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Cancer Investigation Volume 28, 2010 - Issue 4
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ORIGINAL ARTICLECellular and Molecular Biology

Simultaneous Inhibition of MEK and CDK4 Leads to Potent Apoptosis in Human Melanoma Cells

Jing LiDepartment of Pathology and Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA
,
Meixiang XuDepartment of Pathology and Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA
,
Zhen YangDepartment of Pathology and Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA
,
Albert LiDepartment of Pathology and Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA
&
Jianli DongDepartment of Pathology and Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA
Pages 350-356 | Published online: 22 Apr 2010

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Liliana Rincon, Michael P Sedrak, Huijian Sun, Gregorio Garza, Brent Kelly & Jianli Dong. (2014) K-type human endogenous retroviral elements in human melanoma. Advances in Genomics and Genetics 4, pages 153-159.
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Zhongwu Li, Tao Sheng, Xiaohua Wan, Tianshuang Liu, Hai Wu & Jianli Dong. (2010) Expression of HERV-K Correlates With Status of MEK–ERK and p16INK4A–CDK4 Pathways in Melanoma Cells. Cancer Investigation 28:10, pages 1031-1037.
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Articles from other publishers (17)

Jiating Qi & Zhuqing Ouyang. (2022) Targeting CDK4/6 for Anticancer Therapy. Biomedicines 10:3, pages 685.
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Verena Wagner & Jesús Gil. (2020) Senescence as a therapeutically relevant response to CDK4/6 inhibitors. Oncogene 39:29, pages 5165-5176.
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Carlos N. Prieto-Granada, John Van Arnam, Kabeer K. Shah, Aleodor A. Andea & Alexander J. Lazar. 2019. Genomic Applications in Pathology. Genomic Applications in Pathology 509 540 .
Priya K. Gopalan, Andres Gordillo Villegas, Chunxia Cao, Mary Pinder-Schenck, Alberto Chiappori, Wei Hou, Maria Zajac-Kaye, Alison M. Ivey & Frederic J. Kaye. (2018) CDK4/6 inhibition stabilizes disease in patients with p16-null non-small cell lung cancer and is synergistic with mTOR inhibition. Oncotarget 9:100, pages 37352-37366.
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Han Bit Baek, Alan P. Lombard, Stephen J. Libertini, Aleida Fernandez-Rubio, Ruth Vinall, Regina Gandour-Edwards, Rachel Nakagawa, Kathleen Vidallo, Kristine Nishida, Salma Siddiqui, Hiromi Wettersten, Yosef Landesman, Robert H. Weiss, Paramita M. Ghosh & Maria Mudryj. (2018) XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies. Oncotarget 9:77, pages 34567-34581.
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Peng JiangWilliam R. SellersX. Shirley Liu. (2018) Big Data Approaches for Modeling Response and Resistance to Cancer Drugs. Annual Review of Biomedical Data Science 1:1, pages 1-27.
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John E. Bisi, Jessica A. Sorrentino, Jamie L. Jordan, David D. Darr, Patrick J. Roberts, Francis X. Tavares & Jay C. Strum. (2017) Preclinical development of G1T38: A novel, potent and selective inhibitor of cyclin dependent kinases 4/6 for use as an oral antineoplastic in patients with CDK4/6 sensitive tumors. Oncotarget 8:26, pages 42343-42358.
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Charles J. Sherr, David Beach & Geoffrey I. Shapiro. (2016) Targeting CDK4 and CDK6: From Discovery to Therapy. Cancer Discovery 6:4, pages 353-367.
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Dale Han & Keiran SM Smalley. 2015. BRAF Targets in Melanoma. BRAF Targets in Melanoma 137 162 .
Rajasekharan Somasundaram, Nicole Facompre & Meenhard Herlyn. 2014. Cancer Stem Cells. Cancer Stem Cells 223 234 .
Gengming Huang, Joseph D. Krocker, Jason L. Kirk, Shehzad N. Merwat, Hyunsu Ju, Roger D. Soloway, Lucas R. Wieck, Albert Li, Anthony O. Okorodudu, John R. Petersen, Nihal E. Abdulla, Andrea Duchini, Luca Cicalese, Cristiana Rastellini, Peter C. Hu & Jianli Dong. (2014) Evaluation of INK4A promoter methylation using pyrosequencing and circulating cell-free DNA from patients with hepatocellular carcinoma. Clinical Chemistry and Laboratory Medicine (CCLM) 52:6.
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Matthew S. Evans, SubbaRao V. Madhunapantula, Gavin P. Robertson & Joseph J. Drabick. 2013. Impact of Genetic Targets on Cancer Therapy. Impact of Genetic Targets on Cancer Therapy 223 255 .
Ken Dutton-Regester, Darryl Irwin, Priscilla Hunt, Lauren G. Aoude, Varsha Tembe, Gulietta M. Pupo, Cathy Lanagan, Candace D. Carter, Linda O'Connor, Michael O'Rourke, Richard A. Scolyer, Graham J. Mann, Christopher W. Schmidt, Adrian Herington & Nicholas K. Hayward. (2012) A High-Throughput Panel for Identifying Clinically Relevant Mutation Profiles in Melanoma. Molecular Cancer Therapeutics 11:4, pages 888-897.
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Ivan Pacheco, Cristina Buzea & Victor Tron. (2011) Towards new therapeutic approaches for malignant melanoma. Expert Reviews in Molecular Medicine 13.
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Kyucheol Noh, Kyung-Ok Kim, Neel R Patel, J Robert Staples, Hiroshi Minematsu, Kumar Nair & Francis Young-In Lee. (2011) Targeting Inflammatory Kinase as an Adjuvant Treatment for Osteosarcomas. The Journal of Bone and Joint Surgery-American Volume 93:8, pages 723-732.
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Eric Lau & Ze’ev A. Ronai. 2011. Melanoma Development. Melanoma Development 137 163 .
. (2010) Current World Literature. Current Opinion in Supportive & Palliative Care 4:4, pages 293-304.
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