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Articles

The Effects of Probiotic Supplementation on Gene Expression Related to Inflammation, Insulin, and Lipids in Patients With Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial

, MSc, , MD, , MD, , PhD, , MSc, , PhD & , PhD show all
Pages 660-665 | Received 13 May 2017, Accepted 22 Jun 2017, Published online: 18 Sep 2017

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Soumya Sundaram, Dinoop Korol Ponnambath & Sruthi S. Nair. 2022. Human Microbiome. Human Microbiome 147 167 .
Zakira Naureen, Saima Farooq, Tayyaba Zahoor & Syed Abdullah Gilani. 2022. Microbiome-Gut-Brain Axis. Microbiome-Gut-Brain Axis 383 399 .
Sílvia Cabré, Kenneth J. O’Riordan & John F. Cryan. 2022. Evolution, Biodiversity and a Reassessment of the Hygiene Hypothesis. Evolution, Biodiversity and a Reassessment of the Hygiene Hypothesis 339 392 .
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Crossref
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Crossref
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Crossref
Kontham Kulangara Varsha, Arun Padmakumar Maheshwari & Kesavan Madhavan Nampoothiri. (2021) Accomplishment of probiotics in human health pertaining to immunoregulation and disease control. Clinical Nutrition ESPEN 44, pages 26-37.
Crossref
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Crossref
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Crossref
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Crossref
Soudeh Ghafouri-Fard, Kasra Honarmand & Mohammad Taheri. (2021) A comprehensive review on the role of chemokines in the pathogenesis of multiple sclerosis. Metabolic Brain Disease 36:3, pages 375-406.
Crossref
Mahmoud Salami. (2021) Interplay of Good Bacteria and Central Nervous System: Cognitive Aspects and Mechanistic Considerations. Frontiers in Neuroscience 15.
Crossref
Hao-Ming Xu, Hong-Li Huang, You-Lian Zhou, Hai-Lan Zhao, Jing Xu, Di-Wen Shou, Yan-Di Liu, Yong-Jian Zhou & Yu-Qiang Nie. (2021) Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain. Gastroenterology Research and Practice 2021, pages 1-20.
Crossref
Nithin K. K, Prakash Patil, Satheesh Kumar Bhandary, Vikram Haridas, Suchetha Kumari N, Sarathkumar E & Praveenkumar Shetty. (2021) Is butyrate a natural alternative to dexamethasone in the management of CoVID-19?. F1000Research 10, pages 273.
Crossref
Jiaqi Tong, Senthil Kumaran Satyanarayanan & Huanxing Su. (2020) Nutraceuticals and probiotics in the management of psychiatric and neurological disorders: A focus on microbiota-gut-brain-immune axis. Brain, Behavior, and Immunity 90, pages 403-419.
Crossref
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Crossref
Alexandra Reiter, Susanne A. Bengesser, Anne-Christin Hauschild, Anna-Maria Birkl-Töglhofer, Frederike T. Fellendorf, Martina Platzer, Tanja Färber, Matthias Seidl, Lilli-Marie Mendel, Renate Unterweger, Melanie Lenger, Sabrina Mörkl, Nina Dalkner, Armin Birner, Robert Queissner, Carlo Hamm, Alexander Maget, Rene Pilz, Alexandra Kohlhammer-Dohr, Jolana Wagner-Skacel, Kathrin Kreuzer, Helmut Schöggl, Daniela Amberger-Otti, Theresa Lahousen, Birgitta Leitner-Afschar, Johannes Haybäck, Hans-Peter Kapfhammer & Eva Reininghaus. (2020) Interleukin-6 Gene Expression Changes after a 4-Week Intake of a Multispecies Probiotic in Major Depressive Disorder—Preliminary Results of the PROVIT Study. Nutrients 12:9, pages 2575.
Crossref
Natalie E Parks, Caitlin S Jackson-Tarlton, Laura Vacchi, Roah Merdad & Bradley C Johnston. (2020) Dietary interventions for multiple sclerosis-related outcomes. Cochrane Database of Systematic Reviews 2020:5.
Crossref
Omid Reza Tamtaji, Tooba Hadinezhad, Maryam Fallah, Arash Rezaei Shahmirzadi, Mohsen Taghizadeh, Mohammad Behnam & Zatollah Asemi. (2020) The Therapeutic Potential of Quercetin in Parkinson’s Disease: Insights into its Molecular and Cellular Regulation. Current Drug Targets 21:5, pages 509-518.
Crossref
John F Cryan, Kenneth J O'Riordan, Kiran Sandhu, Veronica Peterson & Timothy G Dinan. (2020) The gut microbiome in neurological disorders. The Lancet Neurology 19:2, pages 179-194.
Crossref
Dawood Aghamohammadi, Hormoz Ayromlou, Neda Dolatkhah, Fatemeh Jahanjoo & Seyed Kazem Shakouri. (2019) The effects of probiotic Saccharomyces boulardii on the mental health, quality of life, fatigue, pain, and indices of inflammation and oxidative stress in patients with multiple sclerosis: study protocol for a double-blind randomized controlled clinical trial. Trials 20:1.
Crossref
Mahtab Babadi, Ahmad Khorshidi, Esmat Aghadavood, Mansooreh Samimi, Elham Kavossian, Fereshteh Bahmani, Alireza Mafi, Rana Shafabakhsh, Mahbobeh Satari & Zatollah Asemi. (2018) The Effects of Probiotic Supplementation on Genetic and Metabolic Profiles in Patients with Gestational Diabetes Mellitus: a Randomized, Double-Blind, Placebo-Controlled Trial. Probiotics and Antimicrobial Proteins 11:4, pages 1227-1235.
Crossref
Mahmoud Salami, Ebrahim Kouchaki, Zatollah Asemi & Omid Reza Tamtaji. (2019) How probiotic bacteria influence the motor and mental behaviors as well as immunological and oxidative biomarkers in multiple sclerosis? A double blind clinical trial. Journal of Functional Foods 52, pages 8-13.
Crossref
Gislane Lellis Vilela de Oliveira. 2019. Microbiome and Metabolome in Diagnosis, Therapy, and other Strategic Applications. Microbiome and Metabolome in Diagnosis, Therapy, and other Strategic Applications 325 332 .
L. Mestre, F.J. Carrillo-Salinas, M. Mecha, A. Feliú & C. Guaza. (2018) Gut microbiota, cannabinoid system and neuroimmune interactions: New perspectives in multiple sclerosis. Biochemical Pharmacology 157, pages 51-66.
Crossref
Carlos R Camara-Lemarroy, Luanne M Metz & V Wee Yong. (2018) Focus on the gut-brain axis: Multiple sclerosis, the intestinal barrier and the microbiome. World Journal of Gastroenterology 24:37, pages 4217-4223.
Crossref
Azadeh Agahi, Gholam Ali Hamidi, Reza Daneshvar, Mostafa Hamdieh, Masoud Soheili, Azam Alinaghipour, Seyyed Mohammad Esmaeili Taba & Mahmoud Salami. (2018) Does Severity of Alzheimer's Disease Contribute to Its Responsiveness to Modifying Gut Microbiota? A Double Blind Clinical Trial. Frontiers in Neurology 9.
Crossref
Gislane L.V. de Oliveira. 2018. Probiotics - Current Knowledge and Future Prospects. Probiotics - Current Knowledge and Future Prospects.
Carlos R Camara-Lemarroy, Luanne Metz, Jonathan B Meddings, Keith A Sharkey & V Wee Yong. (2018) The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics. Brain 141:7, pages 1900-1916.
Crossref

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