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Original Article

A Brief Survey of Pineal Gland-Immune System Interrelationships

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Pages 91-113 | Published online: 07 Aug 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Sangita Sutradhar, Anindita Deb & Shiv Shankar Singh. (2022) Melatonin attenuates diabetes-induced oxidative stress in spleen and suppression of splenocyte proliferation in laboratory mice. Archives of Physiology and Biochemistry 128:5, pages 1401-1412.
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Ubaid Ullah, Haroon Badshah, Zulkifal Malik, Zia Uddin, Mahboob Alam, Sadia Sarwar, Akhtar Aman, Arif-ullah Khan & Fawad Ali Shah. (2020) Hepatoprotective effects of melatonin and celecoxib against ethanol-induced hepatotoxicity in rats. Immunopharmacology and Immunotoxicology 42:3, pages 255-263.
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Elif Taslidere, Mukaddes Esrefoglu, Hulya Elbe, Asli Cetin & Burhan Ates. (2014) Protective effects of melatonin and quercetin on experimental lung injury induced by carbon tetrachloride in rats. Experimental Lung Research 40:2, pages 59-65.
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Oguz Aslan Ozen, Murat A. Kus, Ilter Kus, Ozan Alper Alkoc & Ahmet Songur. (2008) Protective Effects of Melatonin Against Formaldehyde-Induced Oxidative Damage and Apoptosis in Rat Testes: An Immunohistochemical and Biochemical Study. Systems Biology in Reproductive Medicine 54:4-5, pages 169-176.
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Katsutaka Oishi, Kentaro Shibusawa, Hitosa Kakazu, Takao Kuriyama, Naoki Ohkura & Kazuhiko Machida. (2006) Extended light exposure suppresses nocturnal increases in cytotoxic activity of splenic natural killer cells in rats. Biological Rhythm Research 37:1, pages 21-35.
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KM Wahidur Rahman, Shigeyuki Sugie, Tomoyuki Watanabe, Takuji Tanaka & Hideki Mori. (2003) Chemopreventive Effects of Melatonin on Diethylnitrosamine and Phenobarbital-Induced Hepatocarcinogenesis in Male F344 Rats. Nutrition and Cancer 47:2, pages 148-155.
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Chandana Haldar, Rajesh Singh & Prasenjit Guchhait. (2001) RELATIONSHIP BETWEEN THE ANNUAL RHYTHMS IN MELATONIN AND IMMUNE SYSTEM STATUS IN THE TROPICAL PALM SQUIRREL, FUNAMBULUS PENNANTI. Chronobiology International 18:1, pages 61-69.
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Alejandro Martin-Cacao, M. A. Lopez-Gonzalez, Juan R. Calvo, Mirta Giordano & Juan M. Guerrero. (1995) Diurnal Variations in [125I]Melatonin Binding by Rat Thymus Membranes: Effects of Continuous Light Exposure and Pinealectomy. Chronobiology International 12:6, pages 382-388.
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Eunsoo Won & Yong-Ku Kim. (2020) Neuroinflammation-Associated Alterations of the Brain as Potential Neural Biomarkers in Anxiety Disorders. International Journal of Molecular Sciences 21:18, pages 6546.
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M. RAMASAMY, R.S. SRIVASTAVA, M. BALAGANGATHARA THLAGAR & D. JAYANTHI. (2016) Effect of pineal proteins/peptides of 10-20 kDa on immunomodulation in guineapigs for brucella abortus strain 19 vaccine. VETERINARY SCIENCE RESEARCH JOURNAL 7:1, pages 31-38.
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Rajesh Kumar Kharwar, Chandana Haldar & Sweta Singh. (2015) Me11b receptor mediated action of melatonin in regulation of lung associated immune system (LAIS) of Perdicula asiatica: An in vitro study. Biologia 70:11, pages 1537-1544.
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Juan R. Calvo, C. González-Yanes & M. D. Maldonado. (2013) The role of melatonin in the cells of the innate immunity: a review. Journal of Pineal Research 55:2, pages 103-120.
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M Ogeturk, I Kus, H Pekmez, H Yekeler, S Sahin & M Sarsilmaz. (2008) Inhibition of carbon tetrachloride–mediated apoptosis and oxidative stress by melatonin in experimental liver fibrosis. Toxicology and Industrial Health 24:4, pages 201-208.
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I Zararsiz, M Sarsilmaz, U Tas, I Kus, S Meydan & E Ozan. (2016) Protective effect of melatonin against formaldehyde-induced kidney damage in rats. Toxicology and Industrial Health 23:10, pages 573-579.
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Chandana Haldar, Seema Rai & Rajesh Singh. (2004) Melatonin blocks dexamethasone-induced immunosuppression in a seasonally breeding rodent Indian palm squirrel, Funambulus pennanti. Steroids 69:6, pages 367-377.
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S. Rai & C. Haldar. (2003) Pineal control of immune status and hematological changes in blood and bone marrow of male squirrels (Funambulus pennanti) during their reproductively active phase. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 136:4, pages 319-328.
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CB Moore & TD Siopes. (2002) Effect of melatonin supplementation on the ontogeny of immunity in the Large White turkey poult. Poultry Science 81:12, pages 1898-1903.
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C.B Moore & T.D Siopes. (2002) Melatonin can produce immunoenhancement in Japanese quail (Coturnix coturnix japonica) without prior immunosuppression. General and Comparative Endocrinology 129:2, pages 122-126.
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Shaoyuan Zhou, Felino R. A. Cagampang, J. Anne Stirland, Andrew S. I. Loudon & Stephen J. Hopkins. (2016) Different Photoperiods Affect Proliferation of Lymphocytes but Not Expression of Cellular, Humoral, or Innate Immunity in Hamsters. Journal of Biological Rhythms 17:5, pages 392-405.
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Brian J. Prendergast, Steven M. Yellon, Long T. Tran & Randy J. Nelson. (2016) Photoperiod Modulates the Inhibitory Effect of In Vitro Melatonin on Lymphocyte Proliferation in Female Siberian Hamsters. Journal of Biological Rhythms 16:3, pages 224-233.
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Deborah L. Drazen, Donna Bilu, Staci D. Bilbo & Randy J. Nelson. (2001) Melatonin enhancement of splenocyte proliferation is attenuated by luzindole, a melatonin receptor antagonist. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 280:5, pages R1476-R1482.
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C. Haldar & Rajesh Singh. (2001) Pineal modulation of thymus and immune function in a seasonally breeding tropical rodent,Funambulus pennanti. Journal of Experimental Zoology 289:2, pages 90-98.
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