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BASIC SCIENCE REVIEW

Cell Permeable Iron Chelators as Potential Cancer Chemotherapeutic Agents

, Ph.D. & , M.D.
Pages 683-691 | Published online: 11 Jun 2009

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Grace Nevil, Michael Roth, Jonathan Gill, Wendong Zhang, Beverly Teicher, Stephen W. Erickson, Gregory Gatto, Malcom Smith, E. Anders Kolb & Richard Gorlick. (2021) Initial in vivo testing of TPO-receptor agonist eltrombopag in osteosarcoma patient-derived xenograft models by the pediatric preclinical testing consortium. Pediatric Hematology and Oncology 38:1, pages 8-13.
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DeborahL. Ornstein & LeoR. Zacharski. (2007) Iron Stimulates Urokinase Plasminogen Activator Expression and Activates NF-kappa B in Human Prostate Cancer Cells. Nutrition and Cancer 58:1, pages 115-126.
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Articles from other publishers (31)

Tharushi P. Wijesinghe, Mahendiran Dharmasivam, Charles C. Dai & Des R. Richardson. (2021) Innovative therapies for neuroblastoma: The surprisingly potent role of iron chelation in up-regulating metastasis and tumor suppressors and down-regulating the key oncogene, N-myc. Pharmacological Research 173, pages 105889.
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You Jung Kang, Claire K. Holley, Mohammad Reza Abidian, Achuthamangalam B. Madhankumar, James Connor & Sheereen Majd. (2020) Tumor Targeted Delivery of an Anti‐Cancer Therapeutic: An In Vitro and In Vivo Evaluation. Advanced Healthcare Materials 10:2, pages 2001261.
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Claire K. Holley, You Jung Kang, Chung-Fan Kuo, Mohammad Reza Abidian & Sheereen Majd. (2019) Development and in vitro assessment of an anti-tumor nano-formulation. Colloids and Surfaces B: Biointerfaces 184, pages 110481.
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Claire K. Holley, Bridgett Sinquefield & Sheereen Majd. (2019) Optimization of the Single Emulsion Method for Encapsulation of a Cancer Drug in Nanoparticles. Optimization of the Single Emulsion Method for Encapsulation of a Cancer Drug in Nanoparticles.
Y.J. Kang, C-F. Kuo & S. Majd. (2017) Nanoparticle-based delivery of an anti-proliferative metal chelator to tumor cells. Nanoparticle-based delivery of an anti-proliferative metal chelator to tumor cells.
Zhongjie Xu, Youxun Liu, Sufeng Zhou, Yun Fu & Changzheng Li. (2016) Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques. International Journal of Molecular Sciences 17:7, pages 1042.
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Cuiping Li, Tengfei Huang, Yun Fu, Youxun Liu, Sufeng Zhou, Zhangyang Qi & Changzheng Li. (2016) Interaction of Di-2-pyridylketone 2-pyridine Carboxylic Acid Hydrazone and Its Copper Complex with BSA: Effect on Antitumor Activity as Revealed by Spectroscopic Studies. Molecules 21:5, pages 563.
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Ufuk ÖZER. (2016) Copper enriches efficacy of Dp44mT in breast cancer cells. TURKISH JOURNAL OF BIOLOGY 40, pages 1185-1191.
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YINGLI YANG, TENGFEI HUANG, SUFENG ZHOU, YUN FU, YOUXUN LIU, YANBIN YUAN, QIONGQING ZHANG, SHAOSHAN LI & CHANGZHENG LI. (2015) Antitumor activity of a 2-pyridinecarboxaldehyde 2-pyridinecarboxylic acid hydrazone copper complex and the related mechanism. Oncology Reports 34:3, pages 1311-1318.
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Lawrence D. HorwitzMarcus A. Horwitz. (2014) The Exochelins of Pathogenic Mycobacteria: Unique, Highly Potent, Lipid- and Water-Soluble Hexadentate Iron Chelators with Multiple Potential Therapeutic Uses. Antioxidants & Redox Signaling 21:16, pages 2246-2261.
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Junye Zhang, Lei Cui, Minhua Xu & Yuanli Zheng. (2014) Restoring the Secretory Function of Irradiation-Damaged Salivary Gland by Administrating Deferoxamine in Mice. PLoS ONE 9:11, pages e113721.
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Kimiko Ishiguro, Z. Ping Lin, Philip G. Penketh, Krishnamurthy Shyam, Rui Zhu, Raymond P. Baumann, Yong-Lian Zhu, Alan C. Sartorelli, Thomas J. Rutherford & Elena S. Ratner. (2014) Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes. Biochemical Pharmacology 91:3, pages 312-322.
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Oriana Marques, Berta Martins da Silva, Graça Porto & Carlos Lopes. (2014) Iron homeostasis in breast cancer. Cancer Letters 347:1, pages 1-14.
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Huangtao Jin, Zhongyu Xu, Dongfeng Li & Jin Huang. (2014) Antiproliferative activity and therapeutic implications of potassium tris(4-methyl-1-pyrazolyl) borohydride in hepatocellular carcinoma. Chemico-Biological Interactions 213, pages 69-76.
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Yun Fu, Sufeng Zhou, Youxun Liu, Yingli Yang, Xingzhi Sun & Changzheng Li. (2014) The Cytotoxicity of Benzaldehyde Nitrogen Mustard-2-Pyridine Carboxylic Acid Hydrazone Being Involved in Topoisomerase II ? Inhibition . BioMed Research International 2014, pages 1-11.
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Angelica M. MerlotDanuta S. KalinowskiDes R. Richardson. (2013) Novel Chelators for Cancer Treatment: Where Are We Now?. Antioxidants & Redox Signaling 18:8, pages 973-1006.
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David B. Lovejoy, Danae M. Sharp, Nicole Seebacher, Peyman Obeidy, Thomas Prichard, Christian Stefani, Maram T. Basha, Philip C. Sharpe, Patric J. Jansson, Danuta S. Kalinowski, Paul V. Bernhardt & Des R. Richardson. (2012) Novel Second-Generation Di-2-Pyridylketone Thiosemicarbazones Show Synergism with Standard Chemotherapeutics and Demonstrate Potent Activity against Lung Cancer Xenografts after Oral and Intravenous Administration in Vivo. Journal of Medicinal Chemistry 55:16, pages 7230-7244.
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Michael RothBritta WillGuillermo SimkinSwathi NarayanagariLaura BarreyroBoris BartholdyRoni TamariConstantine S. MitsiadesAmit Verma & Ulrich Steidl. (2012) Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation. Blood 120:2, pages 386-394.
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Robert L. Elliott & Jonathan F. Head. (2012) Cancer: Tumor Iron Metabolism, Mitochondrial Dysfunction and Tumor Immunosuppression; “A Tight Partnership—Was Warburg Correct?”. Journal of Cancer Therapy 03:04, pages 278-311.
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B. Poljsak & I. Milisav. (2012) The Neglected Significance of “Antioxidative Stress”. Oxidative Medicine and Cellular Longevity 2012, pages 1-12.
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Steven Minear, Allyson F. O'Donnell, Anna Ballew, Guri Giaever, Corey Nislow, Tim Stearns & Martha S. Cyert. (2011) Curcumin Inhibits Growth of Saccharomyces cerevisiae through Iron Chelation. Eukaryotic Cell 10:11, pages 1574-1581.
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David B. Lovejoy, Patric J. Jansson, Ulf T. Brunk, Jacky Wong, Prem Ponka & Des R. Richardson. (2011) Antitumor Activity of Metal-Chelating Compound Dp44mT Is Mediated by Formation of a Redox-Active Copper Complex That Accumulates in Lysosomes. Cancer Research 71:17, pages 5871-5880.
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Angelica M. Merlot, Namfon Pantarat, David B. Lovejoy, Danuta S. Kalinowski & Des R. Richardson. (2010) Membrane Transport and Intracellular Sequestration of Novel Thiosemicarbazone Chelators for the Treatment of Cancer. Molecular Pharmacology 78:4, pages 675-684.
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Heather C Hatcher, Ravi N Singh, Frank M TortiSuzy V Torti. (2009) Synthetic and natural iron chelators: therapeutic potential and clinical use. Future Medicinal Chemistry 1:9, pages 1643-1670.
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Douglas B Kell. (2009) Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Medical Genomics 2:1.
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D.R. Richardson, D.S. Kalinowski, S. Lau, P.J. Jansson & D.B. Lovejoy. (2009) Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents. Biochimica et Biophysica Acta (BBA) - General Subjects 1790:7, pages 702-717.
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Michael K. Kiessling, Claus D. Klemke, Marcin M. Kamiński, Ioanna E. Galani, Peter H. Krammer & Karsten Gülow. (2009) Inhibition of Constitutively Activated Nuclear Factor-κB Induces Reactive Oxygen Species- and Iron-Dependent Cell Death in Cutaneous T-Cell Lymphoma. Cancer Research 69:6, pages 2365-2374.
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Egarit Noulsri, Des R. Richardson, Surada Lerdwana, Suthat Fucharoen, Tetsuo Yamagishi, Danuta S. Kalinowski & Kovit Pattanapanyasat. (2009) Antitumor activity and mechanism of action of the iron chelator, Dp44mT, against leukemic cells. American Journal of Hematology 84:3, pages 170-176.
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S. Defrere, J.C. Lousse, R. Gonzalez-Ramos, S. Colette, J. Donnez & A. Van Langendonckt. (2008) Potential involvement of iron in the pathogenesis of peritoneal endometriosis. Molecular Human Reproduction 14:7, pages 377-385.
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Karin Merschjohann & Dietmar Steverding. (2006) In vitro growth inhibition of bloodstream forms of Trypanosoma brucei and Trypanosoma congolenseby iron chelators. Kinetoplastid Biology and Disease 5:1.
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Sylvie Defrère, Anne Van Langendonckt, Sophie Vaesen, Mathieu Jouret, Reinaldo González Ramos, Dolores Gonzalez & Jacques Donnez. (2006) Iron overload enhances epithelial cell proliferation in endometriotic lesions induced in a murine model. Human Reproduction 21:11, pages 2810-2816.
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