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Drug Development and Industrial Pharmacy Volume 45, 2019 - Issue 1
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Research Article

Mechanism of enhanced oral absorption of akebia saponin D by a self-nanoemulsifying drug delivery system loaded with phospholipid complex

Yuhui WangDepartment of Pharmacology, Guilin Medical University, Guilin, China; View further author information
,
Jinyang ShenInstitute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China; View further author information
,
Xiaolin YangJiangsu Key Laboratory of Research and Development in Marine Bio-resource Pharmaceutics, Nanjing University of Chinese Medicine, Nanjing, China; ;Department of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA; View further author information
,
Ye JinPharmacy Department, Yangzhou Hospital of Traditional Chinese Medicine, Yangzhou, China; View further author information
,
Zhonglin YangState Key laboratory of natural Medicines, China Pharmaceutical University, Nanjing, China; View further author information
,
Rufeng WangDepartment of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA; ;Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Material Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Correspondence[email protected]
View further author information
,
Fuming ZhangDepartment of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA; View further author information
&
Robert J. LinhardtDepartment of Chemical and Biological Engineering, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA; ;Department of Chemistry, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA; ;Departments of Biology, Biomedical Engineering, Center for Biotechnology and Interdisciplinary Studies Rensselaer Polytechnic Institute, Troy, NY, USAView further author information
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Pages 124-129 | Received 16 Oct 2017, Accepted 15 Sep 2018, Published online: 26 Oct 2018

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Swapna Poudwal & Pravin Shende. (2022) Multi-strategic approaches for enhancing active transportation using self-emulsifying drug delivery system. Journal of Drug Targeting 30:7, pages 726-736.
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Yingpeng Tong, Qin Zhang, Wen Shi & Jianxin Wang. (2019) Mechanisms of oral absorption improvement for insoluble drugs by the combination of phospholipid complex and SNEDDS. Drug Delivery 26:1, pages 1155-1166.
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Articles from other publishers (11)

Yulin Mo, Yanjun Yang, Jingqi Zeng, Weikun Ma, Yuxin Guan, Jingxi Guo, Xiaochun Wu, Dingkun Liu, Liang Feng, Xiaobin Jia & Bing Yang. (2023) Enhancing the Biopharmacological Characteristics of Asperosaponin VI: Unveiling Dynamic Self-Assembly Phase Transitions in the Gastrointestinal Environment. International Journal of Nanomedicine Volume 18, pages 7335-7358.
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Yingpeng Tong, Wen Shi, Qin Zhang & Jianxin Wang. (2023) Preparation, Characterization, and In Vivo Evaluation of Gentiopicroside-Phospholipid Complex (GTP-PC) and Its Self-Nanoemulsion Drug Delivery System (GTP-PC-SNEDDS). Pharmaceuticals 16:1, pages 99.
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Róbert Szabó, Csaba Pál Rácz & Francisc Vasile Dulf. (2022) Bioavailability Improvement Strategies for Icariin and Its Derivates: A Review. International Journal of Molecular Sciences 23:14, pages 7519.
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P.K. Suresh. (2022) Saponins-uptake and Targeting Issues for Brain-specific Delivery for Enhanced Cell Death Induction in Glioblastoma. Letters in Drug Design & Discovery 19:6, pages 473-480.
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Jinyang Shen, Yuexia Zhu, Bingxue Zhou, Li Kong, Ye Jin, Di Zhang, Zhiling Cao, Jing Ji & Jiaojiao Li. (2021) In vitro and in vivo evaluation of a water‐in‐oil microemulsion of platycodin D. Archiv der Pharmazie 354:8, pages 2000497.
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Olusola Olalekan Elekofehinti, Opeyemi Iwaloye, Femi Olawale & Esther Opeyemi Ariyo. (2021) Saponins in Cancer Treatment: Current Progress and Future Prospects. Pathophysiology 28:2, pages 250-272.
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Song Yang, Ting Hu, He Liu, Ya-li Lv, Wen Zhang, Han Li, Lingling Xuan, Li-li Gong & Li-hong Liu. (2021) Akebia saponin D ameliorates metabolic syndrome (MetS) via remodeling gut microbiota and attenuating intestinal barrier injury. Biomedicine & Pharmacotherapy 138, pages 111441.
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Aristote B. Buya, Ana Beloqui, Patrick B. Memvanga & Véronique Préat. (2020) Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and Challenges in Oral Drug Delivery. Pharmaceutics 12:12, pages 1194.
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Naseem Akhtar, Salman A.A. Mohammed, Riaz A. Khan, Mohammad Yusuf, Varsha Singh, Hamdoon A. Mohammed, Mohsen S. Al-Omar, Ahmed A.H. Abdellatif, Mamuna Naz & Habeeb Khadri. (2020) Self-Generating nano-emulsification techniques for alternatively-routed, bioavailability enhanced delivery, especially for anti-cancers, anti-diabetics, and miscellaneous drugs of natural, and synthetic origins. Journal of Drug Delivery Science and Technology 58, pages 101808.
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Joaquin Navarro del Hierro, Vieri Piazzini, Guillermo Reglero, Diana Martin & Maria Camilla Bergonzi. (2020) In Vitro Permeability of Saponins and Sapogenins from Seed Extracts by the Parallel Artificial Membrane Permeability Assay: Effect of in Vitro Gastrointestinal Digestion. Journal of Agricultural and Food Chemistry 68:5, pages 1297-1305.
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Peipei Zhou, Xiaolin Yang, Zhonglin Yang, Wenzhe Huang, Junping Kou & Fei Li. (2019) Akebia Saponin D Regulates the Metabolome and Intestinal Microbiota in High Fat Diet-Induced Hyperlipidemic Rats. Molecules 24:7, pages 1268.
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