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Cancer Investigation Volume 26, 2008 - Issue 2
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ORIGINAL ARTICLE Clinical Translational Therapeutics

Klotho Expression in Epithelial Ovarian Cancer and its Association with Insulin-Like Growth Factors and Disease Progression

Lingeng Lu Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USA
,
Dionyssios Katsaros Department of Obstetrics and Gynecology, Gynecologic Oncology and Breast Cancer Unit, University of Turin, Turin, Italy
,
Andrew Wiley Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USA
,
Irene A. Rigault de la Longrais Department of Obstetrics and Gynecology, Gynecologic Oncology and Breast Cancer Unit, University of Turin, Turin, Italy
,
Manuela Puopolo Department of Obstetrics and Gynecology, Gynecologic Oncology and Breast Cancer Unit, University of Turin, Turin, Italy
&
Herbert Yu Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USA
Pages 185-192 | Published online: 11 Jun 2009

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Yun Zhu, Xuehong Cao, Xiaomeng Zhang, Quan Chen, Lei Wen & Ping Wang. (2019) DNA methylation-mediated Klotho silencing is an independent prognostic biomarker of head and neck squamous carcinoma. Cancer Management and Research 11, pages 1383-1390.
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Bing Jiang, Yonghong Gu & Yuxiang Chen. (2014) Identification of Novel Predictive Markers for the Prognosis of Pancreatic Ductal Adenocarcinoma. Cancer Investigation 32:6, pages 218-225.
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Articles from other publishers (41)

Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Sambhu Mondal & Snehasis Jana. (2023) Vitamin D3 supplementation improves spatial memory, muscle function, pain score, and modulates different functional physiological biomarkers in vitamin D3 deficiency diet (VDD)-induced rats model. BMC Nutrition 9:1.
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Kristina I. Nesterova, Yelena Yu. Glinka, Valentina N. Perfilova, Alla A. Nesterova & Kamil D. Kaplanov. (2023) Antiaging Klotho Protein as a Prospective Novel Tumor Suppressor. Annals of the Russian academy of medical sciences 78:1, pages 24-44.
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Geonuk Kim, Heaji Chung, Sungin Lee & Wan Hee Kim. (2022) Reduced Klotho expression and its prognostic significance in canine hepatocellular carcinoma. Veterinary and Comparative Oncology 21:1, pages 91-99.
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Hagai Ligumsky, Keren Merenbakh-Lamin, Noa Keren-Khadmy, Ido Wolf & Tami Rubinek. (2022) The role of α-klotho in human cancer: molecular and clinical aspects. Oncogene 41:40, pages 4487-4497.
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Vsevolod V. Melekhin, Alexander I. Ponomarev, Maria A. Desyatova & Oleg G. Makeev. (2022) Investigation of the Role of Induced Overexpression of the Isolated Secreted Klotho on the A-172 Human Glioblastoma Cells. Journal of Molecular Neuroscience 72:2, pages 401-409.
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William C. Weston, Karen H. Hales & Dale B. Hales. (2021) Flaxseed Increases Animal Lifespan and Reduces Ovarian Cancer Severity by Toxically Augmenting One-Carbon Metabolism. Molecules 26:18, pages 5674.
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Maryam Al‑Zahrani, Fatimah Yahya, Mourad Assidi, Ashraf Dallol & Abdelbaset Buhmeida. (2021) Klotho promoter methylation status and its prognostic value in ovarian cancer. Molecular and Clinical Oncology 15:3.
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Maryam Abolghasemi, Tooba Yousefi, Mahmood Maniati & Durdi Qujeq. (2019) The interplay of Klotho with signaling pathway and microRNAs in cancers. Journal of Cellular Biochemistry 120:9, pages 14306-14317.
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C Martín-González, E González-Reimers, G Quintero-Platt, A Martínez-Riera & F Santolaria-Fernández. (2019) Soluble α-Klotho in Liver Cirrhosis and Alcoholism. Alcohol and Alcoholism 54:3, pages 204-208.
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Qingguo Li, Yaqi Li, Lei Liang, Jing Li, Dakui Luo, Qi Liu, Sanjun Cai & Xinxiang Li. (2018) Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1α axis. Cell Communication and Signaling 16:1.
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Song Mao, Xiaopeng Wang, Liangxia Wu, Dou Zang & Wenjing Shi. (2018) Association between klotho expression and malignancies risk and progression: A meta-analysis. Clinica Chimica Acta 484, pages 14-20.
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Rik Mencke, Geert Harms, Jill Moser, Matijs van Meurs, Arjan Diepstra, Henri G. Leuvenink & Jan-Luuk Hillebrands. (2017) Human alternative Klotho mRNA is a nonsense-mediated mRNA decay target inefficiently spliced in renal disease. JCI Insight 2:20.
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Hannes Olauson, Rik Mencke, Jan-Luuk Hillebrands & Tobias E. Larsson. (2017) Tissue expression and source of circulating αKlotho. Bone 100, pages 19-35.
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Lingling Li, Min Zhang, Liqin Zhang, Yusheng Cheng, Xiongwen Tu & Zhiwei Lu. (2017) Klotho Regulates Cigarette Smoke-Induced Autophagy: Implication in Pathogenesis of COPD. Lung 195:3, pages 295-301.
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Youliang Yan, Yifeng Wang, Yi Xiong, Xiufeng Lin, Ping Zhou & Zhiying Chen. (2017) Reduced Klotho expression contributes to poor survival rates in human patients with ovarian cancer, and overexpression of Klotho inhibits the progression of ovarian cancer partly via the inhibition of systemic inflammation in nude mice. Molecular Medicine Reports.
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TianJun ChenHui RenAsmitanand ThakurTian YangYang LiShuo ZhangTing WangMingWei Chen. (2016) Decreased Level of Klotho Contributes to Drug Resistance in Lung Cancer Cells: Involving in Klotho-Mediated Cell Autophagy. DNA and Cell Biology 35:12, pages 751-757.
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X. Tang, Z. Fan, Y. Wang, G. Ji, M. Wang, J. Lin & S. Huang. (2016) Expression of klotho and β-catenin in esophageal squamous cell carcinoma, and their clinicopathological and prognostic significance. Diseases of the Esophagus 29:3, pages 207-214.
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Xiaowei Tang, Yun Wang, Zhining Fan, Guozhong Ji, Min Wang, Jie Lin, Shu Huang & Stephen J Meltzer. (2016) Klotho: a tumor suppressor and modulator of the Wnt/β-catenin pathway in human hepatocellular carcinoma. Laboratory Investigation 96:2, pages 197-205.
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T. Rubinek & D. Modan-Moses. 2016. Klotho. Klotho 85 118 .
Huidong Sun, Yanchao Gao, Kemei Lu, Guimei Zhao, Xuehua Li, Zhu Li & Hong Chang. (2015) Overexpression of Klotho suppresses liver cancer progression and induces cell apoptosis by negatively regulating wnt/β-catenin signaling pathway. World Journal of Surgical Oncology 13:1.
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Attaya Suvannasankha, Douglas R. Tompkins, Daniel F. Edwards, Katarina V. Petyaykina, Colin D. Crean, Pierrick G. Fournier, Jamie M. Parker, George E. Sandusky, Shoji Ichikawa, Erik A. Imel & John M. Chirgwin. (2015) FGF23 is elevated in multiple myeloma and increases heparanase expression by tumor cells. Oncotarget 6:23, pages 19647-19660.
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Irina Lojkin, Tami Rubinek, Sandra Orsulic, Omer Schwarzmann, Beth Y. Karlan, Shikha Bose & Ido Wolf. (2015) Reduced expression and growth inhibitory activity of the aging suppressor klotho in epithelial ovarian cancer. Cancer Letters 362:2, pages 149-157.
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Xiangxiang Zhou & Xin Wang. (2014) Klotho: a novel biomarker for cancer. Journal of Cancer Research and Clinical Oncology 141:6, pages 961-969.
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Yuechi Xu & Zhongjie Sun. (2015) Molecular Basis of Klotho: From Gene to Function in Aging. Endocrine Reviews 36:2, pages 174-193.
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Ci-Di Chen, Hu Li, Jennifer Liang, Kathryn Hixson, Ella Zeldich & Carmela R. Abraham. (2014) The Anti-Aging and Tumor Suppressor Protein Klotho Enhances Differentiation of a Human Oligodendrocytic Hybrid Cell Line. Journal of Molecular Neuroscience 55:1, pages 76-90.
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Xu-Jun He, Ying-Yu Ma, Sheng Yu, Xiao-Ting Jiang, Yi-Ding Lu, Liang Tao, Hua-Ping Wang, Zhi-Ming Hu & Hou-Quan Tao. (2014) RETRACTED ARTICLE: Up-regulated miR-199a-5p in gastric cancer functions as an oncogene and targets klotho. BMC Cancer 14:1.
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XIN-XIANG LI, LI-YONG HUANG, JUN-JIE PENG, LEI LIANG, DE-BING SHI, HONG-TU ZHENG & SAN-JUN CAI. (2014) Klotho suppresses growth and invasion of colon cancer cells through inhibition of IGF1R-mediated PI3K/AKT pathway. International Journal of Oncology 45:2, pages 611-618.
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Biao Xie, Jianping Zhou, Guoshun Shu, Dong-cai Liu, Jiapeng Zhou, Jinhui Chen & Lianwen Yuan. (2013) Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer. Cancer Cell International 13:1.
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Tracey B. Tucker Zhou, Gwendalyn D. King, CiDi Chen & Carmela R. Abraham. (2013) Biochemical and Functional Characterization of the Klotho-VS Polymorphism Implicated in Aging and Disease Risk. Journal of Biological Chemistry 288:51, pages 36302-36311.
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Biao Xie, Jinhui Chen, Bin Liu & Junkun Zhan. (2013) Klotho Acts as a Tumor Suppressor in Cancers. Pathology & Oncology Research 19:4, pages 611-617.
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Biao Xie, Jianping Zhou, Lianwen Yuan, Feng Ren, Dong-cai Liu, Qinglong Li & Guoshun Shu. (2013) Epigenetic silencing of Klotho expression correlates with poor prognosis of human hepatocellular carcinoma. Human Pathology 44:5, pages 795-801.
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Guoshun Shu, Biao Xie, Feng Ren, Dong-cai Liu, Jiapeng Zhou, Qinglong Li, Jinhui Chen, Lianwen Yuan & Jianping Zhou. (2012) Restoration of klotho expression induces apoptosis and autophagy in hepatocellular carcinoma cells. Cellular Oncology 36:2, pages 121-129.
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Tami Rubinek, Michal Shulman, Shira Israeli, Shikha Bose, Ayelet Avraham, Adi Zundelevich, Ella Evron, Einav Nili Gal-Yam, Bella Kaufman & Ido Wolf. (2011) Epigenetic silencing of the tumor suppressor klotho in human breast cancer. Breast Cancer Research and Treatment 133:2, pages 649-657.
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Yael Laitman, Karoline B. Kuchenbaecker, Johanna Rantala, Frans Hogervorst, Susan Peock, Andrew K. Godwin, Adalgeir Arason, Tomas Kirchhoff, Kenneth Offit, Claudine Isaacs, Rita K. Schmutzler, Barbara Wappenschmidt, Heli Nevanlinna, Xiaoqing Chen, Georgia Chenevix-Trench, Sue Healey, Fergus Couch, Paolo Peterlongo, Paolo Radice, Katherine L. Nathanson, Maria Adelaide Caligo, Susan L. Neuhausen, Patricia Ganz, Olga M. Sinilnikova, Lesley McGuffog, Douglas F. Easton, Antonis C. Antoniou, Ido Wolf & Eitan Friedman. (2012) The KL-VS sequence variant of Klotho and cancer risk in BRCA1 and BRCA2 mutation carriers. Breast Cancer Research and Treatment 132:3, pages 1119-1126.
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Gwendalyn D. KingCiDi ChenMickey M. HuangElla ZeldichPatricia L. BrazeeEli R. SchumanMaxime Robin, Gregory D. CunyMarcie A. GlicksmanCarmela R. Abraham. (2011) Identification of novel small molecules that elevate Klotho expression. Biochemical Journal 441:1, pages 453-461.
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Gamal Badr, Olivier Garraud, Maha Daghestani, Mohammed Saleh Al-Khalifa & Yolande Richard. (2012) Human breast carcinoma cells are induced to apoptosis by samsum ant venom through an IGF-1-dependant pathway, PI3K/AKT and ERK signaling. Cellular Immunology 273:1, pages 10-16.
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S. John Weroha & Paul Haluska. (2008) IGF-1 Receptor Inhibitors in Clinical Trials—Early Lessons. Journal of Mammary Gland Biology and Neoplasia 13:4, pages 471-483.
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