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Original Articles

Crystal Structures of Four Morpholino-Doxorubicin Anticancer Drugs Complexed with d(CGTACG) and d(CGATCG): Implications in Drug-DNA Crosslink

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Pages 103-117 | Received 13 Apr 1995, Published online: 21 May 2012

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Mahboubeh Hosseini-Kharat, Rahmatollah Rahimi, Davit Zargarian, Zohreh Mehri Lighvan, Amir Abbas Momtazi-Borojeni, Tayebeh Sharifi, Elham Abdollahi, Hossein Tavakol & Tecush Mohammadi. (2019) Antiproliferative activity of morpholine-based compounds on MCF-7 breast cancer, colon carcinoma C26, and normal fibroblast NIH-3T3 cell lines and study of their binding affinity to calf thymus-DNA and bovine serum albumin. Journal of Biomolecular Structure and Dynamics 37:14, pages 3788-3802.
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ChristopherA. Hunter & Xiang-Jun Lu. (1997) Construction of Double-helical DNA Structures Based on Dinucleotide Building Blocks. Journal of Biomolecular Structure and Dynamics 14:6, pages 747-756.
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Lijun He, Zhiyang Xie, Xing Long, Chaopeng Zhang, Fei Qi & Nan Zhang. (2023) Electrical modulation properties of DNA drug molecules. Human Molecular Genetics 32:3, pages 357-366.
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Supraja Siddamurthi, Gopichand Gutti, Srabanti Jana, Ashok Kumar & Sushil Kumar Singh. (2020) Anthraquinone: a promising scaffold for the discovery and development of therapeutic agents in cancer therapy. Future Medicinal Chemistry 12:11, pages 1037-1069.
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Xue-Jiao Yang, Xiang-Ling Li, Hong-Yuan Chen & Jing-Juan Xu. (2019) NIR-Activated Spatiotemporally Controllable Nanoagent for Achieving Synergistic Gene-Chemo-Photothermal Therapy in Tumor Ablation. ACS Applied Bio Materials 2:7, pages 2994-3001.
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Camila R. Paludo, Eduardo A. da Silva-Junior, Raquel A. Santos, Mônica T. Pupo, Flávio S. Emery & Niege A.J.C. Furtado. (2013) Microbial transformation of β-lapachone to its glycosides by Cunninghamella elegans ATCC 10028b. Phytochemistry Letters 6:4, pages 657-661.
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Stefania Mazzini, Leonardo Scaglioni, Rosanna Mondelli, Michele Caruso & Federico Riccardi Sirtori. (2012) The interaction of nemorubicin metabolite PNU-159682 with DNA fragments d(CGTACG)2, d(CGATCG)2 and d(CGCGCG)2 shows a strong but reversible binding to G:C base pairs. Bioorganic & Medicinal Chemistry 20:24, pages 6979-6988.
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Kendall G. Byler, Chen Wang & William N. Setzer. (2009) Quinoline alkaloids as intercalative topoisomerase inhibitors. Journal of Molecular Modeling 15:12, pages 1417-1426.
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Raffaella Colombo, Angelo Carotti, Marco Catto, Marco Racchi, Cristina Lanni, Laura Verga, Gabriele Caccialanza & Ersilia De Lorenzi. (2009) CE can identify small molecules that selectively target soluble oligomers of amyloid β protein and display antifibrillogenic activity. ELECTROPHORESIS 30:8, pages 1418-1429.
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Kazuo Nakamoto, Masamichi Tsuboi & Gary D. Strahan. 2008. Drug–DNA Interactions. Drug–DNA Interactions 119 208 .
Pascale Saminadin, Alain Dautant, Martine Mondon, Béatrice Langlois d’Estaintot, Christian Courseille & Gilles Précigoux. (2001) Release of the cyano moiety in the crystal structure of N ‐cyanomethyl‐ N ‐(2‐methoxyethyl)‐daunomycin complexed with d(CGATCG) . European Journal of Biochemistry 267:2, pages 457-464.
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Yi‐gui Gao, Waldemar Priebe & Andrew H.‐J. Wang. (2004) Substitutions at C2′ of Daunosamine in the Anticancer Drug Daunorubicin Alter Its DNA‐Binding Sequence Specificity. European Journal of Biochemistry 240:2, pages 331-335.
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Andrew H.-J. Wang. 1996. 59 100 .

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