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Sequential Analysis
Design Methods and Applications
Volume 38, 2019 - Issue 2
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Articles

Adaptive two-stage optimal designs for phase II clinical studies that allow early futility stopping

Guogen ShanEpidemiology and Biostatistics Program, Department of Environmental and Occupational Health, School of Public Health, University of Nevada Las Vegas, Las Vegas, Nevada, USA; Correspondence[email protected]
,
Hua ZhangSchool of Computer and Information Engineering, Zhejiang Gongshang University, Hangzhou, Zhejiang, China;
&
Tao JiangDepartment of Statistics, Zhejiang Gongshang University, Hangzhou, Zhejiang, ChinaCorrespondence[email protected]
Pages 199-213 | Received 13 Nov 2017, Accepted 20 Apr 2019, Published online: 09 Jul 2019

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Read on this site (5)

Guogen Shan. (2023) Response adaptive randomization design for a two-stage study with binary response. Journal of Biopharmaceutical Statistics 33:5, pages 575-585.
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Peter Chang, Rongzi Liu, Tingting Hou, Xinyu Yan & Guogen Shan. (2022) Continuity corrected score confidence interval for the difference in proportions in paired data. Journal of Applied Statistics 0:0, pages 1-14.
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Guogen Shan. (2022) Conservative confidence intervals for the intraclass correlation coefficient for clustered binary data. Journal of Applied Statistics 49:10, pages 2535-2549.
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Rezoanoor Rahman & M. Iftakhar Alam. (2022) Stopping for efficacy in single-arm phase II clinical trials. Journal of Applied Statistics 49:10, pages 2447-2466.
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Guogen Shan. (2020) Two-stage optimal designs based on exact variance for a single-arm trial with survival endpoints. Journal of Biopharmaceutical Statistics 30:5, pages 797-805.
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