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Journal of the American Nutrition Association Volume 41, 2022 - Issue 3
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Articles

Low Vitamin D Status at Admission as a Risk Factor for Poor Survival in Hospitalized Patients With COVID-19: An Italian Retrospective Study

Marco Infantea Department of Systems Medicine, Diabetes Research Institute Federation (DRIF), CTO Hospital ASL Roma 2, University of Rome Tor Vergata, Rome, Italy;b UniCamillus, Saint Camillus International University of Health Sciences, Rome, Italy;c Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Rome, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2032-8735
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Andrea Buosod Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy;e Infectious Disease Clinic, Tor Vergata University Hospital (PTV), Rome, ItalyORCID Iconhttps://orcid.org/0000-0001-9303-7993
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Massimo Pierif Clinical Biochemistry and Molecular Biology, Department of Experimental Medicine, Faculty of Medicine, University of Rome Tor Vergata, Rome, Italy;g Clinical Biochemistry Department, Tor Vergata University Hospital (PTV), Rome, ItalyORCID Iconhttps://orcid.org/0000-0002-3463-0268
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Santina Lupisellaf Clinical Biochemistry and Molecular Biology, Department of Experimental Medicine, Faculty of Medicine, University of Rome Tor Vergata, Rome, ItalyORCID Iconhttps://orcid.org/0000-0001-6355-6987
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Marzia Nuccetellif Clinical Biochemistry and Molecular Biology, Department of Experimental Medicine, Faculty of Medicine, University of Rome Tor Vergata, Rome, ItalyORCID Iconhttps://orcid.org/0000-0002-8702-1116
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Sergio Bernardinif Clinical Biochemistry and Molecular Biology, Department of Experimental Medicine, Faculty of Medicine, University of Rome Tor Vergata, Rome, Italy;g Clinical Biochemistry Department, Tor Vergata University Hospital (PTV), Rome, ItalyORCID Iconhttps://orcid.org/0000-0003-1984-6834
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Andrea Fabbria Department of Systems Medicine, Diabetes Research Institute Federation (DRIF), CTO Hospital ASL Roma 2, University of Rome Tor Vergata, Rome, ItalyORCID Iconhttps://orcid.org/0000-0003-2269-1554
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Marco Iannettad Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy;e Infectious Disease Clinic, Tor Vergata University Hospital (PTV), Rome, ItalyORCID Iconhttps://orcid.org/0000-0002-6938-8627
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Massimo Andreonid Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy;e Infectious Disease Clinic, Tor Vergata University Hospital (PTV), Rome, ItalyORCID Iconhttps://orcid.org/0000-0002-3205-9758
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Vittorio Colizzih UNESCO Chair of Biotechnology & Bioethics, University of Rome Tor Vergata, Rome, ItalyORCID Iconhttps://orcid.org/0000-0003-0007-8580
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Maria Morellof Clinical Biochemistry and Molecular Biology, Department of Experimental Medicine, Faculty of Medicine, University of Rome Tor Vergata, Rome, Italy;g Clinical Biochemistry Department, Tor Vergata University Hospital (PTV), Rome, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9023-1106
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Pages 250-265 | Received 31 Oct 2020, Accepted 12 Jan 2021, Published online: 18 Feb 2021

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Katherine M. DiGuilio, Elizabeth Rybakovsky, Yoongyeong Baek, Mary Carmen Valenzano & James M. Mullin. (2023) The multiphasic TNF-α-induced compromise of Calu-3 airway epithelial barrier function. Experimental Lung Research 49:1, pages 72-85.
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Armin Ebrahimzadeh, Shokouh Mohseni, Behnaz Narimani, Anahita Ebrahimzadeh, Soroosh Kazemi, Fatemeh Keshavarz, Mohammad Javad Yaghoubi & Alireza Milajerdi. (2023) Association between vitamin D status and risk of covid-19 in-hospital mortality: A systematic review and meta-analysis of observational studies. Critical Reviews in Food Science and Nutrition 63:21, pages 5033-5043.
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Marco Infante, Massimo Pieri, Santina Lupisella, Ali Mohamad, Sergio Bernardini, David Della-Morte, Andrea Fabbri, Alberto De Stefano, Marco Iannetta, Lorenzo Ansaldo, Angela Crea, Massimo Andreoni & Maria Morello. (2023) Admission eGFR predicts in-hospital mortality independently of admission glycemia and C-peptide in patients with type 2 diabetes mellitus and COVID-19. Current Medical Research and Opinion 39:4, pages 505-516.
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Mehmet Güven & Hamza Gültekin. (2022) Association of 25-Hydroxyvitamin D Level with COVID-19-Related in-Hospital Mortality: A Retrospective Cohort Study. Journal of the American Nutrition Association 41:6, pages 577-586.
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Seshadri Reddy Varikasuvu, Balachandar Thangappazham, Alekya Vykunta, Pragathi Duggina, Munikumar Manne, Hemanth Raj & Sowjanya Aloori. (2022) COVID-19 and vitamin D (Co-VIVID study): a systematic review and meta-analysis of randomized controlled trials. Expert Review of Anti-infective Therapy 20:6, pages 907-913.
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Sadaf Jamal Gilani, May Nasser Bin-Jumah, Muhammad Shahid Nadeem & Imran Kazmi. (2022) Vitamin D attenuates COVID-19 complications via modulation of proinflammatory cytokines, antiviral proteins, and autophagy. Expert Review of Anti-infective Therapy 20:2, pages 231-241.
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Articles from other publishers (21)

Elizabeth Rybakovsky, Katherine M. DiGuilio, Mary Carmen Valenzano, Sophie Geagan, Kaithlyn Pham, Ronald N. Harty & James M. Mullin. (2023) Calcitriol modifies tight junctions, improves barrier function, and reduces TNF‐α‐induced barrier leak in the human lung‐derived epithelial cell culture model, 16HBE 14o‐ . Physiological Reports 11:7.
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Annamaria D’Alessandro, Domenico Ciavardelli, Anna Pastore, Santina Lupisella, Rosa Carmela Cristofaro, Giovina Di Felice, Roberta Salierno, Marco Infante, Alberto De Stefano, Andrea Onetti Muda, Maria Morello & Ottavia Porzio. (2023) Contribution of vitamin D3 and thiols status to the outcome of COVID-19 disease in Italian pediatric and adult patients. Scientific Reports 13:1.
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K. A. Golovatyuk, A. A. Mikhailova, D. I. Lagutina, A. T. Chernikova & T. L. Karonova. (2023) 100 years of vitamin D. The impact of vitamin D level in the time of COVID-19 pandemic. Russian Journal for Personalized Medicine 2:6, pages 33-41.
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Neven Sarhan, Ahmed E. Abou Warda, Rania M. Sarhan, Marian S. Boshra, Gomaa Mostafa-Hedeab, Bashayer F. ALruwaili, Haytham Soliman Ghareeb Ibrahim, Mona F. Schaalan & Shaimaa Fathy. (2022) Evidence for the Efficacy of a High Dose of Vitamin D on the Hyperinflammation State in Moderate-to-Severe COVID-19 Patients: A Randomized Clinical Trial. Medicina 58:10, pages 1358.
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Qingcong Zheng, Du Wang, Rongjie Lin, Qi Lv & Wanming Wang. (2022) IFI44 is an immune evasion biomarker for SARS-CoV-2 and Staphylococcus aureus infection in patients with RA. Frontiers in Immunology 13.
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Marco Infante, Andrea Fabbri, Nathalia Padilla, Francesca Pacifici, Pasquale Di Perna, Laura Vitiello, Alessandra Feraco, Maria Giuliano, Marina Passeri, Massimiliano Caprio, Camillo Ricordi, David Della-Morte & Luigi Uccioli. (2022) BNT162b2 mRNA COVID-19 Vaccine Does Not Impact the Honeymoon Phase in Type 1 Diabetes: A Case Report. Vaccines 10:7, pages 1096.
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Irene Karampela, Natalia Vallianou, Faidon Magkos, Caroline M. Apovian & Maria Dalamaga. (2022) Obesity, Hypovitaminosis D, and COVID-19: the Bermuda Triangle in Public Health. Current Obesity Reports 11:3, pages 116-125.
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Özgür Can, Gunal Bilek & Sibel Sahan. (2021) Risk factors for infection and mortality among hemodialysis patients during COVID-19 pandemic. International Urology and Nephrology 54:3, pages 661-669.
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Federica Saponaro, Maria Franzini, Chukwuma Okoye, Rachele Antognoli, Beatrice Campi, Marco Scalese, Tommaso Neri, Laura Carrozzi, Fabio Monzani, Riccardo Zucchi, Alessandro Celi, Aldo Paolicchi & Alessandro Saba. (2022) Is There a Crucial Link Between Vitamin D Status and Inflammatory Response in Patients With COVID-19?. Frontiers in Immunology 12.
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Sandro Giannini, Andrea Giusti, Salvatore Minisola, Nicola Napoli, Giovanni Passeri, Maurizio Rossini & Luigi Sinigaglia. (2022) The Immunologic Profile of Vitamin D and Its Role in Different Immune-Mediated Diseases: An Expert Opinion. Nutrients 14:3, pages 473.
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Iacopo Chiodini, Davide Gatti, Davide Soranna, Daniela Merlotti, Christian Mingiano, Angelo Fassio, Giovanni Adami, Alberto Falchetti, Cristina Eller-Vainicher, Maurizio Rossini, Luca Persani, Antonella Zambon & Luigi Gennari. (2021) Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes. Frontiers in Public Health 9.
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Alireza Fatemi, Seyed Hossein Ardehali, Ghazaleh Eslamian, Morvarid Noormohammadi & Shirin Malek. (2021) Association of vitamin D deficiency with COVID-19 severity and mortality in Iranian people: a prospective observational study. Acute and Critical Care 36:4, pages 300-307.
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Paola Triggianese, Carlo Perricone, Erica De Martino, Arianna D’Antonio, Maria Sole Chimenti, Paola Conigliaro, Sara Ferrigno, Ilio Giambini, Elisabetta Greco & Caterina De Carolis. (2021) Human Leukocyte Antigen (HLA) Typing Study Identifies Maternal DQ2 Susceptibility Alleles among Infertile Women: Potential Associations with Autoimmunity and Micronutrients. Nutrients 13:9, pages 3270.
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Tatiana L. Karonova, Alena T. Andreeva, Ksenia A. Golovatuk, Ekaterina S. Bykova, Anna V. Simanenkova, Maria A. Vashukova, William B. Grant & Evgeny V. Shlyakhto. (2021) Low 25(OH)D Level Is Associated with Severe Course and Poor Prognosis in COVID-19. Nutrients 13:9, pages 3021.
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Cristiano Ialongo, Antonella Farina, Raffaella Labriola, Antonio Angeloni & Emanuela Anastasi. (2021) Vitamin D, SARS-CoV-2 and Causal Associations in Transversal Studies: The Time-Series Analysis to Reveal Potential Confounders. Comment on Gaudio et al. Vitamin D Levels Are Reduced at the Time of Hospital Admission in Sicilian SARS-CoV-2-Positive Patients. Int. J. Environ. Res. Public Health 2021, 18, 3491. International Journal of Environmental Research and Public Health 18:13, pages 6793.
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Lourdes Herrera-Quintana, Yenifer Gamarra-Morales, Héctor Vázquez-Lorente, Jorge Molina-López, José Castaño-Pérez, Juan Francisco Machado-Casas, Ramón Coca-Zúñiga, José Miguel Pérez-Villares & Elena Planells. (2021) Bad Prognosis in Critical Ill Patients with COVID-19 during Short-Term ICU Stay regarding Vitamin D Levels. Nutrients 13:6, pages 1988.
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Marcelo Maia Pinheiro, Andrea Fabbri & Marco Infante. (2021) Cytokine storm modulation in COVID-19: a proposed role for vitamin D and DPP-4 inhibitor combination therapy (VIDPP-4i). Immunotherapy 13:9, pages 753-765.
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Mario Cazzola, Vito de Novellis, Andrea Bianco, Paola Rogliani & Maria Gabriella Matera. (2021) Disputes over the production and dissemination of misinformation in the time of COVID-19. Respiratory Medicine 182, pages 106380.
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Agostino Gaudio, Andrea Murabito, Antonella Agodi, Arturo Montineri & Pietro Castellino. (2021) Vitamin D Levels Are Reduced at the Time of Hospital Admission in Sicilian SARS-CoV-2-Positive Patients. International Journal of Environmental Research and Public Health 18:7, pages 3491.
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David PoulinDt.P.Dt.P.. (2021) Revue du rôle possible de la vitamine D dans le traitement de la COVID-19 et recommandations pratiques. Nutrition Science en évolution: La revue de l'Ordre professionnel des diététistes du Québec 19:2, pages 19.
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Linda Bui, Zahra Zhu, Stephanie Hawkins, Alonso Cortez-Resendiz & Alfredo Bellon. (2021) Vitamin D regulation of the immune system and its implications for COVID-19: A mini review. SAGE Open Medicine 9, pages 205031212110140.
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