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Critical Reviews in Biotechnology Volume 42, 2022 - Issue 4
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Review Articles

Physiological effects, biosynthesis, and derivatization of key human milk tetrasaccharides, lacto-N-tetraose, and lacto-N-neotetraose

Yingying Zhua State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaView further author information
,
Guocong Luoa State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaView further author information
,
Li Wana State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaView further author information
,
Jiawei Menga State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, ChinaView further author information
,
Sang Yup Leeb Department of Chemical and Biomolecular Engineering (BK21 Plus Program), Metabolic and Biomolecular Engineering National Research Laboratory, Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea;c Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, KAIST, Daejeon, Republic of Korea;d BioProcess Engineering Research Center and BioInformatics Research Center, KAIST, Daejeon, Republic of KoreaCorrespondence[email protected]
View further author information
&
Wanmeng Mua State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China;e International Joint Laboratory on Food Safety, Jiangnan University, Wuxi, ChinaCorrespondence[email protected]
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Pages 578-596 | Received 15 Jan 2021, Accepted 01 May 2021, Published online: 04 Aug 2021

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Zeyu Li, Yingying Zhu, Dawei Ni, Wenli Zhang & Wanmeng Mu. (2023) Occurrence, functional properties, and preparation of 3-fucosyllactose, one of the smallest human milk oligosaccharides. Critical Reviews in Food Science and Nutrition 63:28, pages 9364-9378.
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Longhao Yang, Yingying Zhu, Jiawei Meng, Wenli Zhang & Wanmeng Mu. (2023) Recent progress in fucosylated derivatives of lacto-N-tetraose and lacto-N-neotetraose. Critical Reviews in Food Science and Nutrition 0:0, pages 1-13.
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Longhao Yang, Yingying Zhu, Wenli Zhang & Wanmeng Mu. (2023) Recent progress in health effects and biosynthesis of lacto-N-tetraose, the most dominant core structure of human milk oligosaccharide. Critical Reviews in Food Science and Nutrition 0:0, pages 1-10.
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Articles from other publishers (12)

Junrui Wu, Ruixue Ding, Shuyi Qi, Shuang Zhang, Liang Zhao, Guanghui Xiao, Yajie Cai, Hanchen Wang, Xueying Mao & Rina Wu. (2023) In vivo immunomodulatory alleviating effects of animal milk oligosaccharides on murine NEC: A study. Food Bioscience 53, pages 102643.
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Jiawei Meng, Yingying Zhu, Hao Wang, Hongzhi Cao & Wanmeng Mu. (2023) Biosynthesis of Human Milk Oligosaccharides: Enzyme Cascade and Metabolic Engineering Approaches. Journal of Agricultural and Food Chemistry 71:5, pages 2234-2243.
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Yingying Zhu, Jiameng Zhang, Wenli Zhang & Wanmeng Mu. (2023) Recent progress on health effects and biosynthesis of two key sialylated human milk oligosaccharides, 3′-sialyllactose and 6′-sialyllactose. Biotechnology Advances 62, pages 108058.
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Wenyuan Zhang, Jacques Vervoort, Jiancun Pan, Peng Gao, Huiquan Zhu, Xiaodan Wang, Yumeng Zhang, Baorong Chen, Ying Liu, Yuanyuan Li, Xiaoyang Pang, Shuwen Zhang, Shilong Jiang, Jing Lu & Jiaping Lyu. (2022) Comparison of twelve human milk oligosaccharides in mature milk from different areas in China in the Chinese Human Milk Project (CHMP) study. Food Chemistry 395, pages 133554.
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Yuanlin Liu, Yingying Zhu, Hao Wang, Li Wan, Wenli Zhang & Wanmeng Mu. (2022) Strategies for Enhancing Microbial Production of 2′-Fucosyllactose, the Most Abundant Human Milk Oligosaccharide. Journal of Agricultural and Food Chemistry 70:37, pages 11481-11499.
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Pan Zhang, Yingying Zhu, Zeyu Li, Wenli Zhang, Cuie Guang & Wanmeng Mu. (2022) Designing a Highly Efficient Biosynthetic Route for Lacto- N -Neotetraose Production in Escherichia coli . Journal of Agricultural and Food Chemistry 70:32, pages 9961-9968.
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Zeyu Li, Yingying Zhu, Pan Zhang, Wenli Zhang & Wanmeng Mu. (2022) Pathway Optimization and Uridine 5′-Triphosphate Regeneration for Enhancing Lacto- N -Tetraose Biosynthesis in Engineered Escherichia coli . Journal of Agricultural and Food Chemistry 70:25, pages 7727-7735.
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Pan Zhang, Yingying Zhu, Zeyu Li, Wenli Zhang & Wanmeng Mu. (2022) Recent Advances on Lacto- N -neotetraose, a Commercially Added Human Milk Oligosaccharide in Infant Formula . Journal of Agricultural and Food Chemistry 70:15, pages 4534-4547.
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Geng Chen, Hao Wu, Yingying Zhu, Li Wan, Wenli Zhang & Wanmeng Mu. (2022) Glycosyltransferase from Bacteroides gallinaceum Is a Novel α-1,3-Fucosyltransferase that Can Be Used for 3-Fucosyllactose Production In Vivo by Metabolically Engineered Escherichia coli . Journal of Agricultural and Food Chemistry 70:6, pages 1934-1942.
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Yingying Zhu, Guocong Luo, Zeyu Li, Pan Zhang, Wenli Zhang & Wanmeng Mu. (2022) Efficient biosynthesis of lacto-N-neotetraose by a novel β-1,4-galactosyltransferase from Aggregatibacter actinomycetemcomitans NUM4039. Enzyme and Microbial Technology 153, pages 109912.
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Duoduo Hu, Hao Wu, Yingying Zhu, Wenli Zhang & Wanmeng Mu. (2021) Engineering Escherichia coli for highly efficient production of lacto-N-triose II from N-acetylglucosamine, the monomer of chitin. Biotechnology for Biofuels 14:1.
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Yingying Zhu, Zeyu Li, Guocong Luo, Hao Wu, Wenli Zhang & Wanmeng Mu. (2021) Metabolic Engineering of Escherichia coli for Efficient Biosynthesis of Lacto- N -tetraose Using a Novel β-1,3-Galactosyltransferase from Pseudogulbenkiania ferrooxidans . Journal of Agricultural and Food Chemistry 69:38, pages 11342-11349.
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