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Original Articles

A Trimeric Structural Subdomain of the HIV-1 Transmembrane Glycoprotein

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Pages 465-471 | Received 12 Oct 1997, Published online: 21 May 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Dongmei Zhang, Wen Li & Shibo Jiang. (2015) Peptide fusion inhibitors targeting the HIV-1 gp41: a patent review (2009 – 2014). Expert Opinion on Therapeutic Patents 25:2, pages 159-173.
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Asim K Debnath. (2006) Progress in identifying peptides and small-molecule inhibitors targeted to gp41 of HIV-1. Expert Opinion on Investigational Drugs 15:5, pages 465-478.
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Mark A. Baumeister, Michael A. Chattergoon & David B. Weiner. (2002) Prospects for an HIV Vaccine: Conventional Approaches and DNA Immunization. Biotechnology and Genetic Engineering Reviews 19:1, pages 205-244.
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Articles from other publishers (127)

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Jie Liu, Yiqun Deng, Qunnu Li, Antu K. Dey, John P. Moore & Min Lu. (2010) Role of a Putative gp41 Dimerization Domain in Human Immunodeficiency Virus Type 1 Membrane Fusion. Journal of Virology 84:1, pages 201-209.
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Shuwen Liu, Weiguo Jing, Byron Cheung, Hong Lu, Jane Sun, Xuxia Yan, Jinkui Niu, James Farmar, Shuguang Wu & Shibo Jiang. (2007) HIV gp41 C-terminal Heptad Repeat Contains Multifunctional Domains. Journal of Biological Chemistry 282:13, pages 9612-9620.
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Wang Wei & Carol D. Weiss. 2007. Entry Inhibitors in HIV Therapy. Entry Inhibitors in HIV Therapy 79 97 .
Ofir Korazim, Kelly Sackett & Yechiel Shai. (2006) Functional and Structural Characterization of HIV-1 gp41 Ectodomain Regions in Phospholipid Membranes Suggests that the Fusion-active Conformation Is Extended. Journal of Molecular Biology 364:5, pages 1103-1117.
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Sophie Shnaper, Kelly Sackett, Stephen A. Gallo, Robert Blumenthal & Yechiel Shai. (2004) The C- and the N-terminal Regions of Glycoprotein 41 Ectodomain Fuse Membranes Enriched and Not Enriched with Cholesterol, Respectively. Journal of Biological Chemistry 279:18, pages 18526-18534.
Crossref
Eve de Rosny, Russell Vassell, Shibo Jiang, Renate Kunert & Carol D. Weiss. (2004) Binding of the 2F5 Monoclonal Antibody to Native and Fusion-Intermediate Forms of Human Immunodeficiency Virus Type 1 gp41: Implications for Fusion-Inducing Conformational Changes. Journal of Virology 78:5, pages 2627-2631.
Crossref
Shuwen Liu, Louise Boyer-Chatenet, Hong Lu & Shibo Jiang. (2003) Rapid and Automated Fluorescence-Linked Immunosorbent Assay for High-Throughput Screening of Hiv-1 Fusion Inhibitors Targeting gp41. SLAS Discovery 8:6, pages 685-693.
Crossref
Qian Zhao, Hong Lu, Dominique Schols, Erik De Clercq & Shibo Jiang. (2003) Development of a Cell-Based Enzyme-Linked Immunosorbent Assay for High-Throughput Screening of HIV Type 1 Entry Inhibitors Targeting the Coreceptor CXCR4. AIDS Research and Human Retroviruses 19:11, pages 947-955.
Crossref
Shuwen Liu, Qian Zhao & Shibo Jiang. (2003) Determination of the HIV-1 gp41 fusogenic core conformation modeled by synthetic peptides: applicable for identification of HIV-1 fusion inhibitors. Peptides 24:9, pages 1303-1313.
Crossref
Nicole R. Kilgore, Karl Salzwedel, Mary Reddick, Graham P. Allaway & Carl T. Wild. (2003) Direct Evidence that C-Peptide Inhibitors of Human Immunodeficiency Virus Type 1 Entry Bind to the gp41 N-Helical Domain in Receptor-Activated Viral Envelope. Journal of Virology 77:13, pages 7669-7672.
Crossref
Hong Lu, Qian Zhao, Zhikai Xu & Shibo Jiang. (2003) Automatic quantitation of HIV-1 mediated cell-to-cell fusion with a digital image analysis system (DIAS): application for rapid screening of HIV-1 fusion inhibitors. Journal of Virological Methods 107:2, pages 155-161.
Crossref
Shi-Hua Xiang, Peter D. Kwong, Rishi Gupta, Carlo D. Rizzuto, David J. Casper, Richard Wyatt, Liping Wang, Wayne A. Hendrickson, Michael L. Doyle & Joseph Sodroski. (2002) Mutagenic Stabilization and/or Disruption of a CD4-Bound State Reveals Distinct Conformations of the Human Immunodeficiency Virus Type 1 gp120 Envelope Glycoprotein. Journal of Virology 76:19, pages 9888-9899.
Crossref
Ruben M. Markosyan, Xiuwen Ma, Min Lu, Fredric S. Cohen & Grigory B. Melikyan. (2002) The Mechanism of Inhibition of HIV-1 Env-Mediated Cell–Cell Fusion by Recombinant Cores of gp41 Ectodomain. Virology 302:1, pages 174-184.
Crossref
Kathryn E. Follis, Scott J. Larson, Min Lu & Jack H. Nunberg. (2002) Genetic Evidence that Interhelical Packing Interactions in the gp41 Core Are Critical for Transition of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein to the Fusion-Active State. Journal of Virology 76:14, pages 7356-7362.
Crossref
Hana Golding, Marina Zaitseva, Eve de Rosny, Lisa R. King, Jody Manischewitz, Igor Sidorov, Miroslaw K. Gorny, Susan Zolla-Pazner, Dimiter S. Dimitrov & Carol D. Weiss. (2002) Dissection of Human Immunodeficiency Virus Type 1 Entry with Neutralizing Antibodies to gp41 Fusion Intermediates. Journal of Virology 76:13, pages 6780-6790.
Crossref
Annette Alfsen & Morgane Bomsel. (2002) HIV-1 gp41 Envelope Residues 650–685 Exposed on Native Virus Act as a Lectin to Bind Epithelial Cell Galactosyl Ceramide. Journal of Biological Chemistry 277:28, pages 25649-25659.
Crossref
Bimal K. Chakrabarti, Wing-pui Kong, Bei-yue Wu, Zhi-Yong Yang, Jacques Friborg, Xu Ling, Steven R. King, David C. Montefiori & Gary J. Nabel. (2002) Modifications of the Human Immunodeficiency Virus Envelope Glycoprotein Enhance Immunogenicity for Genetic Immunization. Journal of Virology 76:11, pages 5357-5368.
Crossref
Jie Liu, Shilong Wang, James A. Hoxie, Celia C. LaBranche & Min Lu. (2002) Mutations That Destabilize the gp41 Core Are Determinants for Stabilizing the Simian Immunodeficiency Virus-CPmac Envelope Glycoprotein Complex. Journal of Biological Chemistry 277:15, pages 12891-12900.
Crossref
Larry M. Gordon, Patrick W. Mobley, Rosemarie Pilpa, Mark A. Sherman & Alan J. Waring. (2002) Conformational mapping of the N-terminal peptide of HIV-1 gp41 in membrane environments using 13C-enhanced Fourier transform infrared spectroscopy. Biochimica et Biophysica Acta (BBA) - Biomembranes 1559:2, pages 96-120.
Crossref
Justin T. Ernst, Olaf Kutzki, Asim K. Debnath, Shibo Jiang, Hong Lu & Andrew D. Hamilton. (2002) Design of a Protein Surface Antagonist Based onα-Helix Mimicry: Inhibition of gp41 Assembly and Viral Fusion. Angewandte Chemie 114:2, pages 288-291.
Crossref
Min Lu, Marisa O. Stoller, Shilong Wang, Jie Liu, Melinda B. Fagan & Jack H. Nunberg. (2001) Structural and Functional Analysis of Interhelical Interactions in the Human Immunodeficiency Virus Type 1 gp41 Envelope Glycoprotein by Alanine-Scanning Mutagenesis. Journal of Virology 75:22, pages 11146-11156.
Crossref
Debra M. Eckert & Peter S. Kim. (2001) Design of potent inhibitors of HIV-1 entry from the gp41 N-peptide region. Proceedings of the National Academy of Sciences 98:20, pages 11187-11192.
Crossref
Debra M. EckertPeter S. Kim. (2001) Mechanisms of Viral Membrane Fusion and Its Inhibition. Annual Review of Biochemistry 70:1, pages 777-810.
Crossref
Patrick W. MobleyRosemarie PilpaCraig BrownAlan J. WaringLarry M. Gordon. (2001) Membrane-Perturbing Domains of HIV Type 1 Glycoprotein 41. AIDS Research and Human Retroviruses 17:4, pages 311-327.
Crossref
Ilian Jelesarov & Min Lu. (2001) Thermodynamics of trimer-of-hairpins formation by the SIV gp41 envelope protein11Edited by I. B. Holland. Journal of Molecular Biology 307:2, pages 637-656.
Crossref
Shunji Matsuda & Masahiro Noda. (2013) Detection of IgA‐Binding Sites on Human Immunodeficiency Virus Type‐1 Envelope Glycoproteins, Gp120 and Gp41. Microbiology and Immunology 44:11, pages 923-929.
Crossref
Yingying Le, Shibo Jiang, Jinyue Hu, Wanghua Gong, Shaobo Su, Nancy M. Dunlop, Weiping Shen, Baoqun Li & Ji Ming Wang. (2000) N36, a Synthetic N-Terminal Heptad Repeat Domain of the HIV-1 Envelope Protein gp41, Is an Activator of Human Phagocytes. Clinical Immunology 96:3, pages 236-242.
Crossref
Yossef Kliger, Sergio Gerardo Peisajovich, Robert Blumenthal & Yechiel Shai. (2000) Membrane-induced conformational change during the activation of HIV-1 gp41 1 1Edited by A. R. Fersht. Journal of Molecular Biology 301:4, pages 905-914.
Crossref
YVES CHAPRON, JEAN-MICHEL PEYRIN, SERGE CROUZY, ALEXANDRE JAEGLY & DOMINIQUE DORMONT. (2000) Theoretical Analysis of the Implication of PrP in Neuronal Death during Transmissible Subacute Spongiform Encephalopathies: Hypothesis of a PrP Oligomeric Channel. Journal of Theoretical Biology 204:1, pages 103-111.
Crossref
Wei Shu, Hong Ji & Min Lu. (2000) Interactions between HIV-1 gp41 Core and Detergents and Their Implications for Membrane Fusion. Journal of Biological Chemistry 275:3, pages 1839-1845.
Crossref
Yossef Kliger & Yechiel Shai. (2000) Inhibition of HIV-1 entry before gp41 folds into its fusion-active conformation. Journal of Molecular Biology 295:2, pages 163-168.
Crossref
Hong Ji, Wei Shu, F. Temple Burling, Shibo Jiang & Min Lu. (1999) Inhibition of Human Immunodeficiency Virus Type 1 Infectivity by the gp41 Core: Role of a Conserved Hydrophobic Cavity in Membrane Fusion. Journal of Virology 73:10, pages 8578-8586.
Crossref
Debra M. Eckert, Vladimir N. Malashkevich, Lily H. Hong, Peter A. Carr & Peter S. Kim. (1999) Inhibiting HIV-1 Entry. Cell 99:1, pages 103-115.
Crossref
Eun Ju Park & Gerald V. QuinnanJr.Jr.. (1999) Both Neutralization Resistance and High Infectivity Phenotypes Are Caused by Mutations of Interacting Residues in the Human Immunodeficiency Virus Type 1 gp41 Leucine Zipper and the gp120 Receptor- and Coreceptor-Binding Domains. Journal of Virology 73:7, pages 5707-5713.
Crossref
Shibo Jiang, Kang Lin, Li Zhang & Asim K Debnath. (1999) A screening assay for antiviral compounds targeted to the HIV-1 gp41 core structure using a conformation-specific monoclonal antibody. Journal of Virological Methods 80:1, pages 85-96.
Crossref
Min Lu, Hong Ji & Steven Shen. (1999) Subdomain Folding and Biological Activity of the Core Structure from Human Immunodeficiency Virus Type 1 gp41: Implications for Viral Membrane Fusion. Journal of Virology 73:5, pages 4433-4438.
Crossref
A. M. Schultz. 1999. Vaccines. Vaccines 357 396 .
David C. Chan, Christine T. Chutkowski & Peter S. Kim. (1998) Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target. Proceedings of the National Academy of Sciences 95:26, pages 15613-15617.
Crossref
Shibo Jiang, Kang Lin & Min Lu. (1998) A Conformation-Specific Monoclonal Antibody Reacting with Fusion-Active gp41 from the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein. Journal of Virology 72:12, pages 10213-10217.
Crossref
Vladimir N. Malashkevich, David C. Chan, Christine T. Chutkowski & Peter S. Kim. (1998) Crystal structure of the simian immunodeficiency virus (SIV) gp41 core: Conserved helical interactions underlie the broad inhibitory activity of gp41 peptides. Proceedings of the National Academy of Sciences 95:16, pages 9134-9139.
Crossref

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