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Annals of Medicine Volume 54, 2022 - Issue 1
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Gastroenterology & Hepatology

Role of silymarin as antioxidant in clinical management of chronic liver diseases: a narrative review

Alessio Aghemoa Department of Biomedical Sciences, Humanitas Research Hospital IRCCS, Rozzano, ItalyView further author information
,
Olga P. Alekseevab Gastroenterological Center, Semashko National Research University, Moscow, RussiaView further author information
,
Francesco Angelicoc Sapienza School of Medicine, Rome, ItalyView further author information
,
Igor G. Bakulind Department of Propaedeutics of Internal Diseases, Federal State Medical University of Ministry of Health of Russia, Chief Specialist-Therapist of the North-Western Federal district, Moscow, RussiaView further author information
,
Natalia V. Bakulinae Department of Therapy and Clinical Pharmacology, North-Western State Medical University, Moscow, RussiaView further author information
,
Dmitry Bordinf Department of Pancreatic, Biliary, and Upper Digestive Tract Disorders, A.S. Loginov Moscow Clinical Scientific Center, Moscow, RussiaView further author information
,
Alexey O. Bueverovg Department of Gastroenterology and Hepatology, Moscow Medical Academy, Moscow, RussiaView further author information
,
Oxana M. Drapkinah Ministry of Health of the Russian Federation, Chief Specialist of Therapy and General Practice Ministry of Health of Russia, Grozny, Russia;View further author information
,
Anton Gillesseni Department of Internal Medicine, Herz-Jesu-Hospital, Muenster, GermanyView further author information
,
Elvira M. Kagarmanovaj Gastroenterological Department, GBUZ RB City clinical Hospital, Sterlitamak, RussiaView further author information
,
Natalia V. Korochanskayak Gastroenterology Center, Regional Clinical Hospital, Tyumen, RussiaView further author information
,
U. A. Kucheryaviil Department of Propaedeutics of Internal Diseases and Gastroenterology, Moscow State University of Medicine and Dentistry, Moscow, RussiaView further author information
,
Leonid B. Lazebnikm Department of Polyclinic Therapy, Moscow State University of Medicine and Dentistry, Moscow, RussiaCorrespondence[email protected]
View further author information
,
Maria A. Livzann Department of Faculty Therapy, Omsk State Medical University, Omsk, RussiaView further author information
,
Igor V. Maevo Department of Propedeutics of Internal Diseases and Gastroenterology, Moscow State University of Medicine and Dentistry, Moscow, RussiaView further author information
,
Anatolii I. Martynovp Department of Internal Diseases, Moscow State University of Medicine and Dentistry, Moscow, RussiaView further author information
,
Marina F. Osipenkoq Department for Science, Innovations and Informatization, Novosibirsk State Medical University, Novosibirsk, RussiaView further author information
,
Evgenii I. Sasr 2nd Department of Therapy, Ministry of Defense of the Russian Federation, Moscow, RussiaView further author information
,
Antonina Starodubovas Department of Scientific and Clinical Work, INSTITUTE "Federal Research Center of Nutrition and Biotechnologies", Moscow, RussiaView further author information
,
Yurii P. Uspenskyt Department of faculty therapy, Saint Petersburg State Pediatric Medical University (Spbpgmu) of the RF MOH, St. Petersburg, RussiaView further author information
,
Elena V. Vinnitskayau Department of Hepatology, Moscow Clinical Research and Practice Center, Moscow, RussiaView further author information
,
Emilia P. Yakovenkov Department of Gastroenterology, Faculty of Advanced Medical Education of the Russian National Research Medical University, Moscow, RussiaView further author information
&
Alexey A. Yakovlevw Department of gastroenterology and endoscopy, Rostov State Medical, Rostov, RussiaView further author information
 show all
Pages 1548-1560 | Received 17 Dec 2021, Accepted 19 Apr 2022, Published online: 28 May 2022

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He Tong, Li Wang, Jing Shi, Haowei Jin, Kefan Zhang, Yulong Bao, Yongshuai Wu, Yipeng Cheng, Pengxia Liu & Changshan Wang. (2022) Upregulated miR-322-5p regulates cell cycle and promotes cell proliferation and apoptosis by directly targeting Wee1 in mice liver injury. Cell Cycle 21:24, pages 2635-2650.
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Articles from other publishers (10)

Esmaeil Zangani, Hossein Rabbi Angourani, Babak Andalibi, Saeid Vaezi Rad & Andrea Mastinu. (2023) Sodium Nitroprusside Improves the Growth and Behavior of the Stomata of Silybum marianum L. Subjected to Different Degrees of Drought. Life 13:4, pages 875.
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Chun-Ye Zhang, Shuai Liu & Ming Yang. (2023) Antioxidant and anti-inflammatory agents in chronic liver diseases: Molecular mechanisms and therapy. World Journal of Hepatology 15:2, pages 180-200.
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Robert Kyle Phillips, Jörg M. Steiner, Jan S. Suchodolski & Jonathan A. Lidbury. (2023) Urinary 15-F2t-Isoprostane Concentrations in Dogs with Liver Disease. Veterinary Sciences 10:2, pages 82.
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Mohammad Sadiq Jeeyavudeen, Shahanas KA Khan, Sherouk Fouda & Joseph M Pappachan. (2023) Management of metabolic-associated fatty liver disease: The diabetology perspective. World Journal of Gastroenterology 29:1, pages 126-143.
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Rolf Teschke. (2022) Treatment of Drug-Induced Liver Injury. Biomedicines 11:1, pages 15.
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Weipei Yang, Zhongxu Liang, Chengming Wen, Xuehua Jiang & Ling Wang. (2022) Silymarin Protects against Acute Liver Injury Induced by Acetaminophen by Downregulating the Expression and Activity of the CYP2E1 Enzyme. Molecules 27:24, pages 8855.
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Ting Xiao, Zhenghong Guo, Min Fu, Jiaoyan Huang, Xiaowei Wang, Yuqing Zhao, Ling Tao & Xiangchun Shen. (2022) Amelioration of Alcoholic Liver Disease by Activating PXR-Cytochrome P450s Axis with Blackberry Extract. Separations 9:10, pages 321.
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Moon Nyeo Park, Md. Ataur Rahman, Md. Hasanur Rahman, Jong Woo Kim, Min Choi, Jeong Woo Kim, Jinwon Choi, Myunghan Moon, Kazi Rejvee Ahmed & Bonglee Kim. (2022) Potential Therapeutic Implication of Herbal Medicine in Mitochondria-Mediated Oxidative Stress-Related Liver Diseases. Antioxidants 11:10, pages 2041.
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Qi Wang, Xiaoli Zhan, Baikui Wang, Fei Wang, Yuanhao Zhou, Shujie Xu, Xiang Li, Li Tang, Qian Jin, Weifen Li, Li Gong & Aikun Fu. (2022) Modified Montmorillonite Improved Growth Performance of Broilers by Modulating Intestinal Microbiota and Enhancing Intestinal Barriers, Anti-Inflammatory Response, and Antioxidative Capacity. Antioxidants 11:9, pages 1799.
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Jie Song, Xiaoxue Zhang, Meng Wei, Yakun Bo, Xianhui Zhou & Baopeng Tang. (2022) Association between lipoprotein(a) and thromboembolism in patients with non-valvular atrial fibrillation: a cross-sectional study. Lipids in Health and Disease 21:1.
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