Advanced search
Publication Cover
Annals of Medicine Volume 37, 2005 - Issue 1
Submit an article Journal homepage
786
Views
100
CrossRef citations to date
0
Altmetric
Review Article

Role of endothelin in fibrosis and anti‐fibrotic potential of bosentan

Martine Clozel Innovation Centre, Actelion Pharmaceuticals Ltd, Allschwil, SwitzerlandCorrespondence[email protected]
&
Hashem Salloukh Innovation Centre, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland
Pages 2-12 | Published online: 08 Jul 2009

Citations (100)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Harpreet K Lota & Athol U Wells. (2013) The evolving pharmacotherapy of pulmonary fibrosis. Expert Opinion on Pharmacotherapy 14:1, pages 79-89.
Read now
Debendra Pattanaik, Monica Brown & Arnold E Postlethwaite. (2011) Vascular involvement in systemic sclerosis (scleroderma). Journal of Inflammation Research 4, pages 105-125.
Read now
John-David Aubert & Lucienne Juillerat-Jeanneret. (2009) Therapeutic potential of endothelin receptor modulators: lessons from human clinical trials. Expert Opinion on Therapeutic Targets 13:9, pages 1069-1084.
Read now
Jeffrey J Swigris & Kevin K Brown. (2008) Evaluation of bosentan for idiopathic pulmonary fibrosis. Expert Review of Respiratory Medicine 2:3, pages 315-321.
Read now

Articles from other publishers (96)

Hermann A.M. Mucke. (2023) Drug Repurposing Patent Applications April–June 2023. ASSAY and Drug Development Technologies.
Crossref
Nidhi V. Dwivedi, Souvik Datta, Karim El‐Kersh, Ruxana T. Sadikot, Apar K. Ganti, Surinder K. Batra & Maneesh Jain. (2023) GPCRs and fibroblast heterogeneity in fibroblast‐associated diseases . The FASEB Journal 37:8.
Crossref
Aayush Sehgal, Tapan Behl, Sukhbir Singh, Neelam Sharma, Mohammed Albratty, Hassan A. Alhazmi, Abdulkarim M. Meraya, Lotfi Aleya, Aditi Sharma & Simona Bungau. (2022) Exploring the pivotal role of endothelin in rheumatoid arthritis. Inflammopharmacology 30:5, pages 1555-1567.
Crossref
Shailendra K. Gautam, Vipin Dalal, Balasrinivasa R. Sajja, Suprit Gupta, Mansi Gulati, Nidhi V. Dwivedi, Abhijit Aithal, Jesse L. Cox, Satyanarayana Rachagani, Yutong Liu, Vincent Chung, Ravi Salgia, Surinder K. Batra & Maneesh Jain. (2022) Endothelin-axis antagonism enhances tumor perfusion in pancreatic cancer. Cancer Letters 544, pages 215801.
Crossref
Mikko P. K. Liukkonen, Jussi J. Paterno, Niko Kivinen, Leea Siintamo, Ali K. J. Koskela & Kai Kaarniranta. (2021) Epithelial–mesenchymal transition‐related serum markers ET‐1, IL‐8 and TGF‐β2 are elevated in a Finnish wet age‐related macular degeneration cohort. Acta Ophthalmologica 100:5.
Crossref
Necati Örmeci. (2022) Endothelins and liver cirrhosis. Portal Hypertension & Cirrhosis 1:1, pages 66-72.
Crossref
Katharina Schimmel, Kenzo Ichimura, Sushma Reddy, Francois Haddad & Edda Spiekerkoetter. (2022) Cardiac Fibrosis in the Pressure Overloaded Left and Right Ventricle as a Therapeutic Target. Frontiers in Cardiovascular Medicine 9.
Crossref
Andrew L. Koenig, Irina Shchukina, Junedh Amrute, Prabhakar S. Andhey, Konstantin Zaitsev, Lulu Lai, Geetika Bajpai, Andrea Bredemeyer, Gabriella Smith, Cameran Jones, Emily Terrebonne, Stacey L. Rentschler, Maxim N. Artyomov & Kory J. Lavine. (2022) Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure. Nature Cardiovascular Research 1:3, pages 263-280.
Crossref
Kareem Ahmad, Vikramjit Khangoora & Steven D. Nathan. (2022) Lung Disease–Related Pulmonary Hypertension. Cardiology Clinics 40:1, pages 77-88.
Crossref
Krasimir Kostov. (2021) The Causal Relationship between Endothelin-1 and Hypertension: Focusing on Endothelial Dysfunction, Arterial Stiffness, Vascular Remodeling, and Blood Pressure Regulation. Life 11:9, pages 986.
Crossref
Soyoung Son, Jung Min Shin, Sol Shin, Chan Ho Kim, Jae Ah Lee, Hyewon Ko, Eun Sook Lee, Jae Min Jung, Jeongyun Kim & Jae Hyung Park. (2021) Repurposing macitentan with nanoparticle modulates tumor microenvironment to potentiate immune checkpoint blockade. Biomaterials 276, pages 121058.
Crossref
Adriana Torres Crigna, Barbara Link, Marek Samec, Frank A. Giordano, Peter Kubatka & Olga Golubnitschaja. (2021) Endothelin-1 axes in the framework of predictive, preventive and personalised (3P) medicine. EPMA Journal 12:3, pages 265-305.
Crossref
David Dolivo, Adrian Rodrigues, Lauren Sun, Yingxing Li, Chun Hou, Robert Galiano, Seok Jong Hong & Thomas Mustoe. (2021) The Nax (SCN7A) channel: an atypical regulator of tissue homeostasis and disease. Cellular and Molecular Life Sciences 78:14, pages 5469-5488.
Crossref
Hung-Sheng Hua, Heng-Ching Wen, Chih-Ming Weng, Hong-Sheng Lee, Bing-Chang Chen & Chien-Huang Lin. (2021) Histone deacetylase 7 mediates endothelin-1-induced connective tissue growth factor expression in human lung fibroblasts through p300 and activator protein-1 activation. Journal of Biomedical Science 28:1.
Crossref
Valentina Masola, Gianluigi Zaza, Arduino Arduini, Maurizio Onisto & Giovanni Gambaro. (2021) Endothelial Glycocalyx as a Regulator of Fibrotic Processes. International Journal of Molecular Sciences 22:6, pages 2996.
Crossref
Matthew Webber, Stephen P. Jackson, James C. Moon & Gabriella Captur. (2020) Myocardial Fibrosis in Heart Failure: Anti-Fibrotic Therapies and the Role of Cardiovascular Magnetic Resonance in Drug Trials. Cardiology and Therapy 9:2, pages 363-376.
Crossref
Frederik C. Enevoldsen, Jayashree Sahana, Markus Wehland, Daniela Grimm, Manfred Infanger & Marcus Krüger. (2020) Endothelin Receptor Antagonists: Status Quo and Future Perspectives for Targeted Therapy. Journal of Clinical Medicine 9:3, pages 824.
Crossref
Johan van der Vlag & Baranca Buijsers. 2020. Heparanase. Heparanase 647 667 .
Jie Liu, Tao Zhuang, Xiaoli Chen, Lin Zhang & Yuzhen Zhang. (2019) The Roles of a Matricellular CCN Family Protein CCN5 in Cardiac Fibrosis of Heart Failure. Nano LIFE 09:03, pages 1941003.
Crossref
Yi Feng, Zi-Li Sun, Si-Yu Liu, Jun-Jie Wu, Bin-Hong Zhao, Guo-Zhong Lv, Yong Du, Shun Yu, Ming-Lie Yang, Feng-Lai Yuan & Xiao-Jin Zhou. (2019) Direct and Indirect Roles of Macrophages in Hypertrophic Scar Formation. Frontiers in Physiology 10.
Crossref
Liteng Yang, Xin Liu, Ning Zhang, Lifang Chen, Jingyi Xu & Wencheng Tang. (2019) Investigation of circular RNAs and related genes in pulmonary fibrosis based on bioinformatics analysis. Journal of Cellular Biochemistry 120:7, pages 11022-11032.
Crossref
Z. M Akhilgova, M. V Kurkina, Z. R Dzhioeva, A. A Puhaeva & A. G Avtandilov. (2018) Diagnosis and the debatable issues of the treatment of heart failure with preserved ejection fraction. CardioSomatics 9:4, pages 32-37.
Crossref
Lucienne Juillerat-Jeanneret, John-David Aubert, Josip Mikulic & Dela Golshayan. (2018) Fibrogenic Disorders in Human Diseases: From Inflammation to Organ Dysfunction. Journal of Medicinal Chemistry 61:22, pages 9811-9840.
Crossref
Akira Takeda & Yoshiki Ishii. 2017. Contemporary Topics of Pneumonia. Contemporary Topics of Pneumonia.
Scott L. Friedman. 2017. Schiff's Diseases of the Liver. Schiff's Diseases of the Liver 269 289 .
Zaid Abassi, Shadi Hamoud, Ahmad Hassan, Iyad Khamaysi, Omri Nativ, Samuel N. Heyman, Rabia Shekh Muhammad, Neta Ilan, Preeti Singh, Edward Hammond, Gianluigi Zaza, Antonio Lupo, Maurizio Onisto, Gloria Bellin, Valentina Masola, Israel Vlodavsky & Giovani Gambaro. (2017) Involvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545. Oncotarget 8:21, pages 34191-34204.
Crossref
Lu Fang, Andrew J. Murphy & Anthony M. Dart. (2017) A Clinical Perspective of Anti-Fibrotic Therapies for Cardiovascular Disease. Frontiers in Pharmacology 8.
Crossref
Florian Rieder, Claudio Fiocchi & Gerhard Rogler. (2017) Mechanisms, Management, and Treatment of Fibrosis in Patients With Inflammatory Bowel Diseases. Gastroenterology 152:2, pages 340-350.e6.
Crossref
Marjolein Garsen, Olivia Lenoir, Angelique L.W.M.M. Rops, Henry B. Dijkman, Brigith Willemsen, Toin H. van Kuppevelt, Ton J. Rabelink, Jo H.M. Berden, Pierre-Louis Tharaux & Johan van der Vlag. (2016) Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular Glycocalyx. Journal of the American Society of Nephrology 27:12, pages 3545-3551.
Crossref
John-David Aubert & Lucienne Juillerat-Jeanneret. (2016) Endothelin-Receptor Antagonists beyond Pulmonary Arterial Hypertension: Cancer and Fibrosis. Journal of Medicinal Chemistry 59:18, pages 8168-8188.
Crossref
Kundan Iqbal & Clive Kelly. (2015) Treatment of rheumatoid arthritis-associated interstitial lung disease: a perspective review. Therapeutic Advances in Musculoskeletal Disease 7:6, pages 247-267.
Crossref
Tyler Greer, Ling Hao, Anatoliy Nechyporenko, Sanghee Lee, Chad M. Vezina, Will A. Ricke, Paul C. Marker, Dale E. Bjorling, Wade Bushman & Lingjun Li. (2015) Custom 4-Plex DiLeu Isobaric Labels Enable Relative Quantification of Urinary Proteins in Men with Lower Urinary Tract Symptoms (LUTS). PLOS ONE 10:8, pages e0135415.
Crossref
Jianxin Hu, Michael P. Verzi, Ashley S. Robinson, Paul Ling-Fung Tang, Lisa L. Hua, Shan-Mei Xu, Pui-Yan Kwok & Brian L. Black. (2015) Endothelin signaling activates Mef2c expression in the neural crest through a MEF2C-dependent positive-feedback transcriptional pathway . Development.
Crossref
Chih-Ming Weng, Chung-Chi Yu, Min-Liang Kuo, Bing-Chang Chen & Chien-Huang Lin. (2014) Endothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by ETAR-dependent JNK/AP-1 pathway. Biochemical Pharmacology 88:3, pages 402-411.
Crossref
Jianchun Huang, XiaoJun Tang, Xingmei Liang, Qingwei Wen, Shijun Zhang, Feifei Xuan, Jie Jian, Xing Lin & Renbin Huang. (2014) The Effects of 17-Methoxyl-7-Hydroxy-Benzene-Furanchalcone on the Pressure Overload-Induced Progression of Cardiac Hypertrophy to Cardiac Failure. PLoS ONE 9:3, pages e91834.
Crossref
Mark K. Friedberg, Mi-Young Cho, Jing Li, Renato S. Assad, Mei Sun, Sagar Rohailla, Osami Honjo, Christian Apitz & Andrew N. Redington. (2013) Adverse Biventricular Remodeling in Isolated Right Ventricular Hypertension Is Mediated by Increased Transforming Growth Factor–β1 Signaling and Is Abrogated by Angiotensin Receptor Blockade. American Journal of Respiratory Cell and Molecular Biology 49:6, pages 1019-1028.
Crossref
Tamilselvan Subramani, Vidhya Rathnavelu & Noorjahan Banu Alitheen. (2013) The Possible Potential Therapeutic Targets for Drug Induced Gingival Overgrowth. Mediators of Inflammation 2013, pages 1-9.
Crossref
Amresh Raina, Edward T. Horn & Raymond L. Benza. (2012) The Pathophysiology of Endothelin in Complications After Solid Organ Transplantation. Transplantation 94:9, pages 885-893.
Crossref
Wang Ju, Yu Zhihong, Zhou Zhiyou, Huang Qin, Wang Dingding, Sun Li, Zhu Baowei, Wei Xing, He Ying & Hong An. (2012) Inhibition of α-SMA by the Ectodomain of FGFR2c Attenuates Lung Fibrosis. Molecular Medicine 18:6, pages 992-1002.
Crossref
Harry Karmouty‐Quintana, Hongyan Zhong, Luis Acero, Tingting Weng, Ernestina Melicoff, James D. West, Anna Hemnes, Almut Grenz, Holger K. Eltzschig, Timothy S. Blackwell, Yang Xia, Richard A. Johnston, Dewan Zeng, Luiz Belardinelli & Michael R. Blackburn. (2012) The A 2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease . The FASEB Journal 26:6, pages 2546-2557.
Crossref
Brent Boyer, Kimberly W. Hart, Matthew I. Sperling, Christopher J. Lindsell & Sean P. Collins. (2011) Biomarker Changes During Acute Heart Failure Treatment. Congestive Heart Failure 18:2, pages 91-97.
Crossref
Serap Gur, Philip J. Kadowitz & Wayne J.G. Hellstrom. (2012) Drugs of the future for Peyronie’s disease. Medical Hypotheses 78:2, pages 305-311.
Crossref
Konstantinos Kambas, Akrivi Chrysanthopoulou, Ioannis Kourtzelis, Marianna Skordala, Ioannis Mitroulis, Stavros Rafail, Stergios Vradelis, Ioannis Sigalas, You-Qiang Wu, Matthaios Speletas, George Kolios & Konstantinos Ritis. (2011) Endothelin-1 Signaling Promotes Fibrosis In Vitro in a Bronchopulmonary Dysplasia Model by Activating the Extrinsic Coagulation Cascade. The Journal of Immunology 186:11, pages 6568-6575.
Crossref
Andrew Leask. (2011) Possible strategies for anti-fibrotic drug intervention in scleroderma. Journal of Cell Communication and Signaling 5:2, pages 125-129.
Crossref
Fen Guo, David E. Carter & Andrew Leask. (2011) Mechanical Tension Increases CCN2/CTGF Expression and Proliferation in Gingival Fibroblasts via a TGFβ-Dependent Mechanism. PLoS ONE 6:5, pages e19756.
Crossref
Michael S. Simonson & Faramarz Ismail-Beigi. (2011) Endothelin-1 Increases Collagen Accumulation in Renal Mesangial Cells by Stimulating a Chemokine and Cytokine Autocrine Signaling Loop. Journal of Biological Chemistry 286:13, pages 11003-11008.
Crossref
Ingo Strack, Sigrid Schulte, Heike Varnholt, Stephanie Schievenbusch, Ulrich Töx, Katharina Wendland, Hans-Michael Steffen, Uta Drebber, Hans-Peter Dienes & Margarete Odenthal. (2011) β-Adrenoceptor blockade in sclerosing cholangitis of Mdr2 knockout mice: antifibrotic effects in a model of nonsinusoidal fibrosis. Laboratory Investigation 91:2, pages 252-261.
Crossref
Samrina Rehman, Royston Goodacre, Philip J Day, Ardeshir Bayat & Hans V Westerhoff. (2011) Dupuytren's: a systems biology disease. Arthritis Research & Therapy 13:5, pages 238.
Crossref
Carmen Fonseca, David Abraham & Elisabetta A. Renzoni. (2011) Endothelin in Pulmonary Fibrosis. American Journal of Respiratory Cell and Molecular Biology 44:1, pages 1-10.
Crossref
John Varga & Robert Lafyatis. 2011. Rheumatology. Rheumatology 1387 1402.e5 .
Marc Iglarz & Martine Clozel. (2010) At the heart of tissue: endothelin system and end-organ damage. Clinical Science 119:11, pages 453-463.
Crossref
Elizabeth LosadaAnita J. Moon-GradyWilliam C. StrohsnitterDanny WuPhilip C. Ursell. (2010) Anomalous Mitral Arcade in Twin-Twin Transfusion Syndrome. Circulation 122:15, pages 1456-1463.
Crossref
Andrew Leask. (2010) Potential Therapeutic Targets for Cardiac Fibrosis. Circulation Research 106:11, pages 1675-1680.
Crossref
Xiaoqiu Liu, Fengying Li, Shu Qiang Sun, Muthusamy Thangavel, Joseph Kaminsky, Louisa Balazs & Rennolds S. Ostrom. (2010) Fibroblast-specific expression of AC6 enhances β-adrenergic and prostacyclin signaling and blunts bleomycin-induced pulmonary fibrosis. American Journal of Physiology-Lung Cellular and Molecular Physiology 298:6, pages L819-L829.
Crossref
Hong-Jun Peng, De-Zai Dai, Hui Ji & Yin Dai. (2010) The separate roles of endothelin receptors participate in remodeling of matrix metalloproteinase and connexin 43 of cardiac fibroblasts in maladaptive response to isoproterenol. European Journal of Pharmacology 634:1-3, pages 101-106.
Crossref
Ziv Paz & Yehuda Shoenfeld. (2009) Antifibrosis: To Reverse the Irreversible. Clinical Reviews in Allergy & Immunology 38:2-3, pages 276-286.
Crossref
Jeffrey J. Swigris & Kevin K. Brown. (2010) The Role of Endothelin-1 in the Pathogenesis of Idiopathic Pulmonary Fibrosis. BioDrugs 24:1, pages 49-54.
Crossref
Bryan Ross, Pedro D'Orléans-Juste & Adel Giaid. (2010) Potential Role of Endothelin-1 in Pulmonary Fibrosis. American Journal of Respiratory Cell and Molecular Biology 42:1, pages 16-20.
Crossref
Noriyuki Hatano, Yuka Itoh & Katsuhiko Muraki. (2009) Cardiac fibroblasts have functional TRPV4 activated by 4α-phorbol 12,13-didecanoate. Life Sciences 85:23-26, pages 808-814.
Crossref
S. Gao, C.-L. Long, R.-H. Wang & H. Wang. (2009) KATP activation prevents progression of cardiac hypertrophy to failure induced by pressure overload via protecting endothelial function. Cardiovascular Research 83:3, pages 444-456.
Crossref
Nicolas Jullien, Karl Blirando, Fabien Milliat, Jean-Christophe Sabourin, Marc Benderitter & Agnès François. (2009) Up-Regulation of Endothelin Type A Receptor in Human and Rat Radiation Proctitis: Preclinical Therapeutic Approach With Endothelin Receptor Blockade. International Journal of Radiation Oncology*Biology*Physics 74:2, pages 528-538.
Crossref
Masanori Funauchi, K. Kishimoto, H. Shimazu, Y. Nagare, S. Hino, T. Yano & K. Kinoshita. (2008) Effects of bosentan on the skin lesions: an observational study from a single center in Japan. Rheumatology International 29:7, pages 769-775.
Crossref
Ricardo Ladeiras-Lopes, João Ferreira-Martins & Adelino F. Leite-Moreira. (2009) Acute neurohumoral modulation of diastolic function. Peptides 30:2, pages 419-425.
Crossref
Brit Fitzner, Peter Brock, Stephanie-Anna Holzhüter, Horst Nizze, Gisela Sparmann, Jörg Emmrich, Stefan Liebe & Robert Jaster. (2008) Synergistic Growth Inhibitory Effects of the Dual Endothelin-1 Receptor Antagonist Bosentan on Pancreatic Stellate and Cancer Cells. Digestive Diseases and Sciences 54:2, pages 309-320.
Crossref
Anika Jonitz, Brit Fitzner & Robert Jaster. (2009) Molecular determinants of the profibrogenic effects of endothelin-1 in pancreatic stellate cells. World Journal of Gastroenterology 15:33, pages 4143.
Crossref
Angela Clerk, Timothy E. Cullingford, Stephen J. Fuller, Alejandro Giraldo & Peter H. Sugden. (2009) Endothelin-1 regulation of immediate early gene expression in cardiac myocytes: negative feedback regulation of interleukin 6 by Atf3 and Klf2. Advances in Enzyme Regulation 49:1, pages 30-42.
Crossref
Alexander Scriabine & Daniel U. Rabin. 2009. Contemporary Aspects of Biomedical Research - Drug Discovery. Contemporary Aspects of Biomedical Research - Drug Discovery 419 464 .
D. Abraham & M. Dashwood. (2008) Endothelin--role in vascular disease. Rheumatology 47:Supplement 5, pages v23-v24.
Crossref
Mohit Kapoor, Shangxi Liu, Xu Shi-wen, Kun Huh, Matthew McCann, Christopher P. Denton, James R. Woodgett, David J. Abraham & Andrew Leask. (2008) GSK-3β in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1–dependent mechanism. Journal of Clinical Investigation.
Crossref
Marjan Boerma, Junru Wang, Ashwini Kulkarni, Kerrey A. Roberto, Xiaohua Qiu, Richard H. Kennedy & Martin Hauer-Jensen. (2008) Influence of Endothelin 1 Receptor Inhibition on Functional, Structural and Molecular Changes in the Rat Heart after Irradiation. Radiation Research 170:3, pages 275-283.
Crossref
Christian F. Opitz, Ralf Ewert, Wilhelm Kirch & David Pittrow. (2008) Inhibition of endothelin receptors in the treatment of pulmonary arterial hypertension: does selectivity matter?. European Heart Journal 29:16, pages 1936-1948.
Crossref
Andrew Leask. (2008) Targeting the TGFβ, endothelin-1 and CCN2 axis to combat fibrosis in scleroderma. Cellular Signalling 20:8, pages 1409-1414.
Crossref
Vidhya R. Rao, Raghu R. Krishnamoorthy & Thomas Yorio. (2008) Endothelin-1 mediated regulation of extracellular matrix collagens in cells of human lamina cribrosa. Experimental Eye Research 86:6, pages 886-894.
Crossref
María Iribarne, Liliana Ogawa, Vanesa Torbidoni, Cristian M. Dodds, Ricardo A. Dodds & Angela M. Suburo. (2008) Blockade of Endothelinergic Receptors Prevents Development of Proliferative Vitreoretinopathy in Mice. The American Journal of Pathology 172:4, pages 1030-1042.
Crossref
Bashar Kahaleh. (2008) Vascular Disease in Scleroderma: Mechanisms of Vascular Injury. Rheumatic Disease Clinics of North America 34:1, pages 57-71.
Crossref
Thierry C. Gillebert & Adelino F. Leite-Moreira. 2008. Diastolic Heart Failure. Diastolic Heart Failure 21 39 .
Donald P. Bottaro, Nelly Tan & W. Marston Linehan. 2008. Angiogenesis. Angiogenesis 181 191 .
Xu Shi‐wen, Laura Kennedy, Elisabetta A. Renzoni, George Bou‐Gharios, Roland M. du Bois, Carol M. Black, Christopher P. Denton, David J. Abraham & Andrew Leask. (2007) Endothelin is a downstream mediator of profibrotic responses to transforming growth factor β in human lung fibroblasts. Arthritis & Rheumatism 56:12, pages 4189-4194.
Crossref
Xu Shi-Wen, Elisabetta A. Renzoni, Laura Kennedy, Sarah Howat, Yunliang Chen, Jeremy D. Pearson, George Bou-Gharios, Michael R. Dashwood, Roland M. du Bois, Carol M. Black, Christopher P. Denton, David J. Abraham & Andrew Leask. (2007) Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts. Matrix Biology 26:8, pages 625-632.
Crossref
Makoto Kawamura, Hiroaki Itoh, Shigeo Yura, Haruta Mogami, Shin-Ichi Suga, Hisashi Makino, Yoshihiro Miyamoto, Yasunao Yoshimasa, Norimasa Sagawa & Shingo Fujii. (2007) Undernutrition in Utero Augments Systolic Blood Pressure and Cardiac Remodeling in Adult Mouse Offspring: Possible Involvement of Local Cardiac Angiotensin System in Developmental Origins of Cardiovascular Disease. Endocrinology 148:3, pages 1218-1225.
Crossref
Reda E. Girgis & Stephen C. Mathai. (2007) Pulmonary Hypertension Associated with Chronic Respiratory Disease. Clinics in Chest Medicine 28:1, pages 219-232.
Crossref
Leena Kuruvilla, Renuka R. Nair, Umashankar P. R. Arthur, Vijayan Lal & Chandrasekharan Cheranellore Kartha. (2007) Endocardial endothelial celsl stimulate proliferation and collagen synthesis of cardiac fibroblasts. Cell Biochemistry and Biophysics 47:1, pages 65-72.
Crossref
Martine Clozel & Susan Flores. (2007) Endothelin receptors as drug targets in chronic cardiovascular diseases: the rationale for dual antagonism. Drug Development Research 67:11, pages 825-834.
Crossref
Eric Hachulla, David Launay & Marc Humbert. (2006) Bosentan for the treatment of scleroderma. Future Rheumatology 1:5, pages 549-562.
Crossref
K. Ahmadi-Simab, B. Hellmich & W. L. Gross. (2006) Bosentan for severe pulmonary arterial hypertension related to systemic sclerosis with interstitial lung disease. European Journal of Clinical Investigation 36:s3, pages 44-48.
Crossref
C. F. Opitz & R. Ewert. (2006) Dual ETA/ETB vs. selective ETA endothelin receptor antagonism in patients with pulmonary hypertension. European Journal of Clinical Investigation 36:s3, pages 1-9.
Crossref
W. Neuhofer & D. Pittrow. (2006) Role of endothelin and endothelin receptor antagonists in renal disease. European Journal of Clinical Investigation 36:s3, pages 78-88.
Crossref
D. Bonderman, R. Nowotny, N. Skoro-Sajer, C. Adlbrecht & I. M. Lang. (2006) Bosentan therapy for pulmonary arterial hypertension associated with hereditary haemorrhagic telangiectasia. European Journal of Clinical Investigation 36:s3, pages 71-72.
Crossref
Iram Siddiqui, Zia A. Khan, Dameng Lian, Jifu Jiang, Robert Zhong, Bertha Garcia & Subrata Chakrabarti. (2006) Endothelin-Mediated Oncofetal Fibronectin Expression in Chronic Allograft Nephropathy. Transplantation 82:3, pages 406-414.
Crossref
Friedrich Brunner, Carmen Brás-Silva, Ana Sofia Cerdeira & Adelino F. Leite-Moreira. (2006) Cardiovascular endothelins: Essential regulators of cardiovascular homeostasis. Pharmacology & Therapeutics 111:2, pages 508-531.
Crossref
Teresa M Seccia, Anna S Belloni, Diego Guidolin, Daniele Sticchi, Gastone G Nussdorfer, Achille C Pessina & Gian Paolo Rossi. (2006) The renal antifibrotic effects of angiotensin-converting enzyme inhibition involve bradykinin B2 receptor activation in angiotensin II-dependent hypertension. Journal of Hypertension 24:7, pages 1419-1427.
Crossref
Jaspreet Singh Jaggi, Surya V. Seshan, Michael R. McDevitt, George Sgouros, Elizabeth Hyjek & David A. Scheinberg. (2006) Mitigation of radiation nephropathy after internal α-particle irradiation of kidneys. International Journal of Radiation Oncology*Biology*Physics 64:5, pages 1503-1512.
Crossref
Reem M. Haj, J. Erric Cinco & C. David Mazer. (2006) Treatment of pulmonary hypertension with selective pulmonary vasodilators. Current Opinion in Anaesthesiology 19:1, pages 88-95.
Crossref
Lorraine C. Racusen. (2006) Protocol Transplant Biopsies in Kidney Allografts: Why and When Are They Indicated?: Table 1.. Clinical Journal of the American Society of Nephrology 1:1, pages 144-147.
Crossref
A. P. Davenport & J. J. Maguire. 2006. The Vascular Endothelium I. The Vascular Endothelium I 295 329 .
Marc Humbert & Gérald Simonneau. (2005) Drug Insight: endothelin-receptor antagonists for pulmonary arterial hypertension in systemic rheumatic diseases. Nature Clinical Practice Rheumatology 1:2, pages 93-101.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.