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Original Articles

Computational Evidence to Inhibition of Human Acetyl Cholinesterase by Withanolide A for Alzheimer Treatment

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Pages 651-662 | Received 28 Apr 2011, Published online: 15 May 2012

Keep up to date with the latest research on this topic with citation updates for this article.

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Pawan Kumar, Samudra P. Banik, Apurva Goel, Sanjoy Chakraborty, Manashi Bagchi & Debasis Bagchi. (2023) Revisiting the Multifaceted Therapeutic Potential of Withaferin A (WA), a Novel Steroidal Lactone, W-ferinAmax Ashwagandha, from Withania Somnifera (L) Dunal. Journal of the American Nutrition Association 0:0, pages 1-16.
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Deepa S. Mandlik (Ingawale)Ajay G. Namdeo. (2021) Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects. Journal of Dietary Supplements 18:2, pages 183-226.
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Zahra Rabiei & Mahbubeh Setorki. (2018) Effect of hydroalcoholic Echium amoenum extract on scopolamine-induced learning and memory impairment in rats. Pharmaceutical Biology 56:1, pages 672-677.
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Arun Bahadur Gurung, Kripamoy Aguan, Sivaprasad Mitra & Atanu Bhattacharjee. (2017) Identification of molecular descriptors for design of novel Isoalloxazine derivatives as potential Acetylcholinesterase inhibitors against Alzheimer’s disease. Journal of Biomolecular Structure and Dynamics 35:8, pages 1729-1742.
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Namrata Misra, Mahesh Chandra Patra, Prasanna Kumar Panda, Lala Bihari Sukla & Barada Kanta Mishra. (2013) Homology modeling and docking studies of FabH (β-ketoacyl-ACP synthase III) enzyme involved in type II fatty acid biosynthesis of Chlorella variabilis: a potential algal feedstock for biofuel production. Journal of Biomolecular Structure and Dynamics 31:3, pages 241-257.
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Abhinav Grover, Shashank Prakash Katiyar, Jeyaraman Jeyakanthan, Vikash Kumar Dubey & Durai Sundar. (2012) Mechanistic insights into the dual inhibition strategy for checking Leishmaniasis. Journal of Biomolecular Structure and Dynamics 30:4, pages 474-487.
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Articles from other publishers (33)

Sukriti Srivastava, Shilpa Sharma, Shashank Deep & Sunil Kumar Khare. (2023) Screening of Multitarget-Directed Natural Compounds as Drug Candidates for Alzheimer’s Disease Using In Silico Techniques: Their Extraction and In Vitro Validation . ACS Omega 8:41, pages 38118-38129.
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Suchitra Nishal, Parmita Phaugat, Jyoti Bazaad, Rubal Dhaka, Sarita Khatkar, Anurag Khatkar, Maryam Khayatkashani, Pooyan Alizadeh, Shima Motavalli Haghighi, Mohammad Mehri & Hamid Reza Khayat Kashani. (2023) A Concise Review of Common Plant-derived Compounds as a Potential Therapy for Alzheimer's Disease and Parkinson's Disease: Insight into Structure-Activity-Relationship. CNS & Neurological Disorders - Drug Targets 22:7, pages 1057-1069.
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Arnob Chakrovorty, Banani Bhattacharjee, Aaruni Saxena, Asmita Samadder & Sisir Nandi. (2023) Current Naturopathy to Combat Alzheimer’s Disease. Current Neuropharmacology 21:4, pages 808-841.
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Rajeev K. Singla, Shikha Joon, Baivab Sinha, Mohammad Amjad Kamal, Jesus Simal-Gandara, Jianbo Xiao & Bairong Shen. (2023) Current trends in natural products for the treatment and management of dementia: Computational to clinical studies. Neuroscience & Biobehavioral Reviews 147, pages 105106.
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Arsalan Bashir, Masarat Nabi, Nahida Tabassum, Suhaib Afzal & Mehrose Ayoub. (2023) An updated review on phytochemistry and molecular targets of Withania somnifera (L.) Dunal (Ashwagandha). Frontiers in Pharmacology 14.
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Mahmoud Tareq Abdelwahed, Maha A. Hegazy & Ekram H. Mohamed. (2023) Major biochemical constituents of Withania somnifera (ashwagandha) extract: A review of chemical analysis . Reviews in Analytical Chemistry 42:1.
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M. Muralidhara. 2023. Ayurvedic Herbal Preparations in Neurological Disorders. Ayurvedic Herbal Preparations in Neurological Disorders 165 189 .
Javeed Ahmad Bhat, Tahira Akther, Rauf Ahmad Najar, Faheem Rasool & Abid Hamid. (2022) Withania somnifera (L.) Dunal (Ashwagandha); current understanding and future prospect as a potential drug candidate. Frontiers in Pharmacology 13.
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Widad Ben Bakrim, Laila El Bouzidi, Houria Manouze, Jawhar Hafsa, Mansour Sobeh, Saadia Ba-M'hamed, Khalid Bekkouche & Lamfeddal Kouisni. (2022) Anti-amnesic effects of withaferin A, a steroidal lactone isolated from Withania adpressa, on scopolamine-induced memory impairment in mice. Arabian Journal of Chemistry 15:1, pages 103529.
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Vaibhav Rathi, Ashwani K. Dhingra & Bhawna Chopra. 2021. Naturally Occurring Chemicals Against Alzheimer's Disease. Naturally Occurring Chemicals Against Alzheimer's Disease 401 407 .
Md. Abdul Hannan, Raju Dash, Md. Nazmul Haque, Sung Min Choi & Il Soo Moon. (2020) Integrated System Pharmacology and In Silico Analysis Elucidating Neuropharmacological Actions of Withania somnifera in the Treatment of Alzheimer’s Disease . CNS & Neurological Disorders - Drug Targets 19:7, pages 541-556.
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Sultan Zahiruddin, Parakh Basist, Abida Parveen, Rabea Parveen, Washim Khan, Gaurav & Sayeed Ahmad. (2020) Ashwagandha in brain disorders: A review of recent developments. Journal of Ethnopharmacology 257, pages 112876.
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Zihong Zhang, Hui Liu, Zhe Zhao, Caixia Zang, Cheng Ju, Fangyuan Li, Lu Wang, Hanyu Yang, Xiuqi Bao, Yang Yu, Xinsheng Yao & Dan Zhang. (2020) GJ-4 alleviates Aβ25-35-induced memory dysfunction in mice through protecting the neurovascular unit. Biomedicine & Pharmacotherapy 127, pages 110131.
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Erika A. Crane, Wolfgang Heydenreuter, Katharina R. Beck, Petra Strajhar, Jan Vomacka, Martin Smiesko, Elma Mons, Lydia Barth, Markus Neuburger, Angelo Vedani, Alex Odermatt, Stephan A. Sieber & Karl Gademann. (2019) Profiling withanolide A for therapeutic targets in neurodegenerative diseases. Bioorganic & Medicinal Chemistry 27:12, pages 2508-2520.
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Sandeep K. Singh, Guru R. Valicherla, Pankaj Joshi, Sudhir Shahi, Anees A. Syed, Anand P. Gupta, Zakir Hossain, Kishan Italiya, Vishal Makadia, Shio K. Singh, Mohammad Wahajuddin & Jiaur R. Gayen. (2018) Determination of permeability, plasma protein binding, blood partitioning, pharmacokinetics and tissue distribution of Withanolide A in rats: A neuroprotective steroidal lactone. Drug Development Research 79:7, pages 339-351.
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Sheikh Rayees & Fayaz Malik. 2017. Science of Ashwagandha: Preventive and Therapeutic Potentials. Science of Ashwagandha: Preventive and Therapeutic Potentials 81 103 .
Kallol Dutta, Vivek Swarup & Jean-Pierre Julien. 2017. Science of Ashwagandha: Preventive and Therapeutic Potentials. Science of Ashwagandha: Preventive and Therapeutic Potentials 389 415 .
Rajat Sandhir & Abhilasha Sood. 2017. Science of Ashwagandha: Preventive and Therapeutic Potentials. Science of Ashwagandha: Preventive and Therapeutic Potentials 373 387 .
K. N. Roy Chengappa, Jessica M. Gannon, Luna Acharya & Abhishek Rai. 2017. Science of Ashwagandha: Preventive and Therapeutic Potentials. Science of Ashwagandha: Preventive and Therapeutic Potentials 345 371 .
Renu Wadhwa, Rajkumar S. Kalra, Anupama Chaudhary & Sunil C. Kaul. 2017. Science of Ashwagandha: Preventive and Therapeutic Potentials. Science of Ashwagandha: Preventive and Therapeutic Potentials 283 304 .
Renu Wadhwa, Arpita Konar & Sunil C. Kaul. (2016) Nootropic potential of Ashwagandha leaves: Beyond traditional root extracts. Neurochemistry International 95, pages 109-118.
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Peter T. White, Chitra Subramanian, Hashim F. Motiwala & Mark S. Cohen. 2016. Anti-inflammatory Nutraceuticals and Chronic Diseases. Anti-inflammatory Nutraceuticals and Chronic Diseases 329 373 .
Nawab John Dar, Abid Hamid & Muzamil Ahmad. (2015) Pharmacologic overview of Withania somnifera, the Indian Ginseng. Cellular and Molecular Life Sciences 72:23, pages 4445-4460.
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Peter J. Reilly & Carme Rovira. (2015) Computational Studies of Glycoside, Carboxylic Ester, and Thioester Hydrolase Mechanisms: A Review. Industrial & Engineering Chemistry Research 54:42, pages 10138-10161.
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Chetna Tyagi, Jochen Bathke, Sukriti Goyal, Marina Fischer, Hans-Martin Dahse, Sajeev Chacko, Katja Becker & Abhinav Grover. (2015) Targeting the intersubunit cavity of Plasmodium falciparum glutathione reductase by a novel natural inhibitor: Computational and experimental evidence. The International Journal of Biochemistry & Cell Biology 61, pages 72-80.
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Chakshu Vats, Jaspreet Kaur Dhanjal, Sukriti Goyal, Navneeta Bharadvaja & Abhinav Grover. (2014) Computational design of novel flavonoid analogues as potential AChE inhibitors: analysis using group-based QSAR, molecular docking and molecular dynamics simulations. Structural Chemistry 26:2, pages 467-476.
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Vikas Kumar, Amitabha Dey, Mallinath B. Hadimani, Tatjana Marcovic & Mila Emerald. (2015) Chemistry and pharmacology of withania somnifera: An update. TANG [HUMANITAS MEDICINE] 5:1, pages 1.1-1.13.
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Chandrabhan Seniya, Ghulam Jilani Khan & Kuldeep Uchadia. (2014) Identification of Potential Herbal Inhibitor of Acetylcholinesterase Associated Alzheimer’s Disorders Using Molecular Docking and Molecular Dynamics Simulation. Biochemistry Research International 2014, pages 1-7.
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Yixi Xie, Weijie Yang, Xiaoqing Chen & Jianbo Xiao. (2014) Inhibition of flavonoids on acetylcholine esterase: binding and structure–activity relationship. Food Funct. 5:10, pages 2582-2589.
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Zhi-Kun Sun, Hong-Qi Yang & Sheng-Di Chen. (2013) Traditional Chinese medicine: a promising candidate for the treatment of Alzheimer’s disease. Translational Neurodegeneration 2:1.
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Abhinav Grover, Gaurav Samuel, Virendra S. Bisaria & Durai Sundar. (2013) Enhanced withanolide production by overexpression of squalene synthase in Withania somnifera. Journal of Bioscience and Bioengineering 115:6, pages 680-685.
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Parul Gupta, Ridhi Goel, Sumya Pathak, Apeksha Srivastava, Surya Pratap Singh, Rajender Singh Sangwan, Mehar Hasan Asif & Prabodh Kumar Trivedi. (2013) De Novo Assembly, Functional Annotation and Comparative Analysis of Withania somnifera Leaf and Root Transcriptomes to Identify Putative Genes Involved in the Withanolides Biosynthesis. PLoS ONE 8:5, pages e62714.
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Abhinav Grover, Shashank Prakash Katiyar, Jeyaraman Jeyakanthan, Vikash Kumar Dubey & Durai Sundar. (2012) Blocking Protein kinase C signaling pathway: mechanistic insights into the anti-leishmanial activity of prospective herbal drugs from Withania somnifera. BMC Genomics 13:S7.
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