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Drug Development and Industrial Pharmacy Volume 44, 2018 - Issue 3
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Research Article

A step forward towards the development of stable freeze-dried liposomes: a quality by design approach (QbD)

Bianca SylvesterDepartment of Pharmaceutical Technology and Biopharmaceutics, University of Medicine and Pharmacy ‘Iuliu Haţieganu’, Cluj-Napoca, Romania; View further author information
,
Alina PorfireDepartment of Pharmaceutical Technology and Biopharmaceutics, University of Medicine and Pharmacy ‘Iuliu Haţieganu’, Cluj-Napoca, Romania; Correspondence[email protected]
View further author information
,
Marcela AchimDepartment of Pharmaceutical Technology and Biopharmaceutics, University of Medicine and Pharmacy ‘Iuliu Haţieganu’, Cluj-Napoca, Romania; View further author information
,
Lucia RusDepartment of Drug Analysis, University of Medicine and Pharmacy ‘Iuliu Haţieganu’, Cluj-Napoca, RomaniaView further author information
&
Ioan TomuţăDepartment of Pharmaceutical Technology and Biopharmaceutics, University of Medicine and Pharmacy ‘Iuliu Haţieganu’, Cluj-Napoca, Romania; ORCID Iconhttp://orcid.org/0000-0002-5094-008XView further author information
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Pages 385-397 | Received 08 May 2017, Accepted 13 Oct 2017, Published online: 08 Nov 2017

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Gloria Clua-Palau, Enric Jo, Sasha Nikolic, Jordi Coello & Santiago Maspoch. (2020) Robust freeze-drying process re-design of a legacy product based on risk analysis and design of experiments. Drug Development and Industrial Pharmacy 46:12, pages 2022-2031.
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Articles from other publishers (20)

Teona Paresishvili & Zurab Kakabadze. (2023) Freeze‐Dried Mesenchymal Stem Cells: From Bench to Bedside. Review. Advanced Biology.
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Ruth M. Galindo-Camacho, Isabel Haro, María J. Gómara, Marta Espina, Joel Fonseca, Carlos Martins-Gomes, Antoni Camins, Amélia M. Silva, María L. García & Eliana B. Souto. (2023) Cell penetrating peptides-functionalized Licochalcone-A-loaded PLGA nanoparticles for ocular inflammatory diseases: Evaluation of in vitro anti-proliferative effects, stabilization by freeze-drying and characterization of an in-situ forming gel. International Journal of Pharmaceutics 639, pages 122982.
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Pinaki Ghosh & Probir Kumar Ghosh. 2023. Liposomal Encapsulation in Food Science and Technology. Liposomal Encapsulation in Food Science and Technology 255 268 .
Walhan Alshaer, Hamdi Nsairat, Zainab Lafi, Omar M. Hourani, Abdulfattah Al-Kadash, Ezaldeen Esawi & Alaaldin M. Alkilany. (2022) Quality by Design Approach in Liposomal Formulations: Robust Product Development. Molecules 28:1, pages 10.
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Sang-Ho Lee, Jin-Ki Kim, Jun-Pil Jee, Dong-Jin Jang, Young-Joon Park & Joo-Eun Kim. (2022) Quality by Design (QbD) application for the pharmaceutical development process. Journal of Pharmaceutical Investigation 52:6, pages 649-682.
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Daniela M. Zagalo, Branca M.A. Silva, Cláudia Silva, Sérgio Simões & João José Sousa. (2022) A quality by design (QbD) approach in pharmaceutical development of lipid-based nanosystems: A systematic review. Journal of Drug Delivery Science and Technology 70, pages 103207.
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Hadel A. Abo El-Enin, Marwa F. Ahmed, Ibrahim A. Naguib, Shaymaa W. El-Far, Mohammed M. Ghoneim, Izzeddin Alsalahat & Hend Mohamed Abdel-Bar. (2022) Utilization of Polymeric Micelles as a Lucrative Platform for Efficient Brain Deposition of Olanzapine as an Antischizophrenic Drug via Intranasal Delivery. Pharmaceuticals 15:2, pages 249.
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Bhupinder Singh, Teenu Sharma, Ranjot Kaur, Sumant Saini, Ripandeep Kaur & Sarwar Beg. 2022. Biomedical Translational Research. Biomedical Translational Research 315 350 .
Dina O. Helal, Nadia Rouatbi, Shunping Han, Julie Tzu-Wen Wang, Adam A. Walters, Mona M.A. Abdel-Mottaleb, Amany O. Kamel, Ahmed-Shawky Geneidi, Gehanne A.S. Awad & Khuloud T. Al-Jamal. (2021) A natural protein based platform for the delivery of Temozolomide acid to glioma cells. European Journal of Pharmaceutics and Biopharmaceutics 169, pages 297-308.
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Arto Merivaara, Jacopo Zini, Elle Koivunotko, Sami Valkonen, Ossi Korhonen, Francisco M. Fernandes & Marjo Yliperttula. (2021) Preservation of biomaterials and cells by freeze-drying: Change of paradigm. Journal of Controlled Release 336, pages 480-498.
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Zsófia Németh, Edina Pallagi, Dorina Gabriella Dobó, Gábor Kozma, Zoltán Kónya & Ildikó Csóka. (2021) An Updated Risk Assessment as Part of the QbD-Based Liposome Design and Development. Pharmaceutics 13:7, pages 1071.
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Hend Mohamed Abdel‐Bar, Adam A. Walters, Julie Tzu‐Wen Wang & Khuloud T. Al‐Jamal. (2021) Combinatory Delivery of Etoposide and siCD47 in a Lipid Polymer Hybrid Delays Lung Tumor Growth in an Experimental Melanoma Lung Metastatic Model. Advanced Healthcare Materials 10:7, pages 2001853.
Crossref
Janaína Artem Ataide, Danilo Costa Geraldes, Eloah Favero Gérios, Fernanda Mazon Bissaco, Letícia Caramori Cefali, Laura Oliveira-Nascimento & Priscila Gava Mazzola. (2021) Freeze-dried chitosan nanoparticles to stabilize and deliver bromelain. Journal of Drug Delivery Science and Technology 61, pages 102225.
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Poonam Negi, Chetna Hemrajani & Shweta Agarwal. 2021. Design of Experiments for Pharmaceutical Product Development. Design of Experiments for Pharmaceutical Product Development 129 150 .
Mohamed Hamdi, Hend Mohamed Abdel-Bar, Enas Elmowafy, Khuloud T. Al-Jamal & Gehanne A. S. Awad. (2020) An integrated vitamin E-coated polymer hybrid nanoplatform: A lucrative option for an enhanced in vitro macrophage retention for an anti-hepatitis B therapeutic prospect. PLOS ONE 15:1, pages e0227231.
Crossref
Yuwei Wang & David W. Grainger. (2019) Lyophilized liposome-based parenteral drug development: Reviewing complex product design strategies and current regulatory environments. Advanced Drug Delivery Reviews 151-152, pages 56-71.
Crossref
Alina Porfire, Marcela Achim, Cristina Barbalata, Iulia Rus, Ioan Tomuta & Cecilia Cristea. 2019. Liposomes - Advances and Perspectives. Liposomes - Advances and Perspectives.
Alina Porfire, Ioan Tomuta, Sonia Iurian & Tibor Casian. 2019. Pharmaceutical Quality by Design. Pharmaceutical Quality by Design 193 207 .
Silvia Franzé, Francesca Selmin, Elena Samaritani, Paola Minghetti & Francesco Cilurzo. (2018) Lyophilization of Liposomal Formulations: Still Necessary, Still Challenging. Pharmaceutics 10:3, pages 139.
Crossref
Ken-ichi Izutsu. 2018. Survival Strategies in Extreme Cold and Desiccation. Survival Strategies in Extreme Cold and Desiccation 371 383 .

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