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Cancer Investigation Volume 26, 2008 - Issue 2
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ORIGINAL ARTICLE Cellular and Molecular Biology

The Synthetic Triterpenoid CDDO-Im Inhibits Fatty Acid Synthase Expression and Has Antiproliferative and Proapoptotic Effects in Human Liposarcoma Cells

David T. Hughes Department of Surgery, Section of Surgical Oncology, Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA; Dartmouth Medical School, Hanover, New Hampshire, USA
,
Peter M. Martel Dartmouth Medical School, Hanover, New Hampshire, USA; Department of Medicine, Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA
,
William B. Kinlaw Dartmouth Medical School, Hanover, New Hampshire, USA; Department of Medicine, Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA
&
Burton L. Eisenberg Department of Surgery, Section of Surgical Oncology, Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA; Dartmouth Medical School, Hanover, New Hampshire, USA
Pages 118-127 | Published online: 11 Jun 2009

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Christina Donnelly, ArneM. Olsen, LionelD. Lewis, BurtonL. Eisenberg, Alan Eastman & WilliamB. Kinlaw. (2008) Conjugated Linoleic Acid (CLA) Inhibits Expression of the Spot 14 (THRSP) and Fatty Acid Synthase Genes and Impairs the Growth of Human Breast Cancer and Liposarcoma Cells. Nutrition and Cancer 61:1, pages 114-122.
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Articles from other publishers (14)

Prasanta Dey, Amit Kundu, Babli Kar, Anushree Bhakta, Vineet Vishal, S. Keerthana, Anoop Kumar, Tejendra Bhakta, Suvakanta Dash & Hyung Sik Kim. 2021. Evidence Based Validation of Traditional Medicines. Evidence Based Validation of Traditional Medicines 29 75 .
Donna D. Zhang & Eli Chapman. (2020) The role of natural products in revealing NRF2 function. Natural Product Reports 37:6, pages 797-826.
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Beate K. Straub, Hagen R. Witzel, Lena M. Pawella, Marcus Renner, Eva Eiteneuer, Merita Hashani, Peter Schirmacher, Wilfried Roth & Gunhild Mechtersheimer. (2019) Perilipin 1 Expression Differentiates Liposarcoma from Other Types of Soft Tissue Sarcoma. The American Journal of Pathology 189:8, pages 1547-1558.
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Angela R. Guerra, Maria F. Duarte & Iola F. Duarte. (2018) Targeting Tumor Metabolism with Plant-Derived Natural Products: Emerging Trends in Cancer Therapy. Journal of Agricultural and Food Chemistry 66:41, pages 10663-10685.
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Cui Huang, Dong Dong, Qian Jiao, Hui Pan, Lei Ma & Rui Wang. (2017) Sarsasapogenin-AA13 ameliorates A β -induced cognitive deficits via improving neuroglial capacity on A β clearance and antiinflammation . CNS Neuroscience & Therapeutics 23:6, pages 498-509.
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William B. Kinlaw, Paul W. Baures, Leslie E. Lupien, Wilson L. Davis & Nancy B. Kuemmerle. (2016) Fatty Acids and Breast Cancer: Make Them on Site or Have Them Delivered. Journal of Cellular Physiology 231:10, pages 2128-2141.
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Xin Wang & Chunxu Hai. (2015) Redox modulation of adipocyte differentiation: hypothesis of “Redox Chain” and novel insights into intervention of adipogenesis and obesity. Free Radical Biology and Medicine 89, pages 99-125.
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Margit M. McGowan, Burton L. Eisenberg, Lionel D. Lewis, Heather M. Froehlich, Wendy A. Wells, Alan Eastman, Nancy B. Kuemmerle, Kari M. Rosenkrantz, Richard J. BarthJr.Jr., Gary N. Schwartz, Zhongze Li, Tor D. Tosteson, Bernard B. BeaulieuJr.Jr. & William B. Kinlaw. (2013) A proof of principle clinical trial to determine whether conjugated linoleic acid modulates the lipogenic pathway in human breast cancer tissue. Breast Cancer Research and Treatment 138:1, pages 175-183.
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Karen T. Liby & Michael B. Sporn. (2012) Synthetic Oleanane Triterpenoids: Multifunctional Drugs with a Broad Range of Applications for Prevention and Treatment of Chronic Disease. Pharmacological Reviews 64:4, pages 972-1003.
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Eun-Hee Kim, Chuxia Deng, Michael B. Sporn, Darlene B. Royce, Renee Risingsong, Charlotte R. Williams & Karen T. Liby. (2012) CDDO-Methyl Ester Delays Breast Cancer Development in Brca1 -Mutated Mice . Cancer Prevention Research 5:1, pages 89-97.
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Nancy B. Kuemmerle, Evelien Rysman, Portia S. Lombardo, Alison J. Flanagan, Brea C. Lipe, Wendy A. Wells, Jason R. Pettus, Heather M. Froehlich, Vincent A. Memoli, Peter M. Morganelli, Johannes V. Swinnen, Luika A. Timmerman, Leila Chaychi, Catherine J. Fricano, Burton L. Eisenberg, William B. Coleman & William B. Kinlaw. (2011) Lipoprotein Lipase Links Dietary Fat to Solid Tumor Cell Proliferation. Molecular Cancer Therapeutics 10:3, pages 427-436.
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Ling Yang, Jun Liu, Mu Liu, Meirui Qian, Minzhou Zhang & Huajun Hu. (2011) Identification of fatty acid synthase from the Pacific white shrimp, Litopenaeus vannamei and its specific expression profiles during white spot syndrome virus infection. Fish & Shellfish Immunology 30:2, pages 744-749.
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Alessia Petronelli, Gaetano Pannitteri & Ugo Testa. (2009) Triterpenoids as new promising anticancer drugs. Anti-Cancer Drugs 20:10, pages 880-892.
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Soona Shin, Junko Wakabayashi, Melinda S. Yates, Nobunao Wakabayashi, Patrick M. Dolan, Susan Aja, Karen T. Liby, Michael B. Sporn, Masayuki Yamamoto & Thomas W. Kensler. (2009) Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide. European Journal of Pharmacology 620:1-3, pages 138-144.
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