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ORIGINAL ARTICLE Cellular and Molecular Biology

Urocortin's Inhibition of Tumor Growth and Angiogenesis in Hepatocellular Carcinoma via Corticotrophin-Releasing Factor Receptor 2

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Pages 359-368 | Published online: 11 Jun 2009

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L. Sherlock, D.E.F. Mckeegan, Z. Cheng, C.M. Wathes & D.C. Wathes. (2012) Effects of contact dermatitis on hepatic gene expression in broilers. British Poultry Science 53:4, pages 439-452.
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Juejin Wang, Lai Jin, Jie Chen & Shengnan Li. (2009) Activation of Corticotropin-Releasing Factor Receptor 2 Inhibits the Growth of Human Small Cell Lung Carcinoma Cells. Cancer Investigation 28:2, pages 146-155.
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Angélica Araceli Ramírez-Guerrero, Christian Octavio González-Villaseñor, Evelia Leal-Ugarte, Melva Gutiérrez-Angulo, Mario Ramírez-Flores, Iván Delgado-Enciso & Nelly Margarita Macías-Gómez. (2023) Association between Genetic Variant rs2267716 of CRHR2 Gene with Colorectal Cancer . Journal of Investigative Medicine 70:4, pages 947-952.
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Pouriya Faraj Tabrizi, Anahit Mohebbi Tafrechi, Inga Peters, Faranaz Atschekzei, Markus Antonius Kuczyk, Jürgen Serth & Hossein Tezval. (2019) Cancer-Specific Loss of Urocortin 3 in Human Renal Cancer. Advances in Therapy 37:1, pages 288-299.
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Hossein Tezval, Natalia Dubrowinskaja, Inga Peters, Christel Reese, Katrin Serth, Faranaz Atschekzei, J?rg Hennenlotter, Arnulf Stenzl, Markus A. Kuczyk & J?rgen Serth. (2016) Tumor Specific Epigenetic Silencing of Corticotropin Releasing Hormone -Binding Protein in Renal Cell Carcinoma: Association of Hypermethylation and Metastasis. PLOS ONE 11:10, pages e0163873.
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Caterina Squillacioti, Adriana De Luca, Giovanna Liguori, Sabrina Al?Giuseppe Germano, Giuseppe Vassalotti, Luigi Navas & Nicola Mirabella. (2016) Urocortinergic system in the testes of normal and cryptorchid dogs. Annals of Anatomy - Anatomischer Anzeiger 207, pages 91-96.
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Jorge A. Rodriguez, Sara Huerta-Yepez, Ivy Ka Man Law, Guillermina J. Baay-Guzman, Belen Tirado-Rodriguez, Jill M. Hoffman, Dimitrios Iliopoulos, Daniel W. Hommes, Hein W. Verspaget, Lin Chang, Charalabos Pothoulakis & Stavroula Baritaki. (2015) Diminished Expression of Corticotropin-Releasing Hormone Receptor 2 in Human Colon Cancer Promotes Tumor Growth and Epithelial-to-Mesenchymal Transition via Persistent Interleukin-6/Stat3 Signaling. Cellular and Molecular Gastroenterology and Hepatology 1:6, pages 610-630.
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Sang Hoon Rhee, Elise L. Ma, Yunna Lee, Yvette Taché, Charalabos Pothoulakis & Eunok Im. (2015) Corticotropin Releasing Hormone and Urocortin 3 Stimulate Vascular Endothelial Growth Factor Expression through the cAMP/CREB Pathway. Journal of Biological Chemistry 290:43, pages 26194-26203.
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Daniel Wai-Hung Ho, Alan Ka-Lun Kai & Irene Oi-Lin Ng. (2015) TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways in hepatocellular carcinoma. Frontiers of Medicine 9:3, pages 322-330.
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Omair Anwar Mohiuddin & Chris Biggs. (2015) Evaluation of the effect of natural peptide 'Urocortin' on corticotrophin releasing factor (CRF) receptor expression in ND7/23 cells. Brazilian Journal of Pharmaceutical Sciences 51:1, pages 233-239.
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Shu Xu, QiuYi Wu, Gang Guo & XinSheng Ding. (2015) The protective effects of urocortin1 against intracerebral hemorrhage by activating JNK1/2 and p38 phosphorylation and further increasing VEGF via corticotropin-releasing factor receptor 2. Neuroscience Letters 589, pages 31-36.
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Eunok Im. (2015) Multi-facets of Corticotropin-releasing Factor in Modulating Inflammation and Angiogenesis. Journal of Neurogastroenterology and Motility 21:1, pages 025-032.
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Marjolaine A. Pelissier-Rota, Nicolas T. Chartier & Muriel R. Jacquier-Sarlin. 2015. Intercellular Communication in Cancer. Intercellular Communication in Cancer 53 149 .
Chao Zhu, Zongxing Sun, Chuanhua Li, Rui Guo, Li Li, Lai Jin, Rong Wan & Shengnan Li. (2014) Urocortin affects migration of hepatic cancer cell lines via differential regulation of cPLA2 and iPLA2. Cellular Signalling 26:5, pages 1125-1134.
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L. Jin, C. Li, R. Li, Z. Sun, X. Fang & S. Li. (2014) Corticotropin-releasing hormone receptors mediate apoptosis via cytosolic calcium-dependent phospholipase A2 and migration in prostate cancer cell RM-1. Journal of Molecular Endocrinology 52:3, pages 255-267.
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Lai Jin, Jiandong Chen, Li Li, Chuanhua Li, Cheng Chen & Shengnan Li. (2014) CRH suppressed TGFβ1-induced Epithelial–Mesenchymal Transition via induction of E-cadherin in breast cancer cells. Cellular Signalling 26:4, pages 757-765.
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Eunok Im. (2014) Corticotropin-releasing Hormone and Its Biological Diversity toward Angiogenesis. Intestinal Research 12:2, pages 96.
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Hossein Tezval, Faranaz Atschekzei, Inga Peters, Sandra Waalkes, J?rg Hennenlotter, Arnulf Stenzl, Jan U Becker, Axel S Merseburger, Markus A Kuczyk & J?rgen Serth. (2013) Reduced mrna expression level of corticotropin-releasing hormone-binding protein is associated with aggressive human kidney cancer. BMC Cancer 13:1.
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Sae Hwan Lee, Young‐Hwa Chung, Jeong A. Kim, Danbi Lee, Young‐Joo Jin, Ju Hyun Shim, Myoung‐Kuk Jang, Eun‐Young Cho, Eun‐Soon Shin, Jong‐Eun Lee, Neung Hwa Park, Eunsil Yu & Young Joo Lee. (2011) Single nucleotide polymorphisms associated with metastatic tumour antigen 1 overexpression in patients with hepatocellular carcinoma. Liver International 32:3, pages 457-466.
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Lai Jin, Qichun Zhang, Rui Guo, Lina Wang, Juejin Wang, Rong Wan, Rongjian Zhang, Youhua Xu & Shengnan Li. (2011) Different effects of corticotropin-releasing factor and urocortin 2 on apoptosis of prostate cancer cells in vitro. Journal of Molecular Endocrinology 47:2, pages 219-227.
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Theophilus I. Emeto, Joseph V. Moxon, Catherine Rush, Lynn Woodward & Jonathan Golledge. (2011) Relevance of urocortins to cardiovascular disease. Journal of Molecular and Cellular Cardiology 51:3, pages 299-307.
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P. M. Jamieson, M. E. Cleasby, Y. Kuperman, N. M. Morton, P. A. T. Kelly, D. G. Brownstein, K. J. Mustard, J. M. Vaughan, R. N. Carter, C. N. Hahn, D. G. Hardie, J. R. Seckl, A. Chen & W. W. Vale. (2011) Urocortin 3 transgenic mice exhibit a metabolically favourable phenotype resisting obesity and hyperglycaemia on a high-fat diet. Diabetologia 54:9, pages 2392-2403.
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Huayuan Zhu, Juejin Wang, Jianyong Li & Shengnan Li. (2011) Corticotropin-releasing factor family and its receptors: pro-inflammatory or anti-inflammatory targets in the periphery?. Inflammation Research 60:8, pages 715-721.
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Idoia Gamez, Robert P. Ryan, Lakesha D. Reid, Sheri M. Routt & Beth A. Hollister. (2010) Corticorelin acetate, a synthetic corticotropin-releasing factor with preclinical antitumor activity, alone and with bevacizumab, against human solid tumor models. Cancer Chemotherapy and Pharmacology 67:6, pages 1415-1422.
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Alicia Arranz, Maria Venihaki, Berber Mol, Ariadne Androulidaki, Erini Dermitzaki, Olga Rassouli, Jorge Ripoll, Efstathios N Stathopoulos, Rosa P Gomariz, Andrew N Margioris & Christos Tsatsanis. (2010) The impact of stress on tumor growth: peripheral CRF mediates tumor-promoting effects of stress. Molecular Cancer 9:1.
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Kuntal Pal, Kunchithapadam Swaminathan, H. Eric Xu & Augen A. Pioszak. (2010) Structural Basis for Hormone Recognition by the Human CRFR2α G Protein-coupled Receptor. Journal of Biological Chemistry 285:51, pages 40351-40361.
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Kazunori Kageyama, Komaki Hanada & Toshihiro Suda. (2010) Differential regulation and roles of urocortins in human adrenal H295R cells. Regulatory Peptides 162:1-3, pages 18-25.
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Konstantinos A. Paschos, Chara Charsou, Theodoros C. Constantinidis, Stavros Anagnostoulis, Maria Lambropoulou, Fotini Papachristou, Konstantinos Simopoulos & Ekaterini Chatzaki. (2010) Corticotropin-Releasing Hormone Receptors Mediate Opposing Effects in Cholestasis-Induced Liver Cell Apoptosis. Endocrinology 151:4, pages 1704-1712.
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Athina Kaprara, Kalliopi Pazaitou-Panayiotou, Alexandros Kortsaris & Ekaterini Chatzaki. (2010) The corticotropin releasing factor system in cancer: expression and pathophysiological implications. Cellular and Molecular Life Sciences 67:8, pages 1293-1306.
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Xing Gu, Peng Qi, Feiguo Zhou, Qiang Ji, Hao Wang, Tonghai Dou, Yunpeng Zhao & Chunfang Gao. (2009) An intronic polymorphism in the corticotropin-releasing hormone receptor 2 gene increases susceptibility to HBV-related hepatocellular carcinoma in Chinese population. Human Genetics 127:1, pages 75-81.
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Sean M. Davidson & Derek M. Yellon. (2009) Urocortin: A Few Inflammatory Remarks. Endocrinology 150:12, pages 5205-5207.
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Rihong Cong, Qingmin Sun, Li Yang, Haijuan Gu, Ying Zeng & Bin Wang. (2009) Effect of Genistein on vasculogenic mimicry formation by human uveal melanoma cells. Journal of Experimental & Clinical Cancer Research 28:1.
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Hossein Tezval, Stefanie Jurk, Farahnaz Atschekzei, Jan U. Becker, Olaf Jahn, Jürgen Serth & Markus A. Kuczyk. (2009) Urocortin and corticotropin-releasing factor receptor 2 in human renal cell carcinoma: disruption of an endogenous inhibitor of angiogenesis and proliferation. World Journal of Urology 27:6.
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Youhua Xu, Rongjian Zhang, Jie Chen, Qichun Zhang, Juejin Wang, Jue Hu, Xiaowei Guan, Lai Jin, Hong Fu, Bo Gui, Yuanyuan Guo & Shengnan Li. (2009) Urocortin promotes the development of vasculitis in a rat model of thromboangiitis obliterans via corticotrophin-releasing factor type 1 receptors. British Journal of Pharmacology 157:8, pages 1368-1379.
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Xuan Li, Jue Hu, Qichun Zhang, Xiaoyu Sun & Shengnan Li. (2009) Urocortin 1 improves renal function in rats with streptozotocin‐induced diabetes by inhibiting overproduction of TGF‐β1 and VEGF. British Journal of Pharmacology 157:6, pages 994-1003.
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Hossein Tezval, Steffanie Jurk, Farahnaz Atschekzei, Jürgen Serth, Markus A. Kuczyk & Axel S. Merseburger. (2008) The involvement of altered corticotropin releasing factor receptor 2 expression in prostate cancer due to alteration of anti‐angiogenic signaling pathways. The Prostate 69:4, pages 443-448.
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Sean M. Davidson, Aneta E. Rybka & Paul A. Townsend. (2009) The powerful cardioprotective effects of urocortin and the corticotropin releasing hormone (CRH) family. Biochemical Pharmacology 77:2, pages 141-150.
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