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Critical Reviews in Biotechnology Volume 39, 2019 - Issue 2
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Review Article

Current status and perspectives of 2-phenylethanol production through biological processes

Xiujuan QianState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China; View further author information
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Wei YanState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China; View further author information
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Wenming ZhangState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China; ;Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing, China; View further author information
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Weiliang DongState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China; ;Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing, China; View further author information
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Jiangfeng MaState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China; ;Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing, China; View further author information
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Katrin OchsenreitherInstitute of Process Engineering in Life Sciences, Section II: Technical Biology, Karlsruhe Institute of Technology, Karlsruhe, GermanyView further author information
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Min JiangState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China; ;Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing, China; Correspondence[email protected]
View further author information
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Fengxue XinState Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China; ;Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing, China; Correspondence[email protected]
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Pages 235-248 | Received 11 Jan 2018, Accepted 01 Sep 2018, Published online: 20 Dec 2018

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Mariana Valdez Castillo, Vinayak Laxman Pachapur, Satinder Kaur Brar, Mitra Naghdi, Sonia Arriaga & Antonio Ávalos Ramirez. (2020) Yeast-driven whey biorefining to produce value-added aroma, flavor, and antioxidant compounds: technologies, challenges, and alternatives. Critical Reviews in Biotechnology 40:7, pages 930-950.
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Articles from other publishers (35)

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Sheng Yin, Mingquan Huang, Jiaxuan Wang, Bo Liu & Qing Ren. (2023) Microbial Community Dynamics and the Correlation between Specific Bacterial Strains and Higher Alcohols Production in Tartary Buckwheat Huangjiu Fermentation. Foods 12:14, pages 2664.
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Jie Lu, Jie Li, Lei Li, Linlu Qi, Yuxi Wang, Shuai Yang, Guangyuan Xu, Daolong Dou, Jia Liu & Xiaodan Wang. (2023) Natural product 2-Phenylethanol inhibits ATP synthesis of P. infestans by blocking the oxidative phosphorylation pathway to prevent potato late blight. Postharvest Biology and Technology 199, pages 112310.
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Haixai Xu, Zhi Li, Leyi Li, Xiaomei Xie, Dongbo Cai, Zhi Wang, Yangyang Zhan & Shouwen Chen. (2023) Sustainable production of 2-phenylethanol from agro-industrial wastes by metabolically engineered Bacillus licheniformis. LWT 173, pages 114414.
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Yangyang Zhan, Jiao Shi, Yuan Xiao, Fei Zhou, Huan Wang, Haixia Xu, Zhi Li, Shihui Yang, Dongbo Cai & Shouwen Chen. (2022) Multilevel metabolic engineering of Bacillus licheniformis for de novo biosynthesis of 2-phenylethanol. Metabolic Engineering 70, pages 43-54.
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Adelaide Braga, Bruna Freitas, Ana Cordeiro & Isabel Belo. (2021) Valorization of crude glycerol as carbon source for the bioconversion of L‐phenylamine to 2‐phenylethanol by Yarrowia species . Journal of Chemical Technology & Biotechnology 96:10, pages 2940-2949.
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Jun Dai, Huili Xia, Chunlei Yang & Xiong Chen. (2021) Sensing, Uptake and Catabolism of L-Phenylalanine During 2-Phenylethanol Biosynthesis via the Ehrlich Pathway in Saccharomyces cerevisiae. Frontiers in Microbiology 12.
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Shufang Tian, Xiaolin Liang, Jian Chen, Weizhu Zeng, Jingwen Zhou & Guocheng Du. (2020) Enhancement of 2-phenylethanol production by a wild-type Wickerhamomyces anomalus strain isolated from rice wine. Bioresource Technology 318, pages 124257.
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Yuqin Wang, Zhongyuan Zhang, Xinyao Lu, Hong Zong & Bin Zhuge. (2020) Genetic engineering of an industrial yeast Candida glycerinogenes for efficient production of 2-phenylethanol. Applied Microbiology and Biotechnology 104:24, pages 10481-10491.
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Ivan Červeňanský, Mário Mihaľ & Jozef Markoš. (2020) Pertraction-adsorption in situ product removal system: Intensification of 2-phenyelthanol bioproduction. Separation and Purification Technology 251, pages 117283.
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Jinbin Liu, Yajun Bai, Tai-ping FanXiaohui Zheng & Yujie Cai. (2020) Unveiling the Multipath Biosynthesis Mechanism of 2-Phenylethanol in Proteus mirabilis . Journal of Agricultural and Food Chemistry 68:29, pages 7684-7690.
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Yang Gu, Jingbo Ma, Yonglian Zhu & Peng Xu. (2020) Refactoring Ehrlich Pathway for High-Yield 2-Phenylethanol Production in Yarrowia lipolytica . ACS Synthetic Biology 9:3, pages 623-633.
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Wei Yan, Shangjie Zhang, Min Wu, Wenming Zhang, Jie Zhou, Weiliang Dong, Xiujuan Qian, Min Jiang & Fengxue Xin. (2019) The draft genome sequence of Meyerozyma guilliermondii strain YLG18, a yeast capable of producing and tolerating high concentration of 2-phenylethanol. 3 Biotech 9:12.
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