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Drug Development and Industrial Pharmacy Volume 45, 2019 - Issue 8
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Research Article

Drug–polymer miscibility, interactions, and precipitation inhibition studies for the development of amorphous solid dispersions for the poorly soluble anticancer drug flutamide

Anne TrivinoWilliam S. Middleton Memorial Veterans Hospital, Madison, WI, USA; View further author information
,
Ashwini GumireddySchool of Pharmacy and Health Professionals, Creighton University, Omaha, NE, USA; View further author information
,
Fan MengCollege of Pharmacy, University of Texas, Austin, TX, USA; View further author information
,
Dev PrasadFormulation and Product Development, Fresenius Kabi, Skokie, IL, USA; View further author information
&
Harsh ChauhanSchool of Pharmacy and Health Professionals, Creighton University, Omaha, NE, USACorrespondence[email protected]
View further author information
Pages 1277-1291 | Received 14 Jul 2018, Accepted 03 Apr 2019, Published online: 21 May 2019

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Fan Meng, Sagar Kumar Paul, Shambhavi Borde & Harsh Chauhan. (2021) Investigating crystallization tendency, miscibility, and molecular interactions of drug–polymer systems for the development of amorphous solid dispersions. Drug Development and Industrial Pharmacy 47:4, pages 579-608.
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Pei Liu, Jian-yu Zhou, Jin-hua Chang, Xi-gang Liu, He-fei Xue, Ru-xing Wang, Zhong-si Li, Chun-shi Li, Jian Wang & Cui-zhe Liu. (2020) Soluplus-Mediated Diosgenin Amorphous Solid Dispersion with High Solubility and High Stability: Development, Characterization and Oral Bioavailability. Drug Design, Development and Therapy 14, pages 2959-2975.
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Prashanth Reddy Kolimi, Amruta Prabhakar Padakanti, Naveen Kolagani, Srikanth Ponneganti, Vijayakumar Gangipangi, Sudhagar Selvaraju, Radhakrishnanand Pullapanthula, Amit Alexander & Naveen Chella. (2023) Polymeric amorphous dispersion as a carrier to enhance the in vitro dissolution in vivo pharmacokinetics and cytotoxicity of niclosamide. Polymers for Advanced Technologies 34:12, pages 3696-3710.
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Varsha Rani, Rinki Verma, Krishan Kumar & Ruchi Chawla. (2023) pH-influenced self-assembled stealth nanoscaffolds encapsulating memantine for treatment of Alzheimer’s disease. Journal of Biosciences 48:3.
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Guillermo Tejada, Natalia L. Calvo, Mauro Morri, Maximiliano Sortino, Celina Lamas, Vera A. Álvarez & Darío Leonardi. (2023) Miconazole Nitrate Microparticles in Lidocaine Loaded Films as a Treatment for Oropharyngeal Candidiasis. Materials 16:9, pages 3586.
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MUQDAM MAHDI MOHAMAD ALI ALALI, JINAN M. AL-MOUSAWY, ZAHRAA MOHAMMED KADHIM & JAMAL ALI ASHOOR. (2023) IMPROVING SOLUBILITY OF METHOTREXATE BY SOLID DISPERSION. International Journal of Applied Pharmaceutics, pages 173-177.
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Dawid Heczko, Barbara Hachuła, Paulina Maksym, Kamil Kamiński, Andrzej Zięba, Luiza Orszulak, Marian Paluch & Ewa Kamińska. (2022) The Effect of Various Poly (N-vinylpyrrolidone) (PVP) Polymers on the Crystallization of Flutamide. Pharmaceuticals 15:8, pages 971.
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Patrícia Pereira, Arménio C. Serra & Jorge F.J. Coelho. (2021) Vinyl Polymer-based technologies towards the efficient delivery of chemotherapeutic drugs. Progress in Polymer Science 121, pages 101432.
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Samarth D. Thakore, Junia Akhtar, Ranjna Jain, Amrit Paudel & Arvind K. Bansal. (2021) Analytical and Computational Methods for the Determination of Drug-Polymer Solubility and Miscibility. Molecular Pharmaceutics 18:8, pages 2835-2866.
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Nguyen Ngoc Sao Mai, Riko Nakai, Yayoi Kawano & Takehisa Hanawa. (2020) Enhancing the Solubility of Curcumin Using a Solid Dispersion System with Hydroxypropyl-β-Cyclodextrin Prepared by Grinding, Freeze-Drying, and Common Solvent Evaporation Methods. Pharmacy 8:4, pages 203.
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G. Tejada, M. G. Barrera, P. García, M. Sortino, M. C. Lamas, V. Lassalle, V. Alvarez & D. Leonardi. (2020) Nanoparticulated Systems Based on Natural Polymers Loaded with Miconazole Nitrate and Lidocaine for the Treatment of Topical Candidiasis. AAPS PharmSciTech 21:7.
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Marta F. Simões, Alexandra Pereira, Sara Cardoso, Stephanie Cadonau, Karl Werner, Rui M. A. Pinto & Sérgio Simões. (2020) Five-Stage Approach for a Systematic Screening and Development of Etravirine Amorphous Solid Dispersions by Hot-Melt Extrusion. Molecular Pharmaceutics.
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