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Original Articles

Potassium-Induced Loop Conformational Transition of a Potent Anti-HIV Oligonucleotide

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Pages 573-585 | Received 21 Jun 1997, Published online: 21 May 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Danzhou Yang & LaurenceH. Hurley. (2006) Structure of the Biologically Relevant G-Quadruplex in The c-MYC Promoter. Nucleosides, Nucleotides & Nucleic Acids 25:8, pages 951-968.
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Jocelyn Yelle, Gilles Sauvé & Khampoune Sayasith. (2001) Targeting HIV-1 integrase. Expert Opinion on Therapeutic Targets 5:4, pages 443-464.
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Naijie Jing. (2000) Developing G-quartet oligonucleotides as novel anti-HIV agents: focus on anti-HIV drug design. Expert Opinion on Investigational Drugs 9:8, pages 1777-1785.
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Articles from other publishers (36)

Nabeel Tariq, Christine Xu, Jingtong Wang, Takuma Kume & Robert B. MacgregorJrJr. (2023) Enhancement of the thermal stability of G-quadruplex structures by urea. Biophysical Chemistry 299, pages 107043.
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Adam Pruška, Adrien Marchand & Renato Zenobi. (2021) Novel Insight into Proximal DNA Domain Interactions from Temperature‐Controlled Electrospray Ionization Mass Spectrometry. Angewandte Chemie International Edition 60:28, pages 15390-15398.
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Adam Pruška, Adrien Marchand & Renato Zenobi. (2021) Novel Insight into Proximal DNA Domain Interactions from Temperature‐Controlled Electrospray Ionization Mass Spectrometry. Angewandte Chemie 133:28, pages 15518-15526.
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Yue-Ting K. Lau, Malini Ramaiyer, Daniel E. Johnson & Jennifer R. Grandis. (2019) Targeting STAT3 in Cancer with Nucleotide Therapeutics. Cancers 11:11, pages 1681.
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Fengjin Hao, Yushu Ma & Yifu Guan. (2019) Effects of Central Loop Length and Metal Ions on the Thermal Stability of G-Quadruplexes. Molecules 24:10, pages 1863.
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Elisa Rivieccio, Luciana Tartaglione, Veronica Esposito, Carmela Dell'Aversano, P.C. Koneru, Maria Scuotto, Antonella Virgilio, Luciano Mayol, Mamuka Kvaratskhelia & Michela Varra. (2019) Structural studies and biological evaluation of T30695 variants modified with single chiral glycerol-T reveal the importance of LEDGF/p75 for the aptamer anti-HIV-integrase activities. Biochimica et Biophysica Acta (BBA) - General Subjects 1863:2, pages 351-361.
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Colin G. Wu & Maria Spies. (2016) G-quadruplex recognition and remodeling by the FANCJ helicase. Nucleic Acids Research 44:18, pages 8742-8753.
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A. M. Ogloblina, V. A. Bannikova, A. N. Khristich, T. S. Oretskaya, M. G. Yakubovskaya & N. G. Dolinnaya. (2015) Parallel G-quadruplexes formed by guanine-rich microsatellite repeats inhibit human topoisomerase I. Biochemistry (Moscow) 80:8, pages 1026-1038.
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Run Hao, Yameng Liu & Rugang Zhong. (2014) Application of electrospray ionization mass spectrometry for the evaluation of alkaloids binding to G-quadruplex of HIV-1 integrase inhibitors. Analytical Methods 6:4, pages 1059.
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Naijie Jing. 2012. Cell Signaling & Molecular Targets in Cancer. Cell Signaling & Molecular Targets in Cancer 167 190 .
Vineeth Thachappilly Mukundan, Ngoc Quang Do & Anh Tuân Phan. (2011) HIV-1 integrase inhibitor T30177 forms a stacked dimeric G-quadruplex structure containing bulges. Nucleic Acids Research 39:20, pages 8984-8991.
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Ngoc Quang Do, Kah Wai Lim, Ming Hoon Teo, Brahim Heddi & Anh Tuân Phan. (2011) Stacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activity†. Nucleic Acids Research 39:21, pages 9448-9457.
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Erik B. Pedersen, Jakob T. Nielsen, Claus Nielsen & Vyacheslav V. Filichev. (2011) Enhanced anti-HIV-1 activity of G-quadruplexes comprising locked nucleic acids and intercalating nucleic acids. Nucleic Acids Research 39:6, pages 2470-2481.
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Mariana Borgognone, Pablo Armas & Nora B. Calcaterra. (2010) Cellular nucleic-acid-binding protein, a transcriptional enhancer of c- Myc , promotes the formation of parallel G-quadruplexes . Biochemical Journal 428:3, pages 491-498.
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Ming-Hui Li, Yi-Han Zhou, Quan Luo & Ze-Sheng Li. (2009) The 3D structures of G-Quadruplexes of HIV-1 integrase inhibitors: molecular dynamics simulations in aqueous solution and in the gas phase. Journal of Molecular Modeling 16:4, pages 645-657.
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Robert D. Gray, Luigi Petraccone, John O. Trent & Jonathan B. Chaires. (2009) Characterization of a K + -Induced Conformational Switch in a Human Telomeric DNA Oligonucleotide Using 2-Aminopurine Fluorescence . Biochemistry 49:1, pages 179-194.
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Yongli Guan, Kavitha Ramasamy Reddy, Qiqing Zhu, Yifei Li, KangAe Lee, Priya Weerasinghe, Josef Prchal, Gregg L Semenza & Naijie Jing. (2010) G-rich Oligonucleotides Inhibit HIF-1α and HIF-2α and Block Tumor Growth. Molecular Therapy 18:1, pages 188-197.
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Huihui Li & Gu Yuan. (2009) Collision-Induced Dissociation of Dimeric G-Quadruplexes of HIV-1 Integrase Inhibitors and Their Complexes by Tandem-in-Time Mass Spectrometry. European Journal of Mass Spectrometry 15:6, pages 731-737.
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Wataru Yoshida, Eriko Mochizuki, Madoka Takase, Hijiri Hasegawa, Yo Morita, Hiroki Yamazaki, Koji Sode & Kazunori Ikebukuro. (2009) Selection of DNA aptamers against insulin and construction of an aptameric enzyme subunit for insulin sensing. Biosensors and Bioelectronics 24:5, pages 1116-1120.
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D. Michalowski, R. Chitima-Matsiga, D. M. Held & D. H. Burke. (2008) Novel bimodular DNA aptamers with guanosine quadruplexes inhibit phylogenetically diverse HIV-1 reverse transcriptases. Nucleic Acids Research 36:22, pages 7124-7135.
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Priya Weerasinghe, Yifei Li, Yongli Guan, Ruiwen Zhang, David J. Tweardy & Naijie Jing. (2008) T40214/PEI complex: A potent therapeutics for prostate cancer that targets STAT3 signaling. The Prostate 68:13, pages 1430-1442.
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Hui Hui Li & Gu Yuan. (2008) Investigation of formation of dimeric G-quadruplex of HIV-1 integrase inhibitor by nuclear magnetic resonance. Chinese Chemical Letters 19:9, pages 1108-1110.
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Huihui Li, Gu Yuan & Daming Du. (2011) Investigation of formation, recognition, stabilization, and conversion of dimeric G-quadruplexes of HIV-1 integrase inhibitors by electrospray ionization mass spectrometry. Journal of the American Society for Mass Spectrometry 19:4, pages 550-559.
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Phillip A. Rachwal, I. Stuart Findlow, Joern M. Werner, Tom Brown & Keith R. Fox. (2007) Intramolecular DNA quadruplexes with different arrangements of short and long loops. Nucleic Acids Research 35:12, pages 4214-4222.
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Anh Tuân Phan, Vitaly Kuryavyi, Jin-Biao Ma, Aurélie Faure, Marie-Line Andréola & Dinshaw J. Patel. (2005) An interlocked dimeric parallel-stranded DNA quadruplex: A potent inhibitor of HIV-1 integrase. Proceedings of the National Academy of Sciences 102:3, pages 634-639.
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Hidehito Urata, Tetsuya Kumashiro, Takuya Kawahata, Toru Otake & Masao Akagi. (2004) Anti-HIV-1 activity and mode of action of mirror image oligodeoxynucleotide analogue of zintevir. Biochemical and Biophysical Research Communications 313:1, pages 55-61.
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Adam Siddiqui-Jain, Cory L. Grand, David J. Bearss & Laurence H. Hurley. (2002) Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c- MYC transcription . Proceedings of the National Academy of Sciences 99:18, pages 11593-11598.
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Naijie Jing, Weijun Xiong, Yongli Guan, Luke Pallansch & Shimei Wang. (2002) Potassium-Dependent Folding:  A Key to Intracellular Delivery of G-Quartet Oligonucleotides as HIV Inhibitors. Biochemistry 41:17, pages 5397-5403.
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Naijie Jing, Christophe Marchand, Yongli Guan, Jie Liu, Luke Pallansch, Carol Lackman-Smith, Erik De Clercq & Yves Pommier. (2001) Structure–Activity of Inhibition of HIV-1 Integrase and Virus Replication by G-quartet Oligonucleotides. DNA and Cell Biology 20:8, pages 499-508.
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Naijie Jing, Christophe Marchand, Jie Liu, Rahul Mitra, Michael E. Hogan & Yves Pommier. (2000) Mechanism of Inhibition of HIV-1 Integrase by G-tetrad-forming Oligonucleotides in Vitro. Journal of Biological Chemistry 275:28, pages 21460-21467.
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V. M. Marathias & P. H. Bolton. (2000) Structures of the potassium-saturated, 2:1, and intermediate, 1:1, forms of a quadruplex DNA. Nucleic Acids Research 28:9, pages 1969-1977.
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Naijie Jing, Erik De Clercq, Robert F. Rando, Luke Pallansch, Carol Lackman-Smith, Sandy Lee & Michael E. Hogan. (2000) Stability-Activity Relationships of a Family of G-tetrad Forming Oligonucleotides as Potent HIV Inhibitors. Journal of Biological Chemistry 275:5, pages 3421-3430.
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C. El Amri, O. Mauffret, M. Monnot, G. Tevanian, E. Lescot, H. Porumb & S. Fermandjian. (1999) A DNA hairpin with a single residue loop closed by a strongly distorted watson-crick G·C base-pair. Journal of Molecular Biology 294:2, pages 427-442.
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Nad'a Špačková, Imre Berger & Jiří Šponer. (1999) Nanosecond Molecular Dynamics Simulations of Parallel and Antiparallel Guanine Quadruplex DNA Molecules. Journal of the American Chemical Society 121:23, pages 5519-5534.
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Naijie Jing & Michael E. Hogan. (1998) Structure-Activity of Tetrad-forming Oligonucleotides as a Potent Anti-HIV Therapeutic Drug. Journal of Biological Chemistry 273:52, pages 34992-34999.
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Serge Bouaziz, Abdelali Kettani & Dinshaw J Patel. (1998) A K cation-induced conformational switch within a loop spanning segment of a DNA quadruplex containing G-G-G-C repeats 1 1Edited by I. Tinoco. Journal of Molecular Biology 282:3, pages 637-652.
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