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Annals of Medicine Volume 40, 2008 - Issue 6
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Review Article

Does the renin-angiotensin system also regulate intra-ocular pressure?

Anu Vaajanen Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
,
Satu Luhtala Department of Biological and Environmental Science, University of Jyväskylä, Finland; Division of Biotechnology, University of Jyväskylä, Finland
,
Olli Oksala Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
&
Professor Heikki Vapaatalo Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
Pages 418-427 | Received 17 Dec 2007, Published online: 08 Jul 2009

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Mervi Holappa, Heikki Vapaatalo & Anu Vaajanen. (2020) Local ocular renin–angiotensin–aldosterone system: any connection with intraocular pressure? A comprehensive review. Annals of Medicine 52:5, pages 191-206.
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Marcella Nebbioso, Giuseppe Buomprisco, Antonia Pascarella & Nicola Pescosolido. (2017) Modulatory effects of 1,25-dihydroxyvitamin D3 on eye disorders: A critical review. Critical Reviews in Food Science and Nutrition 57:3, pages 559-565.
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Phatsawee Jansook, Chutimon Muankaew, Einar Stefánsson & Thorsteinn Loftsson. (2015) Development of eye drops containing antihypertensive drugs: formulation of aqueous irbesartan/γCD eye drops. Pharmaceutical Development and Technology 20:5, pages 626-632.
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June Chen, Stephen A Runyan & Michael R Robinson. (2011) Novel ocular antihypertensive compounds in clinical trials. Clinical Ophthalmology 5, pages 667-677.
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Heikki Vapaatalo, Hanna Kotikoski & Olli Oksala. (2010) Role of nitric oxide in the regulation of intraocular pressure: a possibility for glaucoma treatment. Expert Review of Ophthalmology 5:6, pages 751-758.
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Erdinc Aydin, Helin Deniz Demir & Semsettin Sahin. (2010) Plasma and Aqueous Humor Angiotensin-Converting Enzyme Levels in Patients with Diabetic Retinopathy. Current Eye Research 35:3, pages 230-234.
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EKATERINA V. POPOVA, VICTORIA E. TIKHOMIROVA, OLGA V. BEZNOS, NATALIA B. CHESNOKOVA, YURI V. GRIGORIEV & OLGA A. KOST. (2023) CHITOSAN NANOPARTICLES - THE DRUG DELIVERY SYSTEM TO THE ANTERIOR SEGMENT OF THE EYE. Lomonosov chemistry journal 64:№2, 2023, pages 141-151.
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E. V. Popova, V. E. Tikhomirova, O. V. Beznos, N. B. Chesnokova, Y. V. Grigoriev & O. A. Kost. (2023) Chitosan Nanoparticles: The Drug Delivery System to the Anterior Segment of the Eye. Moscow University Chemistry Bulletin 78:2, pages 82-88.
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Farhan Khashim Alswailmi. (2023) A Cross Talk between the Endocannabinoid System and Different Systems Involved in the Pathogenesis of Hypertensive Retinopathy. Pharmaceuticals 16:3, pages 345.
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Ekaterina Popova, Olesya Matveeva, Olga Beznos, Victoria Tikhomirova, Elena Kudryashova, Yuri Grigoriev, Natalia Chesnokova & Olga Kost. (2023) Chitosan-Covered Calcium Phosphate Particles Co-Loaded with Superoxide Dismutase 1 and ACE Inhibitor: Development, Characterization and Effect on Intraocular Pressure. Pharmaceutics 15:2, pages 550.
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Brandon Huynh, Peter Shah, Freda Sii, Damien Hunter, Nicole Carnt & Andrew White. (2021) Low systemic vitamin D as a potential risk factor in primary open-angle glaucoma: a review of current evidence. British Journal of Ophthalmology 105:5, pages 595-601.
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Tae Ryom Oh, Kyung-Do Han, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma & Soo Wan Kim. (2021) Hypertension as a risk factor for retinal vein occlusion in menopausal women. Medicine 100:43, pages e27628.
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Preenie deS Senanayake, Vera L Bonilha, John W Peterson, Yoshiro Yamada, Sadashiva S Karnik, Firouz Daneshgari, K Bridget Brosnihan & Joe G Hollyfield. (2018) Retinal angiotensin II and angiotensin-(1-7) response to hyperglycemia and an intervention with captopril. Journal of the Renin-Angiotensin-Aldosterone System 19:3, pages 147032031878932.
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Mervi Holappa, Heikki Vapaatalo & Anu Vaajanen. (2017) Many Faces of Renin-angiotensin System - Focus on Eye. The Open Ophthalmology Journal 11:1, pages 122-142.
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Justin C Sherwin, Jan Kokavec & Simon N Thornton. (2015) Hydration, fluid regulation and the eye: in health and disease. Clinical & Experimental Ophthalmology 43:8, pages 749-764.
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Najam A. Sharif. (2015) Novel Potential Treatment Modalities for Ocular Hypertension: Focus on Angiotensin and Bradykinin System Axes. Journal of Ocular Pharmacology and Therapeutics 31:3, pages 131-145.
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Mervi Holappa, Jarkko Valjakka & Anu Vaajanen. (2015) Angiotensin(1-7) and ACE2, “The Hot Spots” of Renin-Angiotensin System, Detected in the Human Aqueous Humor. The Open Ophthalmology Journal 9:1, pages 28-32.
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Mervi Holappa. (2015) Ocular renin-angiotensin system with special reference in the anterior part of the eye. World Journal of Ophthalmology 5:3, pages 110.
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Augusto C. Montezano, Aurelie Nguyen Dinh Cat, Francisco J. Rios & Rhian M. Touyz. (2014) Angiotensin II and Vascular Injury. Current Hypertension Reports 16:6.
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Michael J. Giese & Robert C. Speth. (2014) The ocular renin–angiotensin system: A therapeutic target for the treatment of ocular disease. Pharmacology & Therapeutics 142:1, pages 11-32.
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John KuchteyRachel W. Kuchtey. (2014) The Microfibril Hypothesis of Glaucoma: Implications for Treatment of Elevated Intraocular Pressure. Journal of Ocular Pharmacology and Therapeutics 30:2-3, pages 170-180.
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Vasiliki Katsi, Maria Marketou, Charalambos Vlachopoulos, Dimitris Tousoulis, George Souretis, Nikolaos Papageorgiou, Christodoulos Stefanadis, Panos Vardas & Ioannis Kallikazaros. (2012) Impact of Arterial Hypertension on the Eye. Current Hypertension Reports 14:6, pages 581-590.
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Galina D. Kutuzova, B’Ann T. Gabelt, Julie A. Kiland, Elizabeth A. Hennes-Beann, Paul L. Kaufman & Hector F. DeLuca. (2012) 1α,25-Dihydroxyvitamin D3 and its analog, 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 (2MD), suppress intraocular pressure in non-human primates. Archives of Biochemistry and Biophysics 518:1, pages 53-60.
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Rong-Fang Wang, Steven M. Podos, Janet B. Serle & Ovidiu C. Baltatu. (2012) Effect of SPP 635, a renin inhibitor, on intraocular pressure in glaucomatous monkey eyes. Experimental Eye Research 94:1, pages 146-149.
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Anu Vaajanen & Heikki Vapaatalo. (2011) Local Ocular Renin-Angiotensin System - A Target for Glaucoma Therapy?. Basic & Clinical Pharmacology & Toxicology 109:4, pages 217-224.
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Carmine Savoia, Dylan Burger, Nobu Nishigaki, Augusto Montezano & Rhian M. Touyz. (2011) Angiotensin II and the vascular phenotype in hypertension. Expert Reviews in Molecular Medicine 13.
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Anita MehtaLaxmi IyerSanjay ParmarGaurang ShahRamesh Goyal. (2010) Oculohypotensive effect of perindopril in acute and chronic models of glaucoma in rabbits. Canadian Journal of Physiology and Pharmacology 88:5, pages 595-600.
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Tomohiko Usui, Susumu Ishida & Shiro Amano. (2009) Inflammatory Corneal Neovascularization and Tissue Renin-Angiotensin System. Cornea 28:11, pages S54-S57.
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. (2009) Current World Literature. Current Opinion in Endocrinology, Diabetes & Obesity 16:3, pages 260-277.
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Satu LuhtalaAnu VaajanenOlli OksalaJarkko ValjakkaHeikki Vapaatalo. (2009) Activities of Angiotensin-Converting Enzymes ACE1 and ACE2 and Inhibition by Bioactive Peptides in Porcine Ocular Tissues. Journal of Ocular Pharmacology and Therapeutics 25:1, pages 23-28.
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