Efficient Preparation of Cyclic 3′,5′-Phosphoramidites and -Amidates of Antiviral and Antitumor 5-X-2′-Deoxyuridines (X = H, CH₃, I, F, CF₃, trans-CH=CHBr)

Wesley G. Bentrude Department of Chemistry, University of Utah, Salt Lake City, Utah, 84112

Mamunur R. Khan Department of Chemistry, University of Utah, Salt Lake City, Utah, 84112

M. R. Saadein Department of Chemistry, University of Utah, Salt Lake City, Utah, 84112

Alan E. Sopchik Department of Chemistry, University of Utah, Salt Lake City, Utah, 84112

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Efficient Preparation of Cyclic 3′,5′-Phosphoramidites and -Amidates of Antiviral and Antitumor 5-X-2′-Deoxyuridines (X = H, CH₃, I, F, CF₃, trans-CH=CHBr)

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Efficient Preparation of Cyclic 3′,5′-Phosphoramidites and -Amidates of Antiviral and Antitumor 5-X-2′-Deoxyuridines (X = H, CH3, I, F, CF3, trans-CH=CHBr)

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Efficient Preparation of Cyclic 3′,5′-Phosphoramidites and -Amidates of Antiviral and Antitumor 5-X-2′-Deoxyuridines (X = H, CH₃, I, F, CF₃, trans-CH=CHBr)