Citations (46)
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Ramón C. Hermida, Michael H. Smolensky, Artemio Mojón & José R. Fernández. (2023) Critical appraisal of recent translational chronopharmacology and chronotherapeutic reviews, meta-analyses, and pragmatic patient trials discloses significant deficiencies of design and conduct and suspect findings. Chronobiology International 40:8, pages 1146-1167.
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Yong-Jian Geng, Michael H. Smolensky, Oliver Sum-Ping, Ramon Hermida & Richard J. Castriotta. (2023) Circadian rhythms of risk factors and management in atherosclerotic and hypertensive vascular disease: Modern chronobiological perspectives of an ancient disease. Chronobiology International 40:1, pages 33-62.
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Ramón C. Hermida, Ramón G. Hermida-Ayala, Michael H. Smolensky, Artemio Mojón & José R. Fernández. (2020) Ingestion-time – relative to circadian rhythms – differences in the pharmacokinetics and pharmacodynamics of hypertension medications. Expert Opinion on Drug Metabolism & Toxicology 16:12, pages 1159-1173.
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Ramón C. Hermida, Artemio Mojón & José R. Fernández. (2020) Ambulatory blood pressure-based inclusion criteria in the Hygia Chronotherapy Trial. Rebuttal to Lemmer and Middeke. Chronobiology International 37:8, pages 1270-1272.
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Ramón C. Hermida, Michael H. Smolensky, Artemio Mojón, Juan J. Crespo, María T. Ríos, Manuel Domínguez-Sardiña, Alfonso Otero & José R. Fernández. (2020) New perspectives on the definition, diagnosis, and treatment of true arterial hypertension. Expert Opinion on Pharmacotherapy 21:10, pages 1167-1178.
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Reinhold Kreutz, Sverre E. Kjeldsen, Michel Burnier, Krzysztof Narkiewicz, Suzanne Oparil & Giuseppe Mancia. (2020) Blood pressure medication should not be routinely dosed at bedtime. We must disregard the data from the HYGIA project. Blood Pressure 29:3, pages 135-136.
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Juan J. Crespo, Manuel Domínguez-Sardiña, Alfonso Otero, Ana Moyá, María T. Ríos, Elvira Sineiro, María C. Castiñeira, Pedro A. Callejas, Lorenzo Pousa, José L. Salgado, Carmen Durán, Juan J. Sánchez, Artemio Mojón, José R. Fernández & Ramón C. Hermida. (2020) Bedtime hypertension chronotherapy best reduces cardiovascular disease risk as corroborated by the Hygia Chronotherapy Trial. Rebuttal to European Society of Hypertension officials.. Chronobiology International 37:5, pages 771-780.
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Juan J. Crespo, Manuel Domínguez-Sardiña, Alfonso Otero, Ana Moyá, María T. Ríos, Elvira Sineiro, María C. Castiñeira, Pedro A. Callejas, Lorenzo Pousa, José L. Salgado, Carmen Durán & Juan J. Sánchez. (2020) The Hygia Project and Hygia Chronotherapy Trial: insights of we clinical investigators on the impact of the embedded continuing medical education on primary-care practice and improved patient cardiovascular health. Chronobiology International 37:5, pages 759-766.
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Ramón C. Hermida, José R. Fernández & Artemio Mojón. (2020) Current evidence on the circadian-time-dependent effects of hypertension medications and their combinations in relation to findings of MAPEC and Hygia Chronotherapy Trial. Chronobiology International 37:5, pages 751-758.
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José R. Fernández, Artemio Mojón & Ramón C. Hermida. (2020) Chronotherapy of hypertension: advantages of 48-h ambulatory blood pressure monitoring assessments in MAPEC and Hygia Chronotherapy Trial. Chronobiology International 37:5, pages 739-750.
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Ramón C. Hermida, Artemio Mojón & José R. Fernández. (2020) Bedtime hypertension chronotherapy best reduces cardiovascular disease risk as documented by MAPEC and Hygia Chronotherapy outcomes trials. Chronobiology International 37:5, pages 731-738.
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Björn Lemmer & Martin Middeke. (2020) A commentary on the Spanish hypertension studies MAPEC and HYGIA. Chronobiology International 37:5, pages 728-730.
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Ramón C. Hermida, Diana E. Ayala, Artemio Mojón, Michael H. Smolensky & José R. Fernández. (2019) Diagnosis and management of hypertension: around-the-clock ambulatory blood pressure monitoring is substantially more effective and less costly than daytime office blood pressure measurements. Chronobiology International 36:11, pages 1515-1527.
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Ningyin Li, Ruixin Ma, Shixiong Wang, Yang Zhao, Ping Wang, Zhitao Yang, Lingling Jin, Panpan Zhang, Hong Ding, Feng Bai & Jing Yu. (2019) The potential role of testosterone in hypertension and target organ damage in hypertensive postmenopausal women. Clinical Interventions in Aging 14, pages 743-752.
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Alain E. Reinberg, Michael H. Smolensky, Marc Riedel, Cedric Riedel, Eric Brousse & Yvan Touitou. (2017) Do night and around-the-clock firefighters’ shift schedules induce deviation in tau from 24 hours of systolic and diastolic blood pressure circadian rhythms?. Chronobiology International 34:8, pages 1158-1174.
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D. G. Gubin, D. Weinert, S. V. Rybina, L. A. Danilova, S. V. Solovieva, A. M. Durov, N. Y. Prokopiev & P. A. Ushakov. (2017) Activity, sleep and ambient light have a different impact on circadian blood pressure, heart rate and body temperature rhythms. Chronobiology International 34:5, pages 632-649.
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Articles from other publishers (30)
Chau Le Bao Ho & Christopher M. Reid. (2022) Update on trials examining effects of night-time blood pressure lowering drug treatment on prevention of cardiovascular disease. Exploration of Medicine 2:3, pages 461-467.
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Monica L. Guzman-LimonShuai JiangDerek NgJoseph T. Flynn, Bradley WaradySusan L. FurthJoshua A. Samuels. (2022) Nocturnal Hypertension in Children With Chronic Kidney Disease Is Common and Associated With Progression to Kidney Replacement Therapy. Hypertension 79:10, pages 2288-2297.
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Christian Ott & Roland E. Schmieder. (2022) Diagnosis and treatment of arterial hypertension 2021. Kidney International 101:1, pages 36-46.
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Brian P. Delisle, Alfred L. GeorgeJrJr, Jeanne M. Nerbonne, Joseph T. Bass, Crystal M. Ripplinger, Mukesh K. JainTracey O. Hermanstyne, Martin E. Young, Prince J. Kannankeril, Jeanne F. Duffy, Joshua I. Goldhaber, Martica H. HallVirend K. Somers, Michael H. Smolensky, Christine E. Garnett, Ron C. Anafi, Frank A.J.L. Scheer, Kalyanam Shivkumar, Steven A. Shea & Ravi C. Balijepalli. (2021) Understanding Circadian Mechanisms of Sudden Cardiac Death: A Report From the National Heart, Lung, and Blood Institute Workshop, Part 2: Population and Clinical Considerations. Circulation: Arrhythmia and Electrophysiology 14:11.
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Ramón C. Hermida, Diana E. Ayala, Artemio Mojón, Michael H. Smolensky, Juan J. Crespo, Alfonso Otero, Manuel Domínguez-Sardiña, Ana Moyá, María T. Ríos, María C. Castiñeira, Pedro A. Callejas, Lorenzo Pousa, Elvira Sineiro, José L. Salgado, Carmen Durán, Juan J. Sánchez & José R. Fernández. (2021) La presión arterial ambulatoria, en comparación con la medida clínica, mejora notablemente la estratificación del riesgo cardiovascular de Framingham. Revista Española de Cardiología 74:11, pages 953-961.
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Ramón C. Hermida, Diana E. Ayala, Artemio Mojón, Michael H. Smolensky, Juan J. Crespo, Alfonso Otero, Manuel Domínguez-Sardiña, Ana Moyá, María T. Ríos, María C. Castiñeira, Pedro A. Callejas, Lorenzo Pousa, Elvira Sineiro, José L. Salgado, Carmen Durán, Juan J. Sánchez & José R. Fernández. (2021) Cardiovascular disease risk stratification by the Framigham score is markedly improved by ambulatory compared with office blood pressure. Revista Española de Cardiología (English Edition) 74:11, pages 953-961.
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Ricky D. Turgeon, Andrew D. Althouse, Jordana B. CohenBogdan EnacheJohn B. HogeneschMichael E. JohansenRaj MehtaGideon Meyerowitz-Katz, Boback Ziaeian & Swapnil Hiremath. (2021) Lowering Nighttime Blood Pressure With Bedtime Dosing of Antihypertensive Medications: Controversies in Hypertension - Con Side of the Argument. Hypertension 78:3, pages 871-878.
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Mattias Brunström, Sverre E. Kjeldsen, Reinhold Kreutz, Knut Gjesdal, Krzysztof Narkiewicz, Michel Burnier, Suzanne Oparil & Giuseppe Mancia. (2021) Missing Verification of Source Data in Hypertension Research: The HYGIA PROJECT in Perspective. Hypertension 78:2, pages 555-558.
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Chau L. B. Ho, Enayet K. Chowdhury, Jenny Doust, Mark R. Nelson & Christopher M. Reid. (2021) The effect of taking blood pressure lowering medication at night on cardiovascular disease risk. A systematic review. Journal of Human Hypertension 35:4, pages 308-314.
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Michael H Smolensky, Ramon C Hermida & Yong-Jian Geng. (2021) Chronotherapy of cardiac and vascular disease: timing medications to circadian rhythms to optimize treatment effects and outcomes. Current Opinion in Pharmacology 57, pages 41-48.
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Ramón C Hermida, Juan J Crespo, Manuel Domínguez-Sardiña, Alfonso Otero, Ana Moyá, María T Ríos, Elvira Sineiro, María C Castiñeira, Pedro A Callejas, Lorenzo Pousa, José L Salgado, Carmen Durán, Juan J Sánchez, José R Fernández, Artemio Mojón & Diana E Ayala. (2020) Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial. European Heart Journal 41:48, pages 4565-4576.
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Thomas F Lüscher, Kim Fox, Christian Hamm, Rickey E Carter, Stefano Taddei, Maarten Simoons & Filippo Crea. (2020) Scientific integrity: what a journal can and cannot do. European Heart Journal 41:48, pages 4552-4555.
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Ramón C. Hermida, Artemio Mojón, José R. Fernández, Alfonso Otero, Juan J. Crespo, Manuel Domínguez-Sardiña, María T. Ríos & Michael H. Smolensky. (2020) Ambulatory blood pressure monitoring-based definition of true arterial hypertension. Minerva Medica 111:6.
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Reinhold Kreutz, Sverre E. Kjeldsen, Michel Burnier, Krzysztof Narkiewicz, Suzanne Oparil & Giuseppe Mancia. (2020) Disregard the reported data from the HYGIA project: blood pressure medication not to be routinely dosed at bedtime. Journal of Hypertension 38:11, pages 2144-2145.
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Michel Burnier, Reinhold Kreutz, Krzysztof Narkiewicz, Sverre Kjeldsen, Suzanne Oparil & Giuseppe Mancia. (2020) Circadian variations in blood pressure and their implications for the administration of antihypertensive drugs: is dosing in the evening better than in the morning?. Journal of Hypertension 38:8, pages 1396-1406.
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Ramón C Hermida, Artemio Mojón & José R Fernández. (2020) Comparing the design of the primary-care based Hygia Chronotherapy Trial and the Internet-Based TIME Study. European Heart Journal 41:16, pages 1608-1608.
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Greg Guthrie, (Neil Poulter, Thomas Macdonald, Ian Ford, Isla Mackenzie, Evelyn Findlay, Bryan Williams, Morris Brown, Chim Lang & David Webb. (2020) Chronotherapy in hypertension: the devil is in the details. European Heart Journal 41:16, pages 1606-1607.
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Martin Middeke, Björn Lemmer, Reinhold Kreutz, Joachim Schrader & Heinrich Holzgreve. (2020) Antihypertensiva nicht generell abends nehmen. MMW - Fortschritte der Medizin 162:6, pages 34-36.
Crossref
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Liyuan Yan, Jianling Jin, Shili Jiang, Wei Zhu, Meiwen Gao, Xin Zhao & Jiamin Yuan. (2020) QTc interval predicts disturbed circadian blood pressure variation. Open Medicine 15:1, pages 139-146.
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Reham H. Soliman, Jermaine G. Johnston, Eman Y. Gohar, Crystal M. Taylor & David M. Pollock. (2020) Greater natriuretic response to ENaC inhibition in male versus female Sprague-Dawley rats. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 318:2, pages R418-R427.
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Ramón C Hermida, Juan J Crespo, Alfonso Otero, Manuel Domínguez-Sardiña, Ana Moyá, María T Ríos, María C Castiñeira, Pedro A Callejas, Lorenzo Pousa, Elvira Sineiro, José L Salgado, Carmen Durán, Juan J Sánchez, José R Fernández, Artemio Mojón & Diana E Ayala. (2018) Asleep blood pressure: significant prognostic marker of vascular risk and therapeutic target for prevention. European Heart Journal 39:47, pages 4159-4171.
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Lucas De Lavallaz & Carlos G. Musso. (2018) Chronobiology in nephrology: the influence of circadian rhythms on renal handling of drugs and renal disease treatment. International Urology and Nephrology 50:12, pages 2221-2228.
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N. P. Bowles, S. S. Thosar, M. X. Herzig & S. A. Shea. (2018) Chronotherapy for Hypertension. Current Hypertension Reports 20:11.
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G Ryan Crislip, Sarah H Masten & Michelle L Gumz. (2018) Recent advances in understanding the circadian clock in renal physiology. Current Opinion in Physiology 5, pages 38-44.
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Ramón C. Hermida, Diana E. Ayala, José R. Fernández, Artemio Mojón & Michael H. Smolensky. (2018) Hypertension: New perspective on its definition and clinical management by bedtime therapy substantially reduces cardiovascular disease risk. European Journal of Clinical Investigation 48:5.
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Ramón C. Hermida, Diana E. Ayala, Artemio Mojón & José R. Fernández. (2018) Risk of incident chronic kidney disease is better reduced by bedtime than upon-awakening ingestion of hypertension medications. Hypertension Research 41:5, pages 342-353.
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Anabel L. Castro-Grattoni, Gerard Torres, Montserrat Martínez-Alonso, Ferran Barbé, Cecilia Turino, Alicia Sánchez-de-la-Torre, Anunciacion Cortijo, Joaquin Duran-Cantolla, Carlos Egea, Gonzalo Cao & Manuel Sánchez-de-la-Torre. (2017) Blood pressure response to CPAP treatment in subjects with obstructive sleep apnoea: the predictive value of 24-h ambulatory blood pressure monitoring. European Respiratory Journal 50:4, pages 1700651.
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Michael H. Smolensky, Ramón C. Hermida, Diana E. Ayala, Artemio Mojón & José R. Fernández. (2017) Bedtime Chronotherapy with Conventional Hypertension Medications to Target Increased Asleep Blood Pressure Results in Markedly Better Chronoprevention of Cardiovascular and Other Risks than Customary On-awakening Therapy. Heart Failure Clinics 13:4, pages 775-792.
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Ramón C. Hermida, Diana E. Ayala, José R. Fernández, Artemio Mojón, Juan J. Crespo, María T. Ríos & Michael H. Smolensky. (2017) Bedtime Blood Pressure Chronotherapy Significantly Improves Hypertension Management. Heart Failure Clinics 13:4, pages 759-773.
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Ramón C. Hermida, Diana E. Ayala, Michael H. Smolensky, José R. Fernández, Artemio Mojón & Francesco Portaluppi. (2017) Sleep-time blood pressure: Unique sensitive prognostic marker of vascular risk and therapeutic target for prevention. Sleep Medicine Reviews 33, pages 17-27.
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