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Research Article

Formulation optimization and the absorption mechanisms of nanoemulsion in improving baicalin oral exposure

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Pages 266-275 | Received 20 Jan 2017, Accepted 09 Oct 2017, Published online: 26 Oct 2017

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Jie Yang, Kailing Li, Dan He, Jing Gu, Jingyu Xu, Jiaxi Xie, Min Zhang, Yuying Liu, Qunyou Tan & Jingqing Zhang. (2020) Toward a better understanding of metabolic and pharmacokinetic characteristics of low-solubility, low-permeability natural medicines. Drug Metabolism Reviews 52:1, pages 19-43.
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Qian Xu, An Zhou, Hongfei Wu & Yujie Bi. (2019) Development and in vivo evaluation of baicalin-loaded W/O nanoemulsion for lymphatic absorption. Pharmaceutical Development and Technology 24:9, pages 1155-1163.
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Siyu Song, Lu Ding, Guangwen Liu, Tian Chen, Meiru Zhao, Xueyan Li, Min Li, Hongyu Qi, Jinjin Chen, Ziyuan Wang, Ying Wang, Jing Ma, Qi Wang, Xiangyan Li & Zeyu Wang. (2023) The protective effects of baicalin for respiratory diseases: an update and future perspectives. Frontiers in Pharmacology 14.
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Jilin Wang, Xiaojiao Feng, Ziwei Li, Yiting Liu, Wenzhuo Yang, Tingen Zhang, Pan Guo, Zhidong Liu, Dongli Qi & Jiaxin Pi. (2023) The Flavonoid Components of Scutellaria baicalensis: Biopharmaceutical Properties and their Improvement using Nanoformulation Techniques. Current Topics in Medicinal Chemistry 23:1, pages 17-29.
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María Carpena Rodriguez, Cristina Caleja, Bernabe Nuñez-Estevez, Eliana Pereira, Maria Fraga-Corral, Filipa S. Reis, Jesus Simal-Gandara, Isabel C.F.R. Ferreira, Miguel A. Prieto & Lillian Barros. 2022. Natural Food Additives. Natural Food Additives.
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Dalia O. Saleh, Maha Nasr, Azza Hassan, Sally A. El‐Awdan & Gehad A. Abdel Jaleel. (2022) Curcumin nanoemulsion ameliorates brain injury in diabetic rats. Journal of Food Biochemistry 46:7.
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Morgane Renault–Mahieux, Nathalie Mignet, Johanne Seguin, Khair Alhareth, Muriel Paul & Karine Andrieux. (2022) Co–encapsulation of flavonoids with anti–cancer drugs: A challenge ahead. International Journal of Pharmaceutics 623, pages 121942.
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Alaa Ibrahim, Maha Nasr & Ibrahim M. El-Sherbiny. (2022) Baicalin as an emerging magical nutraceutical molecule: Emphasis on pharmacological properties and advances in pharmaceutical delivery. Journal of Drug Delivery Science and Technology 70, pages 103269.
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Maha Nasr, Hend Abd-Allah, Omar A H Ahmed-Farid, Rofanda M Bakeer, Nabila S Hassan & Rania F Ahmed. (2022) A comparative study between curcumin and curcumin nanoemulsion on high-fat, high-fructose diet-induced impaired spermatogenesis in rats. Journal of Pharmacy and Pharmacology 74:2, pages 268-281.
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Samar A Rizk, Manal A Elsheikh, Yosra S R Elnaggar & Ossama Y Abdallah. (2021) Novel bioemulsomes for baicalin oral lymphatic targeting: development, optimization and pharmacokinetics. Nanomedicine 16:22, pages 1983-1998.
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Oi Jin Tan, Hooi Leong Loo, Gayathiri Thiagarajah, Uma Devi Palanisamy & Usha Sundralingam. (2021) Improving oral bioavailability of medicinal herbal compounds through lipid-based formulations – A Scoping Review. Phytomedicine 90, pages 153651.
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Priyanka Pandya, Prabhanjan Giram, Ritesh P. Bhole, Hsin-I Chang & Sushil Y. Raut. (2021) Nanocarriers based oral lymphatic drug targeting: Strategic bioavailability enhancement approaches. Journal of Drug Delivery Science and Technology 64, pages 102585.
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Zichen Zhang, Yi Lu, Jianping Qi & Wei Wu. (2021) An update on oral drug delivery via intestinal lymphatic transport. Acta Pharmaceutica Sinica B 11:8, pages 2449-2468.
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Kunwei Li, Yiyu Liang, Ao Cheng, Qi Wang, Ying Li, Haocheng Wei, Changzheng Zhou & Xinhuan Wan. (2021) Antiviral Properties of Baicalin: a Concise Review. Revista Brasileira de Farmacognosia 31:4, pages 408-419.
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Fanyu Zeng, Dandan Wang, Yan Tian, Min Wang, Rui Liu, Zhining Xia & Yike Huang. (2021) Nanoemulsion for Improving the Oral Bioavailability of Hesperetin: Formulation Optimization and Absorption Mechanism. Journal of Pharmaceutical Sciences 110:6, pages 2555-2561.
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Shilpi Singh, Abha Meena & Suaib Luqman. (2021) Baicalin mediated regulation of key signaling pathways in cancer. Pharmacological Research 164, pages 105387.
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Ashok Kumar Jangid, Poonam Jain, Kanakaraju Medicherla, Deep Pooja & Hitesh Kulhari. (2020) Solid-state properties, solubility, stability and dissolution behaviour of co-amorphous solid dispersions of baicalin. CrystEngComm 22:37, pages 6128-6136.
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Shimon Ben-Shabat, Ludmila Yarmolinsky, Daniel Porat & Arik Dahan. (2019) Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies. Drug Delivery and Translational Research 10:2, pages 354-367.
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Juanjuan Zhao, Jun Yang & Yan Xie. (2019) Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: An overview. International Journal of Pharmaceutics 570, pages 118642.
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Robert Ancuceanu, Mihaela Dinu, Cristina Dinu-Pirvu, Valentina Anuţa & Vlad Negulescu. (2019) Pharmacokinetics of B-Ring Unsubstituted Flavones. Pharmaceutics 11:8, pages 370.
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Thi Nhu Quynh Phan, Iram Shahzadi & Andreas Bernkop-Schnürch. (2019) Hydrophobic ion-pairs and lipid-based nanocarrier systems: The perfect match for delivery of BCS class 3 drugs. Journal of Controlled Release 304, pages 146-155.
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Panpan Song, Changjiangsheng Lai, Junbo Xie & Yanqing Zhang. (2019) The preparation and investigation of spinosin–phospholipid complex self-microemulsifying drug delivery system based on the absorption characteristics of spinosin. Journal of Pharmacy and Pharmacology 71:6, pages 898-909.
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Ting Huang, Yanan Liu & Chengliang Zhang. (2018) Pharmacokinetics and Bioavailability Enhancement of Baicalin: A Review. European Journal of Drug Metabolism and Pharmacokinetics 44:2, pages 159-168.
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