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ORIGINAL ARTICLE Clinical Translational Therapeutics

Carboxylesterase 2 is Downregulated in Colorectal Cancer Following Progression of the Disease

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Pages 178-181 | Published online: 11 Jun 2009

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Shi-Yu Liu, Xiaoting Zou, Yu Guo & Xing Gao. (2022) A highly sensitive and selective enzyme activated fluorescent probe for in vivo profiling of carboxylesterase 2. Analytica Chimica Acta 1221, pages 340126.
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Karishma Kailass, Oleg Sadovski, Warren R. Zipfel & Andrew A. Beharry. (2022) Two-Photon Photodynamic Therapy Targeting Cancers with Low Carboxylesterase 2 Activity Guided by Ratiometric Fluorescence. Journal of Medicinal Chemistry 65:13, pages 8855-8868.
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Xingyu Liu, Xiangqian Li, Pei Dong, Zhiming Wu, Jinwei Gao & Qianming Wang. (2020) Near-infrared emission tracks inter-individual variability of carboxylesterase-2 via a novel molecular substrate. Microchimica Acta 187:6.
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Chien-Chih Ke, Lih-Chyang Chen, Chia-Cheng Yu, Wei-Chung Cheng, Chao-Yuan Huang, Victor C. Lin, Te-Ling Lu, Shu-Pin Huang & Bo-Ying Bao. (2020) Genetic Analysis Reveals a Significant Contribution of CES1 to Prostate Cancer Progression in Taiwanese Men. Cancers 12:5, pages 1346.
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Benjamin Goeppert, Marcus Renner, Stephan Singer, Thomas Albrecht, Qiangnu Zhang, Arianeb Mehrabi, Anita Pathil, Christoph Springfeld, Bruno Köhler, Christian Rupp, Karl Heinz Weiss, Anja A. Kühl, Ruza Arsenic, Ulrich Frank Pape, Arndt Vogel, Peter Schirmacher, Stephanie Roessler & Nalân Utku. (2019) Prognostic Impact of Carboxylesterase 2 in Cholangiocarcinoma. Scientific Reports 9:1.
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Sang Jun Park, Yun Ji Kim, Ji Su Kang, In Young Kim, Kyeong Sook Choi & Hwan Myung Kim. (2018) Carboxylesterase-2-Selective Two-Photon Ratiometric Probe Reveals Decreased Carboxylesterase-2 Activity in Breast Cancer Cells. Analytical Chemistry 90:15, pages 9465-9471.
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Anja A. Kühl, Ulrike Erben, Constanze Cieluch, Simone Spieckermann, Jörn Gröne, Philipp Lohneis, Ulrich Frank Pape, Ruza Arsenic & Nalân Utku. (2016) Tissue-infiltrating plasma cells are an important source of carboxylesterase 2 contributing to the therapeutic efficacy of prodrugs. Cancer Letters 378:1, pages 51-58.
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Kentaro Yoshioka, Toru Komatsu, Akihiro Nakada, Jun Onagi, Yugo Kuriki, Mitsuyasu Kawaguchi, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Tetsuo Nagano & Yasuteru Urano. (2015) Identification of Tissue-Restricted Bioreaction Suitable for in Vivo Targeting by Fluorescent Substrate Library-Based Enzyme Discovery. Journal of the American Chemical Society 137:38, pages 12187-12190.
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Nur Zarina Ali Hassan, Norfilza Mohd Mokhtar, Teow Kok Sin, Isa Mohamed Rose, Ismail Sagap, Roslan Harun & Rahman Jamal. (2014) Integrated Analysis of Copy Number Variation and Genome-Wide Expression Profiling in Colorectal Cancer Tissues. PLoS ONE 9:4, pages e92553.
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C. C. Wong, K.-W. Cheng, G. Xie, D. Zhou, C.-H. Zhu, P. P. Constantinides & B. Rigas. (2011) Carboxylesterases 1 and 2 Hydrolyze Phospho-Nonsteroidal Anti-Inflammatory Drugs: Relevance to Their Pharmacological Activity. Journal of Pharmacology and Experimental Therapeutics 340:2, pages 422-432.
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Roger S. Holmes, Laura A. Cox & John L. VandeBerg. (2010) Mammalian carboxylesterase 3: comparative genomics and proteomics. Genetica 138:7, pages 695-708.
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Edward L. HuttlinXiaodi ChenGregory A. Barrett-WiltAdrian D. Hegeman, Richard B. HalbergAmy C. HarmsMichael A. NewtonWilliam F. Dove & Michael R. Sussman. (2009) Discovery and validation of colonic tumor-associated proteins via metabolic labeling and stable isotopic dilution. Proceedings of the National Academy of Sciences 106:40, pages 17235-17240.
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Roger S. Holmes, Laura A. Cox & John L. VandeBerg. (2009) Horse carboxylesterases: Evidence for six CES1 and four families of CES genes on chromosome 3. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 4:1, pages 54-65.
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