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Journal of Biomolecular Structure and Dynamics Volume 41, 2023 - Issue 21
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Research Articles

Discovery of new quinoline and isatine derivatives as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative, docking and MD simulation studies

Mohammed S. Taghoura Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptORCID Iconhttps://orcid.org/0000-0003-0630-709XView further author information
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Hazem Elkadya Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-0893-6703View further author information
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Wagdy M. Eldehnab Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, EgyptORCID Iconhttps://orcid.org/0000-0001-6996-4017View further author information
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Nehal El-Deebc Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, Egypt;d Pharmaceutical and Fermentation Industries Development Center, City of Scientific Research and Technological Applications (SRTA city), Alexandria, EgyptView further author information
,
Ahmed M. Kenawye Nucleic Acids Research Department, Genetic Engineering and Biotechnology Research Institute. City of Scientific Research and Technological Applications (SRTA-City), Alexandria, EgyptView further author information
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Abeer E Abd El-Wahabf Medical Biotechnology Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, Egypt;d Pharmaceutical and Fermentation Industries Development Center, City of Scientific Research and Technological Applications (SRTA city), Alexandria, EgyptView further author information
,
Eslam B. Elkaeedg Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi ArabiaORCID Iconhttps://orcid.org/0000-0002-2546-8035View further author information
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Bshra A. Alsfoukh Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi ArabiaView further author information
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Ahmed M. Metwalyi Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt;c Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8566-1980View further author information
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Ibrahim H. Eissaa Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-6955-2263View further author information
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Pages 11535-11550 | Received 05 Jul 2022, Accepted 26 Dec 2022, Published online: 08 Jan 2023

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Mohammed A. Dahab, Hazem A. Mahdy, Hazem Elkady, Mohammed S. Taghour, Alaa Elwan, Mohamed A. Elkady, Elsayed G. E. Elsakka, Eslam B. Elkaeed, Aisha A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly & Ibrahim H. Eissa. (2023) Semi-synthesized anticancer theobromine derivatives targeting VEGFR-2: in silico and in vitro evaluations. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-20.
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Articles from other publishers (2)

José-Luis Rodríguez, Raquel Mateos, Olga Palomino, Maria S. Fernández-Alfonso, Norma Ramos-Cevallos, Luis Inostroza-Ruiz, Nadia Panduro-Tenazoa, Wendy Bada-Laura, Noé Ramírez-Flores & Luis Goya. (2023) Cytoprotective–Antioxidant Effect of Brunfelsia grandiflora Extract on Neuron-like Cells. Applied Sciences 13:22, pages 12233.
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Ibrahim H. Eissa, Reda G. Yousef, Hazem Elkady, Eslam B. Elkaeed, Bshra A. Alsfouk, Dalal Z. Husein, Mostafa A. Asmaey, Ibrahim M. Ibrahim & Ahmed M. Metwaly. (2023) Anti-breast cancer potential of a new xanthine derivative: In silico, antiproliferative, selectivity, VEGFR-2 inhibition, apoptosis induction and migration inhibition studies. Pathology - Research and Practice 251, pages 154894.
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