Advanced search
Publication Cover
Journal of Carbohydrate Chemistry Volume 30, 2011 - Issue 4-6: The 5th Glycan Forum in Berlin
Submit an article Journal homepage
660
Views
47
CrossRef citations to date
0
Altmetric
Original Articles

Synthesis of Laminarin Fragments and Evaluation of a β-(1,3) Glucan Hexasaccaride-CRM197 Conjugate as Vaccine Candidate against Candida albicans

Roberto Adamo Novartis Vaccines & Diagnostics Research Center, Via Fiorentina 1, 53100, Siena, Italy
,
Marta Tontini Novartis Vaccines & Diagnostics Research Center, Via Fiorentina 1, 53100, Siena, Italy
,
Giulia Brogioni Novartis Vaccines & Diagnostics Research Center, Via Fiorentina 1, 53100, Siena, Italy
,
Maria Rosaria Romano Novartis Vaccines & Diagnostics Research Center, Via Fiorentina 1, 53100, Siena, Italy
,
Gabriele Costantini Novartis Vaccines & Diagnostics Research Center, Via Fiorentina 1, 53100, Siena, Italy
,
Elisa Danieli Novartis Vaccines & Diagnostics Research Center, Via Fiorentina 1, 53100, Siena, Italy
,
Daniela Proietti Novartis Vaccines & Diagnostics Research Center, Via Fiorentina 1, 53100, Siena, Italy
,
Francesco Berti Novartis Vaccines & Diagnostics Research Center, Via Fiorentina 1, 53100, Siena, Italy
&
Paolo Costantino Novartis Vaccines & Diagnostics Research Center, Via Fiorentina 1, 53100, Siena, Italy
 show all
Pages 249-280 | Received 09 May 2011, Accepted 07 Jul 2011, Published online: 09 Nov 2011

Citations (47)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Henderson Zhu, Christine S. Rollier & Andrew J. Pollard. (2021) Recent advances in lipopolysaccharide-based glycoconjugate vaccines. Expert Review of Vaccines 20:12, pages 1515-1538.
Read now

Articles from other publishers (46)

Linda Del Bino, Maria R. Romano & Roberto Adamo. 2023. Carbohydrate‐Based Therapeutics. Carbohydrate‐Based Therapeutics 57 72 .
Jorge L.C. Carvalho, Mackenzie E. Malo, Kevin J.H. Allen, Connor Frank, Zhiwen Xiao, Rubin Jiao & Ekaterina Dadachova. (2023) Radioimmunotherapy as a pathogen-agnostic treatment method for opportunistic mucormycosis infections. Access Microbiology 5:12.
Crossref
Gurpreet Kaur, Sonam Chawla, Piyush Kumar & Ritu Singh. (2023) Advancing Vaccine Strategies against Candida Infections: Exploring New Frontiers. Vaccines 11:11, pages 1658.
Crossref
Tomoya Ota, Wataru Saburi, Shiro Komba & Haruhide Mori. (2023) Chemical synthesis of oligosaccharide derivatives with partial structure of β1-3/1-6 glucan, using monomeric units for the formation of β1-3 and β1-6 glucosidic linkages. Bioscience, Biotechnology, and Biochemistry.
Crossref
Linda Del Bino, Kitt Emilie Østerlid, Dung-Yeh Wu, Francesca Nonne, Maria Rosaria Romano, Jeroen Codée & Roberto Adamo. (2022) Synthetic Glycans to Improve Current Glycoconjugate Vaccines and Fight Antimicrobial Resistance. Chemical Reviews 122:20, pages 15672-15716.
Crossref
E.A. Khatuntseva & N.E. Nifantiev. (2022) Cross reacting material (CRM197) as a carrier protein for carbohydrate conjugate vaccines targeted at bacterial and fungal pathogens. International Journal of Biological Macromolecules 218, pages 775-798.
Crossref
Johan Cornil, Zhaoyu Hu, Marion Bouchet & Laurence A. Mulard. (2021) Multigram synthesis of an orthogonally-protected pentasaccharide for use as a glycan precursor in a Shigella flexneri 3a conjugate vaccine: application to a ready-for-conjugation decasaccharide . Organic Chemistry Frontiers 8:22, pages 6279-6299.
Crossref
Patrick Ross & Mark P. Farrell. (2021) The Road to Structurally Defined β‐Glucans. The Chemical Record 21:11, pages 3178-3193.
Crossref
Manisha Shukla, Pankaj Chandley & Soma Rohatgi. (2021) The Role of B-Cells and Antibodies against Candida Vaccine Antigens in Invasive Candidiasis. Vaccines 9:10, pages 1159.
Crossref
Giulio Fittolani, Theodore Tyrikos-Ergas, Denisa Vargová, Manishkumar A Chaube & Martina Delbianco. (2021) Progress and challenges in the synthesis of sequence controlled polysaccharides. Beilstein Journal of Organic Chemistry 17, pages 1981-2025.
Crossref
Michelle M. Kuttel, Francesco Berti & Neil Ravenscroft. (2021) Molecular modeling provides insights into the loading of sialic acid‐containing antigens onto CRM197: the role of chain flexibility in conjugation efficiency and glycoconjugate architecture. Glycoconjugate Journal 38:4, pages 411-419.
Crossref
Barbara Richichi, Giuseppe Stefanetti, Giacomo Biagiotti & Luigi Lay. 2021. Comprehensive Glycoscience. Comprehensive Glycoscience 676 705 .
Hiroki Hamagami, Yoshiki Yamaguchi & Hiroshi Tanaka. (2020) Chemical Synthesis of Residue-Selectively 13 C and 2 H Double-Isotope-Labeled Oligosaccharides as Chemical Probes for the NMR-Based Conformational Analysis of Oligosaccharides . The Journal of Organic Chemistry 85:24, pages 16115-16127.
Crossref
Linda Del Bino & Maria Rosaria Romano. (2020) Role of carbohydrate antigens in antifungal glycoconjugate vaccines and immunotherapy. Drug Discovery Today: Technologies 38, pages 45-55.
Crossref
Vadim B. Krylov & Nikolay E. Nifantiev. (2020) Synthetic carbohydrate based anti-fungal vaccines. Drug Discovery Today: Technologies 35-36, pages 35-43.
Crossref
Jacopo Enotarpi, Marta Tontini, Cristiana Balocchi, Daan van der Es, Ludovic Auberger, Evita Balducci, Filippo Carboni, Daniela Proietti, Daniele Casini, Dmitri V. Filippov, Hermen S. Overkleeft, Gijsbert A. van der Marel, Cinzia Colombo, Maria Rosaria Romano, Francesco Berti, Paolo Costantino, Jeroen D. C. Codeé, Luigi Lay & Roberto Adamo. (2020) A stabilized glycomimetic conjugate vaccine inducing protective antibodies against Neisseria meningitidis serogroup A. Nature Communications 11:1.
Crossref
Paolo Costantino. 2020. Recent Trends in Carbohydrate Chemistry. Recent Trends in Carbohydrate Chemistry 315 334 .
Jun Li, Chao Cai, Chendong Yang, Jianghua Li, Tiantian Sun & Guangli Yu. (2019) Recent Advances in Pharmaceutical Potential of Brown Algal Polysaccharides and their Derivatives. Current Pharmaceutical Design 25:11, pages 1290-1311.
Crossref
Zixuan Wang, Qingting Hua & You Yang. (2019) Gold(I)-promoted synthesis of a β-(1,3)-glucan hexadecasaccharide via the highly convergent strategy. Carbohydrate Research 482, pages 107735.
Crossref
Cinzia Colombo, Olimpia Pitirollo & Luigi Lay. (2018) Recent Advances in the Synthesis of Glycoconjugates for Vaccine Development. Molecules 23:7, pages 1712.
Crossref
Gao‐Lan Zhang & Xin‐Shan Ye. (2018) Synthetic Glycans and Glycomimetics: A Promising Alternative to Natural Polysaccharides. Chemistry – A European Journal 24:26, pages 6696-6704.
Crossref
Francesca Micoli, Paolo Costantino & Roberto Adamo. (2018) Potential targets for next generation antimicrobial glycoconjugate vaccines. FEMS Microbiology Reviews 42:3, pages 388-423.
Crossref
Xiaobei Zhan & Hongtao Zhang. 2017. Functional Carbohydrates. Functional Carbohydrates 43 92 .
Christine Kinnaert, Mathilde Daugaard, Faranak Nami & Mads H. Clausen. (2017) Chemical Synthesis of Oligosaccharides Related to the Cell Walls of Plants and Algae. Chemical Reviews 117:17, pages 11337-11405.
Crossref
M. Garcia-Vaquero, G. Rajauria, J.V. O'Doherty & T. Sweeney. (2017) Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification. Food Research International 99, pages 1011-1020.
Crossref
Roberto Adamo. (2017) Advancing Homogeneous Antimicrobial Glycoconjugate Vaccines. Accounts of Chemical Research 50:5, pages 1270-1279.
Crossref
David J. Harvey. (2017) Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: An update for 2011-2012. Mass Spectrometry Reviews 36:3, pages 255-422.
Crossref
Yanhui Wang, Xiaoke Zhao, Qiuyun Kong, Jiajian Yao, Xiangbao Meng & Zhongjun Li. (2017) Assembly of a β-(1 → 3)-glucan laminarihexaose on ionic liquid support. Tetrahedron Letters 58:16, pages 1655-1658.
Crossref
Ema Paulovi?ov?, Lucia Paulovi?ov?, Ru?ena Pili?iov?, Viera Jan?inov?, Dmitry V. Yashunsky, Alexander A. Karelin, Yury E. Tsvetkov & Nikolay E. Nifantiev. (2016) The evaluation of ?-(1???3)-nonaglucoside as an anti- Candida albicans immune response inducer . Cellular Microbiology 18:9, pages 1294-1307.
Crossref
M. Tontini, M.R. Romano, D. Proietti, E. Balducci, F. Micoli, C. Balocchi, L. Santini, V. Masignani, F. Berti & P. Costantino. (2016) Preclinical studies on new proteins as carrier for glycoconjugate vaccines. Vaccine 34:35, pages 4235-4242.
Crossref
Guochao Liao, Zhifang Zhou, Jun Liao, Luning Zu, Qiuye Wu & Zhongwu Guo. (2015) 6- O -Branched Oligo-β-glucan-Based Antifungal Glycoconjugate Vaccines . ACS Infectious Diseases 2:2, pages 123-131.
Crossref
Dmitry V. Yashunsky, Yury E. Tsvetkov, Alexey A. Grachev, Alexander O. Chizhov & Nikolay E. Nifantiev. (2016) Synthesis of 3-aminopropyl glycosides of linear β-(1→3)-d-glucooligosaccharides. Carbohydrate Research 419, pages 8-17.
Crossref
Agnese Donadei, Simona Gallorini, Francesco Berti, Derek T. O’Hagan, Roberto Adamo & Barbara C. Baudner. (2015) Rational Design of Adjuvant for Skin Delivery: Conjugation of Synthetic β-Glucan Dectin-1 Agonist to Protein Antigen. Molecular Pharmaceutics 12:5, pages 1662-1672.
Crossref
Hassan R.H. Elsaidi, Eugenia Paszkiewicz & David R. Bundle. (2015) Synthesis of a 1,3 β-glucan hexasaccharide designed to target vaccines to the dendritic cell receptor, Dectin-1. Carbohydrate Research 408, pages 96-106.
Crossref
Yu. E. Tsvetkov, E. A. Khatuntseva, D. V. Yashunsky & N. E. Nifantiev. (2016) Synthetic β-(1→3)-d-glucooligosaccharides: model compounds for the mechanistic study of β-(1→3)-d-glucan bioactivities and design of antifungal vaccines. Russian Chemical Bulletin 64:5, pages 990-1013.
Crossref
Guochao Liao, Srinivas Burgula, Zhifang Zhou & Zhongwu Guo. (2015) A Convergent Synthesis of 6‐ O ‐Branched β‐Glucan Oligosaccharides . European Journal of Organic Chemistry 2015:13, pages 2942-2951.
Crossref
Guochao Liao, Zhifang Zhou, Srinivas Burgula, Jun Liao, Cheng Yuan, Qiuye Wu & Zhongwu Guo. (2015) Synthesis and Immunological Studies of Linear Oligosaccharides of β-Glucan As Antigens for Antifungal Vaccine Development. Bioconjugate Chemistry 26:3, pages 466-476.
Crossref
Wenjing Shang, Zhongying Xiao, Zaikuan Yu, Na Wei, Guohui Zhao, Qing Zhang, Mohui Wei, Xuan Wang, Peng George Wang & Tiehai Li. (2015) Chemical synthesis of the outer core oligosaccharide of Escherichia coli R3 and immunological evaluation. Organic & Biomolecular Chemistry 13:14, pages 4321-4330.
Crossref
Stefano Crotti, Huili Zhai, Jing Zhou, Martin Allan, Daniela Proietti, Werner Pansegrau, Qi-Ying Hu, Francesco Berti & Roberto Adamo. (2014) Defined Conjugation of Glycans to the Lysines of CRM 197 Guided by their Reactivity Mapping . ChemBioChem 15:6, pages 836-843.
Crossref
Roberto Adamo, Qi-Ying Hu, Antonella Torosantucci, Stefano Crotti, Giulia Brogioni, Martin Allan, Paola Chiani, Carla Bromuro, Douglas Quinn, Marta Tontini & Francesco Berti. (2014) Deciphering the structure–immunogenicity relationship of anti- Candida glycoconjugate vaccines . Chem. Sci. 5:11, pages 4302-4311.
Crossref
Eduardo Marca, Jessika Valero-Gonzalez, Ignacio Delso, Tomás Tejero, Ramon Hurtado-Guerrero & Pedro Merino. (2013) Synthesis of O- and C-glycosides derived from β-(1,3)-d-glucans. Carbohydrate Research 382, pages 9-18.
Crossref
Qi Gao, Marta Tontini, Giulia Brogioni, Alberto Nilo, Sara Filippini, Carole Harfouche, Laura Polito, Maria R. Romano, Paolo Costantino, Francesco Berti, Roberto Adamo & Luigi Lay. (2013) Immunoactivity of Protein Conjugates of Carba Analogues from Neisseria meningitidis A Capsular Polysaccharide . ACS Chemical Biology 8:11, pages 2561-2567.
Crossref
Ema Paulovičová, Lucia Paulovičová, Ruzena Pilišiová, Slavomir Bystrický, Dmitri V. Yashunsky, Alexander A. Karelin, Yury E. Tsvetkov & Nikolay E. Nifantiev. (2013) Synthetically prepared glycooligosaccharides mimicking Candida albicans cell wall glycan antigens - novel tools to study host-pathogen interactions . FEMS Yeast Research 13:7, pages 659-673.
Crossref
Markus W. Weishaupt, Stefan Matthies & Peter H. Seeberger. (2013) Automated Solid‐Phase Synthesis of a β‐(1,3)‐Glucan Dodecasaccharide. Chemistry – A European Journal 19:37, pages 12497-12503.
Crossref
Qi-Ying Hu, Martin Allan, Roberto Adamo, Doug Quinn, Huili Zhai, Guangxiang Wu, Kirk Clark, Jing Zhou, Sonia Ortiz, Bing Wang, Elisa Danieli, Stefano Crotti, Marta Tontini, Giulia Brogioni & Francesco Berti. (2013) Synthesis of a well-defined glycoconjugate vaccine by a tyrosine-selective conjugation strategy. Chemical Science 4:10, pages 3827.
Crossref
Roberto Adamo, Maria R. Romano, Francesco Berti, Rosanna Leuzzi, Marta Tontini, Elisa Danieli, Emilia Cappelletti, Osman S. Cakici, Erwin Swennen, Vittoria Pinto, Barbara Brogioni, Daniela Proietti, Cesira L. Galeotti, Luigi Lay, Mario A. Monteiro, Maria Scarselli & Paolo Costantino. (2012) Phosphorylation of the Synthetic Hexasaccharide Repeating Unit Is Essential for the Induction of Antibodies to Clostridium difficile PSII Cell Wall Polysaccharide . ACS Chemical Biology 7:8, pages 1420-1428.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.