Advanced search
Publication Cover
Journal of Biomolecular Structure and Dynamics Volume 40, 2022 - Issue 3
Journal homepage
1,893
Views
14
CrossRef citations to date
0
Altmetric
Research Articles

A computational approach to drug repurposing against SARS-CoV-2 RNA dependent RNA polymerase (RdRp)

Giovanni Ribaudoa Department of Molecular and Translational Medicine, University of Brescia, Brescia, ItalyView further author information
,
Alberto Ongaroa Department of Molecular and Translational Medicine, University of Brescia, Brescia, ItalyView further author information
,
Erika Oselladoreb Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, ItalyView further author information
,
Giuseppe Zagottob Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, ItalyView further author information
,
Maurizio Memoa Department of Molecular and Translational Medicine, University of Brescia, Brescia, ItalyView further author information
&
Alessandra Gianoncellia Department of Molecular and Translational Medicine, University of Brescia, Brescia, ItalyCorrespondence[email protected]
View further author information
Pages 1101-1108 | Received 13 Jul 2020, Accepted 06 Sep 2020, Published online: 18 Sep 2020

Citations (14)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Shashank M. Patil, Reshma Mary Martiz, Ramith Ramu, Prithvi S. Shirahatti, Ashwini Prakash, Jagadeep Chandra S & V. Lakshmi Ranganatha. (2022) In silico identification of novel benzophenone–coumarin derivatives as SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitors. Journal of Biomolecular Structure and Dynamics 40:23, pages 13032-13048.
Read now
Shruti Pyasi, Nisha Amarnath Jonniya, Md Fulbabu Sk, Debasis Nayak & Parimal Kar. (2022) Finding potential inhibitors against RNA-dependent RNA polymerase (RdRp) of bovine ephemeral fever virus (BEFV): an in-silico study. Journal of Biomolecular Structure and Dynamics 40:20, pages 10403-10421.
Read now

Articles from other publishers (12)

Giovanni Ribaudo, Xiaoyun Yun, Alberto Ongaro, Erika Oselladore, Jerome P. L. Ng, Richard K. Haynes, Betty Yuen Kwan Law, Maurizio Memo, Vincent Kam Wai Wong, Paolo Coghi & Alessandra Gianoncelli. (2022) Combining computational and experimental evidence on the activity of antimalarial drugs on papain‐like protease of SARS‐CoV ‐2: A repurposing study . Chemical Biology & Drug Design 101:4, pages 809-818.
Crossref
Dylan Brunt, Phillip M. Lakernick & Chun Wu. (2022) Discovering new potential inhibitors to SARS-CoV-2 RNA dependent RNA polymerase (RdRp) using high throughput virtual screening and molecular dynamics simulations. Scientific Reports 12:1.
Crossref
Mena Abdelsayed, Eric J. Kort, Stefan Jovinge & Mark Mercola. (2022) Repurposing drugs to treat cardiovascular disease in the era of precision medicine. Nature Reviews Cardiology 19:11, pages 751-764.
Crossref
Sheeba Saifi, Varsha Ravi, Sparsh Sharma, Aparna Swaminathan, Nar Singh Chauhan & Rajesh Pandey. (2022) SARS-CoV-2 VOCs, Mutational diversity and clinical outcome: Are they modulating drug efficacy by altered binding strength?. Genomics 114:5, pages 110466.
Crossref
Mohamed Fadlalla, Mazin Ahmed, Musab Ali, Abdulrhman A. Elshiekh & Bashir A. Yousef. (2022) Molecular Docking as a Potential Approach in Repurposing Drugs Against COVID-19: a Systematic Review and Novel Pharmacophore Models. Current Pharmacology Reports 8:3, pages 212-226.
Crossref
Alireza Jalalvand, Somayeh Behjat Khatouni, Zahra Bahri Najafi, Foroozan Fatahinia, Narges Ismailzadeh & Behrokh Farahmand. (2022) Computational drug repurposing study of antiviral drugs against main protease, RNA polymerase, and spike proteins of SARS-CoV-2 using molecular docking method. Journal of Basic and Clinical Physiology and Pharmacology 33:1, pages 85-95.
Crossref
Amit Lochab, Rakhi Thareja, Sangeeta D. Gadre & Reena Saxena. (2021) Potential Protein and Enzyme Targets for In‐silico Development and Repurposing of Drug Against Coronaviruses. ChemistrySelect 6:46, pages 13363-13381.
Crossref
Alberto Ongaro, Erika Oselladore, Maurizio Memo, Giovanni Ribaudo & Alessandra Gianoncelli. (2021) Insight into the LFA-1/SARS-CoV-2 Orf7a Complex by Protein–Protein Docking, Molecular Dynamics, and MM-GBSA Calculations. Journal of Chemical Information and Modeling 61:6, pages 2780-2787.
Crossref
Raul Pérez-Moraga, Jaume Forés-Martos, Beatriz Suay-García, Jean-Louis Duval, Antonio Falcó & Joan Climent. (2021) A COVID-19 Drug Repurposing Strategy through Quantitative Homological Similarities Using a Topological Data Analysis-Based Framework. Pharmaceutics 13:4, pages 488.
Crossref
Marco Bortoli, Andrea Madabeni, Pablo Andrei Nogara, Folorunsho B. Omage, Giovanni Ribaudo, Davide Zeppilli, Joao B. T. Rocha & Laura Orian. (2021) Chalcogen-Nitrogen Bond: Insights into a Key Chemical Motif. Catalysts 11:1, pages 114.
Crossref
Devvret Verma, Debasis Mitra, Manish Paul, Priya Chaudhary, Anshul Kamboj, Hrudayanath Thatoi, Pracheta Janmeda, Divya Jain, Periyasamy Panneerselvam, Rakesh Shrivastav, Kumud Pant & Pradeep K. Das Mohapatra. (2021) Potential inhibitors of SARS-CoV-2 (COVID 19) proteases PLpro and Mpro/ 3CLpro: molecular docking and simulation studies of three pertinent medicinal plant natural components. Current Research in Pharmacology and Drug Discovery 2, pages 100038.
Crossref
Koichi Watashi. (2021) Identifying and repurposing antiviral drugs against severe acute respiratory syndrome coronavirus 2 with in silico and in vitro approaches. Biochemical and Biophysical Research Communications 538, pages 137-144.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.