Citations (82)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (11)
Sisi Li, Zhujun Wang, Xiaoping Guo, Ping Chen & Yongmin Tang. (2022) Potent anti-tumor activity of CD45RA-targeting Hm3A4-Ranpirnase against myeloid lineage leukemias. Bioengineered 13:4, pages 8631-8642.
Read now
Read now
Jianying Qi, Xianlong Ye, Lingling Li, Haijing Bai & Cunshuan Xu. (2018) Improving the specific antitumor efficacy of ONC by fusion with N-terminal domain of transferrin. Bioscience, Biotechnology, and Biochemistry 82:7, pages 1153-1158.
Read now
Read now
J. Porter Hunt, Seung Ook Yang, Kristen M. Wilding & Bradley C. Bundy. (2017) The growing impact of lyophilized cell-free protein expression systems. Bioengineered 8:4, pages 325-330.
Read now
Read now
Emyr Bakker, Alice Guazzelli, Marija Krstic-Demonacos, Michael Lisanti, Federica Sotgia & Luciano Mutti. (2017) Current and prospective pharmacotherapies for the treatment of pleural mesothelioma. Expert Opinion on Orphan Drugs 5:6, pages 455-465.
Read now
Read now
Tanja Kunej, Jana Obsteter, Ziva Pogacar, Simon Horvat & George Adrian Calin. (2014) The decalog of long non-coding RNA involvement in cancer diagnosis and monitoring. Critical Reviews in Clinical Laboratory Sciences 51:6, pages 344-357.
Read now
Read now
Nadezhda Mironova, Irina Petrushanko, Olga Patutina, Aexandra V. Sen’kova, Olga Simonenko, Vladimir Mitkevich, Oleg Markov, Marina Zenkova & Alexander A. Makarov. (2013) Ribonuclease binase inhibits primary tumor growth and metastases via apoptosis induction in tumor cells. Cell Cycle 12:13, pages 2120-2131.
Read now
Read now
Thomas Schirrmann, Jürgen Krauss, Michaela AE Arndt, Susanna M Rybak & Stefan Dübel. (2009) Targeted therapeutic RNases (ImmunoRNases). Expert Opinion on Biological Therapy 9:1, pages 79-95.
Read now
Read now
Camillo Porta, Chiara Paglino & Luciano Mutti. (2008) Ranpirnase and its potential for the treatment of unresectable malignant mesothelioma. Biologics: Targets and Therapy 2:4, pages 601-609.
Read now
Read now
Intae Lee. (2008) Ranpirnase (Onconase®), a cytotoxic amphibian ribonuclease, manipulates tumour physiological parameters as a selective killer and a potential enhancer for chemotherapy and radiation in cancer therapy. Expert Opinion on Biological Therapy 8:6, pages 813-827.
Read now
Read now
Andrew J Kaufman & Harvey I Pass. (2008) Current concepts in malignant pleural mesothelioma. Expert Review of Anticancer Therapy 8:2, pages 293-303.
Read now
Read now
Nick Pavlakis & Nicholas J Vogelzang. (2006) Ranpirnase – an antitumour ribonuclease: its potential role in malignant mesothelioma. Expert Opinion on Biological Therapy 6:4, pages 391-399.
Read now
Read now
Articles from other publishers (71)
Qilei Han, Ruling Shen, Kai Li & Jian Fei. (2023) Inducible Expression of Amphinase in Neuroblastoma Cells using Cre/LoxP System. Journal of Pediatric Surgery 58:7, pages 1311-1316.
Crossref
Crossref
Takeo Tatsuta & Masahiro Hosono. 2023. Glycosignals in Cancer. Glycosignals in Cancer
125
147
.
Yesuf Adem Siraj. (2022) Promises of eukaryotic ribonucleases for cancer treatment: a systematic review. Translational Medicine Communications 7:1.
Crossref
Crossref
Takeo Tatsuta. (2022) Basic Research on Bullfrog Egg-derived Sialic Acid-binding Lectin for Cancer Treatmentがん治療への応用を目指したウシガエル卵由来シアル酸結合性レクチン（cSBL）の基礎研究. YAKUGAKU ZASSHI 142:10, pages 1045-1053.
Crossref
Crossref
Marta Menegazzi & Giovanni Gotte. (2022) Role of the Ribonuclease ONCONASE in miRNA Biogenesis and tRNA Processing: Focus on Cancer and Viral Infections. International Journal of Molecular Sciences 23:12, pages 6556.
Crossref
Crossref
Takeo Tatsuta & Masahiro Hosono. (2022) Discovery of antitumor effects of leczymes. Glycoconjugate Journal 39:2, pages 157-165.
Crossref
Crossref
Patrizia Cioni, Edi Gabellieri, Barbara Campanini, Stefano Bettati & Samanta Raboni. (2022) Use of Exogenous Enzymes in Human Therapy: Approved Drugs and Potential Applications. Current Medicinal Chemistry 29:3, pages 411-452.
Crossref
Crossref
Elisa De Tomi, Rachele Campagnari, Elisa Orlandi, Alessia Cardile, Valentina Zanrè, Marta Menegazzi, Macarena Gomez-Lira & Giovanni Gotte. (2022) Upregulation of miR-34a-5p, miR-20a-3p and miR-29a-3p by Onconase in A375 Melanoma Cells Correlates with the Downregulation of Specific Onco-Proteins. International Journal of Molecular Sciences 23:3, pages 1647.
Crossref
Crossref
Yuan Luo, Yunfeng Chen, Xing Yang, Yueming Wang, Yunxia Li, Xueping Gu, Jian Zhang, Jun Chen, Yuefeng Hao & Gang Shen. (2021)
One-Step Synthesis of Ribonucleases A–Ag Nanocomposites as Fluorescent Nanodrugs for
in vivo
Delivery
. Nano 16:09.
Crossref
Crossref
Jessica Castro, Marc Ribó, Maria Vilanova & Antoni Benito. (2021) Strengths and Challenges of Secretory Ribonucleases as AntiTumor Agents. Pharmaceutics 13:1, pages 82.
Crossref
Crossref
Kathleen Noble, Aarushi Rohaj, Lisa M. Abegglen & Joshua D. Schiffman. (2020) Cancer therapeutics inspired by defense mechanisms in the animal kingdom. Evolutionary Applications 13:7, pages 1681-1700.
Crossref
Crossref
Raineri, Fasoli, Campagnari, Gotte & Menegazzi. (2019) Onconase Restores Cytotoxicity in Dabrafenib-Resistant A375 Human Melanoma Cells and Affects Cell Migration, Invasion and Colony Formation Capability. International Journal of Molecular Sciences 20:23, pages 5980.
Crossref
Crossref
Nadezhda Mironova & Valentin Vlassov. (2019) Surveillance of Tumour Development: The Relationship Between Tumour-Associated RNAs and Ribonucleases. Frontiers in Pharmacology 10.
Crossref
Crossref
Alice Raineri, Sara Prodomini, Sabrina Fasoli, Giovanni Gotte & Marta Menegazzi. (2019) Influence of onconase in the therapeutic potential of PARP inhibitors in A375 malignant melanoma cells. Biochemical Pharmacology 167, pages 173-181.
Crossref
Crossref
Takeo Tatsuta, Shoko Sato, Toshiyuki Sato, Shigeki Sugawara, Tsuneyoshi Suzuki, Akiyoshi Hara & Masahiro Hosono. (2018) Sialic Acid-Binding Lectin from Bullfrog Eggs Exhibits an Anti-Tumor Effect Against Breast Cancer Cells Including Triple-Negative Phenotype Cells. Molecules 23:10, pages 2714.
Crossref
Crossref
Rhonda M. BrandAaron SiegelAshley MyerskiE. Jeffery MetterJarret EngstromRandall E. BrandLuis SquiqueraThomas HodgeJamie SulleyRoss D. CranstonIan McGowan. (2018) Ranpirnase Reduces HIV-1 Infection and Associated Inflammatory Changes in a Human Colorectal Explant Model. AIDS Research and Human Retroviruses 34:10, pages 838-848.
Crossref
Crossref
Tomáš Koval & Jan Dohnálek. (2018) Characteristics and application of S1–P1 nucleases in biotechnology and medicine. Biotechnology Advances 36:3, pages 603-612.
Crossref
Crossref
Nadezhda Mironova, Olga Patutina, Evgenyi Brenner, Alexander Kurilshikov, Valentin Vlassov & Marina Zenkova. (2017) The systemic tumor response to RNase A treatment affects the expression of genes involved in maintaining cell malignancy. Oncotarget 8:45, pages 78796-78810.
Crossref
Crossref
L. A. Alexeeva, O. A. Patutina, A. V. Sen’kova, M. A. Zenkova & N. L. Mironova. (2017) Inhibition of invasive properties of murine melanoma by bovine pancreatic DNase I in vitro and in vivo. Molecular Biology 51:4, pages 562-570.
Crossref
Crossref
Baptiste Martin, Bruno Canard & Etienne Decroly. (2017) Filovirus proteins for antiviral drug discovery: Structure/function bases of the replication cycle. Antiviral Research 141, pages 48-61.
Crossref
Crossref
Luis Squiquera, Debra J Taxman, Sarah A Brendle, Roberto Torres, Jamie Sulley, Thomas Hodge, Neil Christensen & David Sidransky. (2016) Ranpirnase Eradicates Human Papillomavirus in Cultured Cells and Heals Anogenital Warts in a Phase I Study. Antiviral Therapy 22:3, pages 247-255.
Crossref
Crossref
Anna Vert, Jessica Castro, Marc Ribó, Antoni Benito & Maria Vilanova. (2016) Activating transcription factor 3 is crucial for antitumor activity and to strengthen the antiviral properties of Onconase. Oncotarget 8:7, pages 11692-11707.
Crossref
Crossref
Thomas Hodge, Ken Draper, Trevor Brasel, Alexander Freiberg, Luis Squiquera, David Sidransky, Jamie Sulley & Debra J. Taxman. (2016) Antiviral effect of ranpirnase against Ebola virus. Antiviral Research 132, pages 210-218.
Crossref
Crossref
Vadim Sergeevich Pokrovskii, E.M. Treshchalina, N.V. Andronova & S.M. Deev. (2016) Ribonucleases with Antiproliferative Properties: Molecular Biological and Biochemical Characteristics. Clinical oncohematology 9:2, pages 130-137.
Crossref
Crossref
Inés Fernández-Ulibarri, Katharina Hammer, Michaela A.E. Arndt, Johanna K. Kaufmann, Dominik Dorer, Sarah Engelhardt, Roland E. Kontermann, Jochen Hess, Heike Allgayer, Jürgen Krauss & Dirk M. Nettelbeck. (2015) Genetic delivery of an immunoRNase by an oncolytic adenovirus enhances anticancer activity. International Journal of Cancer 136:9, pages 2228-2240.
Crossref
Crossref
Carmela Fimognari. (2015) Role of Oxidative RNA Damage in Chronic-Degenerative Diseases. Oxidative Medicine and Cellular Longevity 2015, pages 1-8.
Crossref
Crossref
Rakesh K. Tekade, Susanne R. Youngren-Ortiz, Haining Yang, Rahul Haware & Mahavir B. Chougule. (2014) Designing Hybrid Onconase Nanocarriers for Mesothelioma Therapy: A Taguchi Orthogonal Array and Multivariate Component Driven Analysis. Molecular Pharmaceutics 11:10, pages 3671-3683.
Crossref
Crossref
A.V. Sen'kova, N.L. Mironova, O.A. Patutina, V.A. Mitkevich, O.V. Markov, I.Y. Petrushanko, K.M. Burnysheva, M.A. Zenkova & A.A. Makarov. (2014) Ribonuclease binase decreases destructive changes of the liver and restores its regeneration potential in mouse lung carcinoma model. Biochimie 101, pages 256-259.
Crossref
Crossref
Weiyan Huang, Mei Zhao, Na Wei, Xiaoxia Wang, Huqing Cao, Quan Du & Zicai Liang. (2014) Site-Specific RNase A Activity Was Dramatically Reduced in Serum from Multiple Types of Cancer Patients. PLoS ONE 9:5, pages e96490.
Crossref
Crossref
Piotr Smolewski, Magdalena Witkowska, Malgorzata Zwolinska, Barbara Cebula-Obrzut, Agata Majchrzak, Aleksandra Jeske, Zbigniew Darzynkiewicz, Wojciech Ardelt, Barbara Ardelt & Tadeusz Robak. (2014) Cytotoxic activity of the amphibian ribonucleases onconase and r-amphinase on tumor cells from B cell lymphoproliferative disorders. International Journal of Oncology.
Crossref
Crossref
GIOU-TENG YIANG, HSIU-FENG TSAI, JER-RONG CHEN, PEI-LUN CHOU, TSAI-KUN WU, HSIAO-CHUN LIU, WEI-JUNG CHANG, LIANG-CHIH LIU, HSU-HUNG TSENG & YUNG-LUEN YU. (2014) RC-6 ribonuclease induces caspase activation, cellular senescence and neuron-like morphology in NT2 embryonal carcinoma cells. Oncology Reports 31:4, pages 1738-1744.
Crossref
Crossref
Tsutomu Shimazu, Oleg Mirochnitchenko, Sangita Phadtare & Masayori Inouye. (2014) Regression of Solid Tumors by Induction of MazF, a Bacterial mRNA Endoribonuclease. Microbial Physiology 24:4, pages 228-233.
Crossref
Crossref
Takeo Tatsuta, Shigeki Sugawara, Kohta Takahashi, Yukiko Ogawa, Masahiro Hosono & Kazuo Nitta. (2014) Leczyme: A New Candidate Drug for Cancer Therapy. BioMed Research International 2014, pages 1-10.
Crossref
Crossref
Nadezhda Mironova, Olga Patutina, Evgenyi Brenner, Alexander Kurilshikov, Valentin Vlassov & Marina Zenkova. (2013) MicroRNA Drop in the Bloodstream and MicroRNA Boost in the Tumour Caused by Treatment with Ribonuclease A Leads to an Attenuation of Tumour Malignancy. PLoS ONE 8:12, pages e83482.
Crossref
Crossref
Nadia K. Sundlass, Chelcie H. Eller, Qiang Cui & Ronald T. Raines. (2013) Contribution of Electrostatics to the Binding of Pancreatic-Type Ribonucleases to Membranes. Biochemistry 52:37, pages 6304-6312.
Crossref
Crossref
Kazuo Nitta. (2013) Sialic acid-binding lectin (leczyme) induces caspase-dependent apoptosis-mediated mitochondrial perturbation in Jurkat cells. International Journal of Oncology.
Crossref
Crossref
Ya-Ming HouXiaolu Yang. (2013) Regulation of Cell Death by Transfer RNA. Antioxidants & Redox Signaling 19:6, pages 583-594.
Crossref
Crossref
Wojciech Ardelt. 2013. Fusion Protein Technologies for Biopharmaceuticals. Fusion Protein Technologies for Biopharmaceuticals
337
353
.
Mariona Call?s, Soraya Serrano, Antoni Benito, Douglas V. Laurents, Maria Vilanova, Marta Bruix & Marc Rib?. (2013) Towards Tricking a Pathogen?s Protease into Fighting Infection: The 3D Structure of a Stable Circularly Permuted Onconase Variant Cleavedby HIV-1 Protease. PLoS ONE 8:1, pages e54568.
Crossref
Crossref
Anna Vert, Jessica Castro, Santiago Ruiz-Martínez, Pere Tubert, Diego Escribano, Marc Ribó, Maria Vilanova & Antoni Benito. (2012) Generation of New Cytotoxic Human Ribonuclease Variants Directed to the Nucleus. Molecular Pharmaceutics 9:10, pages 2894-2902.
Crossref
Crossref
Jessica Castro, Marc Ribó, Teresa Puig, Ramon Colomer, Maria Vilanova & Antoni Benito. (2011) A cytotoxic ribonuclease reduces the expression level of P-glycoprotein in multidrug-resistant cell lines. Investigational New Drugs 30:3, pages 880-888.
Crossref
Crossref
Jessica Castro, Marc Ribó, Susanna Navarro, Maria Victòria Nogués, Maria Vilanova & Antoni Benito. (2011) A human ribonuclease induces apoptosis associated with p21WAF1/CIP1induction and JNK inactivation. BMC Cancer 11:1.
Crossref
Crossref
Nadia K. Sundlass & Ronald T. Raines. (2011) Arginine Residues Are More Effective than Lysine Residues in Eliciting the Cellular Uptake of Onconase. Biochemistry 50:47, pages 10293-10299.
Crossref
Crossref
Pere Tubert, Montserrat Rodríguez, Marc Ribó, Antoni Benito & Maria Vilanova. (2010) The nuclear transport capacity of a human-pancreatic ribonuclease variant is critical for its cytotoxicity. Investigational New Drugs 29:5, pages 811-817.
Crossref
Crossref
Chyou-Wei Wei, Pei-Lun Chou, Yu-Ting Hung & Giou-Teng Yiang. (2011) Synergistic cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and Rana catesbeiana ribonuclease-6 in hepatoma cells. Tzu Chi Medical Journal 23:1, pages 9-15.
Crossref
Crossref
Carima Andrady, Surinder K Sharma & Kerry A Chester. (2011) Antibody–enzyme fusion proteins for cancer therapy. Immunotherapy 3:2, pages 193-211.
Crossref
Crossref
Marc Ribó, Antoni Benito & Maria Vilanova. 2011. Ribonucleases. Ribonucleases
55
88
.
Deborah A Altomare, Susanna M Rybak, Jianming Pei, Jacob V Maizel, Mitchell Cheung, Joseph R Testa & Kuslima Shogen. (2010) Onconase responsive genes in human mesothelioma cells: implications for an RNA damaging therapeutic agent. BMC Cancer 10:1.
Crossref
Crossref
Giou-Teng Yiang. (2010) RC6 Exerts an Anticancer Effect Through the Caspase-dependent Apoptosis Pathway. Tzu Chi Medical Journal 22:4, pages 189-194.
Crossref
Crossref
Thomas J. Rutkoski, John A. Kink, Laura E. Strong, Christine I. Schilling & Ronald T. Raines. (2010) Antitumor Activity of Ribonuclease Multimers Created by Site-Specific Covalent Tethering. Bioconjugate Chemistry 21:9, pages 1691-1702.
Crossref
Crossref
Yide Mei, Aaron Stonestrom, Ya-Ming Hou & Xiaolu Yang. (2010) Apoptotic regulation and tRNA. Protein & Cell 1:9, pages 795-801.
Crossref
Crossref
Chien-Hsing Chang, Pankaj Gupta, Rosana Michel, Meiyu Loo, Yang Wang, Thomas M. Cardillo & David M. Goldenberg. (2010) Ranpirnase (Frog RNase) Targeted with a Humanized, Internalizing, Anti–Trop-2 Antibody Has Potent Cytotoxicity against Diverse Epithelial Cancer Cells. Molecular Cancer Therapeutics 9:8, pages 2276-2286.
Crossref
Crossref
Yide Mei, Jeongsik Yong, Hongtu Liu, Yigong Shi, Judy Meinkoth, Gideon Dreyfuss & Xiaolu Yang. (2010) tRNA Binds to Cytochrome c and Inhibits Caspase Activation. Molecular Cell 37:5, pages 668-678.
Crossref
Crossref
Rebecca F. Turcotte, Luke D. Lavis & Ronald T. Raines. (2009) Onconase cytotoxicity relies on the distribution of its positive charge. FEBS Journal 276:14, pages 3846-3857.
Crossref
Crossref
Dianne L. Newton, Luke H. Stockwin & Susanna M. Rybak. 2009. Therapeutic Antibodies. Therapeutic Antibodies
425
443
.
Debrah M. Thompson, Cheng Lu, Pamela J. Green & Roy Parker. (2008) tRNA cleavage is a conserved response to oxidative stress in eukaryotes. RNA 14:10, pages 2095-2103.
Crossref
Crossref
Gerard Torrent, Antoni Benito, Jessica Castro, Marc Ribó & Maria Vilanova. (2008) Contribution of the C30/C75 disulfide bond to the biological properties of onconase. Biological Chemistry 0:ja, pages 080808065103147-30.
Crossref
Crossref
Intae Lee & Kuslima Shogen. (2007) Mechanisms of enhanced tumoricidal efficacy of multiple small dosages of ranpirnase, the novel cytotoxic ribonuclease, on lung cancer. Cancer Chemotherapy and Pharmacology 62:2, pages 337-346.
Crossref
Crossref
Amanda K Beck, Harvey I Pass, Michele CarboneHaining Yang. (2008) Ranpirnase as a potential antitumor ribonuclease treatment for mesothelioma and other malignancies. Future Oncology 4:3, pages 341-349.
Crossref
Crossref
Helene F Rosenberg. (2008) RNase A ribonucleases and host defense: an evolving story. Journal of Leukocyte Biology 83:5, pages 1079-1087.
Crossref
Crossref
Olga N. Ilinskaya, Andreas Koschinski, Holger Repp, Vladimir A. Mitkevich, Florian Dreyer, J. Martin Scholtz, C. Nick Pace & Alexander A. Makarov. (2008) RNase-induced apoptosis: Fate of calcium-activated potassium channels. Biochimie 90:5, pages 717-725.
Crossref
Crossref
Luciano Mutti & Giovanni Gaudino. (2008) The therapeutic potential of the novel ribonuclease ranpirnase (Onconase®) in the treatment of malignant mesothelioma. Oncology Reviews 2:1, pages 61-65.
Crossref
Crossref
J Eugene Lee & Ronald T Raines. (2008) Ribonucleases as Novel Chemotherapeutics. BioDrugs 22:1, pages 53-58.
Crossref
Crossref
Gerard Torrent, Antoni Benito, Jessica Castro, Marc Ribó & Maria Vilanova. (2008) Contribution of the C30/C75 disulfide bond to the biological properties of onconase. Biological Chemistry 389:8.
Crossref
Crossref
Du-Juan Dong, Hong-Juan He, Lian-Qin Chai, Xiao-Juan Jiang, Jin-Xing Wang & Xiao-Fan Zhao. (2007) Identification of genes differentially expressed during larval molting and metamorphosis of Helicoverpa armigera. BMC Developmental Biology 7:1.
Crossref
Crossref
Avvaru N. Suhasini & Ravi Sirdeshmukh. (2007) Onconase action on tRNALys3, the primer for HIV-1 reverse transcription. Biochemical and Biophysical Research Communications 363:2, pages 304-309.
Crossref
Crossref
Umesh P. Singh, Wojciech Ardelt, Shailendra K. Saxena, Daniel E. Holloway, Eugene Vidunas, Hung-Suen Lee, Abha Saxena, Kuslima Shogen & K. Ravi Acharya. (2007) Enzymatic and Structural Characterisation of Amphinase, a Novel Cytotoxic Ribonuclease from Rana pipiens Oocytes. Journal of Molecular Biology 371:1, pages 93-111.
Crossref
Crossref
Betty Schwartz, Oded Shoseyov, Vladislava O. Melnikova, Marya McCarty, Michael Leslie, Levava Roiz, Patricia Smirnoff, Guo-fu Hu, Dina Lev & Menashe Bar-Eli. (2007) ACTIBIND, a T2 RNase, Competes with Angiogenin and Inhibits Human Melanoma Growth, Angiogenesis, and Metastasis. Cancer Research 67:11, pages 5258-5266.
Crossref
Crossref
Ester Boix & M. Victòria Nogués. (2007) Mammalian antimicrobial proteins and peptides: overview on the RNase A superfamily members involved in innate host defence. Molecular BioSystems 3:5, pages 317.
Crossref
Crossref
Takeaki Nitto, Kimberly D. Dyer, Meggan Czapiga & Helene F. Rosenberg. (2006) Evolution and Function of Leukocyte RNase A Ribonucleases of the Avian Species, Gallus gallus. Journal of Biological Chemistry 281:35, pages 25622-25634.
Crossref
Crossref
Haining YangMaurizio BocchettaBarbara KroczynskaAmira G. ElmishadYuanbin ChenZemin LiuConcetta BubiciBrooke T. Mossman, Harvey I. Pass, Joseph R. TestaGuido FranzosoMichele Carbone. (2006) TNF-α inhibits asbestos-induced cytotoxicity via a NF-κB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis. Proceedings of the National Academy of Sciences 103:27, pages 10397-10402.
Crossref
Crossref