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REVIEW ARTICLE

Update on pathophysiology of scleroderma with special reference to immunoinflammatory events

Pages 42-53 | Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Ebru Esen, Didem Arslan Tas, Selcuk Sizmaz, Ipek Turk, Ilker Unal & Nihal Demircan. (2017) Evaluating Choroidal Characteristics in Systemic Sclerosis Using Enhanced Depth Imaging Optical Coherence Tomography. Ocular Immunology and Inflammation 25:3, pages 356-362.
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Yves Wimmersberger & Doris Zuercher. (2009) Graves’ Disease Associated with Primary Systemic Sclerosis. Orbit 28:4, pages 262-263.
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Gleb Slobodin, Elsa Pavlotzky, Julia Panov, Itzhak Rosner, Aharon Kessel & Elias Toubi. (2008) Endothelin-1 Does Not Change the Function of Monocyte-Derived Dendritic Cells Grown from Patients with Systemic Sclerosis. Immunological Investigations 37:8, pages 841-848.
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Magdalena Chrabaszcz, Jolanta Małyszko, Mariusz Sikora, Rosanna Alda-Malicka, Anna Stochmal, Joanna Matuszkiewicz-Rowinska & Lidia Rudnicka. (2020) Renal Involvement in Systemic Sclerosis: An Update. Kidney and Blood Pressure Research 45:4, pages 532-548.
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E. V. Dolgova, A. A. Fedorovich, T. V. Martynyuk, A. N. Rogoza & I. Ye. Chazova. (2019) Functional state of peripheral and microcirculatory blood flow in patients with pulmonary hypertension on the background of systemic connective tissue diseases. Regional blood circulation and microcirculation 18:4, pages 11-18.
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Faizan Babar & Scott D. Cohen. (2018) Thrombotic Microangiopathies with Rheumatologic Involvement. Rheumatic Disease Clinics of North America 44:4, pages 635-649.
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Nadia Bouchenaki, Christine Fardeau, Carlo Chizzolini & Phuc Lehoang. 2016. Intraocular Inflammation. Intraocular Inflammation 821 828 .
Isabel Almeida, Sara Vieira Silva, Ana Raquel Fonseca, Ivone Silva, Carlos Vasconcelos & Margarida Lima. (2015) T and NK Cell Phenotypic Abnormalities in Systemic Sclerosis: a Cohort Study and a Comprehensive Literature Review. Clinical Reviews in Allergy & Immunology 49:3, pages 347-369.
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Debendra Pattanaik, Monica Brown, Bradley C. Postlethwaite & Arnold E. Postlethwaite. (2015) Pathogenesis of Systemic Sclerosis. Frontiers in Immunology 6.
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Dorothea Emig, Alexander Ivliev, Olga Pustovalova, Lee Lancashire, Svetlana Bureeva, Yuri Nikolsky & Marina Bessarabova. (2013) Drug Target Prediction and Repositioning Using an Integrated Network-Based Approach. PLoS ONE 8:4, pages e60618.
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Akhilesh Kumar Shakya & Kutty Selva Nandakumar. (2013) Applications of polymeric adjuvants in studying autoimmune responses and vaccination against infectious diseases. Journal of The Royal Society Interface 10:79, pages 20120536.
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DANIEL E. FURST, ANCILLA W. FERNANDES, SERBAN R. IORGA, WARREN GRETH & TIM BANCROFT. (2012) Annual Medical Costs and Healthcare Resource Use in Patients with Systemic Sclerosis in an Insured Population. The Journal of Rheumatology 39:12, pages 2303-2309.
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Swati Bhattacharyya, Jun Wei, Warren G Tourtellotte, Monique Hinchcliff, Cara G Gottardi & John Varga. (2012) Fibrosis in systemic sclerosis: common and unique pathobiology. Fibrogenesis & Tissue Repair 5:S1.
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Weronica Ek, Anna-Stina Sahlqvist, Lucy Crooks, Roswitha Sgonc, Hermann Dietrich, Georg Wick, Olov Ekwall, Leif Andersson, Örjan Carlborg, Olle Kämpe & Susanne Kerje. (2012) Mapping QTL affecting a systemic sclerosis-like disorder in a cross between UCD-200 and red jungle fowl chickens. Developmental & Comparative Immunology 38:2, pages 352-359.
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Yavuz Pehlivan, Ahmet Mesut Onat, Nurdan Ceylan, Ibrahim Halil Turkbeyler, Hakan Buyukhatipoglu, Gazi Comez, Taner Babacan & Mehmet Tarakcioglu. (2012) Serum leptin, resistin and TNF ‐α levels in patients with systemic sclerosis: the role of adipokines in scleroderma . International Journal of Rheumatic Diseases 15:4, pages 374-379.
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DANIEL E. FURST, ANCILLA W. FERNANDES, ŞERBAN R. IORGA, WARREN GRETH & TIM BANCROFT. (2012) Epidemiology of Systemic Sclerosis in a Large US Managed Care Population. The Journal of Rheumatology 39:4, pages 784-786.
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M Lidar, N Agmon-Levin, P Langevitz & Y Shoenfeld. (2012) Silicone and scleroderma revisited. Lupus 21:2, pages 121-127.
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Judy A. Fulop & John Varga. 2012. Scleroderma. Scleroderma 615 628 .
Patrizia Fuschiotti. (2011) Role of IL-13 in systemic sclerosis. Cytokine 56:3, pages 544-549.
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Thomas A. MedsgerJr.Jr., Dana E. Ivanco, Lela Kardava, Penelope A. Morel, Mary R. Lucas & Patrizia Fuschiotti. (2011) GATA-3 up-regulation in CD8+ T cells as a biomarker of immune dysfunction in systemic sclerosis, resulting in excessive interleukin-13 production. Arthritis & Rheumatism 63:6, pages 1738-1747.
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Gedson Rodrigues de Morais Lima, Camila de Albuquerque Montenegro, Cynthia Layse Ferreira de Almeida, Petrônio Filgueiras de Athayde-Filho, José Maria Barbosa-Filho & Leônia Maria Batista. (2011) Database Survey of Anti-Inflammatory Plants in South America: A Review. International Journal of Molecular Sciences 12:4, pages 2692-2749.
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P. Dieudé, M. Guedj, M. E. Truchetet, J. Wipff, L. Revillod, G. Riemekasten, M. Matucci‐Cerinic, I. Melchers, E. Hachulla, P. Airo, E. Diot, N. Hunzelmann, L. Mouthon, J. Cabane, J. L. Cracowski, V. Riccieri, J. Distler, Z. Amoura, G. Valentini, P. Camaraschi, I. Tarner, C. Frances, P. Carpentier, N. C. Brembilla, O. Meyer, A. Kahan, C. Chizzolini, C. Boileau & Y. Allanore. (2011) Association of the CD226 Ser 307 variant with systemic sclerosis: Evidence of a contribution of costimulation pathways in systemic sclerosis pathogenesis . Arthritis & Rheumatism 63:4, pages 1097-1105.
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Carlo Chizzolini, Nicolò C. Brembilla, Elisa Montanari & Marie-Elise Truchetet. (2011) Fibrosis and immune dysregulation in systemic sclerosis. Autoimmunity Reviews 10:5, pages 276-281.
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Jun Wei, Swati Bhattacharyya, Warren G. Tourtellotte & John Varga. (2011) Fibrosis in systemic sclerosis: Emerging concepts and implications for targeted therapy. Autoimmunity Reviews 10:5, pages 267-275.
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Marie-Elise Truchetet, Nicolò C Brembilla, Elisa Montanari, Yannick Allanore & Carlo Chizzolini. (2011) Increased frequency of circulating Th22 in addition to Th17 and Th2 lymphocytes in systemic sclerosis: association with interstitial lung disease. Arthritis Research & Therapy 13:5, pages R166.
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Georg Wick, Aleksandar Backovic, Evelyn Rabensteiner, Nadine Plank, Christian Schwentner & Roswitha Sgonc. (2010) The immunology of fibrosis: innate and adaptive responses. Trends in Immunology 31:3, pages 110-119.
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Ibrahim Batal, Robyn T. Domsic, Thomas A. Medsger & Sheldon Bastacky. (2010) Scleroderma Renal Crisis: A Pathology Perspective. International Journal of Rheumatology 2010, pages 1-7.
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Ibrahim Batal, Robyn T. Domsic, Aaron Shafer, Thomas A. MedsgerJr.Jr., Lawrence P. Kiss, Parmjeet Randhawa & Sheldon Bastacky. (2009) Renal biopsy findings predicting outcome in scleroderma renal crisis. Human Pathology 40:3, pages 332-340.
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Yerra Koteswara Rao, Shih-Hua Fang, Shih-Chuan Hsieh, Tsung-Hsien Yeh & Yew-Min Tzeng. (2009) The constituents of Anisomeles indica and their anti-inflammatory activities. Journal of Ethnopharmacology 121:2, pages 292-296.
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Sharon Adler & Cynthia C. Nast. 2009. Primer on Kidney Diseases. Primer on Kidney Diseases 242 249 .
Serena Fineschi, Laurence Goffin, Roger Rezzonico, Franco Cozzi, Jean-Michel Dayer, Pier Luigi Meroni & Carlo Chizzolini. (2008) Antifibroblast antibodies in systemic sclerosis induce fibroblasts to produce profibrotic chemokines, with partial exploitation of toll-like receptor 4. Arthritis & Rheumatism 58:12, pages 3913-3923.
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Carlo Chizzolini. (2008) T cells, B cells, and polarized immune response in the pathogenesis of fibrosis and systemic sclerosis. Current Opinion in Rheumatology 20:6, pages 707-712.
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Serena Fineschi, Massimo Bongiovanni, Yves Donati, Souad Djaafar, Filippo Naso, Laurence Goffin, Constance Barazzone Argiroffo, Jean-Claude Pache, Jean-Michel Dayer, Sylvie Ferrari-Lacraz & Carlo Chizzolini. (2008) In Vivo Investigations on Anti-Fibrotic Potential of Proteasome Inhibition in Lung and Skin Fibrosis . American Journal of Respiratory Cell and Molecular Biology 39:4, pages 458-465.
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Francesco Del Galdo, Federica Sotgia, Cecilia J. de Almeida, Jean-Francois Jasmin, Megan Musick, Michael P. Lisanti & Sergio A. Jiménez. (2008) Decreased expression of caveolin 1 in patients with systemic sclerosis: Crucial role in the pathogenesis of tissue fibrosis. Arthritis & Rheumatism 58:9, pages 2854-2865.
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Maria Trojanowska & John Varga. (2007) Molecular pathways as novel therapeutic targets in systemic sclerosis. Current Opinion in Rheumatology 19:6, pages 568-573.
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M. Fabri & T. Krieg. (2007) Pathogenese der systemischen SklerodermiePathogenesis of systemic sclerosis. Der Hautarzt 58:10, pages 838-843.
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Francesco Del Galdo & Sergio A. Jiménez. (2007) T cells expressing allograft inflammatory factor 1 display increased chemotaxis and induce a profibrotic phenotype in normal fibroblasts in vitro. Arthritis & Rheumatism 56:10, pages 3478-3488.
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