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Editorials

Zinc Deficiency in Humans: A Neglected Problem

, MD, PhD, MACN
Pages 542-543 | Received 01 Sep 1998, Published online: 08 Jun 2013

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Ersin Tural, Cihan Meral, Selami Suleymanoglu, Ferhan Karademir, Secil Aydinoz, Halit Özkaya, Mustafa Gültepe, Osman Metin Ipcıoglu & Ismail Gocmen. (2010) Renal Zinc Clearance/Glomerular Filtration Rate Ratio as an Indicator of Marginal Zinc Deficiency Associated with Iron Deficiency in Childhood. Journal of the American College of Nutrition 29:2, pages 107-112.
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Rama P. Tupe & Shashi A. Chiplonkar. (2009) Zinc Supplementation Improved Cognitive Performance and Taste Acuity in Indian Adolescent Girls. Journal of the American College of Nutrition 28:4, pages 388-396.
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Nazir Ahmad Dar, Mohammad Muzaffar Mir, Irfana Salam, Mushtaq Ahmad Malik, Ghulam Mohammad Gulzar, Ghulam Nabi Yatoo, Aquil Ahmad & Azra Shah. (2008) Association Between Copper Excess, Zinc Deficiency, and TP53 Mutations in Esophageal Squamous Cell Carcinoma From Kashmir Valley, India—A High Risk Area. Nutrition and Cancer 60:5, pages 585-591.
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Bruce H. Grahn, Phyllis G. Paterson, Katherine T. Gottschall-Pass & Zhen Zhang. (2001) Zinc and the Eye. Journal of the American College of Nutrition 20:2, pages 106-118.
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Articles from other publishers (36)

Emily Ho, Carmen P. Wong & Janet C. King. (2022) Impact of zinc on DNA integrity and age-related inflammation. Free Radical Biology and Medicine 178, pages 391-397.
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Farhan Rafiq, Muhammad Ijaz, Abdul Sattar, Muhammad Shahid, Ahmad Sher, Sami Ul-Allah & Anees Ur Rehman. 2022. Hazardous and Trace Materials in Soil and Plants. Hazardous and Trace Materials in Soil and Plants 15 32 .
Hugo De Groote, Masresha Tessema, Samuel Gameda & Nilupa S. Gunaratna. (2021) Soil zinc, serum zinc, and the potential for agronomic biofortification to reduce human zinc deficiency in Ethiopia. Scientific Reports 11:1.
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Mousumi Banerjee, Rohan Chawla & Atul Kumar. (2021) Antioxidant supplements in age-related macular degeneration: are they actually beneficial?. Therapeutic Advances in Ophthalmology 13, pages 251584142110304.
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J. Haribabu, S. Priyarega, N. S. P. Bhuvanesh & R. Karvembu. (2020) Synthesis and Molecular Structure of the Zinc(II) Complex Bearing an N, S Donor Ligand. Journal of Structural Chemistry 61:1, pages 66-72.
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Aysegul Yildiz, Yesim Kaya & Ozgur Tanriverdi. (2019) Effect of the Interaction Between Selenium and Zinc on DNA Repair in Association With Cancer Prevention. Journal of Cancer Prevention 24:3, pages 146-154.
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Christina E. Kostara, Panagiotis Lekkas, Patra Vezyraki, Charalampos Angelidis, Ioannis-Konstantinos Deligiannis, Eleni T. Bairaktari & Vasiliki Kalfakakou. (2018) Lipidome of plasma lipoproteins and liver is zinc- modulated in High fat diet treated mice. Journal of Trace Elements in Medicine and Biology 50, pages 268-275.
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Milos V. Nikolic, Marina Z. Mijajlovic, Dusan Lj. Tomovic, Andriana M. Bukonjic, Verica V. Jevtic, Zoran R. Ratkovic, Srecko R. Trifunovic & Gordana P. Radic. (2018) Synthesis and Characterization of Zinc(II)-Complexes with S-Alkyl Derivatives of Thiosalicylic Acid. Serbian Journal of Experimental and Clinical Research 19:2, pages 113-117.
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Anjana Kuldeep, Neena Nair & Ranveer Singh Bedwal. (2016) Tracing of Zinc Nanocrystals in the Anterior Pituitary of Zinc-Deficient Wistar Rats. Biological Trace Element Research 177:2, pages 316-322.
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V. Sloup, Ivana Jankovská, S. Nechybová, P. Peřinková & I. Langrová. (2017) Zinc in the Animal Organism: A Review. Scientia Agriculturae Bohemica 48:1, pages 13-21.
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Bamini Gopinath. 2016. Molecular Basis of Nutrition and Aging. Molecular Basis of Nutrition and Aging 433 446 .
Arturo Jiménez-Sánchez, Benjamín Ortíz, Vianney Ortiz Navarrete, Norberto Farfán & Rosa Santillan. (2015) Two fluorescent Schiff base sensors for Zn 2+ : the Zn 2+ /Cu 2+ ion interference . The Analyst 140:17, pages 6031-6039.
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Bartosz Pula, Tadeusz Tazbierski, Aleksandra Zamirska, Bozena Werynska, Andrzej Bieniek, Jacek Szepietowski, Janusz Rys, Piotr Dziegiel & Marzena Podhorska-Okolow. (2014) Metallothionein 3 Expression in Normal Skin and Malignant Skin Lesions. Pathology & Oncology Research 21:1, pages 187-193.
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JM Anchordoquy, JP Anchordoquy, MA Sirini, SJ Picco, P Peral-García & CC Furnus. (2014) The Importance of Having Zinc During In Vitro Maturation of Cattle Cumulus-Oocyte Complex: Role of Cumulus Cells . Reproduction in Domestic Animals 49:5, pages 865-874.
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Ubaid H. Shah, Amani K. Abu-Shaheen, Mohammad A. Malik, Seema Alam, Muhammad Riaz & Mohamad A. AL-Tannir. (2013) The efficacy of zinc supplementation in young children with acute lower respiratory infections: A randomized double-blind controlled trial. Clinical Nutrition 32:2, pages 193-199.
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Nidhi Rawat, Barbara Laddomada & Bikram S. Gill. 2013. Cereal Genomics II. Cereal Genomics II 247 274 .
Samina Alam & Shannon L. Kelleher. (2012) Cellular Mechanisms of Zinc Dysregulation: A Perspective on Zinc Homeostasis as an Etiological Factor in the Development and Progression of Breast Cancer. Nutrients 4:8, pages 875-903.
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Razinah Sharif, Philip Thomas, Peter Zalewski & Michael Fenech. (2012) The role of zinc in genomic stability. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 733:1-2, pages 111-121.
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Smita Gautam, Kalpana Platel & Krishnapura Srinivasan. (2011) Assessment of zinc deficiency and effect of dietary carrot, amchur and onion on zinc status during repletion in zinc‐deficient rats . Journal of the Science of Food and Agriculture 92:1, pages 165-170.
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A. Banas, K. Banas, W. M. Kwiatek, M. Gajda, B. Pawlicki & T. Cichocki. (2011) Neoplastic disorders of prostate glands in the light of synchrotron radiation and multivariate statistical analysis. JBIC Journal of Biological Inorganic Chemistry 16:8, pages 1187-1196.
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Giovanni Dinelli, Ilaria Marotti, Sara Bosi, Diana Di Gioia, Bruno Biavati & Pietro Catizone. 2009. Advances in Food Biochemistry. Advances in Food Biochemistry 239 289 .
Jairo Lisboa Rodrigues, Bruno Lemos Batista, Myriam Fillion, Carlos J.S. Passos, Donna Mergler & Fernando BarbosaJr.Jr.. (2009) Trace element levels in whole blood of riparian villagers of the Brazilian Amazon. Science of The Total Environment 407:13, pages 4168-4173.
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Ghulam Abbas Kandhro, Tasneem Gul Kazi, Hassan Imran Afridi, Naveed Kazi, Jameel Ahmed Baig, Mohammad Balal Arain, Sirajuddin, Abdul Qadir Shah, Raja Adil Sarfraz, Mohammad Khan Jamali & Nasreen Syed. (2009) Effect of zinc supplementation on the zinc level in serum and urine and their relation to thyroid hormone profile in male and female goitrous patients. Clinical Nutrition 28:2, pages 162-168.
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John H. Laity & Glen K. Andrews. (2007) Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1). Archives of Biochemistry and Biophysics 463:2, pages 201-210.
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M.T. Adewumi .C.H. Njoku .Y. Saidu .M.K. Abubakar .R.A. Shehu .L.S. Bilbis .. (2007) Serum Chromium, Copper and Manganese Levels of Diabetic Subjects in Katsina, Nigeria. Asian Journal of Biochemistry 2:4, pages 284-288.
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Somdat Mahabir, Margaret R. Spitz, Stephanie L. Barrera, Shao Hua Beaver, Carol Etzel & Michele R. Forman. (2007) Dietary zinc, copper and selenium, and risk of lung cancer. International Journal of Cancer 120:5, pages 1108-1115.
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David F Garvin, Ross M Welch & John W Finley. (2006) Historical shifts in the seed mineral micronutrient concentration of US hard red winter wheat germplasm. Journal of the Science of Food and Agriculture 86:13, pages 2213-2220.
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Jodi Dufner‐Beattie, Zhixin L. Huang, Jim Geiser, Wenhao Xu & Glen K. Andrews. (2006) Mouse ZIP1 and ZIP3 genes together are essential for adaptation to dietary zinc deficiency during pregnancy . genesis 44:5, pages 239-251.
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Ali Arslantas, A. Devrim, Neceti Kaya & Hacali Necefoglu. (2006) Studies on the Interaction between Zinc-Hydroxybenzoite Complex and Genomic DNA. International Journal of Molecular Sciences 7:4, pages 111-118.
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Russell Rising, Julio F Scaglia, Conrad Cole, Rozalia Tverskaya, Debora Duro & Fima Lifshitz. (2005) Exogenous recombinant human growth hormone effects during suboptimal energy and zinc intake. Nutrition & Metabolism 2:1.
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Liping Huang, Catherine P. Kirschke, Yunfan Zhang & Yan Yiu Yu. (2005) The ZIP7 Gene (Slc39a7) Encodes a Zinc Transporter Involved in Zinc Homeostasis of the Golgi Apparatus. Journal of Biological Chemistry 280:15, pages 15456-15463.
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Emily Ho. (2004) Zinc deficiency, DNA damage and cancer risk. The Journal of Nutritional Biochemistry 15:10, pages 572-578.
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Aruna S. Jaiswal & Satya Narayan. (2004) Zinc stabilizes adenomatous polyposis coli (APC) protein levels and induces cell cycle arrest in colon cancer cells. Journal of Cellular Biochemistry 93:2, pages 345-357.
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Fernanda KampDoris JandelImke HoenickeKlaus PietrzkRainer Gross, Nadia M.F. TrugoCarmen M. Donangelo. (2016) Bioavailability of Iron, Zinc, Folate, and Vitamin C in the Iris Multi-Micronutrient Supplement: Effect of Combination with a Milk-Based Cornstarch Porridge. Food and Nutrition Bulletin 24:3_suppl_1, pages S20-S26.
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Dae Kee Lee, Jim Geiser, Jodi Dufner-Beattie & Glen K. Andrews. (2003) Pancreatic Metallothionein-I May Play a Role in Zinc Homeostasis during Maternal Dietary Zinc Deficiency in Mice. The Journal of Nutrition 133:1, pages 45-50.
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Glen K. Andrews & Jim Geiser. (1999) Expression of the Mouse Metallothionein-I and -II Genes Provides a Reproductive Advantage during Maternal Dietary Zinc Deficiency. The Journal of Nutrition 129:9, pages 1643-1648.
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