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Drug Development and Industrial Pharmacy Volume 44, 2018 - Issue 12
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Research Article

Mechanochemical preparation of kaempferol intermolecular complexes for enhancing the solubility and bioavailability

Wenhao XuNational Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China;
,
Murong WenNational Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China;
,
Jingbo YuNational Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China;
,
Qihong ZhangNational Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China;
,
Nikolay E. PolyakovInstitute of Chemical Kinetics and Combustion of Siberian Branch of Russian Academy of Sciences, Novosibirsk,Russia;
,
Alexandr V. DushkinNational Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China; ;Institute of Solid State Chemistry and Mechanochemistry, Novosibirsk,Russia;
&
Weike SuNational Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China; ;Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, PR ChinaCorrespondence[email protected]
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Pages 1924-1932 | Received 28 Nov 2017, Accepted 12 Jul 2018, Published online: 11 Sep 2018

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Dabu Zhu, Qiuqin Zhang, Yifang Chen, Minghua Xie, Jianbo Li, Shen Yao, Ming Li, Zhao Lou, Yue Cai & Xuanrong Sun. (2022) Mechanochemical preparation of triptolide-loaded self-micelle solid dispersion with enhanced oral bioavailability and improved anti-tumor activity. Drug Delivery 29:1, pages 1398-1408.
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Devendrasingh Tomar, Pankaj K. Singh, Sajidul Hoque, Sheela Modani, Anitha Sriram, Rahul Kumar, Jitender Madan, Dharmendra Khatri & Kamal Dua. (2022) Amorphous systems for delivery of nutraceuticals: challenges opportunities. Critical Reviews in Food Science and Nutrition 62:5, pages 1204-1221.
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Articles from other publishers (13)

Babafemi Siji Ajisebiola, Johnson Olaleye Oladele & Akindele Oluwatosin Adeyi. (2023) Kaempferol from Moringa oleifera demonstrated potent antivenom activities via inhibition of metalloproteinase and attenuation of Bitis arietans venom–induced toxicities. Toxicon 233, pages 107242.
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Tatiana A. Akopova, Tatiana N. Popyrina & Tatiana S. Demina. (2022) Mechanochemical Transformations of Polysaccharides: A Systematic Review. International Journal of Molecular Sciences 23:18, pages 10458.
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Mariana Colombo, Luana Roberta Michels, Helder Ferreira Teixeira & Letícia Scherer Koester. (2021) Flavonoid delivery by solid dispersion: a systematic review. Phytochemistry Reviews 21:3, pages 783-808.
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Teresa Gervasi, Antonella Calderaro, Davide Barreca, Ester Tellone, Domenico Trombetta, Silvana Ficarra, Antonella Smeriglio, Giuseppina Mandalari & Giuseppe Gattuso. (2022) Biotechnological Applications and Health-Promoting Properties of Flavonols: An Updated View. International Journal of Molecular Sciences 23:3, pages 1710.
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Zhuomin Xu, Shanshan Zheng, Xin Gao, Yulu Hong, Yue Cai, Qiuqin Zhang, Jiani Xiang, Dehui Xie, Fuxing Song, Huawei Zhang, Hong Wang & Xuanrong Sun. (2021) Mechanochemical preparation of chrysomycin A self-micelle solid dispersion with improved solubility and enhanced oral bioavailability. Journal of Nanobiotechnology 19:1.
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Wenhao Xu, Mingli Liang, Wenjing Su, Jinli Yang, Faxiang Pu, Zhangfu Xie, Kongliang Jin, Nikolay E. Polyakov, Alexander V. Dushkin & Weike Su. (2021) Self-assembled nanocapsules of celery (Apium graveolens Linn) seed oil: Mechanochemical preparation, characterization and urate-lowering activity. Journal of Drug Delivery Science and Technology 66, pages 102810.
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Yamixa Delgado, Céline Cassé, Yancy Ferrer-Acosta, Ivette J. Suárez-Arroyo, José Rodríguez-Zayas, Anamaris Torres, Zally Torres-Martínez, Daraishka Pérez, Michael J. González, Ricardo A. Velázquez-Aponte, Josué Andino, Clarissa Correa-Rodríguez, Jean C. Franco, Wandaliz Milán, Gabriela Rosario, Eddian Velázquez, Jaisy Vega, Janmary Colón & Christopher Batista. (2021) Biomedical Effects of the Phytonutrients Turmeric, Garlic, Cinnamon, Graviola, and Oregano: A Comprehensive Review. Applied Sciences 11:18, pages 8477.
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Tatiana A. Akopova, Tatiana S. Demina, Mukhamed A. Khavpachev, Tatiana N. Popyrina, Andrey V. Grachev, Pavel L. Ivanov & Alexander N. Zelenetskii. (2021) Hydrophobic Modification of Chitosan via Reactive Solvent-Free Extrusion. Polymers 13:16, pages 2807.
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Igor Lomovskiy, Aleksey Bychkov, Oleg Lomovsky & Tatiana Skripkina. (2020) Mechanochemical and Size Reduction Machines for Biorefining. Molecules 25:22, pages 5345.
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O.Yu Selyutina, E.A. Shelepova, E.D. Paramonova, L.A. Kichigina, S.S. Khalikov & N.E. Polyakov. (2020) Glycyrrhizin-induced changes in phospholipid dynamics studied by 1H NMR and MD simulation. Archives of Biochemistry and Biophysics 686, pages 108368.
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Xueni Wang, Yuting Yang, Yating An & Gang Fang. (2019) The mechanism of anticancer action and potential clinical use of kaempferol in the treatment of breast cancer. Biomedicine & Pharmacotherapy 117, pages 109086.
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Jie Ren, Yifei Lu, Yanhong Qian, Bozhou Chen, Tao Wu & Guang Ji. (2019) Recent progress regarding kaempferol for the treatment of various diseases (Review). Experimental and Therapeutic Medicine.
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Tatiana A. Akopova, Tatiana S. Demina, Georgii V. Cherkaev, Mukhamed A. Khavpachev, Kseniya N. Bardakova, Andrey V. Grachev, Leonid V. Vladimirov, Alexander N. Zelenetskii & Petr S. Timashev. (2019) Solvent-free synthesis and characterization of allyl chitosan derivatives. RSC Advances 9:36, pages 20968-20975.
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