Synthesis and Anti-Retroviral Activity of O,O′-BIS(3′-Azido-2′,3′-Dideoxythymidin-5′-yl) Phosphoramidate Derivatives

Inger Kers Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91, Stockholm, Sweden

Jacek Stawiński Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91, Stockholm, Sweden

Jean-Luc Girardet Laboratoire de Chimie Bioorganique, UMR CNRS 5625, Universite Montpellier II, 34095, Montpellier, Cedex, 5, France

Jean-Louis Imbach Laboratoire de Chimie Bioorganique, UMR CNRS 5625, Universite Montpellier II, 34095, Montpellier, Cedex, 5, France

Christian Perigaud Laboratoire de Chimie Bioorganique, UMR CNRS 5625, Universite Montpellier II, 34095, Montpellier, Cedex, 5, France

Gilles Gosselin Laboratoire de Chimie Bioorganique, UMR CNRS 5625, Universite Montpellier II, 34095, Montpellier, Cedex, 5, France

Anne-Marie Aubertin Institut de Virologie de la Faculté de Médecine de Strasbourg, Unité INSERM 74, 3 rue de Koberlé, 67000, Strasbourg, France

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P.D. Shakya, D.K. Dubey, Deepak Pardasani, Meehir Palit & A.K. Gupta. (2005) EFFICIENT AND COST-EFFECTIVE SYNTHESIS OF DIALKYL CHLOROPHOSPHATES. Organic Preparations and Procedures International 37:6, pages 569-574.
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Hemendra K. Gupta, Avik Mazumder, Prabhat Garg, Pranav K. Gutch & Devendra K. Dubey. (2008) N,N-Dichloro poly(styrene-co-divinyl benzene) sulfonamide polymeric beads: an efficient and recyclable reagent for the synthesis of dialkyl chlorophosphates from dialkylphosphites at room temperature. Tetrahedron Letters 49:47, pages 6704-6706.
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Michal Sobkowski, Jacek Stawinski & Adam Kraszewski. (2008) Stereochemistry of internucleotide bond formation by the H-phosphonate method. Part 6: Optimization of the reaction conditions towards highest stereoselectivity. Tetrahedron: Asymmetry 19:21, pages 2508-2518.
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Agnieszka Szymańska, Marzena Szymczak, Jerzy Boryski, Jacek Stawiński, Adam Kraszewski, Gabriella Collu, Giseppina Sanna, Gabriele Giliberti, Roberta Loddo & Paolo La Colla. (2006) Aryl nucleoside H-phosphonates. Part 15: Synthesis, properties and, anti-HIV activity of aryl nucleoside 5′-α-hydroxyphosphonates. Bioorganic & Medicinal Chemistry 14:6, pages 1924-1934.
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Lisa J. Whalen, Kerry A. McEvoy & Randall L. Halcomb. (2003) Synthesis and evaluation of phosphoramidate amino acid-based inhibitors of sialyltransferases. Bioorganic & Medicinal Chemistry Letters 13:2, pages 301-304.
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Qiang Xiao, Yong Ju & Yufen Zhao. (2003) A facile approach to phosphonic acid diesters. Heteroatom Chemistry 14:3, pages 208-210.
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Inger Kers, Jacek Stawinski, Jean‐Luc Girardet, Jean‐Louis Imbach, Christian Perigaud, Gilles Gosselin & Anne‐Marie Aubertin. (2010) ChemInform Abstract: Synthesis and Antiretroviral Activity of O,O′‐Bis(3′‐azido‐2′,3′‐dideoxythymidin‐5′‐yl) Phosphoramidate Derivatives.. ChemInform 31:11.
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Synthesis and Anti-Retroviral Activity of O,O′-BIS(3′-Azido-2′,3′-Dideoxythymidin-5′-yl) Phosphoramidate Derivatives

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Synthesis and Anti-Retroviral Activity of O,O′-BIS(3′-Azido-2′,3′-Dideoxythymidin-5′-yl) Phosphoramidate Derivatives

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