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Research Articles

Withanone and Withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells

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Pages 1-13 | Received 16 May 2020, Accepted 25 May 2020, Published online: 16 Jun 2020

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Crossref
Meltem UÇAR. (2021) The Importance of Propolis in Combating COVID-19. Journal of Apitherapy and Nature 4:1, pages 22-40.
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Reza Jafarzadeh Esfehani, Mohammad Vojdanparast, Saman Soleimanpour, Gordon A. Ferns & Amir Avan. 2021. Coronavirus Therapeutics – Volume I. Coronavirus Therapeutics – Volume I 149 158 .
Renu Wadhwa, Sukant Garg, Mallika Khurana & Sunil C. Kaul. 2021. Nutrition, Food and Diet in Ageing and Longevity. Nutrition, Food and Diet in Ageing and Longevity 589 615 .
Mohammed Sikander, Shabnam Malik, Anyssa Rodriguez, Murali M. Yallapu, Acharan S. Narula, Sanjaya K. Satapathy, Vijian Dhevan, Subhash C. Chauhan & Meena Jaggi. (2020) Role of Nutraceuticals in COVID-19 Mediated Liver Dysfunction. Molecules 25:24, pages 5905.
Crossref
Xiaojun Ma, Huifang Wang, Junwei Huang, Yan Geng, Shuqi Jiang, Qiuping Zhou, Xuan Chen, Hongping Hu, Weifeng Li, Chengbin Zhou, Xinglin Gao, Na Peng & Yiyu Deng. (2020) A nomogramic model based on clinical and laboratory parameters at admission for predicting the survival of COVID-19 patients. BMC Infectious Diseases 20:1.
Crossref
Shichuan Wang, Mirko Trilling, Kathrin Sutter, Ulf Dittmer, Mengji Lu, Xin Zheng, Dongliang Yang & Jia Liu. (2020) A Crowned Killer’s Résumé: Genome, Structure, Receptors, and Origin of SARS-CoV-2. Virologica Sinica 35:6, pages 673-684.
Crossref
Acharya Balkrishna, Siva Kumar Solleti, Sudeep Verma & Anurag Varshney. (2020) Application of Humanized Zebrafish Model in the Suppression of SARS-CoV-2 Spike Protein Induced Pathology by Tri-Herbal Medicine Coronil via Cytokine Modulation. Molecules 25:21, pages 5091.
Crossref
Junqing Huang, Gabriel Tao, Jingwen Liu, Junming Cai, Zhongyu Huang & Jia-xu Chen. (2020) Current Prevention of COVID-19: Natural Products and Herbal Medicine. Frontiers in Pharmacology 11.
Crossref
Vivek K Kashyap, Anupam Dhasmana, Murali M Yallapu, Subhash C Chauhan & Meena Jaggi. (2020) Withania somnifera as a potential future drug molecule for COVID-19 . Future Drug Discovery 2:4.
Crossref
Farhana Rumzum Bhuiyan, Sabbir Howlader, Topu Raihan & Mahmudul Hasan. (2020) Plants Metabolites: Possibility of Natural Therapeutics Against the COVID-19 Pandemic. Frontiers in Medicine 7.
Crossref
Joe M. McCord, Brooks M. Hybertson, Adela Cota-Gomez, Kara P. Geraci & Bifeng Gao. (2020) Nrf2 Activator PB125® as a Potential Therapeutic Agent against COVID-19. Antioxidants 9:6, pages 518.
Crossref
Nilanjan Adhikari, Sk. Abdul Amin & Tarun Jha. 2021. In Silico Modeling of Drugs Against Coronaviruses. In Silico Modeling of Drugs Against Coronaviruses 329 431 .

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