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Cancer Investigation Volume 25, 2007 - Issue 6
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REVIEW

Development of Farnesyltransferase Inhibitors for Clinical Cancer Therapy: Focus on Hematologic Malignancies

Judith E. Karp Director, Leukemia Program, Division of Hematologic Malignancies, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA
, M.D. &
Jeffrey E. Lancet H. Lee Moffitt Cancer Center and Research Institute, Hematologic Malignancies Program, Tampa, Florida, USA
, M.D.
Pages 484-494 | Published online: 11 Jun 2009

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Judith E Karp & Jeffrey E Lancet. (2008) Tipifarnib in the treatment of newly diagnosed acute myelogenous leukemia. Biologics: Targets and Therapy 2:3, pages 491-500.
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Alice Ossoli, Anna Wolska, Alan T. Remaley & Monica Gomaraschi. (2022) High-density lipoproteins: A promising tool against cancer. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1867:1, pages 159068.
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Monica Gomaraschi. (2020) Role of Lipoproteins in the Microenvironment of Hormone-Dependent Cancers. Trends in Endocrinology & Metabolism 31:3, pages 256-268.
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Mei Wang & Patrick J. Casey. (2016) Protein prenylation: unique fats make their mark on biology. Nature Reviews Molecular Cell Biology 17:2, pages 110-122.
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Daphna Mokady & David Meiri. (2015) RhoGTPases – A novel link between cytoskeleton organization and cisplatin resistance. Drug Resistance Updates 19, pages 22-32.
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Joshua D. Ochocki, Urule Igbavboa, W. Gibson Wood, Edgar A. Arriaga, Elizabeth V. Wattenberg & Mark D. Distefano. 2014. Therapeutic Peptides. Therapeutic Peptides 213 223 .
Rachel S. Darken & David H. Gutmann. 2015. Molecular Oncology. Molecular Oncology 679 685 .
Ashkan Emadi & Judith E Karp. (2012) The clinically relevant pharmacogenomic changes in acute myelogenous leukemia. Pharmacogenomics 13:11, pages 1257-1269.
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Judith E. KarpTatiana I. VenerMitch RaponiEllen K. RitchieB. Douglas SmithSteven D. GoreLawrence E. MorrisEric J. FeldmanJacqueline M. GreerSami MalekHetty E. CarrawayValerie IronsideSteven GalkinMark J. LevisMichael A. McDevittGail R. RobozChristopher D. GockeCarlo DerechoJohn PalmaYixin WangScott H. KaufmannJohn J. Wright & Elizabeth Garret-Mayer. (2012) Multi-institutional phase 2 clinical and pharmacogenomic trial of tipifarnib plus etoposide for elderly adults with newly diagnosed acute myelogenous leukemia. Blood 119:1, pages 55-63.
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Husheng Ding, Jennifer Hackbarth, Paula A. Schneider, Kevin L. Peterson, X. Wei Meng, Haiming Dai, Thomas E. Witzig & Scott H. Kaufmann. (2011) Cytotoxicity of farnesyltransferase inhibitors in lymphoid cells mediated by MAPK pathway inhibition and Bim up-regulation. Blood 118:18, pages 4872-4881.
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Weston R. Judd, Paul M. Slattum, Khanh C. Hoang, Leena Bhoite, Liisa Valppu, Glen Alberts, Brita Brown, Bruce Roth, Kirill Ostanin, Liwen Huang, Daniel Wettstein, Burt Richards & J. Adam Willardsen. (2011) Discovery and SAR of Methylated Tetrahydropyranyl Derivatives as Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase (ICMT). Journal of Medicinal Chemistry 54:14, pages 5031-5047.
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Mei Wang. 2011. Protein Prenylation Part B. Protein Prenylation Part B 259 278 .
Kendra E. Hightower & Patrick J. Casey. 2011. Protein Prenylation Part B. Protein Prenylation Part B 1 11 .
Joshua D. Ochocki, Urule Igbavboa, W. Gibson Wood, Elizabeth V. Wattenberg & Mark D. Distefano. (2010) Enlarging the Scope of Cell-Penetrating Prenylated Peptides to Include Farnesylated ‘CAAX’ Box Sequences and Diverse Cell Types. Chemical Biology & Drug Design 76:2, pages 107-115.
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Jingxuan Pan & Sai‐Ching Jim Yeung. 2010. Emerging Cancer Therapy. Emerging Cancer Therapy 367 378 .
B. Douglas Smith & Judith E. Karp. (2009) What Are the Endpoints of Therapy for Acute Leukemias? Old Definitions and New Challenges. Clinical Lymphoma and Myeloma 9, pages S296-S301.
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Yuri K. Peterson, Xiang S. Wang, Patrick J. Casey & Alexander Tropsha. (2009) Discovery of Geranylgeranyltransferase-I Inhibitors with Novel Scaffolds by the Means of Quantitative Structure−Activity Relationship Modeling, Virtual Screening, and Experimental Validation. Journal of Medicinal Chemistry 52:14, pages 4210-4220.
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Niki A. Ottenhof, Anya N. A. Milne, Folkert H. M. Morsink, Paul Drillenburg, Fiebo J. W. ten Kate, Anirban Maitra & G. Johan Offerhaus. (2009) Pancreatic Intraepithelial Neoplasia and Pancreatic Tumorigenesis: Of Mice and Men. Archives of Pathology & Laboratory Medicine 133:3, pages 375-381.
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Alice N. Scott, Clare Hetheridge, Andrew R. Reynolds, Vrinda Nayak, Kairbaan Hodivala-Dilke & Harry Mellor. (2008) Farnesyltransferase inhibitors target multiple endothelial cell functions in angiogenesis. Angiogenesis 11:4, pages 337-346.
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David H. Gutmann. (2008) Using Neurofibromatosis-1 to Better Understand and Treat Pediatric Low-Grade Glioma. Journal of Child Neurology 23:10, pages 1186-1194.
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Clovis Orlando da Fonseca, Rafael Linden, Débora Futuro, Cerli Rocha Gattass & Thereza Quirico-Santos. (2008) Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol. Archivum Immunologiae et Therapiae Experimentalis 56:4, pages 267-276.
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William P. Vaughan & Judith E. Karp. (2008) The Long Road to a Cure for Acute Myelocytic Leukemia: From Intensity to Specificity. Journal of Clinical Oncology 26:21, pages 3475-3477.
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