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Review Article

Cannabinoids and the skeleton: From marijuana to reversal of bone loss

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Pages 560-567 | Published online: 21 Dec 2009

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Read on this site (4)

Dragos Apostu, Ondine Lucaciu, Alexandru Mester, Horea Benea, Daniel Oltean-Dan, Florin Onisor, Mihaela Baciut & Simion Bran. (2019) Cannabinoids and bone regeneration. Drug Metabolism Reviews 51:1, pages 65-75.
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Joanna Makowiecka & Karolina Wielgus. (2014) Therapeutic Potential of Cannabinoids—Perspectives for the Future. Journal of Natural Fibers 11:4, pages 283-311.
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Ioanna Vasileiou, Georgia Fotopoulou, Marina Matzourani, Efstratios Patsouris & Stamatios Theocharis. (2013) Evidence for the involvement of cannabinoid receptors' polymorphisms in the pathophysiology of human diseases. Expert Opinion on Therapeutic Targets 17:4, pages 363-377.
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Itai Bab & Orr Ofek. (2011) Targeting the CB2 cannabinoid receptor in osteoporosis. Expert Review of Endocrinology & Metabolism 6:2, pages 135-138.
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Articles from other publishers (73)

Rivka Ihejirika-Lomedico & Harold Fogel. (2023) Cannabinoids in Spine Surgery: A Comprehensive Review. Operative Techniques in Orthopaedics 33:4, pages 101065.
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Si-jing Hu, Gang Cheng, Gao-ce Chen, Hao Zhou, Qi Zhang, Qi-ming Zhao, Chen-xia Lian, Zi-hui Zhao, Quan-long Zhang, Ting Han, Qiao-yan Zhang & Lu-ping Qin. (2023) Cannabinoid receptors type 2: Function and Development in Agonist Discovery from synthetic and natural sources with Applications for the Therapy of Osteoporosis. Arabian Journal of Chemistry, pages 105536.
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Yao Xiao, Changhao Han, Yunhao Wang, Xinshu Zhang, Rong Bao, Yuange Li, Huajiang Chen, Bo Hu & Shen Liu. (2023) Interoceptive regulation of skeletal tissue homeostasis and repair. Bone Research 11:1.
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Rivka Ihejirika-Lomedico, Karan Patel, Daniel B Buchalter, David J Kirby, Devan Mehta, John F Dankert, Emma Muiños-López, Yael Ihejirika & Philipp Leucht. (2023) Non-psychoactive Cannabidiol Prevents Osteoporosis in an Animal Model and Increases Cell Viability, Proliferation, and Osteogenic Gene Expression in Human Skeletal Stem and Progenitor Cells. Calcified Tissue International 112:6, pages 716-726.
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Lina Yu, Liting Zeng, Zeyu Zhang, Guanxiong Zhu, Zidan Xu, Junyi Xia, Jinlong Weng, Jiang Li & Janak Lal Pathak. (2023) Cannabidiol Rescues TNF-α-Inhibited Proliferation, Migration, and Osteogenic/Odontogenic Differentiation of Dental Pulp Stem Cells. Biomolecules 13:1, pages 118.
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María Gómez-Cañas, Carmen Rodríguez-Cueto, Valentina Satta, Inés Hernández-Fisac, Elisa Navarro & Javier Fernández-Ruiz. 2023. Endocannabinoid Signaling. Endocannabinoid Signaling 67 94 .
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Marlissa A. Campbell, Poorni Iyer, Farla Kaufman, Allegra Kim, Francisco Moran, Yassaman Niknam, Lily Wu, Martha S. Sandy & Lauren Zeise. (2022) Animal evidence considered in determination of cannabis smoke and Δ 9 ‐tetrahydrocannabinol as causing reproductive toxicity (developmental endpoint); Part I. Somatic development . Birth Defects Research 114:18, pages 1143-1154.
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Jianchao Qi, Zhe Zheng, Liqiu Hu, Huizhen Wang, Bin Tang & Lijun Lin. (2022) Development and characterization of cannabidiol-loaded alginate copper hydrogel for repairing open bone defects in vitro. Colloids and Surfaces B: Biointerfaces 212, pages 112339.
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Federica Saponaro, Rebecca Ferrisi, Francesca Gado, Beatrice Polini, Alessandro Saba, Clementina Manera & Grazia Chiellini. (2021) The Role of Cannabinoids in Bone Metabolism: A New Perspective for Bone Disorders. International Journal of Molecular Sciences 22:22, pages 12374.
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Magdalena Kostrzewa, Ali Mokhtar Mahmoud, Roberta Verde, Federica Scotto di Carlo, Fernando Gianfrancesco, Fabiana Piscitelli & Alessia Ligresti. (2021) Modulation of Endocannabinoid Tone in Osteoblastic Differentiation of MC3T3-E1 Cells and in Mouse Bone Tissue over Time. Cells 10:5, pages 1199.
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Benjamin Brennecke, Thais Gazzi, Kenneth Atz, Jürgen Fingerle, Pascal Kuner, Torsten Schindler, Guy de Weck, Marc Nazaré & Uwe Grether. (2021) Cannabinoid receptor type 2 ligands: an analysis of granted patents since 2010. Pharmaceutical Patent Analyst 10:3, pages 111-163.
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Garwin Chin, Brent A. F. Etiz, Ariana M. Nelson, Philip K. Lim & John A. Scolaro. (2021) Knowledge and Opinion on Cannabinoids Among Orthopaedic Traumatologists. JAAOS: Global Research and Reviews 5:4.
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J. Stewart Buck, Ainsley K. Bloomer, Meghan K. Wally, Rachel B. Seymour & Joseph R. Hsu. (2020) The Current Evidence for Marijuana as Medical Treatment. Journal of Bone and Joint Surgery 102:23, pages 2096-2105.
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Joel Ehrenkranz & Michael A Levine. (2019) Bones and Joints: The Effects of Cannabinoids on the Skeleton. The Journal of Clinical Endocrinology & Metabolism 104:10, pages 4683-4694.
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Donald Bourne, Wesley Plinke, Elizabeth R. Hooker & Carrie M. Nielson. (2017) Cannabis use and bone mineral density: NHANES 2007–2010. Archives of Osteoporosis 12:1.
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Cui’e Lu, Linyu Shi, Bei Sun, Yu Zhang, Bailing Hou, Yu’e Sun, Zhengliang Ma & Xiaoping Gu. (2016) A Single Intrathecal or Intraperitoneal Injection of CB2 Receptor Agonist Attenuates Bone Cancer Pain and Induces a Time-Dependent Modification of GRK2. Cellular and Molecular Neurobiology 37:1, pages 101-109.
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Andreas Zimmer. (2016) A collaboration investigating endocannabinoid signalling in brain and bone. Journal of Basic and Clinical Physiology and Pharmacology 27:3, pages 229-235.
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