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Trends in Clinical Practice

Current trends in the assessment and somatic treatment of resistant/refractory major depression: An overview

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Pages 149-159 | Published online: 08 Jul 2009

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Tia Sternat, Kathryn Fotinos, Alexa Fine, Irvin Epstein & Martin A Katzman. (2018) Low hedonic tone and attention-deficit hyperactivity disorder: risk factors for treatment resistance in depressed adults. Neuropsychiatric Disease and Treatment 14, pages 2379-2387.
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Marcelo T. Berlim, Frederique Van den Eynde, Santiago Tovar-Perdomo, Eduardo Chachamovich, Abraham Zangen & Gustavo Turecki. (2014) Augmenting antidepressants with deep transcranial magnetic stimulation (DTMS) in treatment-resistant major depression. The World Journal of Biological Psychiatry 15:7, pages 570-578.
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Vladimír Tuka, Martina Daňková, Karel Riegel & Martin Matoulek. (2017) Physical activity - the Holy Grail of modern medicine?. Vnitřní lékařství 63:10, pages 729-736.
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Masaki NishidaSenichiro KikuchiKoichi NisijimaShiro Suda. (2017) Actigraphy in Patients With Major Depressive Disorder Undergoing Repetitive Transcranial Magnetic Stimulation. The Journal of ECT 33:1, pages 36-42.
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J.C. Morales-Medina, T. Iannitti, A. Freeman & H.K. Caldwell. (2017) The olfactory bulbectomized rat as a model of depression: The hippocampal pathway. Behavioural Brain Research 317, pages 562-575.
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Nolan R. Williams, E. Baron Short, Thomas Hopkins, Brandon S. Bentzley, Greg L. Sahlem, Jaspreet Pannu, Matt Schmidt, Jeff J. Borckardt, Jeffrey E. Korte, Mark S. George, Istvan Takacs & Ziad Nahas. (2016) Five-Year Follow-Up of Bilateral Epidural Prefrontal Cortical Stimulation for Treatment-Resistant Depression. Brain Stimulation 9:6, pages 897-904.
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Vera De Carlo, Raffaella Calati & Alessandro Serretti. (2016) Socio-demographic and clinical predictors of non-response/non-remission in treatment resistant depressed patients: A systematic review. Psychiatry Research 240, pages 421-430.
Crossref
Nolan R Williams & Alan F Schatzberg. (2016) NMDA antagonist treatment of depression. Current Opinion in Neurobiology 36, pages 112-117.
Crossref
Martina Balestri, Raffaella Calati, Daniel Souery, Alexander Kautzky, Siegfried Kasper, Stuart Montgomery, Joseph Zohar, Julien Mendlewicz & Alessandro Serretti. (2016) Socio-demographic and clinical predictors of treatment resistant depression: A prospective European multicenter study. Journal of Affective Disorders 189, pages 224-232.
Crossref
Larry Culpepper, Philip R. Muskin & Stephen M. Stahl. (2015) Major Depressive Disorder: Understanding the Significance of Residual Symptoms and Balancing Efficacy with Tolerability. The American Journal of Medicine 128:9, pages S1-S15.
Crossref
Aaron J Fisher & Hannah G Bosley. (2015) Personalized assessment and treatment of depression. Current Opinion in Psychology 4, pages 67-74.
Crossref
. 2014. Biomarkers of Brain Injury and Neurological Disorders. Biomarkers of Brain Injury and Neurological Disorders 433 459 .
Yoo-Hyun Um, Hyu-Jung Huh, Sun-Young Kim & Jeong-Ho Chae. (2014) Possible cultural effects on the increments of somatic symptoms in subjectively resilient depressed patients. Asia-Pacific Psychiatry 6:3, pages 259-266.
Crossref
David Abookasis, Ariel Shochat, Elimelech Nesher & Albert Pinhasov. (2014) Exploring diazepam’s effect on hemodynamic responses of mouse brain tissue by optical spectroscopic imaging. Biomedical Optics Express 5:7, pages 2184.
Crossref
M. T. Berlim, F. van den Eynde, S. Tovar-Perdomo & Z. J. Daskalakis. (2013) Response, remission and drop-out rates following high-frequency repetitive transcranial magnetic stimulation (rTMS) for treating major depression: a systematic review and meta-analysis of randomized, double-blind and sham-controlled trials. Psychological Medicine 44:2, pages 225-239.
Crossref
Melissa L. Barron, Eryn L. Werry, Iain S. McGregor & Michael Kassiou. 2014. Pathologies of Calcium Channels. Pathologies of Calcium Channels 635 661 .
Thomas L. Schwartz. (2013) A neuroscientific update on monoamine oxidase and its inhibitors. CNS Spectrums 18:s1, pages 22-33.
Crossref
Mubarek Abera, Kenfe Tesfay, Tariku Dejene, Mirkuzie Kerie & Sudhakar Morankar. (2013) Efficacy of repetitive transcranial magnetic stimulation versus electroconvulsive therapy in the treatment of medication resistant major depressive disorder: a systematic review protocol. JBI Database of Systematic Reviews and Implementation Reports 11:11, pages 1-7.
Crossref
Joseph Ciccolo & William KraemerShawn Arent & Brandon Alderman. 2013. Resistance Training for the Prevention and Treatment of Chronic Disease. Resistance Training for the Prevention and Treatment of Chronic Disease 161 176 .
Donald F. Smith. (2013) Benefits of flavanol-rich cocoa-derived products for mental well-being: A review. Journal of Functional Foods 5:1, pages 10-15.
Crossref
Nils Gebhardt, Karl-Jürgen Bär, Michael K. Boettger, Gisela Grecksch, Gerburg Keilhoff, Rupert Reichart & Axel Becker. (2013) Vagus nerve stimulation ameliorated deficits in one-way active avoidance learning and stimulated hippocampal neurogenesis in bulbectomized rats. Brain Stimulation 6:1, pages 78-83.
Crossref
Masatake Kurita, Satoshi Nishino, Maiko Kato, Yukio Numata & Tadahiro Sato. (2012) Plasma Brain-Derived Neurotrophic Factor Levels Predict the Clinical Outcome of Depression Treatment in a Naturalistic Study. PLoS ONE 7:6, pages e39212.
Crossref
Sam Restifo. (2012) Walking on thin ice: the use of triple antidepressant combinations in refractory melancholic depression. Australasian Psychiatry 20:2, pages 134-137.
Crossref
Emily Jenkins & Elliot M. Goldner. (2012) Approaches to Understanding and Addressing Treatment-Resistant Depression: A Scoping Review. Depression Research and Treatment 2012, pages 1-7.
Crossref
Cecilio Lopez-Munoz & Francisco AlamoJulio Morales-Medina & Rémi Quirion. 2011. Neurobiology of Depression. Neurobiology of Depression 325 340 .
Arash Mowla & Ehsan Kardeh. (2011) Topiramate augmentation in patients with resistant major depressive disorder: A double-blind placebo-controlled clinical trial. Progress in Neuro-Psychopharmacology and Biological Psychiatry 35:4, pages 970-973.
Crossref
Marcelo T. Berlim, Alexander McGirr, Marie-Martine Beaulieu & Gustavo Turecki. (2011) High frequency repetitive transcranial magnetic stimulation as an augmenting strategy in severe treatment-resistant major depression: A prospective 4-week naturalistic trial. Journal of Affective Disorders 130:1-2, pages 312-317.
Crossref
Peter J. Carek, Sarah E. Laibstain & Stephen M. Carek. (2011) Exercise for the Treatment of Depression and Anxiety. The International Journal of Psychiatry in Medicine 41:1, pages 15-28.
Crossref
Julio César Morales-Medina, Yvan Dumont & Rémi Quirion. (2010) A possible role of neuropeptide Y in depression and stress. Brain Research 1314, pages 194-205.
Crossref
Jerome Sarris, David J. Kavanagh & Gerard Byrne. (2010) Adjuvant use of nutritional and herbal medicines with antidepressants, mood stabilizers and benzodiazepines. Journal of Psychiatric Research 44:1, pages 32-41.
Crossref
Thorsten Mikoteit & Martin Hatzinger. (2009) Chronische Depression. Zeitschrift für Psychiatrie, Psychologie und Psychotherapie 57:4, pages 245-251.
Crossref
Gin S Malhi. (2008) Upping the ante on antidepressants. Bipolar Disorders 10:8, pages 975-978.
Crossref

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