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Journal of Carbohydrate Chemistry Volume 25, 2006 - Issue 2-3: Glupor VI
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Original Articles

NMR Derivatives for Quantification of 2H and 13C‐Enrichment of Human Glucuronide from Metabolic Tracers

John G. Jones NMR Research Unit, Department of Biochemistry and Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, PortugalCorrespondence[email protected]
,
Cristina Barosa NMR Research Unit, Department of Biochemistry and Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal
,
Filipe Gomes Department of Chemistry, University of Coimbra, Coimbra, Portugal
,
Ana Carina Mendes Department of Chemistry, University of Coimbra, Coimbra, Portugal
,
Teresa C. Delgado NMR Research Unit, Department of Biochemistry and Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal
,
Luisa Diogo Pediatrics Hospital of Coimbra, Coimbra, Portugal
,
Paula Garcia Pediatrics Hospital of Coimbra, Coimbra, Portugal
,
Margarida Bastos Department of Endocrinology, University Hospital of Coimbra, Coimbra, Portugal
,
Luisa Barros Department of Endocrinology, University Hospital of Coimbra, Coimbra, Portugal
,
Ana Fagulha Department of Endocrinology, University Hospital of Coimbra, Coimbra, Portugal
,
Carla Baptista Department of Endocrinology, University Hospital of Coimbra, Coimbra, Portugal
,
Manuela Carvalheiro Department of Endocrinology, University Hospital of Coimbra, Coimbra, Portugal
&
M. Madalena Caldeira Department of Chemistry, University of Coimbra, Coimbra, Portugal
 show all
Pages 203-217 | Received 01 Nov 2005, Accepted 20 Feb 2006, Published online: 17 Aug 2006

Citations (35)

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Camile B. Woitiski, Ronald J. Neufeld, Ana F. Soares, Isabel V. Figueiredo, Francisco J. Veiga & Rui A. Carvalho. (2012) Evaluation of hepatic glucose metabolism via gluconeogenesis and glycogenolysis after oral administration of insulin nanoparticles. Drug Development and Industrial Pharmacy 38:12, pages 1441-1450.
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Catarina Pinto Reis, Ronald Neufeld, Francisco Veiga, Isabel V Figueiredo, John Jones, Ana F Soares, Patrícia Nunes, Christiane Damgé & Rui A Carvalho. (2012) Effects of an oral insulin nanoparticle administration on hepatic glucose metabolism assessed by 13C and 2H isotopomer analysis. Journal of Microencapsulation 29:2, pages 167-176.
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Articles from other publishers (33)

Theresia Sarabhai, Lucia Mastrototaro, Sabine Kahl, Gidon J. Bönhof, Marc Jonuscheit, Pavel Bobrov, Hisayuki Katsuyama, Rainer Guthoff, Martin Wolkersdorfer, Christian Herder, Sven G. Meuth, Sven Dreyer & Michael Roden. (2022) Hyperbaric oxygen rapidly improves tissue-specific insulin sensitivity and mitochondrial capacity in humans with type 2 diabetes: a randomised placebo-controlled crossover trial. Diabetologia 66:1, pages 57-69.
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Ivan Viegas, Giada Di Nunzio, Getachew D. Belew, Alejandra N. Torres, João G. Silva, Luis Perpétuo, Cristina Barosa, Ludgero C. Tavares & John G. Jones. (2022) Integration of Liver Glycogen and Triglyceride NMR Isotopomer Analyses Provides a Comprehensive Coverage of Hepatic Glucose and Fructose Metabolism. Metabolites 12:11, pages 1142.
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Marcello C Laurenti, Chiara Dalla Man, Ron T Varghese, James C Andrews, John G Jones, Cristina Barosa, Robert A Rizza, Aleksey Matveyenko, Giuseppe De Nicolao, Kent R Bailey, Claudio Cobelli & Adrian Vella. (2021) Insulin Pulse Characteristics and Insulin Action in Non-diabetic Humans. The Journal of Clinical Endocrinology & Metabolism 106:6, pages 1702-1709.
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Margarida Coelho, Cristina Barosa, Ludgero Tavares & John G. Jones. (2020) Metabolic incorporation of H 2 18 O into specific glucose‐6‐phosphate oxygens by red‐blood‐cell lysates as observed by 13 C isotope‐shifted NMR signals . NMR in Biomedicine 33:11.
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Getachew D. Belew, Giada Di Nunzio, Ludgero Tavares, Joao G. Silva, Alejandra N. Torres & John G. Jones. (2020) Estimating pentose phosphate pathway activity from the analysis of hepatic glycogen 13 C‐isotopomers derived from [U‐ 13 C]fructose and [U‐ 13 C]glucose . Magnetic Resonance in Medicine 84:5, pages 2765-2771.
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Giada DiNunzio, Getachew D. Belew, Alejandra N. Torres, João Gabriel Silva, Luis P. Silva, Cristina Barosa, Ludgero Tavares & John G. Jones. (2020) Determining the contribution of a high-fructose corn syrup formulation to hepatic glycogen synthesis during ad-libitum feeding in mice. Scientific Reports 10:1.
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Cristina Barosa, Harshitha Shanmugam, Fernando Cabral & John G. Jones. (2020) p-Aminobenzoic acid as an alternative chemical biopsy agent for human hepatic UDP-glucose. Analytical Biochemistry 590, pages 113511.
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Ivana Jarak, Cristina Barosa, Fatima O. Martins, Joao C. P. Silva, Cristiano Santos, Getachew Debas Belew, Joao Rito, Ivan Viegas, Jose Teixeira, Paulo J. Oliveira & John G. Jones. (2019) Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as the sole dietary carbohydrate. Magnetic Resonance in Medicine 81:1, pages 639-644.
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João Rito, Ivan Viegas, Miguel A. Pardal, Isidoro Metón, Isabel V. Baanante & John G. Jones. (2018) Disposition of a Glucose Load into Hepatic Glycogen by Direct and Indirect Pathways in Juvenile Seabass and Seabream. Scientific Reports 8:1.
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Elisa Álvarez Hernández, Sabine Kahl, Anett Seelig, Paul Begovatz, Martin Irmler, Yuliya Kupriyanova, Bettina Nowotny, Peter Nowotny, Christian Herder, Cristina Barosa, Filipa Carvalho, Jan Rozman, Susanne Neschen, John G. Jones, Johannes Beckers, Martin Hrabě de Angelis & Michael Roden. (2017) Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance. Journal of Clinical Investigation 127:2, pages 695-708.
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Ron T. Varghese, Chiara Dalla Man, Anu Sharma, Ivan Viegas, Cristina Barosa, Catia Marques, Meera Shah, John M. Miles, Robert A. Rizza, John G. Jones, Claudio Cobelli & Adrian Vella. (2016) Mechanisms Underlying the Pathogenesis of Isolated Impaired Glucose Tolerance in Humans. The Journal of Clinical Endocrinology & Metabolism 101:12, pages 4816-4824.
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Ron T. Varghese, Ivan Viegas, Cristina Barosa, Catia Marques, Meera Shah, Robert A. Rizza, John G. Jones & Adrian Vella. (2016) Diabetes-Associated Variation in TCF7L2 Is Not Associated With Hepatic or Extrahepatic Insulin Resistance . Diabetes 65:4, pages 887-892.
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Margarida Coelho, Paula Valente-Silva, Anna Tylki-Szymanska, Tiago Henriques, Cristina Barosa, Filipa Carvalho & John G. Jones. (2016) Demonstration of glucose-6-phosphate hydrogen 5 enrichment from deuterated water by transaldolase-mediated exchange alone. Magnetic Resonance in Medicine 75:4, pages 1781-1786.
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J. Jones, S. Kahl, F. Carvalho, C. Barosa & M. Roden. (2015) Simplified analysis of acetaminophen glucuronide for quantifying gluconeogenesis and glycogenolysis using deuterated water. Analytical Biochemistry 479, pages 37-39.
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Patricia M. Nunes, Ivana Jarak, Arend Heerschap & John G. Jones. (2014) Resolving futile glucose cycling and glycogenolytic contributions to plasma glucose levels following a glucose load. Magnetic Resonance in Medicine 71:4, pages 1368-1373.
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Fátima O. Martins, João Rito, Ivana Jarak, Ivan Viegas, Miguel A. Pardal, M. Paula Macedo & John G. Jones. (2013) Disposition of [U-2H7]glucose into hepatic glycogen in rat and in seabass. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 166:2, pages 316-322.
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Sumbul Azmat, Rehana Ifzal, Faryal Vali Mohammad, Viqar Uddin Ahmad & Aqib Zahoor. (2013) A New Glucuronolactone Glycoside Phoenixoside B from the Seeds of Phoenix Dactylifera . Natural Product Communications 8:9, pages 1934578X1300800.
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Aman RajpalSimmi DubeFilipa CarvalhoAna Rita SimoesAngelo Figueiredo, Ananda BasuJohn Jones & Rita Basu. (2013) Effects of transaldolase exchange on estimates of gluconeogenesis in type 2 diabetes. American Journal of Physiology-Endocrinology and Metabolism 305:4, pages E465-E474.
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Cristina Barosa, John G. Jones, Robert Rizza, Ananda Basu & Rita Basu. (2013) Acetaminophen glucuronide and plasma glucose report identical estimates of gluconeogenesis and glycogenolysis for healthy and prediabetic subjects using the deuterated water method. Magnetic Resonance in Medicine 70:2, pages 315-319.
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Rita Basu, Cristina Barosa, John Jones, Simmi Dube, Rickey Carter, Ananda Basu & Robert A. Rizza. (2013) Pathogenesis of Prediabetes: Role of the Liver in Isolated Fasting Hyperglycemia and Combined Fasting and Postprandial Hyperglycemia. The Journal of Clinical Endocrinology & Metabolism 98:3, pages E409-E417.
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Ivan Viegas, João Rito, Ivana Jarak, Sara Leston, Rui A. Carvalho, Isidoro Metón, Miguel A. Pardal, Isabel V. Baanante & John G. Jones. (2012) Hepatic glycogen synthesis in farmed European seabass (Dicentrarchus labrax L.) is dominated by indirect pathway fluxes. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 163:1, pages 22-29.
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Cristina Barosa, Claudia Silva, Ana Fagulha, Luísa Barros, M. Madalena Caldeira, Manuela Carvalheiro & John G. Jones. (2012) Sources of hepatic glycogen synthesis following a milk-containing breakfast meal in healthy subjects. Metabolism 61:2, pages 250-254.
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Cristina Barosa & John G. Jones. 2011. Carbohydrate Chemistry. Carbohydrate Chemistry 208 226 .
Ivan Viegas, Vera M. Mendes, Sara Leston, Ivana Jarak, Rui A. Carvalho, Miguel Â. Pardal, Bruno Manadas & John G. Jones. (2011) Analysis of glucose metabolism in farmed European sea bass (Dicentrarchus labrax L.) using deuterated water. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 160:3, pages 341-347.
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Michaela Kacerovsky, John Jones, Albrecht I. Schmid, Cristina Barosa, Angelika Lettner, Gertrud Kacerovsky-Bielesz, Julia Szendroedi, Marek Chmelik, Peter Nowotny, Visvanathan Chandramouli, Michael Wolzt & Michael Roden. (2011) Postprandial and Fasting Hepatic Glucose Fluxes in Long-Standing Type 1 Diabetes. Diabetes 60:6, pages 1752-1758.
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Rita Basu, Cristina Barosa, Ananda Basu, Vishwanath Pattan, Ahmed Saad, John Jones & Robert Rizza. (2011) Transaldolase exchange and its effects on measurements of gluconeogenesis in humans. American Journal of Physiology-Endocrinology and Metabolism 300:2, pages E296-E303.
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Ana F. Soares, Rui A. Carvalho, Francisco J. Veiga & John G. Jones. (2010) Effects of galactose on direct and indirect pathway estimates of hepatic glycogen synthesis. Metabolic Engineering 12:6, pages 552-560.
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Patricia M. Nunes & John G. Jones. (2009) Quantifying endogenous glucose production and contributing source fluxes from a single 2 H NMR spectrum . Magnetic Resonance in Medicine 62:3, pages 802-807.
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Ana F. Soares, Francisco J. Viega, Rui A. Carvalho & John G. Jones. (2009) Quantifying hepatic glycogen synthesis by direct and indirect pathways in rats under normal ad libitum feeding conditions. Magnetic Resonance in Medicine 61:1, pages 1-5.
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T.C. Delgado, C. Barosa, M.M.C.A. Castro, C.F.G.C. Geraldes, M. Bastos, C. Baptista, A. Fagulha, L. Barros, A. Mota, M. Carvalheiro, J.G. Jones & Matthew Merritt. (2008) Sources of hepatic glucose production by 2 H 2 O ingestion and Bayesian analysis of 2 H glucuronide enrichment . Magnetic Resonance in Medicine 60:3, pages 517-523.
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John G. Jones, Paula Garcia, Cristina Barosa, Teresa C. Delgado, M. Madalena Caldeira & Luisa Diogo. (2008) Quantification of hepatic transaldolase exchange activity and its effects on tracer measurements of indirect pathway flux in humans. Magnetic Resonance in Medicine 59:2, pages 423-429.
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Gerlies Bock, William C. Schumann, Rita Basu, Shawn C. Burgess, Zheng Yan, Visvanathan Chandramouli, Robert A. Rizza & Bernard R. Landau. (2008) Evidence That Processes Other Than Gluconeogenesis May Influence the Ratio of Deuterium on the Fifth and Third Carbons of Glucose. Diabetes 57:1, pages 50-55.
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John G. Jones, Ana Fagulha, Cristina Barosa, Margarida Bastos, Luisa Barros, Carla Baptista, M. Madalena Caldeira & Manuela Carvalheiro. (2006) Noninvasive Analysis of Hepatic Glycogen Kinetics Before and After Breakfast with Deuterated Water and Acetaminophen. Diabetes 55:8, pages 2294-2300.
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