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Journal of Biomolecular Structure and Dynamics Volume 39, 2021 - Issue 9
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Research Articles

Structural insights of catalytic mechanism in mutant pyrazinamidase of Mycobacterium tuberculosis

Muhammad JunaidCollege of Life Sciences and Biotechnology, The State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, China; ;Peng Cheng Laboratory, Shenzhen, Guangdong, P.R China; ;Ministry of Education, Joint Laboratory of International Cooperation in Metabolic and Developmental Sciences, P.R China; View further author information
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Cheng-Dong LiCollege of Life Sciences and Biotechnology, The State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, China; ;Peng Cheng Laboratory, Shenzhen, Guangdong, P.R China; ;Ministry of Education, Joint Laboratory of International Cooperation in Metabolic and Developmental Sciences, P.R China; View further author information
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Jiayi LiCollege of Life Sciences and Biotechnology, The State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, China; View further author information
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Abbas KhanCollege of Life Sciences and Biotechnology, The State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, China; ;Peng Cheng Laboratory, Shenzhen, Guangdong, P.R China; ;Ministry of Education, Joint Laboratory of International Cooperation in Metabolic and Developmental Sciences, P.R China; View further author information
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Syed Shujait AliCenter for Biotechnology and Microbiology, University of Swat, Swat, Pakistan; View further author information
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Syed Baber JamalDepartment of biological sciences, National University of Medical Sciences, Punjab, Rawalpendi, PakistanView further author information
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Shah SaudCollege of Life Sciences and Biotechnology, The State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, China; View further author information
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Arif AliCollege of Life Sciences and Biotechnology, The State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, China; ;Peng Cheng Laboratory, Shenzhen, Guangdong, P.R China; ;Ministry of Education, Joint Laboratory of International Cooperation in Metabolic and Developmental Sciences, P.R China; View further author information
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Dong-Qing WeiCollege of Life Sciences and Biotechnology, The State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, China; ;Peng Cheng Laboratory, Shenzhen, Guangdong, P.R China; ;Ministry of Education, Joint Laboratory of International Cooperation in Metabolic and Developmental Sciences, P.R China; Correspondence[email protected]
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Pages 3172-3185 | Received 07 Aug 2019, Accepted 22 Apr 2020, Published online: 12 May 2020

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Afsar Alam, Mohammad Shahzeb Khan, Yash Mathur, Md Nayab Sulaimani, Naqiya Farooqui, Sheikh F. Ahmad, Ahmed Nadeem, Dharmendra Kumar Yadav & Taj Mohammad. (2023) Structure-based identification of potential inhibitors of ribosomal protein S6 kinase 1, targeting cancer therapy: a combined docking and molecular dynamics simulations approach. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-12.
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Articles from other publishers (5)

Eid A. Alatawi & Fahad M. Alshabrmi. (2022) Structural and Dynamic Insights into the W68L, L85P, and T87A Mutations of Mycobacterium tuberculosis Inducing Resistance to Pyrazinamide. International Journal of Environmental Research and Public Health 19:3, pages 1615.
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Kumaraswamy Naidu Chitrala, Prakash Nagarkatti & Mitzi Nagarkatti. (2021) Computational analysis of deleterious single nucleotide polymorphisms in catechol O-Methyltransferase conferring risk to post-traumatic stress disorder. Journal of Psychiatric Research 138, pages 207-218.
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Adnan Zeb, Syed Shujait Ali, Abul Kalam Azad, Muhammad Safdar, Zeeshan Anwar, Muhammad Suleman, N. Nizam-Uddin, Abbas Khan & Dong-Qing Wei. (2021) Genome-wide screening of vaccine targets prioritization and reverse vaccinology aided design of peptides vaccine to enforce humoral immune response against Campylobacter jejuni. Computers in Biology and Medicine 133, pages 104412.
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Asma Sindhoo Nangraj, Abbas Khan, Shaheena Umbreen, Sana Sahar, Maryam Arshad, Saba Younas, Sajjad Ahmad, Shahid Ali, Syed Shujait Ali, Liaqat Ali & Dong-Qing Wei. (2021) Insights Into Mutations Induced Conformational Changes and Rearrangement of Fe2+ Ion in pncA Gene of Mycobacterium tuberculosis to Decipher the Mechanism of Resistance to Pyrazinamide. Frontiers in Molecular Biosciences 8.
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Taimoor Khan, Abbas Khan, Syed Shujait Ali, Shahid Ali & Dong-Qing Wei. (2021) A computational perspective on the dynamic behaviour of recurrent drug resistance mutations in the pncA gene from Mycobacterium tuberculosis . RSC Advances 11:4, pages 2476-2486.
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