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Endocrine Research Volume 16, 1990 - Issue 1
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Original Article

Potency And Specificity Of CGS-16949A As An Aromatase Inhibitor

R. J. Santen Department of Medicine, Division of Endocrinology, The Milton S. Hershey Medical Center The Pennsylvania State University, P.O. Box 850, Hershey, PA, 17033
,
P. Langecker Department of Medicine, Division of Endocrinology, The Milton S. Hershey Medical Center The Pennsylvania State University, P.O. Box 850, Hershey, PA, 17033
,
S. J. Santner Department of Urology, Harbor/UCLA Medical Center, 1000 W. Carson Street, Torrance, CA, 90509
,
S. Sikka Department of Urology, Harbor/UCLA Medical Center, 1000 W. Carson Street, Torrance, CA, 90509
,
J. Rajfer Department of Urology, Harbor/UCLA Medical Center, 1000 W. Carson Street, Torrance, CA, 90509
&
R. Swerdloff Department of Medicine and Surgery, Divisions of Endocrinology, Harbor/UCLA Medical Center, 1000 W. Carson Street, Torrance, CA, 90509
Pages 77-91 | Published online: 07 Aug 2009

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Angelo Spinello, Ida Ritacco & Alessandra Magistrato. (2019) Recent advances in computational design of potent aromatase inhibitors: open-eye on endocrine-resistant breast cancers. Expert Opinion on Drug Discovery 14:10, pages 1065-1076.
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Celine Nativelle-Serpentini, Safa Moslemi, Said Yous, Chang Ha Park, Daniel Lesieur, Pascal Sourdaine & Gilles-Eric Séralini. (2004) Synthesis and Evaluation of Benzoxazolinonic Imidazoles and Derivatives as Non-steroidal Aromatase Inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 19:2, pages 119-127.
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Safa Moslemi & Gilles-Eric Seralini. (1997) Inhibition and inactivation of equine aromatase by steroidal and non-steroid al compounds. A comparison with human aromatase inhibition. Journal of Enzyme Inhibition 12:4, pages 241-254.
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Richard J. Santen. (1990) Clinical Use of Aromatase Inhibitors: Current Data and Future Perspectives. Journal of Enzyme Inhibition 4:2, pages 79-99.
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Articles from other publishers (13)

Nivin Samara & Robert F. Casper. 2018. Infertility in Women with Polycystic Ovary Syndrome. Infertility in Women with Polycystic Ovary Syndrome 119 133 .
Debashis Ghosh, Jessica Lo & Chinaza Egbuta. (2016) Recent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure–Function Perspective. Journal of Medicinal Chemistry 59:11, pages 5131-5148.
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Daniel L. Villeneuve, Gerald T. Ankley, Elizabeth A. Makynen, Lindsey S. Blake, Katie J. Greene, Eric B. Higley, John L. Newsted, John P. Giesy & Markus Hecker. (2007) Comparison of fathead minnow ovary explant and H295R cell-based steroidogenesis assays for identifying endocrine-active chemicals. Ecotoxicology and Environmental Safety 68:1, pages 20-32.
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Michael S. Breen, Daniel L. Villeneuve, Miyuki Breen, Gerald T. Ankley & Rory B. Conolly. (2007) Mechanistic Computational Model of Ovarian Steroidogenesis to Predict Biochemical Responses to Endocrine Active Compounds. Annals of Biomedical Engineering 35:6, pages 970-981.
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Alan Conley, Samantha Mapes, C.J Corbin, Doug Greger, Karen Walters, John Trant & Sandra Graham. (2001) A comparative approach to structure–function studies of mammalian aromatases. The Journal of Steroid Biochemistry and Molecular Biology 79:1-5, pages 289-297.
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P Auvray, P Sourdaine, S Moslemi, G.-E Séralini, P Sonnet, C Enguehard, J Guillon, P Dallemagne, R Bureau & S Rault. (1999) MR 20492 and MR 20494: two indolizinone derivatives that strongly inhibit human aromatase. The Journal of Steroid Biochemistry and Molecular Biology 70:1-3, pages 59-71.
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Rang ZHANG, Yuko TSUNODA, Kentaroh KAMIYA, Miki SHIBUSAWA, Mitsuo KUSANO, Yukiko SHIMIZU, Yoshiro TOMA & Takumi YANAIHARA. (1998) Antitumor Effect of the Combination of CGS16949A and 5-FU against Human Breast Cancer Cell Lines. The Showa University Journal of Medical Sciences 10:1, pages 33-39.
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Safa Moslemi, Pierre Silberzahn & Jean-Luc Gaillard. (1995) The synthesis of 19-norandrostenedione from dehydroepiandrosterone in equine placenta is inhibited by aromatase inhibitors 4-hydroxyandrostenedione and fadrozole. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 112:4, pages 613-618.
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Juli Wade & Arthur P. Arnold. (1994) Post-hatching inhibition of aromatase activity does not alter sexual differentiation of the zebra finch song system. Brain Research 639:2, pages 347-350.
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Ming-Chung Lin, Jacob Rajfer, Ronald S. Swerdloff & N?stor F. Gonz?lez-Cadavid. (1993) Testosterone down-regulates the levels of androgen receptor mRNA in smooth muscle cells from the rat corpora cavernosa via aromatization to estrogens. The Journal of Steroid Biochemistry and Molecular Biology 45:5, pages 333-343.
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K. H?ffken. (1993) Experience with aromatase inhibitors in the treatment of advanced breast cancer. Cancer Treatment Reviews 19, pages 37-44.
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Joni A. Torsella, Kenneth M. Pruitt & Chan F. Lam. (1992) A method for the analysis of biological transduction phenomena. Mathematical Biosciences 110:2, pages 191-200.
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Richard J. Santen. (1990) Recent progress in development of aromatase inhibitors. The Journal of Steroid Biochemistry and Molecular Biology 37:6, pages 1029-1035.
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