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Drug Development and Industrial Pharmacy Volume 44, 2018 - Issue 10
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Research Article

A novel co-processing method to manufacture an API for extended release formulation via formation of agglomerates of active ingredient and hydroxypropyl methylcellulose during crystallization

Tamar RosenbaumDrug Product Science and Technology, Bristol Myers Squibb, New Brunswick, NJ, USA; ORCID Iconhttp://orcid.org/0000-0003-1521-8865
ORCID Icon,
Deniz ErdemirDrug Product Science and Technology, Bristol Myers Squibb, New Brunswick, NJ, USA;
,
Shih-Ying ChangDrug Product Science and Technology, Bristol Myers Squibb, New Brunswick, NJ, USA; Correspondence[email protected]
,
Don KientzlerDrug Product Science and Technology, Bristol Myers Squibb, New Brunswick, NJ, USA;
,
Steve WangDrug Product Science and Technology, Bristol Myers Squibb, New Brunswick, NJ, USA;
,
Steven H. ChanDrug Product Science and Technology, Bristol Myers Squibb, New Brunswick, NJ, USA;
,
Jonathan BrownDrug Product Science and Technology, Bristol Myers Squibb, Moreton, UK
,
Sarah HanleyDrug Product Science and Technology, Bristol Myers Squibb, Moreton, UK
&
San KiangDrug Product Science and Technology, Bristol Myers Squibb, New Brunswick, NJ, USA;
show all
Pages 1606-1612 | Received 11 Jan 2018, Accepted 28 May 2018, Published online: 14 Aug 2018

Citations (8)

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Read on this site (1)

Prashantkumar K. Parmar, Srilaxmi G. Rao & Arvind K. Bansal. (2021) Co-processing of small molecule excipients with polymers to improve functionality. Expert Opinion on Drug Delivery 18:7, pages 907-928.
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Articles from other publishers (7)

Madhukiran R. Dhondale, Amritha G. Nambiar, Maan Singh, Abhishek R. Mali, Ashish K. Agrawal, Nalini R. Shastri, Pradeep Kumar & Dinesh Kumar. (2023) Current Trends in API Co-Processing: Spherical Crystallization and Co-Precipitation Techniques. Journal of Pharmaceutical Sciences 112:8, pages 2010-2028.
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Deniz Erdemir, John Gawel, Bereket Yohannes, Phillip Yates, Dan Tang, Khan Ha, Brian Breza, Elyse DiMaso, Admassu Abebe & Jessica Zombek. (2023) Continuous Feeding and Blending Demonstration with Co-Processed Drug Substance. Journal of Pharmaceutical Sciences 112:8, pages 2046-2056.
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Kornélia Tacsi, György Stoffán, Dorián László Galata, Éva Pusztai, Martin Gyürkés, Brigitta Nagy, Botond Szilágyi, Zsombor Kristóf Nagy, György Marosi & Hajnalka Pataki. (2023) Improvement of drug processability in a connected continuous crystallizer system using formulation additive. International Journal of Pharmaceutics 635, pages 122725.
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Fu-Cai Chen, Wen-Jun Liu, Wei-Feng Zhu, Ling-Yu Yang, Ji-Wen Zhang, Yi Feng, Liang-Shan Ming & Zhe Li. (2022) Surface Modifiers on Composite Particles for Direct Compaction. Pharmaceutics 14:10, pages 2217.
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Denise Z. L. Ng, Arif Z. Nelson, Gareth Ward, David Lai, Patrick S. Doyle & Saif A. Khan. (2022) Control of Drug-Excipient Particle Attributes with Droplet Microfluidic-based Extractive Solidification Enables Improved Powder Rheology. Pharmaceutical Research 39:2, pages 411-421.
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Luke Schenck, Deniz Erdemir, Lindsey Saunders Gorka, Jeremy M. Merritt, Ivan Marziano, Raimundo Ho, Mei Lee, Joseph Bullard, Moussa Boukerche, Steven Ferguson, Alastair J. Florence, Saif A. Khan & Changquan Calvin Sun. (2020) Recent Advances in Co-processed APIs and Proposals for Enabling Commercialization of These Transformative Technologies. Molecular Pharmaceutics 17:7, pages 2232-2244.
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Deniz Erdemir, Vivek Daftary, Mark Lindrud, David Buckley, Gregory Lane, Adriene Malsbury, Jing Tao, Nathaniel Kopp, Daniel S. Hsieh, Whitney Nikitczuk & Joshua D. Engstrom. (2019) Design and Scale-up of a Co-processing Technology to Improve Powder Properties of Drug Substances. Organic Process Research & Development 23:12, pages 2685-2698.
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