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Endocrine Research Volume 23, 1997 - Issue 1-2
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Original Article

Involvement of arachidonic acid and the lipoxygenase pathway in mediating luteinizing hormone-induced testosterone synthesis in rat leydig cells

Pablo G. Mele Department of Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
,
Laura A. Dada Department of Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
,
Cristina Paz Department of Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
,
Isabel Neuman Department of Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
,
Cora B. Cymeryng Department of Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
,
Carlos F. Mendez Department of Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
,
Carla V. Finkielstein Department of Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
,
Fabiana Cornejo Maciel Department of Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
&
Ernesto J. Podestá Department of Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
 show all
Pages 15-26 | Published online: 07 Aug 2009

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R. Castilla, P. Maloberti, F. Castillo, A. Duarte, F. Cano, F. Cornejo Maciel, I. Neuman, C. F. Mendez, C. Paz & E. J. Podestá. (2004) Arachidonic Acid Regulation of Steroid Synthesis: New Partners in the Signaling Pathway of Steroidogenic Hormones. Endocrine Research 30:4, pages 599-606.
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Rocío Castilla Lozano, Paula Maloberti, Carlos F. Mendez, Cristina Paz & Ernesto J. Podestá. (2002) ACTH REGULATION OF MITOCHONDRIAL ACYL-CoA THIOESTERASE ACTIVITY IN Y1 ADRENOCORTICAL TUMOUR CELLS. Endocrine Research 28:4, pages 331-337.
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P. Maloberti, P. G. Mele, I. Neuman, F. Cornejo Maciel, F. Cano, P. Bey, C. Paz & E. J. Podesté. (2000) Regulation of Arachidonic Acid Release in Steroidogenesis: Role of a New Acyl-Coa Thioesterase (Artist). Endocrine Research 26:4, pages 653-662.
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Articles from other publishers (28)

Yong Huang, Yingying Wang, Huiyi Su, Hexi Wang, Haoyu Xu, Chengwei Xu, Fulin Zhou & Yao Zhang. (2023) Association between polyunsaturated fatty acid intake and the prevalence of erectile dysfunction: A cross-sectional analysis of the NHANES 2001–2004. Lipids in Health and Disease 22:1.
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Walaa Faiad, Chadi Soukkarieh & Abdulsamie Hanano. (2023) 2,3,7,8-tetrachlorodibenzo-p-dioxin induces multigenerational testicular toxicity and biosynthetic disorder of testosterone in BALB/C mice: Transcriptional, histopathological and hormonal determinants. Ecotoxicology and Environmental Safety 263, pages 115233.
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María Mercedes Mori Sequeiros Garcia, Cristina Paz, Ana Fernanda Castillo, Yanina Benzo, Matías A. Belluno, Ariana Balcázar Martínez, Paula Mariana Maloberti, Fabiana Cornejo Maciel & Cecilia Poderoso. (2023) New insights into signal transduction pathways in adrenal steroidogenesis: role of mitochondrial fusion, lipid mediators, and MAPK phosphatases. Frontiers in Endocrinology 14.
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Isabel Neuman, Mariana Cooke, Nicolás Agustín Lemiña, Marcelo G. Kazanietz & Fabiana Cornejo Maciel. (2019) 5-oxo-ETE activates migration of H295R adrenocortical cells via MAPK and PKC pathways. Prostaglandins & Other Lipid Mediators 144, pages 106346.
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Nina Zhang, Liqiang Wang, Guoya Luo, Xiaorong Tang, Lizhu Ma, Yuxin Zheng, Shujie Liu, Christopher A. Price & Zhongliang Jiang. (2019) Arachidonic Acid Regulation of Intracellular Signaling Pathways and Target Gene Expression in Bovine Ovarian Granulosa Cells. Animals 9:6, pages 374.
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Igor Ivanov, Hartmut Kuhn & Dagmar Heydeck. (2015) Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15). Gene 573:1, pages 1-32.
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Melina Dattilo, Isabel Neuman, Mariana Muñoz, Paula Maloberti & Fabiana Cornejo Maciel. (2015) OxeR1 regulates angiotensin II and cAMP-stimulated steroid production in human H295R adrenocortical cells. Molecular and Cellular Endocrinology 408, pages 38-44.
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Mariana Cooke, Hernán Di Cónsoli, Paula Maloberti & Fabiana Cornejo Maciel. (2013) Expression and function of OXE receptor, an eicosanoid receptor, in steroidogenic cells. Molecular and Cellular Endocrinology 371:1-2, pages 71-78.
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Shiro Kurusu, Adam SapirsteinHarumi Sawada, Mitsumori Kawaminami & Joseph V. Bonventre. (2011) Group IVA phospholipase A2 regulates testosterone biosynthesis by murine Leydig cells and is required for timely sexual maturation. Biochemical Journal 439:3, pages 403-411.
Crossref
Cristina Paz, Cecilia Poderoso, Paula Maloberti, Fabiana Cornejo Maciel, Carlos Mendez, Juan J. Poderoso & Ernesto J. Podestá. 2009. Mitochondrial Function, Part B: Mitochondrial Protein Kinases, Protein Phosphatases and Mitochondrial Diseases. Mitochondrial Function, Part B: Mitochondrial Protein Kinases, Protein Phosphatases and Mitochondrial Diseases 169 192 .
Rocío Castilla, Mariana Gadaleta, Ana Fernanda Castillo, Alejandra Duarte, Isabel Neuman, Cristina Paz, Fabiana Cornejo Maciel & Ernesto J. Podestá. (2008) New Enzymes Involved in the Mechanism of Action of Epidermal Growth Factor in a Clonal Strain of Leydig Tumor Cells. Endocrinology 149:7, pages 3743-3752.
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XingJia Wang, Xiangling Yin, Randolph B. Schiffer, Steven R. King, Douglas M. Stocco & Paula Grammas. (2008) Inhibition of Thromboxane A Synthase Activity Enhances Steroidogenesis and Steroidogenic Acute Regulatory Gene Expression in MA-10 Mouse Leydig Cells. Endocrinology 149:2, pages 851-857.
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P. Maloberti, F. Cornejo Maciel, A.F. Castillo, R. Castilla, A. Duarte, M.F. Toledo, F. Meuli, P. Mele, C. Paz & E.J. Podestá. (2007) Enzymes involved in arachidonic acid release in adrenal and Leydig cells. Molecular and Cellular Endocrinology 265-266, pages 113-120.
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Ana Fernanda Castillo, Fabiana Cornejo Maciel, Rocío Castilla, Alejandra Duarte, Paula Maloberti, Cristina Paz & Ernesto J Podestá. (2006) cAMP increases mitochondrial cholesterol transport through the induction of arachidonic acid release inside this organelle in Leydig cells. FEBS Journal 273:22, pages 5011-5021.
Crossref
Anna M. BarronStephanie J. FullerGiuseppe VerdileRalph N. Martins. (2006) Reproductive Hormones Modulate Oxidative Stress in Alzheimer's Disease. Antioxidants & Redox Signaling 8:11-12, pages 2047-2059.
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K.H Janbaz, S.A Saeed & A.H Gilani. (2004) Studies on the protective effects of caffeic acid and quercetin on chemical-induced hepatotoxicity in rodents. Phytomedicine 11:5, pages 424-430.
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Hyung-Sub KIM, Mayumi ISHIZUKA, Akio KAZUSAKA & Shoichi FUJITA. (2004) Alterations of Activities of Cytosolic Phospholipase A2 and Arachidonic Acid-Metabolizing Enzymes in Di-(2-Ethylhexyl)Phthalate-Induced Testicular Atrophy. Journal of Veterinary Medical Science 66:9, pages 1119-1124.
Crossref
XingJia Wang, Matthew T. Dyson, Youngah Jo & Douglas M. Stocco. (2003) Inhibition of Cyclooxygenase-2 Activity Enhances Steroidogenesis and Steroidogenic Acute Regulatory Gene Expression in MA-10 Mouse Leydig Cells. Endocrinology 144:8, pages 3368-3375.
Crossref
Xing Jia Wang, Matthew T Dyson, Youngah Jo, Darrell W Eubank & Douglas M Stocco. (2003) Involvement of 5-lipoxygenase metabolites of arachidonic acid in cyclic AMP-stimulated steroidogenesis and steroidogenic acute regulatory protein gene expression. The Journal of Steroid Biochemistry and Molecular Biology 85:2-5, pages 159-166.
Crossref
Paula Maloberti, Rocío Castilla Lozano, Pablo G. Mele, Florencia Cano, Cecilia Colonna, Carlos F. Mendez, Cristina Paz & Ernesto J. Podestá. (2002) Concerted regulation of free arachidonic acid and hormone‐induced steroid synthesis by acyl‐CoA thioesterases and acyl‐CoA synthetases in adrenal cells. European Journal of Biochemistry 269:22, pages 5599-5607.
Crossref
Laurence Walch & Patricia L. Morris. (2002) Cyclooxygenase 2 Pathway Mediates IL-1β Regulation of IL-1α, -1β, and IL-6 mRNA Levels in Leydig Cell Progenitors. Endocrinology 143:9, pages 3276-3283.
Crossref
Xing Jia Wang, Matthew T. Dyson, Carolina Mondillo, Zoraida Patrignani, Omar Pignataro & Douglas M. Stocco. (2002) Interaction between arachidonic acid and cAMP signaling pathways enhances steroidogenesis and StAR gene expression in MA-10 Leydig tumor cells. Molecular and Cellular Endocrinology 188:1-2, pages 55-63.
Crossref
XingJia Wang, Lance P. Walsh, Adam J. Reinhart & Douglas M. Stocco. (2000) The Role of Arachidonic Acid in Steroidogenesis and Steroidogenic Acute Regulatory (StAR) Gene and Protein Expression. Journal of Biological Chemistry 275:26, pages 20204-20209.
Crossref
Domenico ConteFrancesco RomanelliSilvia FilloLaura Guidetti, Aldo IsidoriFrancesco Franceschi, Maurizio LatiniLuigi di Luigi. (1999) Aspirin inhibits androgen response to chorionic gonadotropin in humans. American Journal of Physiology-Endocrinology and Metabolism 277:6, pages E1032-E1037.
Crossref
XingJia Wang & Douglas M Stocco. (1999) Cyclic AMP and arachidonic acid: a tale of two pathways. Molecular and Cellular Endocrinology 158:1-2, pages 7-12.
Crossref
Isabel Neuman, Constanza Lisdero, Carla Finkielstein, Paula Maloberti, Carlos F. Mendez, Juan José Poderoso & Ernesto J. Podestá. (1999) Activation of a thioesterase specific for very-long-chain fatty acids by adrenergic agonists in perfused hearts. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1451:1, pages 101-108.
Crossref
Brian A. Cooke. (1999) Signal transduction involving cyclic AMP-dependent and cyclic AMP-independent mechanisms in the control of steroidogenesis. Molecular and Cellular Endocrinology 151:1-2, pages 25-35.
Crossref
M.Jesús Marinero, Verónica Penalva, José L Oliva, Begoña Colás, Juan C Prieto & M.Pilar López-Ruiz. (1998) Specific effect of arachidonic acid on 17β-hydroxysteroid dehydrogenase in rat Leydig cells. FEBS Letters 422:1, pages 10-14.
Crossref

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