Discovery of 1H-pyrazolo[3,4-b]pyrazine derivatives as selective allosteric inhibitor of protein tyrosine phosphatase SHP2 for the treatment of KRAS^G12C-mutant non-small cell lung cancer

Wen-Qiang Xua Department of Pharmacy, Binzhou Medical University Hospital, Binzhou, Shandong Province, ChinaView further author information

Shi-Zhou Qia Department of Pharmacy, Binzhou Medical University Hospital, Binzhou, Shandong Province, ChinaView further author information

Ji-Feng Zhaob Shandong Key Laboratory of Medicine and Health (Clinical Applied Pharmacology), Department of Pharmacy, Affiliated Hospital of Weifang Medical University, Weifang, Shandong Province, ChinaView further author information

Li-Peng Lic Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, ChinaView further author information

Chuan-Hua Dingb Shandong Key Laboratory of Medicine and Health (Clinical Applied Pharmacology), Department of Pharmacy, Affiliated Hospital of Weifang Medical University, Weifang, Shandong Province, ChinaCorrespondence[email protected]
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Wen-Shan Liub Shandong Key Laboratory of Medicine and Health (Clinical Applied Pharmacology), Department of Pharmacy, Affiliated Hospital of Weifang Medical University, Weifang, Shandong Province, China;d Clinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang, Shandong Province, ChinaCorrespondence[email protected]
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Discovery of 1H-pyrazolo[3,4-b]pyrazine derivatives as selective allosteric inhibitor of protein tyrosine phosphatase SHP2 for the treatment of KRAS^G12C-mutant non-small cell lung cancer

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Discovery of 1H-pyrazolo[3,4-b]pyrazine derivatives as selective allosteric inhibitor of protein tyrosine phosphatase SHP2 for the treatment of KRASG12C-mutant non-small cell lung cancer

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Discovery of 1H-pyrazolo[3,4-b]pyrazine derivatives as selective allosteric inhibitor of protein tyrosine phosphatase SHP2 for the treatment of KRAS^G12C-mutant non-small cell lung cancer