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Review Article

Can misfolded proteins be beneficial? The HAMLET case

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Pages 162-176 | Received 11 Mar 2008, Published online: 08 Jul 2009

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Chockry Barbana, Lourdes Sánchez & MaríaD. Pérez. (2011) Bioactivity of α-Lactalbumin Related to its Interaction with Fatty Acids: A Review. Critical Reviews in Food Science and Nutrition 51:8, pages 783-794.
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Neha Raina, Amit Kumar Singh, Md. Imtaiyaz Hassan, Faizan Ahmad & Asimul Islam. (2020) Concentration dependent effect of ethylene glycol on the structure and stability of holo α-lactalbumin: Characterization of intermediate state amidst soft interactions. International Journal of Biological Macromolecules 164, pages 2151-2161.
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James C.S. Ho, Aftab Nadeem & Catharina Svanborg. (2017) HAMLET – A protein-lipid complex with broad tumoricidal activity. Biochemical and Biophysical Research Communications 482:3, pages 454-458.
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Arunima Chaudhuri, Xavier Prasanna, Priyanka Agiru, Hirak Chakraborty, Anna Rydström, James C. S. Ho, Catharina Svanborg, Durba Sengupta & Amitabha Chattopadhyay. (2016) Protein-dependent Membrane Interaction of A Partially Disordered Protein Complex with Oleic Acid: Implications for Cancer Lipidomics. Scientific Reports 6:1.
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Saiyi Zhong, Shouchun Liu, Suhua Chen, Hai Liu, Siyi Zhou, Xiaoming Qin & Weimin Wang. (2015) Cytotoxicity and Apoptosis Induction of Bovine Alpha-lactalbumin-oleic Acid Complex in Human Breast Cancer Cells. Food Science and Technology Research 21:1, pages 103-110.
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Manoj Puthia, Petter Storm, Aftab Nadeem, Sabrina Hsiung & Catharina Svanborg. (2014) Prevention and treatment of colon cancer by peroral administration of HAMLET (human α-lactalbumin made lethal to tumour cells). Gut 63:1, pages 131-142.
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Soyoung Min, James Meehan, Louise M. Sullivan, Níal P. Harte, Yongjing Xie, Gavin P. Davey, Catharina Svanborg, André Brodkorb & K. Hun Mok. (2012) Alternatively folded proteins with unexpected beneficial functions. Biochemical Society Transactions 40:4, pages 746-751.
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David M Irwin, Jason M Biegel & Caro-Beth Stewart. (2011) Evolution of the mammalian lysozyme gene family. BMC Evolutionary Biology 11:1.
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Christel Rothe Brinkmann, Christian Würtz Heegaard, Torben Ellebæk Petersen, Jens Christian Jensenius & Steffen Thiel. (2011) The toxicity of bovine α‐lactalbumin made lethal to tumor cells is highly dependent on oleic acid and induces killing in cancer cell lines and noncancer‐derived primary cells. The FEBS Journal 278:11, pages 1955-1967.
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Silvia Lisa, Massimiliano Meli, Gema Cabello, Ruth Gabizon, Giorgio Colombo & María Gasset. (2010) The structural intolerance of the PrP α-fold for polar substitution of the helix-3 methionines. Cellular and Molecular Life Sciences 67:16, pages 2825-2838.
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Károly Lapis. (2010) Gazdavédő peptidek és peptidomimetikumok, mint a rákterápia potenciális új eszközeiHost defense peptides and peptidomimetics as new weapons for cancer treatment. Magyar Onkológia 54:1, pages 47-58.
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Serena Tolin, Giorgia De Franceschi, Barbara Spolaore, Erica Frare, Marcella Canton, Patrizia Polverino de Laureto & Angelo Fontana. (2009) The oleic acid complexes of proteolytic fragments of α‐lactalbumin display apoptotic activity. The FEBS Journal 277:1, pages 163-173.
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Jenny Pettersson-Kastberg, Ann-Kristin Mossberg, Maria Trulsson, Yeon Joong Yong, Soyoung Min, Yoongho Lim, John E. O'Brien, Catharina Svanborg & K. Hun Mok. (2009) α-Lactalbumin, Engineered to be Nonnative and Inactive, Kills Tumor Cells when in Complex with Oleic Acid: A New Biological Function Resulting from Partial Unfolding. Journal of Molecular Biology 394:5, pages 994-1010.
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Kristina Wilhelm, Adas Darinskas, Wim Noppe, Elke Duchardt, K. Hun Mok, Vladana Vukojević, Jürgen Schleucher & Ludmilla A. Morozova-Roche. (2009) Protein oligomerization induced by oleic acid at the solid-liquid interface - equine lysozyme cytotoxic complexes. FEBS Journal 276:15, pages 3975-3989.
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