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Cancer Investigation Volume 25, 2007 - Issue 7
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ORIGINAL ARTICLEPreclinical Therapeutics

Invasive Ability of Human Renal Cell Carcinoma Cell Line Caki-2 Is Accelerated by Gamma-Aminobutyric Acid, via Sustained Activation of ERK1/2 Inducible Matrix Metalloproteinases

Teruo Inamoto Departments of Urology, Osaka Medical College, Osaka, Japan
, M.D., Ph.D.,
Haruhito Azuma Departments of Urology, Osaka Medical College, Osaka, Japan
, M.D., Ph.D.,
Takeshi Sakamoto Departments of Urology, Osaka Medical College, Osaka, Japan
, M.D., Ph.D.,
Satoshi Kiyama Departments of Urology, Osaka Medical College, Osaka, Japan
,
Takanobu Ubai Departments of Urology, Osaka Medical College, Osaka, Japan
, M.D., Ph.D.,
Yatsugu Kotake Departments of Urology, Osaka Medical College, Osaka, Japan
, M.D.,
Masahito Watanabe Departments of Anatomy, Osaka Medical College, Osaka, Japan
, Ph.D. &
Yoji Katsuoka Departments of Urology, Osaka Medical College, Osaka, Japan
, M.D. show all
Pages 574-583 | Published online: 11 Jun 2009

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Yan Li, Shan Ji, Liye Fu, Tao Jiang, Di Wu & Fandong Meng. (2018) Over-expression of ARHGAP18 suppressed cell proliferation, migration, invasion, and tumor growth in gastric cancer by restraining over-activation of MAPK signaling pathways. OncoTargets and Therapy 11, pages 279-290.
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Tsai‐Kun Wu, Tung‐Wei Hung, Yong‐Syuan Chen, Ying‐Ru Pan, Yi‐Hsien Hsieh & Jen‐Pi Tsai. (2023) Corosolic acid inhibits metastatic response of human renal cell carcinoma cells by modulating ERK / MMP2 signaling . Environmental Toxicology.
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Mohammad Amin Elahi Najafi, Masato Yasui, Yuki Teramoto, Tomoyuki Tatenuma, Guiyang Jiang & Hiroshi Miyamoto. (2023) GABBR2 as a Downstream Effector of the Androgen Receptor Induces Cisplatin Resistance in Bladder Cancer. International Journal of Molecular Sciences 24:18, pages 13733.
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Hossein Tahmasebi Dehkordi, Sorayya Ghasemi & Masoumeh Eliyasi Dashtaki. (2023) Various Effects of the GABAergic System on Cancer: The Conditions and Specificities of its use in the Treatment of Some Cancers. Current Topics in Medicinal Chemistry 23:20, pages 1928-1936.
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Ting Luan, Yi Li, Lihui Sun, Siqi Xu, Haifeng Wang, Jiansong Wang & Chong Li. (2022) Systemic immune effects of anesthetics and their intracellular targets in tumors. Frontiers in Medicine 9.
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Balawant Kumar, Rizwan Ahmad, Giovanna A. Giannico, Roy Zent, Geoffrey A. Talmon, Raymond C. Harris, Peter E. Clark, Vinata Lokeshwar, Punita Dhawan & Amar B. Singh. (2021) Claudin-2 inhibits renal clear cell carcinoma progression by inhibiting YAP-activation. Journal of Experimental & Clinical Cancer Research 40:1.
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Bo Wei, Yini Zhu, Peng Yang, Yong Han, Suyun Wang, Xiaomei Wang, Shuai Xia, Xiaoguang Song, Zhongling Zhang, Sheng Wang, Philippe Rondard, Jean-Philippe Pin, Xinnong Jiang & Jianfeng Liu. (2021) GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12. iScience 24:11, pages 103311.
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Hong-Li Li, Qian-Yu Li, Min-Jie Jin, Chao-Fan Lu, Zhao-Yang Mu, Wei-Yi Xu, Jian Song, Yan Zhang & Sai-Yang Zhang. (2021) A review: hippo signaling pathway promotes tumor invasion and metastasis by regulating target gene expression. Journal of Cancer Research and Clinical Oncology 147:6, pages 1569-1585.
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Jianpeng Gao, Hongda Pan, Zhenglun Zhu, Teng Yu, Binhao Huang & Ye Zhou. (2020) Guanine nucleotide-binding protein subunit beta-4 promotes gastric cancer progression via activating Erk1/2. Acta Biochimica et Biophysica Sinica 52:9, pages 975-987.
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Man Yang, Ryan A. Hlady, Dan Zhou, Thai H. Ho & Keith D. Robertson. (2019) In silico DNA methylation analysis identifies potential prognostic biomarkers in type 2 papillary renal cell carcinoma. Cancer Medicine 8:12, pages 5760-5768.
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Kiyoto Kanbara, Yoshinori Otsuki, Masahito Watanabe, Syunichi Yokoe, Yoshiaki Mori, Michio Asahi & Masashi Neo. (2018) GABAB receptor regulates proliferation in the high-grade chondrosarcoma cell line OUMS-27 via apoptotic pathways. BMC Cancer 18:1.
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Yong Sun, Ming Lan, Xiu Chen, Yaolan Dai, XiaoQin Zhao, LiWen Wang, TingTing Zhao, YongBiao Li, Jiali Zhu, Xuemei Zhang, HeZhong Jiang, XiaoQing Wu, Chang Chen, Tiane Zhang & Zhiyong Yan. (2018) Anti-invasion and anti-metastasis effects of Valjatrate E via reduction of matrix metalloproteinases expression and suppression of MAPK/ERK signaling pathway. Biomedicine & Pharmacotherapy 104, pages 817-824.
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Shuai Xia, Cong He, Yini Zhu, Suyun Wang, Huiping Li, Zhongling Zhang, Xinnong Jiang & Jianfeng Liu. (2017) GABA B R-Induced EGFR Transactivation Promotes Migration of Human Prostate Cancer Cells . Molecular Pharmacology 92:3, pages 265-277.
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Xiaofeng Wang, Zhenjia Yu, Quan Zhou, Xiongyan Wu, Xuehua Chen, Jianfang Li, Zhenggang Zhu, Bingya Liu & Liping Su. (2016) Tissue transglutaminase-2 promotes gastric cancer progression via the ERK1/2 pathway . Oncotarget 7:6, pages 7066-7079.
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Gina M. Sizemore, Steven T. Sizemore, Darcie D. Seachrist & Ruth A. Keri. (2014) GABA(A) Receptor Pi (GABRP) Stimulates Basal-like Breast Cancer Cell Migration through Activation of Extracellular-regulated Kinase 1/2 (ERK1/2). Journal of Biological Chemistry 289:35, pages 24102-24113.
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Depu Zhang, Xiaowei Li, Ziming Yao, Chuanfei Wei, Nannan Ning & Jingxin Li. (2014) GABAergic signaling facilitates breast cancer metastasis by promoting ERK1/2-dependent phosphorylation. Cancer Letters 348:1-2, pages 100-108.
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Xinsheng Wang, Lei Luo, Dahai Dong, Qinchao Yu & Kai Zhao. (2014) Clusterin Plays an Important Role in Clear Renal Cell Cancer Metastasis. Urologia Internationalis 92:1, pages 95-103.
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Yan Guo, Ji Ma, Lin Wu, Qianrong Wang, Xia Li, Xiaoming Li, Yuan Zhang, Jian Zhang, Libo Yao, Jing Zhang & Wenchao Liu. (2013) Hyperthermia-Induced NDRG2 Upregulation Inhibits the Invasion of Human Hepatocellular Carcinoma via Suppressing ERK1/2 Signaling Pathway. PLoS ONE 8:4, pages e61079.
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Hui Xie, Yi-xue Xue, Li-bo Liu, Ping Wang, Yun-hui Liu & Hao-qiang Ying. (2010) Expressions of matrix metalloproteinase-7 and matrix metalloproteinase-14 associated with the activation of extracellular signal-regulated kinase1/2 in human brain gliomas of different pathological grades. Medical Oncology 28:S1, pages 433-438.
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Zhi Jie Li & Chi Hin Cho. (2011) Neurotransmitters, more than meets the eye — Neurotransmitters and their perspectives in cancer development and therapy. European Journal of Pharmacology 667:1-3, pages 17-22.
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Hiroshi Hirata, Yuji Hinoda, Shahana Majid, Yi Chen, Mohd S. Zaman, Koji Ueno, Koichi Nakajima, Z. Laura Tabatabai, Nobuhisa Ishii & Rajvir Dahiya. (2010) DICKKOPF‐4 activates the noncanonical c‐Jun‐NH2 kinase signaling pathway while inhibiting the Wnt‐canonical pathway in human renal cell carcinoma. Cancer 117:8, pages 1649-1660.
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Yufeng Miao, Youwei Zhang, Haijun Wan, Longbang Chen & Fangyu Wang. (2010) GABA-receptor agonist, propofol inhibits invasion of colon carcinoma cells. Biomedicine & Pharmacotherapy 64:9, pages 583-588.
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Hong-fang CHEN, Ya-mei ZHANG & Hua-yu DENG. (2009) Effect of Janus kinase inhibition on extracellular signal-regulated protein kinase during invasion and metastasis of human breast cancer cell MDA-MB-231. Academic Journal of Second Military Medical University 28:8, pages 900-903.
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Lee Campbell, Rosa Nuttall, David Griffiths & Mark Gumbleton. (2009) Activated extracellular signal‐regulated kinase is an independent prognostic factor in clinically confined renal cell carcinoma. Cancer 115:15, pages 3457-3467.
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Kathleen A. Dave & Angélique Bordey. (2009) GABA increases Ca 2+ in cerebellar granule cell precursors via depolarization: Implications for proliferation . IUBMB Life 61:5, pages 496-503.
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Kentaro Maemura, Nanako Shiraishi, Kumiko Sakagami, Ken Kawakami, Takuya Inoue, Mitsuyuki Murano, Masahito Watanabe & Yoshinori Otsuki. (2009) Proliferative effects of γ-aminobutyric acid on the gastric cancer cell line are associated with extracellular signal-regulated kinase 1/2 activation. Journal of Gastroenterology and Hepatology 24:4, pages 688-696.
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Jing Zhao, Hong-fang Chen & Hua-yu Deng. (2009) Effects of inhibiting JAK on invasion and metastasis of the human breast cancer cells through ERK signaling transduction pathway. Chinese Journal of Cancer Research 21:1, pages 32-36.
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