chaeho Moon, Zhengrong Cui & Robert O. Williams III. (2022) The Development of Thin-Film Freezing and Its Application to Improve Delivery of Biologics as Dry Powder Aerosols. KONA Powder and Particle Journal 39:0, pages 176-192.
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Keisuke Tsumura, WeiLin Hsu, Masahiro Mimura, Aiko Horiuchi & Kentaro Shiraki. (2022) Lowering the viscosity of a high-concentration antibody solution by protein–polyelectrolyte complex. Journal of Bioscience and Bioengineering 133:1, pages 17-24.
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Heejun Park, Eun-Sol Ha & Min-Soo Kim. (2021) Surface modification strategies for high-dose dry powder inhalers. Journal of Pharmaceutical Investigation 51:6, pages 635-668.
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Helen Haixia Wu, Patrick Garidel & Blech Michaela. (2021) HP-β-CD for the formulation of IgG and Ig-based biotherapeutics. International Journal of Pharmaceutics 601, pages 120531.
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Rachel Yoon Kyung Chang, Michael Y.T. Chow, Dipesh Khanal, Donghao Chen & Hak-Kim Chan. (2021) Dry powder pharmaceutical biologics for inhalation therapy. Advanced Drug Delivery Reviews 172, pages 64-79.
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Lorella Giovannelli, Andrea Milanesi, Elena Ugazio, Letizia Fracchia & Lorena Segale. (2021) Effect of Methyl–β–Cyclodextrin and Trehalose on the Freeze–Drying and Spray–Drying of Sericin for Cosmetic Purposes. Pharmaceuticals 14:3, pages 262.
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Jiang Liu, Xin Ding, Yupeng Fu, Cen Xiang, Yuan Yuan, Yongmin Zhang & Peng Yu. (2021) Cyclodextrins based delivery systems for macro biomolecules. European Journal of Medicinal Chemistry 212, pages 113105.
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Sarun Tuntarawongsa, Nutdanai Lertsuphotvanit, Jongjan Mahadlek & Thawatchai Phaechamud. (2021) Beta-cyclodextrin-based in situ forming micro-particle for intra-periodontal pocket antimicrobial drug delivery. Materials Today: Proceedings 47, pages 3430-3435.
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Michael Y.T. Chow, Rachel Yoon Kyung Chang & Hak-Kim Chan. (2021) Inhalation delivery technology for genome-editing of respiratory diseases. Advanced Drug Delivery Reviews 168, pages 217-228.
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Sabya Sachi Das, P.R.P. Verma, Shubhankar Kumar Singh, Neeru Singh & Sandeep Kumar Singh. 2021. Handbook of Analytical Quality by Design. Handbook of Analytical Quality by Design 71 85 .
Júlia Domján, Panna Vass, Edit Hirsch, Edina Szabó, Eszter Pantea, Sune K. Andersen, Tamás Vigh, Geert Verreck, György Marosi & Zsombor K. Nagy. (2020) Monoclonal antibody formulation manufactured by high-speed electrospinning. International Journal of Pharmaceutics 591, pages 120042.
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Wanling Liang, Harry W. Pan, Driton Vllasaliu & Jenny K. W. Lam. (2020) Pulmonary Delivery of Biological Drugs. Pharmaceutics 12:11, pages 1025.
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Pablo F. Garrido, Martín Calvelo, Alexandre Blanco-González, Uxía Veleiro, Fabián Suárez, Daniel Conde, Alfonso Cabezón, Ángel Piñeiro & Rebeca Garcia-Fandino. (2020) The Lord of the NanoRings: Cyclodextrins and the battle against SARS-CoV-2. International Journal of Pharmaceutics 588, pages 119689.
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Marina Lomónaco, Mariana Sowul, Gerónimo Gutiérrez, Dario Malacari, Irene Álvarez, Natalia Gabriela Porta, Osvaldo Zabal & Karina Trono. (2020) Efficacy of the spray-drying treatment to inactivate the bovine leukemia virus in bovine colostrum. Journal of Dairy Science 103:7, pages 6504-6510.
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Anna Lechanteur & Brigitte Evrard. (2020) Influence of Composition and Spray-Drying Process Parameters on Carrier-Free DPI Properties and Behaviors in the Lung: A review. Pharmaceutics 12:1, pages 55.
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Fakhrossadat Emami, Alireza Vatanara, Faezeh Vakhshiteh, Yejin Kim, Tae Wan Kim & Dong Hee Na. (2019) Amino acid-based stable adalimumab formulation in spray freeze-dried microparticles for pulmonary delivery. Journal of Drug Delivery Science and Technology 54, pages 101249.
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Maryam Amini Pouya, Behnaz Daneshmand, Shabnam Aghababaie, Homa Faghihi & Alireza Vatanara. (2018) Spray-Freeze Drying: a Suitable Method for Aerosol Delivery of Antibodies in the Presence of Trehalose and Cyclodextrins. AAPS PharmSciTech 19:5, pages 2247-2254.
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