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Drying Technology
An International Journal
Volume 28, 2010 - Issue 2
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Original Articles

Development of a High Gain Observer for In-Line Monitoring of Sublimation in Vial Freeze Drying

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Pages 256-268 | Published online: 08 Mar 2010

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Read on this site (12)

Andrea Chia, Jocelyn Bouchard, Éric Poulin & Pierre-Philippe Lapointe-Garant. (2022) Model development for the design of control strategies of the primary drying of lyophilization in vials. Drying Technology 40:15, pages 3292-3309.
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Gustavo N. A. Vieira, Martín Olazar, José T. Freire & Fábio B. Freire. (2019) Real-time monitoring of milk powder moisture content during drying in a spouted bed dryer using a hybrid neural soft sensor. Drying Technology 37:9, pages 1184-1190.
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Serena Bosca, Antonello A. Barresi & Davide Fissore. (2017) On the robustness of the soft sensors used to monitor a vial freeze-drying process. Drying Technology 35:9, pages 1085-1097.
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Serena Bosca, Antonello Barresi & Davide Fissore. (2016) On the use of model-based tools to optimize in-line a pharmaceuticals freeze-drying process. Drying Technology 34:15, pages 1831-1842.
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Serena Bosca, Antonello A. Barresi & Davide Fissore. (2015) Design of a Robust Soft-Sensor to Monitor In-Line a Freeze-Drying Process. Drying Technology 33:9, pages 1039-1050.
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FábioB. Freire, GustavoN. A. Vieira, JoséT. Freire & ArunS. Mujumdar. (2014) Trends in Modeling and Sensing Approaches for Drying Control. Drying Technology 32:13, pages 1524-1532.
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Serena Bosca, Antonello A. Barresi & Davide Fissore. (2014) Use of soft sensors to monitor a pharmaceuticals freeze-drying process in vials. Pharmaceutical Development and Technology 19:2, pages 148-159.
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Serena Bosca, Simone Corbellini, AntonelloA. Barresi & Davide Fissore. (2013) Freeze-Drying Monitoring Using a New Process Analytical Technology: Toward a “Zero Defect” Process. Drying Technology 31:15, pages 1744-1755.
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Elena Niculina Drăgoi, Silvia Curteanu & Davide Fissore. (2013) On the Use of Artificial Neural Networks to Monitor a Pharmaceutical Freeze-Drying Process. Drying Technology 31:1, pages 72-81.
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Davide Fissore, Roberto Pisano & AntonelloA. Barresi. (2012) A Model-Based Framework to Optimize Pharmaceuticals Freeze Drying. Drying Technology 30:9, pages 946-958.
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Roberto Pisano, AntonelloA. Barresi & Davide Fissore. (2011) Innovation in Monitoring Food Freeze Drying. Drying Technology 29:16, pages 1920-1931.
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Articles from other publishers (18)

Hebin Wang, Chunhong Han & Rui Bai. (2018) Sliding Mode Control of the DC-DC Converter Based on High-Gain Observer. Sliding Mode Control of the DC-DC Converter Based on High-Gain Observer.
Davide Fissore, Roberto Pisano & Antonello A. Barresi. (2017) On the use of temperature measurement to monitor a freeze-drying process for pharmaceuticals. On the use of temperature measurement to monitor a freeze-drying process for pharmaceuticals.
Davide Fissore. (2017) Model-Based PAT for Quality Management in Pharmaceuticals Freeze-Drying: State of the Art. Frontiers in Bioengineering and Biotechnology 5.
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Davide Fissore. (2016) On the Design of a Fuzzy Logic–Based Control System for Freeze-Drying Processes. Journal of Pharmaceutical Sciences 105:12, pages 3562-3572.
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Serena Bosca, Davide Fissore & Micaela Demichela. (2015) Risk-Based Design of a Freeze-Drying Cycle for Pharmaceuticals. Industrial & Engineering Chemistry Research 54:51, pages 12928-12936.
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. 2015. Advances in Probiotic Technology. Advances in Probiotic Technology 264 271 .
Davide Fissore & Roberto Pisano. (2015) Computer-Aided Framework for the Design of Freeze-Drying Cycles: Optimization of the Operating Conditions of the Primary Drying Stage. Processes 3:2, pages 406-421.
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Laura Menini & Antonio Tornambè. (2014) High-gain observers for nonlinear systems with trajectories close to unobservability. European Journal of Control 20:3, pages 118-131.
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Antonello A. Barresi & Davide Fissore. 2014. Modern Drying Technology. Modern Drying Technology 91 154 .
Serena Bosca & Davide Fissore. (2014) Monitoring of a Pharmaceuticals Freeze-Drying Process by Model-Based Process Analytical Technology Tools. Chemical Engineering & Technology 37:2, pages 240-248.
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Serena Bosca, Antonello A. Barresi & Davide Fissore. (2013) Fast freeze-drying cycle design and optimization using a PAT based on the measurement of product temperature. European Journal of Pharmaceutics and Biopharmaceutics 85:2, pages 253-262.
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Serena Bosca, Antonello A. Barresi & Davide Fissore. (2013) Use of a soft sensor for the fast estimation of dried cake resistance during a freeze-drying cycle. International Journal of Pharmaceutics 451:1-2, pages 23-33.
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Sabrina Grassini, Marco Parvis & Antonello A. Barresi. (2013) Inert Thermocouple With Nanometric Thickness for Lyophilization Monitoring. IEEE Transactions on Instrumentation and Measurement 62:5, pages 1276-1283.
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Davide Fissore, Roberto Pisano & Antonello A. Barresi. (2012) Model-Based Framework for the Analysis of Failure Consequences in a Freeze-Drying Process. Industrial & Engineering Chemistry Research, pages 120913132455009.
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Elena-Niculina Dragoi, Silvia Curteanu & Davide Fissore. (2012) Freeze-drying modeling and monitoring using a new neuro-evolutive technique. Chemical Engineering Science 72, pages 195-204.
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Serena Bosca & Davide Fissore. (2011) Design and validation of an innovative soft-sensor for pharmaceuticals freeze-drying monitoring. Chemical Engineering Science 66:21, pages 5127-5136.
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Antonello A. Barresi & Davide Fissore. 2011. Modern Drying Technology. Modern Drying Technology 91 154 .
Roberto Pisano, Davide Fissore & Antonello A. Barresi. (2011) Freeze-Drying Cycle Optimization Using Model Predictive Control Techniques. Industrial & Engineering Chemistry Research 50:12, pages 7363-7379.
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