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Original Articles

Comparison of the Structures of the Metal-thiolate Binding Site in Zn(II)-, Cd(II)-, and Hg(II)-Metallothioneins Using Molecular Modeling Techniques

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Pages 393-406 | Received 01 Aug 1996, Published online: 21 May 2012

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Garima Singh, Shubhandra Tripathi, Karuna Shanker & Ashok Sharma. (2019) Cadmium-induced conformational changes in type 2 metallothionein of medicinal plant Coptis japonica: insights from molecular dynamics studies of apo, partially and fully metalated forms. Journal of Biomolecular Structure and Dynamics 37:6, pages 1520-1533.
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Jae-Kwan Kim & Deok-Soo Kim. (2012) BetaSuperposer: superposition of protein surfaces using beta-shapes. Journal of Biomolecular Structure and Dynamics 30:6, pages 684-700.
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Articles from other publishers (31)

Jean-Paul Bourdineaud, Maria Gonzalez-Rey, Mauro Rovezzi, Pieter Glatzel, Kathryn L. Nagy & Alain Manceau. (2019) Divalent Mercury in Dissolved Organic Matter Is Bioavailable to Fish and Accumulates as Dithiolate and Tetrathiolate Complexes. Environmental Science & Technology 53:9, pages 4880-4891.
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Judith S. Scheller, Gordon W. Irvine & Martin J. Stillman. (2018) Unravelling the mechanistic details of metal binding to mammalian metallothioneins from stoichiometric, kinetic, and binding affinity data. Dalton Transactions 47:11, pages 3613-3637.
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Muhammad Tariq Zahid, Farah Rauf Shakoori, Soumble Zulifqar, Ishtiaq Ahmed, Khalid Al-Ghanim, Shahid Mehboob & Abdul Rauf Shakoori. (2016) Molecular Characterization of a Copper Metallothionein Gene From a Ciliate Tetrahymena farahensis . Journal of Cellular Biochemistry 117:8, pages 1843-1854.
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Tomasz Kleszczewski, Ewa Kleszczewska, Leszek Buzun & Beata Modzelewska. (2016) Levels of l-ascorbic acid and cadmium in the saphenous vein of patients with coronary artery disease are negatively correlated. Journal of Trace Elements in Medicine and Biology 36, pages 22-26.
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Gordon W. Irvine & Martin J. Stillman. (2013) Topographical analysis of As-induced folding of α-MT1a. Biochemical and Biophysical Research Communications 441:1, pages 208-213.
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Jason G. Parsons, Kenneth M. Dokken, John McClure & Jorge L. Gardea-Torresdey. (2013) FTIR, XAS, and XRD study of cadmium complexes with l-cysteine. Polyhedron 56, pages 237-242.
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Gordon W. Irvine, Kelly L. Summers & Martin J. Stillman. (2013) Cysteine accessibility during As3+ metalation of the α- and β-domains of recombinant human MT1a. Biochemical and Biophysical Research Communications 433:4, pages 477-483.
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Liping Zhang, Jianping Wu, Xinrong Wang, Bin Liu & Binyin Ma. (2012) Isolation of Metallothionein Genes and in silico Structural Characterization of Their Proteins Using Molecular Modeling from Yak (Bos grunniens). Biochemical Genetics 50:7-8, pages 585-599.
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Ewa Kurowska & Wojciech Bal. 2010. 85 126 .
Francesca Trinchella, Marilisa Riggio, Silvana Filosa, Elio Parisi & Rosaria Scudiero. (2008) Molecular cloning and sequencing of metallothionein in squamates: New insights into the evolution of the metallothionein genes in vertebrates. Gene 423:1, pages 48-56.
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Kelly E. Rigby Duncan, Christopher W. Kirby & Martin J. Stillman. (2008) Metal exchange in metallothioneins – a novel structurally significant Cd 5 species in the alpha domain of human metallothionein 1a . The FEBS Journal 275:9, pages 2227-2239.
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Jayna Chan, Zuyun Huang, Ian Watt, Peter Kille & Martin J Stillman. (2007) Characterization of the conformational changes in recombinant human metallothioneins using ESI-MS and molecular modeling. Canadian Journal of Chemistry 85:10, pages 898-912.
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Feng-Yun Ni, Bin Cai, Zhi-Chun Ding, Fei Zheng, Ming-Jie Zhang, Hou-Ming Wu, Hong-Zhe Sun & Zhong-Xian Huang. (2007) Structural prediction of the β-domain of metallothionein-3 by molecular dynamics simulation. Proteins: Structure, Function, and Bioinformatics 68:1, pages 255-266.
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Roger K. Stankovic, Roger S. Chung & Milena Penkowa. (2007) Metallothioneins I and II: Neuroprotective significance during CNS pathology. The International Journal of Biochemistry & Cell Biology 39:3, pages 484-489.
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Alexander V. Soldatov, Grigory Smolentsev, Galina Yalovega, Jayna Chan & Martin Stillman. (2006) The structure of Cd sites in metallothioneins studied by combination of XAFS and molecular dynamic. Radiation Physics and Chemistry 75:11, pages 1901-1904.
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Kelly E. Rigby Duncan, Thanh T. Ngu, Jayna Chan, Maria T. Salgado, Maureen E. Merrifield & Martin J. Stillman. (2016) Peptide Folding, Metal-Binding Mechanisms, and Binding Site Structures in Metallothioneins. Experimental Biology and Medicine 231:9, pages 1488-1499.
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Kelly E. Rigby, Jayna Chan, Jason Mackie & Martin J. Stillman. (2005) Molecular dynamics study on the folding and metallation of the individual domains of metallothionein. Proteins: Structure, Function, and Bioinformatics 62:1, pages 159-172.
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Jayna Chan, Maureen E. Merrifield, Alexander V. Soldatov & Martin J. Stillman. (2005) XAFS Spectral Analysis of the Cadmium Coordination Geometry in Cadmium Thiolate Clusters in Metallothionein. Inorganic Chemistry 44:14, pages 4923-4933.
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John Dresios, Yuen-Ling Chan & Ira G. Wool. 2005. Zinc Finger Proteins. Zinc Finger Proteins 91 98 .
Maria T Salgado & Martin J Stillman. (2004) Cu+ distribution in metallothionein fragments. Biochemical and Biophysical Research Communications 318:1, pages 73-80.
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Mironel Enescu, Jean-Philippe Renault, Stanislas Pommeret, Jean-Claude Mialocq & Serge Pin. (2003) Ab initio study of Cd–thiol complexes: application to the modelling of the metallothionein active site. Phys. Chem. Chem. Phys. 5:17, pages 3762-3767.
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Maureen E Merrifield, Zuyun Huang, Peter Kille & Martin J Stillman. (2002) Copper speciation in the α and β domains of recombinant human metallothionein by electrospray ionization mass spectrometry. Journal of Inorganic Biochemistry 88:2, pages 153-172.
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R.I. Boysen & M. T. W. Hearn. (2008) The metal binding properties of the CCCH motif of the 50S ribosomal protein L36 from Thermus thermophilus . The Journal of Peptide Research 57:1, pages 19-28.
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Reinhard I Boysen & Milton T.W Hearn. (2000) Direct characterisation by electrospray ionisation mass spectroscopy of mercuro-polypeptide complexes after deprotection of acetamidomethyl groups from protected cysteine residues of synthetic polypeptides. Journal of Biochemical and Biophysical Methods 45:2, pages 157-168.
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Martin J Stillman, Donald Thomas, Colleen Trevithick, Xu Guo & Michael Siu. (2000) Circular dichroism, kinetic and mass spectrometric studies of copper(I) and mercury(II) binding to metallothionein. Journal of Inorganic Biochemistry 79:1-4, pages 11-19.
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Huangxian Ju & Dónal Leech. (2000) Electrochemical study of a metallothionein modified gold disk electrode and its action on Hg2+ cations. Journal of Electroanalytical Chemistry 484:2, pages 150-156.
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Xiangqun Li, Kazuo Suzuki, Ayumi Kashiwada, Hidekazu Hiroaki, Daisuke Kohda & Toshiki Tanaka. (2008) Soft metal ions, Cd(II) and Hg (II), induce triple‐stranded α‐helical assembly and folding of a de novo designed peptide in their trigonal geometries. Protein Science 9:7, pages 1327-1333.
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Connie M. Westhoff, Osvaldo Lopez, Peter Goebel, Larry Carlson, Randall R. Carlson, Fred W. Wagner, Sheldon M. Schuster & Dwane E. Wylie. (1999) Unusual amino acid usage in the variable regions of mercury-binding antibodies. Proteins: Structure, Function, and Genetics 37:3, pages 429-440.
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Hongzhe Sun, Hongyan Li, Ian Harvey & Peter J. Sadler. (1999) Interactions of Bismuth Complexes with Metallothionein(II). Journal of Biological Chemistry 274:41, pages 29094-29101.
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C. C. Chang & P. C. Huang. 1999. Metallothionein IV. Metallothionein IV 45 49 .
Martin J. Stillman, Anna Rae Green, Ziqi Gui, David Fowle & P. Anthony Presta. 1999. Metallothionein IV. Metallothionein IV 23 35 .

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