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Journal of Biomolecular Structure and Dynamics Volume 41, 2023 - Issue 21
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Research Articles

Discovery and optimization of natural-based nanomolar c-Kit inhibitors via in silico and in vitro studies

Hossam Nadaa BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang, Republic of Korea;b Pharmaceutical Chemistry Department, Faculty of Pharmacy, Badr University in Cairo, Cairo, EgyptView further author information
,
Sungdo Kima BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang, Republic of KoreaView further author information
,
Sreenivasulu Godesia BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang, Republic of KoreaView further author information
,
Joohan Leea BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang, Republic of KoreaView further author information
&
Kyeong Leea BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang, Republic of KoreaCorrespondence[email protected]
View further author information
Pages 11904-11915 | Received 18 Oct 2022, Accepted 24 Dec 2022, Published online: 12 Jan 2023

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Abdelbaset Mohamed Elasbali, Waleed Abu Al-Soud, Elyasa Mustafa Elfaki, Hamad H. Alanazi, Bandar Alharbi, Salem Hussain Alharethi, Khalid Anwer, Taj Mohammad & Md. Imtaiyaz Hassan. (2023) Identification of novel c-Kit inhibitors from natural sources using virtual screening and molecular dynamics simulations. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-13.
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Articles from other publishers (5)

Hossam Nada, Anam Rana Gul, Ahmed Elkamhawy, Sungdo Kim, Minkyoung Kim, Yongseok Choi, Tae Jung Park & Kyeong Lee. (2023) Machine Learning-Based Approach to Developing Potent EGFR Inhibitors for Breast Cancer─Design, Synthesis, and In Vitro Evaluation. ACS Omega 8:35, pages 31784-31800.
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Sreenivasulu Godesi, Hossam Nada, Joohan Lee, Joon-Hee Kang, Soo-Youl Kim, Yongseok Choi & Kyeong Lee. (2023) Integration of Hybridization Strategies in Pyridine–Urea Scaffolds for Novel Anticancer Agents: Design, Synthesis, and Mechanistic Insights. Molecules 28:13, pages 4952.
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Hossam Nada, Sungdo Kim, Suin Park, Moo Yeol Lee & Kyeong Lee. (2023) Identification of Potent hDHODH Inhibitors for Lung Cancer via Virtual Screening of a Rationally Designed Small Combinatorial Library. ACS Omega 8:24, pages 21769-21780.
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Sreenivasulu Godesi, Joohan Lee, Hossam Nada, Guofeng Quan, Ahmed Elkamhawy, Yongseok Choi & Kyeong Lee. (2023) Small Molecule c-KIT Inhibitors for the Treatment of Gastrointestinal Stromal Tumors: A Review on Synthesis, Design Strategies, and Structure–Activity Relationship (SAR). International Journal of Molecular Sciences 24:11, pages 9450.
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Sreenivasulu Godesi, Jeong-Ran Han, Jang-Keun Kim, Dong-Ik Kwak, Joohan Lee, Hossam Nada, Minkyoung Kim, Hyun-A Yang, Joo-Young Im, Hyun Seung Ban, Chang Hoon Lee, Yongseok Choi, Misun Won & Kyeong Lee. (2023) Design, Synthesis and Biological Evaluation of Novel MDH Inhibitors Targeting Tumor Microenvironment. Pharmaceuticals 16:5, pages 683.
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